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Review: Ms Contin and Methadone





Summary: drug interactions are reported among people who take Ms Contin and Methadone together.

This review analyzes the effectiveness and drug interactions between Ms Contin and Methadone. It is created by eHealthMe based on reports of 1,554 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Ms Contin and Methadone >>>

What are the drugs

Ms contin has active ingredients of morphine sulfate. It is often used in pain. (latest outcomes from Ms contin 8,253 users)

Methadone Hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadone Hydrochloride 2,835 users)

On Dec, 10, 2014: 1,553 people who take Ms Contin, Methadone Hydrochloride are studied

Ms Contin, Methadone Hydrochloride outcomes

Drug combinations in study:
- Ms Contin (morphine sulfate)
- Methadone Hydrochloride (methadone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Ms Contin is effective0.00%
(0 of 4 people)
20.00%
(1 of 5 people)
25.00%
(1 of 4 people)
33.33%
(1 of 3 people)
33.33%
(2 of 6 people)
60.00%
(3 of 5 people)
0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
Methadone Hydrochloride is effective0.00%
(0 of 4 people)
33.33%
(2 of 6 people)
0.00%
(0 of 2 people)
50.00%
(1 of 2 people)
33.33%
(3 of 9 people)
50.00%
(2 of 4 people)
33.33%
(1 of 3 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DeathDeathArteriosclerosis Coronary ArteryDepressionDental CariesDrug ToxicityDizzinessPain
NauseaDrug DependenceCardiomegalyDrug DependenceOsteonecrosis Of JawAccidental DeathDisturbance In AttentionAnxiety
DysarthriaDysarthriaFallDysarthriaOsteomyelitisEmotional DisorderEmotional DisorderOsteonecrosis Of Jaw
HeadacheDental CariesDental CariesTooth AbscessRib FractureMania AggravatedFatigueBack Pain
Hepatic EncephalopathyAcute Respiratory Distress SyndromePulmonary CongestionAbnormal BehaviourPainRinging In The EarsHypertensionDyspnoea
FatigueConstipationGroin PainDental CariesDeep Vein ThrombosisFailed Back Surgery SyndromeDiabetes MellitusBone Disorder
MalaiseTooth AbscessBack PainDrug AbuseAnxietySeasonal AllergyChest PainInjury
VomitingAbnormal BehaviourUnresponsive To StimuliTooth LossHiatus HerniaHigh Blood CholesterolVisual DisturbanceArthralgia
SomnolenceDepressionVomitingOverdoseArthritisDepressionAnaemiaNausea
ConstipationSomnolencePulmonary OedemaPartner StressKyphosisHeart InjuryAnhedoniaAsthenia

Drug effectiveness by gender :

FemaleMale
Ms Contin is effective26.67%
(4 of 15 people)
30.77%
(4 of 13 people)
Methadone Hydrochloride is effective31.25%
(5 of 16 people)
28.57%
(4 of 14 people)

Most common drug interactions by gender * :

FemaleMale
PainPain
AnxietyAnxiety
Osteonecrosis Of JawOsteonecrosis Of Jaw
Back PainDyspnoea
InjuryBack Pain
DyspnoeaAsthenia
Emotional DistressOsteoarthritis
NauseaBone Disorder
Bone DisorderAnaemia
HypoaesthesiaDeath

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Ms Contin is effectiven/an/a0.00%
(0 of 2 people)
25.00%
(1 of 4 people)
30.00%
(3 of 10 people)
11.11%
(1 of 9 people)
13.33%
(2 of 15 people)
9.09%
(1 of 11 people)
Methadone Hydrochloride is effectiven/an/a50.00%
(1 of 2 people)
0.00%
(0 of 5 people)
11.11%
(1 of 9 people)
20.00%
(2 of 10 people)
15.79%
(3 of 19 people)
33.33%
(2 of 6 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Hepatic FailureApnoeaHypotensionDrug ToxicityPainPainPainPain
Hypoplastic Left Heart SyndromeDysphagiaPyrexiaTherapeutic Agent ToxicityBone DisorderAnxietyAnxietyAnxiety
HypertensionDroolingDecreased AppetiteMultiple Drug OverdoseHeadacheBack PainEmotional DistressOsteomyelitis
UrticariaConstipationHypertensionCardiac ArrestOsteonecrosis Of JawDepressionOsteonecrosis Of JawOsteoarthritis
SepsisAreflexiaBlood Bilirubin IncreasedCompleted SuicideAstheniaConstipationHypoaesthesiaHypotension
Renal Failure AcuteBulbar PalsyPainPulmonary OedemaPain In ExtremityDyspnoeaDyspnoeaAsthenia
Cardiac FailureMuscular WeaknessVomitingDrug AbuserOedema PeripheralOsteonecrosis Of JawArthralgiaConfusional State
HyperhidrosisAstheniaAcute Respiratory Distress SyndromeRespiratory ArrestNauseaNauseaInjuryBone Disorder
HypotensionTracheitisHaematocrit DecreasedAccidental OverdoseBack PainAstheniaBack PainOsteonecrosis Of Jaw
Organ FailureOverdoseLymphopeniaOverdoseMuscular WeaknessFatigueOsteoarthritisMultiple Myeloma

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Ms Contin and Methadone?

You are not alone! Join a related mobile support group:
- support group for people who take Ms Contin and Methadone
- support group for people who take Methadone Hydrochloride
- support group for people who take Ms Contin

Can you answer these questions (Ask a question):

  • Is vomiting all liquids common while taking morphine
    I Recently started taking 6mg of Hydro-Morphine per day for pain. Every time i take the drug i vomit up any liquids I drink. i fell just fine without anything in my stomach but as soon as i eat or drink I instantly become nauseated and vomit everything. It is hard not to drink because the drug is making me very thirsty. So i try to drink and my body rejects it over and over again.. this goes on for hours (3-5)because i am sooo thirsty that I can not stop drinking.
  • Can mrsa cause chronic intestinal pseudo obstruction?
    I had a small bowel obstruction caused by adhesions from an appendectomy carried out 20yrs previously and had grumbling pain ever since but been labelled a malingerer by my family GP until one day at work when I started with terrible tummy ache and sickness like I'd never known, fetching up bile with force. I hated going to hospital after yrs of being called a moaner but after a day of rolling round in pain, temperature of 103 an dehydration, my Mammy insisted we go and I was seen straight away - to my shock I was in theatre within 3hrs with a serious obstruction.
    I never really recovered... The obstruction returned after 2 days and a portion of necrotic bowel was removed, then further fever and cellulitis then MRSA and deaths door.... Isolation in high dependency (intensive care) wound break down, ventilated and all related issues that come with that - chest infection, pneumonia, bed sores. Total time in hospital 8 months. Negative pressure dressing on laparotomy wound, colostomy, picc, 4 rounds of vancomycin, minor flirt with heart failure (just water related) an eventually everything healed. Had a large incisional hernia to repair and some corrective work to the horrific scarring but then the neuropathy started plus problems eating, spewing up after any solid food, more than a few forks, diarrhoea and sickness or constipation nausea and pain driving me mad, tried all manner of drugs, nerve blocks, physio, floating tank, acupuncture, opiates, non opiates, spinal cord stimulation, an now a consultant just had a 'eureka' moment and said were you treated with vancomycin when you had MRSA? If so I'm pretty sure you have chronic intestinal pseudo obstruction and is 90% sure but wants to take a muscle biopsy to be certain. I've had so much surgery and bad news in the last 10yrs I'm terrified of germs, hospital acquired bugs and anaesthetics, is there any other way? Or can I have this test done awake - conscious sedation? I had it before during spinal cord surgery so I know what's involved and it's better than GA as I know what's going on, who is doing what to me etc...
    Does anyone with a medical background know about this ailment/disease? Does it sound feasible that MRSA or it's treatment could have caused this? I was surgically debrided up to every other day when the vac pac/negative pressure machine and dressings were changed and the doctors told me I lost a great deal of tissue and had a lot of nerve damage due to the infection.
    Any patient perspectives on this illness would also be very much valued in helping me make a decision, moving forward. If all this is going to accomplish is to attach a label to the pain but not actually change anything, after fighting it for 10yrs now, avoiding hospital as much as I can, I really can't see the point of exploratory surgerys and biopsys now when it is known that I have this propensity towards adhesions and a new wound means a potentially new adhesion growth site.
    If it helps, the appendectomy happened when I was 10yrs old, the MRSA when I was 30 and I am now 40.
    Beat Wishes.
  • Why would i get copd since i never smoked?
    I have several autoimmune disorders, I was shocked to get the COPD diagnosis since I have never smoked but I had second hand smoke first 23 years of my life.
    My doctor said my Autoimmune Hepatitis and Primary Biliary Cholingitis set me up for COPD.
  • Anyone taking amitza for the relief of constipation associated with taking morphinefor chronic pain? if so, does atmotza provide adequate relief of this type of constipation?
    I am just trying to get effective relief of my extreme constipation that has just recently began following my doctor prescribing morphine for relief of my chronic pain. I am hoping that the medicine Amitza is going to have an Osmotic affect on my constipation. I am very thankful for any helpful responses to this post.

    P.S. I am currently taking 60 mg of Morphine Sulfate (taken once daily)
  • Does loss of taste from morphine come back ?
    I was given morphine 3 months ago and have loss my ability to taste ever since.

More questions for: Methadone Hydrochloride, Ms Contin

You may be interested at these reviews (Write a review):

  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Prostatitis and prostate cancer acceleration due to anaesthetics
    Caught Chlamydia in 1978. Interestingly, the partnered girl's sister worked in an aviary; and I found out later that Chlamydia originates from handling birdshit and birds are the carriers. Chlamydia was undiagnosed at the time, so it was listed under 'Non-specific urethritis'. Chlamydia wasn't named until about 8 years later. I was given tetracycline and told to stay off alcohol and sex. Yeah, really?

    I was 24; highly sexed, and in night clubs and pubs most nights. I laid off the alcohol and after two weeks, I was good. The laying off sex, I understood, because of contamination of others (condoms were little used in 1978 in the singles arena); so I masturbated one night... and that caused me immense in my prostate, and pain and suffering for the rest of my life.

    The ejaculation was extremely painful, and chronic prostatitis started. I was on and off medication for two years. I got light-sensitivity, which means in sunlight, I came out in burning rashes. I became allergic to tetracycline.

    The message? Consultants are generally poor at communicating what not to do, and why not. Lay off sex he said. All he had to say was no sex, no masturbation; or you may suffer for the rest of your life. That would have done it.

    No-one has been able to help me with this chronic prostatitis. In the early years it would come and go, but as the years have gone on, it has become more frequent, and now it is constant.

    Four years ago I went in for major foot surgery, and flat-lined. I was in intensive care for 2 days, on a morphine drip for the pain.
    When I awoke, I knew immediately I was suffering with my prostate. It was aching badly and I was urinating frequently. The nurses were amazed with how many 'bottles' I filled in such a short time.
    For the next few months, I was in agony. I have tried every possible drug going, as well as prostate massage and the indignancy of a urethragram whilst female students were watching.

    In November 2011 I went to see another consultant, who suggested a biopsy. I was diagnosed with prostate cancer. After much research, I now know that my diet and lifestyle, coupled with inflammation of the prostate with prostatitis, has caused prostate cancer. Yes, there is a direct relationship between prostatitis and prostate cancer.

    I am now beating it, without drugs and without surgery. I have changed my diet to a vegan diet, no sugar, very little alcohol, and a lot of supplementation.

    In December 2013, I went in for more foot surgery. I was unaware about the morphine at this time, so didn't consider it being a problem. I talk to the anaesthetist, who wanted me to have an epidural (injection in the spine to numb my lower body). At no point did he talk to me about my prostate history.
    In recovery, I sensed a problem as soon as the anaesthetic began to wear off. It was like my prostate and testicles wanted to explode. I knew I was going to have problems. My intuition reminded me of three years ago with the morphine, so I asked the surgeon if he knew of these complications with morphine, but he didn't.

    I spoke to the head of the post-operative ward and asked her if she had any experience of post-operative patients who suffered with prostatitis after surgery, and she confirmed she had. So here was a nurse who knew of the problems, but the surgeon and anaesthetist didn't. This is typical in the health service... the lack of sharing.

    Not only did I suffer with the chronic prostatitis (and still am 11 month later) I was incontinent. It took 6 months of 4-times daily legal exercises to get back control of my bladder.
    For me, morphine has a dire effect on my prostate.

    Bear in mind that your prostate is designed to eliminate toxins, so it is flooded with morphine. I will do my best to ensure I check for morphine in any drugs or anaesthetics in future.

    My first PSA level was 18, 3 ears ago. I brought it down to 13.5, then 10.4, 10.3, 10.9, 11.3, 14.3 and after the last surgery it spiked at 17.5. As a result, I have gone back to a stricter, greener raw diet to bring it down again.

    Oh, and anther tip; you need to get your vitamin D3 blood count above 200n/mols (UK measure) to have any chance of not getting prostate cancer. Mine was 32 when I was diagnosed. Today it is over 200, from supplementation of 10000 ius a day. Minimum in the UK, recommended by scientists, is 75n/mols, and it's too low. OK if you have a great immune system, but not if you want to fight prostate cancer and prostatitis.

    Black African males in the Northern US states and in Europe have twice as much risk, due to lack of sunlight. Sunlight on skin promotes vitamin D3, which is essential for the immune system and production of calcium.

    Black African males need more sunlight to produce the same amount of vitamin D3 as a caucasian male. Also, any male who is bald and fat has a higher risk, so a Black African, obese bald male, has an extremely high risk of prostate cancer, unless they get their immune system in order.

    The main way to fight all this, is on a clean, raw vegetable diet, pure water, no alcohol, sugar, processed or refined food, no meat, no dairy, no vegetable oil, no exceptions, and some breath-taking regular exercise. Just like we did 100 years ago. Go figure! Look at chronic disease studies of 100 years ago. 85% of all disease was from infection. Today 85% is from chronic disease.

    Your prostate eliminates toxins, and today, we are overloading it. Remove the toxins (and the stress and anxiety) and things will improve. It's a hard road; but with it is you want to be healthier and live longer.

    Good luck.
    Glenn.
  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.
  • Androgel for secondary hypogonadism
    Severe swelling in legs, ankles and feet after being on my feet for more than one hour. Pain in calves and ankles. Feels like they're being squeezed or compressed. Pain dissipates after laying down for a few hours. Swelling never completely dissipates. Always some swelling in ankles.

More reviews for: Methadone Hydrochloride, Ms Contin

Comments from related studies:

  • From this study (2 months ago):

  • Thick uncomfortable ejaculations. Sometimes "chunks" of semen exit my penis durning bowel movements. Ejaculations look like gobs of tiny little round, very thick balls of semen making up large chunks of ejaculate...

    Reply

  • From this study (8 months ago):

  • Extremely thick, chunky like semen. Making it painful to ejaculate. Occasionally semen will come out during bowel movements in glob like increments. Ejaculations appear to be made up of small oblong jelly like balls, mixed together with semi vascular fluid.

    Reply

  • From this study (1 year ago):

  • This isn't working!

    Reply

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Complete drug side effects:

On eHealthMe, Ms Contin (morphine sulfate) is often used to treat pain. Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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