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Review: taking Methadone and Topiramate together

Summary: drug interactions are reported among people who take Methadone and Topiramate together.

This review analyzes the effectiveness and drug interactions between Methadone and Topiramate. It is created by eHealthMe based on reports of 274 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Methadone and Topiramate >>>

On Mar, 22, 2015: 274 people who take Methadone Hydrochloride, Topiramate are studied

Methadone Hydrochloride, Topiramate outcomes

Drug combinations in study:
- Methadone Hydrochloride (methadone hydrochloride)
- Topiramate (topiramate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methadone Hydrochloride is effective0.00%
(0 of 2 people)
(1 of 2 people)
(0 of 1 people)
(4 of 6 people)
(1 of 1 people)
(3 of 5 people)
(1 of 2 people)
Topiramate is effective0.00%
(0 of 2 people)
(2 of 2 people)
(0 of 2 people)
(1 of 3 people)
(2 of 4 people)
(2 of 4 people)

Drug effectiveness by gender :

Methadone Hydrochloride is effective50.00%
(7 of 14 people)
(3 of 5 people)
Topiramate is effective25.00%
(3 of 12 people)
(4 of 5 people)

Drug effectiveness by age :

Methadone Hydrochloride is effectiven/an/an/a40.00%
(2 of 5 people)
(5 of 16 people)
(1 of 16 people)
(1 of 5 people)
(1 of 1 people)
Topiramate is effectiven/an/an/a0.00%
(0 of 4 people)
(3 of 16 people)
(3 of 21 people)
(0 of 5 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DepressionDepressionDepressionDental CariesBone LossAnxietyAngerConvulsion
Abnormal BehaviourDysarthriaTooth AbscessDepressionMajor DepressionNauseaInsomniaPain
Drug DependencePartner StressCardiac DisorderDysarthriaIntervertebral Disc DegenerationLoss Of ConsciousnessDepression SuicidalDepression
DysarthriaDrug DependenceDysarthriaTooth AbscessDiabetes MellitusBipolar DisorderHeadache
Dental CariesDrug AbuseAbnormal BehaviourAbnormal BehaviourArthritisDepressionNausea
Tooth AbscessDental CariesDrug DependenceDrug DependenceAlcoholismConvulsionFatigue
Disturbance In AttentionTooth AbscessChest PainDrug AbuseVision BlurredInsomniaAnxiety
Drug AbuseAbnormal BehaviourDental CariesTooth LossDevice Related InfectionDecreased AppetiteMalaise
Urinary RetentionHypotensionRashPartner StressFallHeadacheRash
AmnesiaDependenceRectal HaemorrhageOverdoseOedema PeripheralAngerVomiting

Most common drug interactions by gender * :

FatigueConfusional State
Chest PainLoss Of Consciousness
FallDrug Toxicity

Most common drug interactions by age * :

n/aErythema MultiformePancreatic PseudocystPulmonary EmbolismCompleted SuicidePainNauseaMyocardial Infarction
PancreatitisCholecystitis AcuteSerotonin SyndromeConvulsionDepressionFeeling Abnormal
Multiple InjuriesNephrolithiasisDrug ToxicityMalaiseTremorDiarrhoea
DepressionHyperglycaemiaIntentional OverdoseHeadacheConvulsionPneumonia
Aspartate Aminotransferase IncreasedGallbladder DisorderWeight IncreasedRashFallFatigue
Congenital Pancreatic AnomalyIncreased Tendency To BruiseType 2 Diabetes MellitusDepressionHeadacheConstipation
Alanine Aminotransferase IncreasedGallbladder EnlargementLoss Of ConsciousnessDrug DependenceAstheniaChest Pain
PainNeuropathy PeripheralNauseaPainRespiratory Failure
AnhedoniaAnxietyAnxietyPain In ExtremityWeight Decreased
InjuryCardio-respiratory ArrestAngerCerebrovascular AccidentMigraine

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methadone and Topiramate?




You are not alone! Join a related support group:
- support group for people who take Methadone Hydrochloride
- support group for people who take Topiramate

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Topiramate (topiramate) is often used to treat migraine. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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