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Review: Lunesta and Benadryl

This review analyzes the effectiveness and drug interactions between Lunesta and Benadryl. It is created by eHealthMe based on 306 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

On Apr, 9, 2014: 306 people who take Lunesta, Benadryl are studied

Lunesta, Benadryl outcomes

Drug combinations in study:
- Lunesta (eszopiclone)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Lunesta is effective9.09%
(1 of 11 people)
0.00%
(0 of 3 people)
0.00%
(0 of 1 people)
28.57%
(2 of 7 people)
50.00%
(1 of 2 people)
100.00%
(5 of 5 people)
n/a
Benadryl is effective20.00%
(1 of 5 people)
0.00%
(0 of 5 people)
50.00%
(1 of 2 people)
n/an/a85.71%
(6 of 7 people)
100.00%
(7 of 7 people)

Drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Common drug interactions Dysgeusia
(9 reports)

Drug Ineffective
(7 reports)

Insomnia
(6 reports)

Dyspnoea
(5 reports)

Pneumonia
(5 reports)

Urticaria
(2 reports)

Insomnia
(1 report)

Dysgeusia
(1 report)

Insomnia
(1 report)

Cardiac Failure Congestive
(2 reports)

Atrial Septal Defect
(2 reports)

Cardiomegaly
(2 reports)

Congenital Cardiovascular Anomaly
(2 reports)

Ventricular Septal Defect
(2 reports)

Urticaria
(1 report)

Pruritus
(1 report)

Abdominal Abscess
(1 report)

Pyrexia
(1 report)

Anorgasmia
(1 report)

Post Procedural Bile Leak
(1 report)

Convulsion
(1 report)

Anger
(1 report)

Sweating - Excessive
(1 report)

Irritability
(1 report)

Panic Attack
(1 report)

Nystagmus
(1 report)

Drug effectiveness by gender :

FemaleMale
Lunesta is effective26.09%
(6 of 23 people)
50.00%
(3 of 6 people)
Benadryl is effective66.67%
(14 of 21 people)
20.00%
(1 of 5 people)

Drug interactions by gender * :

FemaleMale
Common drug interactions Pain
(76 reports)

Weight Decreased
(68 reports)

Nausea
(62 reports)

Dyspnoea
(60 reports)

Insomnia
(60 reports)

Pneumonia
(30 reports)

Osteonecrosis Of Jaw
(24 reports)

Weight Decreased
(22 reports)

Anaemia
(20 reports)

Haemoglobin Decreased
(18 reports)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Lunesta is effectiven/an/an/a0.00%
(0 of 5 people)
14.29%
(1 of 7 people)
87.50%
(7 of 8 people)
0.00%
(0 of 7 people)
50.00%
(1 of 2 people)
Benadryl is effectiven/an/an/a25.00%
(1 of 4 people)
40.00%
(2 of 5 people)
62.50%
(5 of 8 people)
100.00%
(7 of 7 people)
0.00%
(0 of 2 people)

Drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Common drug interactions n/an/aSuicide Attempt
(2 reports)

Abdominal Pain Upper
(2 reports)

Pancreatitis
(2 reports)

Abdominal Pain
(2 reports)

Somnolence
(2 reports)

Vomiting
(8 reports)

Insomnia
(8 reports)

Palpitations
(6 reports)

Nausea
(6 reports)

Back Pain
(6 reports)

Thrombophlebitis Superficial
(10 reports)

Convulsion
(10 reports)

Haemoglobin Decreased
(10 reports)

Excoriation
(10 reports)

Flushing
(8 reports)

Back Pain
(24 reports)

Intervertebral Disc Protrusion
(22 reports)

Pain
(22 reports)

Depression
(22 reports)

Anxiety
(20 reports)

Pain
(26 reports)

Insomnia
(26 reports)

Pain In Extremity
(24 reports)

Nausea
(24 reports)

Anaemia
(18 reports)

Pneumonia
(24 reports)

Weight Decreased
(20 reports)

Fatigue
(20 reports)

Fall
(18 reports)

Arthralgia
(16 reports)

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Benadryl, Lunesta

You can also:

Complete drug side effects:

On eHealthMe, Lunesta (eszopiclone) is often used to treat insomnia. Benadryl (diphenhydramine hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (2 years ago):

  • I have rheumatoid since feb 2010 and having tried multiple meds and shots with no improvement. Decided to try Dandelion with much sucess, but last 2 months have been having gross edema to extremeties and trunk. started Keflex for infected eye glad and by 10:30 pm went to ER for atrial fibrillation. Sent home on Metoprolo, aspirin, and augmentin. Worsening edem to hands, trunk and pitting edema to legs. Not sure what is causing it. have gained at least 15 lbs in a 2 week perion.

    Reply

  • From this study (2 years ago):

  • I a having swelling around my nipples (I'm not pregnant) and just recently increased my lamactal dosage by 1/2. Could this possibly be a side effect?

    Reply

Can you answer these questions (what is this?):

More questions for: Benadryl, Lunesta

You may be interested at these reviews (what is this?):

  • Zopiclone causing sweating and memory loss
    Been on 10mg Zopivane for probably 5 - 10 years. In 2013 migrated to 15mg Zopiclone. Previously experienced hot flashes 3 times a week and in 2013 has increased to 3 to 5 times a night. Usually I have 3 hours sleep, then after midnight the flashed start. In the morning there are sopping wet clothe ...

  • Leg pain and occasional arm and hand pain
    I started having leg pains at night, lower leg felt like the muscle and bone were being pulled causing sharp pain. It was relieved by getting up and walking but would last most of the night. I finally realized after suffering this over and over for months, that it only happened when I had taken be ...

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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