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Review: taking Lunesta and Benadryl together

Summary: drug interactions are reported among people who take Lunesta and Benadryl together. This review analyzes the effectiveness and drug interactions between Lunesta and Benadryl. It is created by eHealthMe based on reports of 309 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>

 

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What are the drugs

Lunesta has active ingredients of eszopiclone. It is often used in insomnia. (latest outcomes from 16,189 Lunesta users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,405 Benadryl users)

On May, 15, 2015: 309 people who take Lunesta, Benadryl are studied

Lunesta, Benadryl outcomes

Drug combinations in study:
- Lunesta (eszopiclone)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lunesta is effective20.00%
(1 of 5 people)
0.00%
(0 of 3 people)
0.00%
(0 of 1 people)
25.00%
(2 of 8 people)
33.33%
(1 of 3 people)
100.00%
(3 of 3 people)
n/an/a
Benadryl is effective16.67%
(1 of 6 people)
0.00%
(0 of 5 people)
50.00%
(1 of 2 people)
n/a0.00%
(0 of 1 people)
75.00%
(3 of 4 people)
50.00%
(1 of 2 people)
n/a

Drug effectiveness by gender :

FemaleMale
Lunesta is effective23.53%
(4 of 17 people)
50.00%
(3 of 6 people)
Benadryl is effective33.33%
(5 of 15 people)
20.00%
(1 of 5 people)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Lunesta is effectiven/an/an/a0.00%
(0 of 5 people)
16.67%
(2 of 12 people)
50.00%
(4 of 8 people)
0.00%
(0 of 7 people)
50.00%
(1 of 2 people)
Benadryl is effectiven/an/an/a25.00%
(1 of 4 people)
20.00%
(2 of 10 people)
25.00%
(2 of 8 people)
14.29%
(1 of 7 people)
0.00%
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DysgeusiaInsomniaInsomniaCardiac Failure CongestiveUrticariaConvulsionAngerPain
Drug IneffectiveDysgeusiaAtrial Septal DefectPruritusPyrexiaSweating - ExcessiveWeight Decreased
InsomniaUrticariaCongenital Cardiovascular AnomalyAbdominal Pain LowerAbdominal AbscessAbdominal Pain LowerNausea
DyspnoeaCardiomegalyPost Procedural Bile LeakIrritabilityOsteonecrosis Of Jaw
NauseaDrug Exposure During PregnancyAnorgasmiaPanic AttackDyspnoea
VomitingPleural EffusionNystagmusInsomnia
PneumoniaVentricular Septal DefectAnxietyPain In Extremity
Initial InsomniaTinnitusDizzinessArthralgia
Multiple Drug OverdoseTongue DisorderAnxiety
FatigueDrug HypersensitivityConstipation

Most common drug interactions by gender * :

FemaleMale
PainPneumonia
Weight DecreasedOsteonecrosis Of Jaw
NauseaWeight Decreased
DyspnoeaAnaemia
InsomniaOsteopenia
ArthralgiaBone Disorder
FatigueAnxiety
Metastases To BoneCompression Fracture
Osteonecrosis Of JawHepatic Steatosis
Gastrooesophageal Reflux DiseaseDepression

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aSuicide AttemptVomitingHaemoglobin DecreasedBack PainInsomniaPneumonia
Abdominal Pain UpperInsomniaExcoriationIntervertebral Disc ProtrusionNauseaWeight Decreased
PancreatitisPalpitationsThrombophlebitis SuperficialPainPainFatigue
Abdominal PainNauseaConvulsionDepressionPain In ExtremityFall
SomnolenceBack PainErectile DysfunctionAnxietyFatigueArthralgia
Initial InsomniaAstheniaDrug AbusePain In ExtremityAnaemiaHyponatraemia
DiarrhoeaDrug Screen PositiveConstipationDyspnoeaNausea
Abdominal PainFlushingOsteonecrosis Of JawHypoaesthesiaOsteoarthritis
PresyncopeHaematocrit DecreasedBone DisorderWeight DecreasedPain
OverdoseHypoglycaemiaSpinal OsteoarthritisGait DisturbancePulmonary Hypertension

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Lunesta and Benadryl on

Do you take Lunesta and Benadryl?

 

You are not alone! Join a related support group:
- support group for people who take Benadryl
- support group for people who take Lunesta

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Benadryl, Lunesta

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Comments from related studies:

  • From this study (12 months ago):

  • Itching in extremeties with no rash apparent. Eyes watery and burning. Twitching is in left eyelid. Itching started 8 days ago. Lotion does not help much. Diphenhydramine does not help much.

    Reply

  • From this study (3 years ago):

  • I have rheumatoid since feb 2010 and having tried multiple meds and shots with no improvement. Decided to try Dandelion with much sucess, but last 2 months have been having gross edema to extremeties and trunk. started Keflex for infected eye glad and by 10:30 pm went to ER for atrial fibrillation. Sent home on Metoprolo, aspirin, and augmentin. Worsening edem to hands, trunk and pitting edema to legs. Not sure what is causing it. have gained at least 15 lbs in a 2 week perion.

    Reply

  • From this study (3 years ago):

  • I a having swelling around my nipples (I'm not pregnant) and just recently increased my lamactal dosage by 1/2. Could this possibly be a side effect?

    Reply

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Complete drug side effects:

On eHealthMe, Lunesta (eszopiclone) is often used to treat insomnia. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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