eHealthMe - Personalized health information & community eHealthMe - Personalized health information & community

Personalized health information & community

  Tools
All drugs: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
All conditions: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Check symptoms       Ask question       Write review       Answered/ Unanswered       Reviews       Community

Review: taking Methadone and Topiramate together

Summary: drug interactions are reported among people who take Methadone and Topiramate together.

This review analyzes the effectiveness and drug interactions between Methadone and Topiramate. It is created by eHealthMe based on reports of 274 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Methadone and Topiramate >>>

What are the drugs

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from 2,848 Methadone hydrochloride users)

Topiramate has active ingredients of topiramate. It is often used in migraine. (latest outcomes from 8,389 Topiramate users)

On Feb, 18, 2015: 274 people who take Methadone Hydrochloride, Topiramate are studied

Methadone Hydrochloride, Topiramate outcomes

Drug combinations in study:
- Methadone Hydrochloride (methadone hydrochloride)
- Topiramate (topiramate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methadone Hydrochloride is effective0.00%
(0 of 2 people)
50.00%
(1 of 2 people)
0.00%
(0 of 1 people)
66.67%
(4 of 6 people)
100.00%
(1 of 1 people)
60.00%
(3 of 5 people)
50.00%
(1 of 2 people)
n/a
Topiramate is effective0.00%
(0 of 2 people)
100.00%
(2 of 2 people)
0.00%
(0 of 2 people)
33.33%
(1 of 3 people)
50.00%
(2 of 4 people)
50.00%
(2 of 4 people)
n/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DepressionDepressionDepressionDental CariesBone LossAnxietyAngerConvulsion
Abnormal BehaviourDysarthriaTooth AbscessDepressionMajor DepressionNauseaInsomniaPain
Drug DependencePartner StressCardiac DisorderDysarthriaIntervertebral Disc DegenerationLoss Of ConsciousnessDepression SuicidalDepression
DysarthriaDrug DependenceDysarthriaTooth AbscessDiabetes MellitusBipolar DisorderHeadache
Dental CariesDrug AbuseAbnormal BehaviourAbnormal BehaviourArthritisDepressionNausea
Tooth AbscessDental CariesDrug DependenceDrug DependenceAlcoholismConvulsionFatigue
Disturbance In AttentionTooth AbscessChest PainDrug AbuseVision BlurredInsomniaAnxiety
Drug AbuseAbnormal BehaviourDental CariesTooth LossDevice Related InfectionDecreased AppetiteMalaise
Urinary RetentionHypotensionRashPartner StressFallHeadacheRash
AmnesiaDependenceRectal HaemorrhageOverdoseOedema PeripheralAngerVomiting

Drug effectiveness by gender :

FemaleMale
Methadone Hydrochloride is effective50.00%
(7 of 14 people)
60.00%
(3 of 5 people)
Topiramate is effective25.00%
(3 of 12 people)
80.00%
(4 of 5 people)

Most common drug interactions by gender * :

FemaleMale
ConvulsionPain
DepressionConvulsion
HeadacheMalaise
NauseaVomiting
FatigueConfusional State
PainRash
PneumoniaAnxiety
Chest PainLoss Of Consciousness
FallDrug Toxicity
ConstipationInsomnia

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methadone Hydrochloride is effectiven/an/an/a40.00%
(2 of 5 people)
31.25%
(5 of 16 people)
6.25%
(1 of 16 people)
20.00%
(1 of 5 people)
100.00%
(1 of 1 people)
Topiramate is effectiven/an/an/a0.00%
(0 of 4 people)
18.75%
(3 of 16 people)
14.29%
(3 of 21 people)
0.00%
(0 of 5 people)
100.00%
(1 of 1 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aErythema MultiformePancreatic PseudocystPulmonary EmbolismCompleted SuicidePainNauseaMyocardial Infarction
PancreatitisCholecystitis AcuteSerotonin SyndromeConvulsionDepressionFeeling Abnormal
Multiple InjuriesNephrolithiasisDrug ToxicityMalaiseTremorDiarrhoea
DepressionHyperglycaemiaIntentional OverdoseHeadacheConvulsionPneumonia
Aspartate Aminotransferase IncreasedGallbladder DisorderWeight IncreasedRashFallFatigue
Congenital Pancreatic AnomalyIncreased Tendency To BruiseType 2 Diabetes MellitusDepressionHeadacheConstipation
Alanine Aminotransferase IncreasedGallbladder EnlargementLoss Of ConsciousnessDrug DependenceAstheniaChest Pain
PainNeuropathy PeripheralNauseaPainRespiratory Failure
AnhedoniaAnxietyAnxietyPain In ExtremityWeight Decreased
InjuryCardio-respiratory ArrestAngerCerebrovascular AccidentMigraine

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methadone and Topiramate?

You are not alone! Join a related mobile support group:
- support group for people who take Methadone and Topiramate
- support group for people who take Methadone Hydrochloride
- support group for people who take Topiramate

Can you answer these questions (Ask a question):

More questions for: Methadone Hydrochloride, Topiramate

You may be interested at these reviews (Write a review):

  • Toperimate has ruined my life!
    On Dec 2, 2015 I started taking Toperimate for severe back pain. Within 48 -36 hours I became very sick - throwing up, nausea, blood in my feces, putrid taste in mouth, blurry eyes, difficulty sleeping, confusion and severe fatigue. I felt like I was poisoning myself! After 7 days I felt no improvement to my back pain and was in pretty bad shape. So I made the decision to go off of it after day 7's dose. On day 9, I woke up with severe VERTIGO. I thought I was dying, it was so bad! Was it a brain tumor (I wondered at the time, horrified!)? I didn't know. I believe (actually I KNOW) it was a side effect of the Toperimate, which can cause vertigo. I also immediately began to feel drunk all the time, even when I wasn't "spinning". I had vertigo and the drunk feeling for 1week and then I went to Urgent Care. The doctor was useless and only gave me Valium. No answers, no improvement. I waited 3 more weeks, desperate, and again went to second UC doctor. This one was competent. He diagnosed me with BVVP ( Benign Paroxysmal Positional Vertigo - which us caused by dislodged calcium crystals in my inner ear.) and set me up to have the Epley Manuever through Vestibular Rehab Physical Therapy. My vertigo was (temporarily) corrected after the first PT visit. Although I was thrilled, I was STILL feeling drunk. I've had both an MRI and MRA to rule out brain rumors, etc. everything, thank God, came out clean. Yes! But I still felt drunk 24/7. 3 weeks after The Physical Therapist corrected my vertigo. It fully came back. I was devastated! But I was able to correct it myself by doing the Epley Maneuver by myself at home. I watched a Youtube Video for instructions. I need to mention that I believe I caused the vertigo to return the second time because the night before it returned, my husband used a vibrating massager on the back of my head/upper neck area because I had pain there. I learned from my PT that the vibrations could have again dislodged the calcium crystals in my inner ear. Strange, right? She said often the PTs use vibration to force the crystals back where they're supposed to be. Apparent, the opposite is true too. Well, today is February 2, 2015. I haven't had a recurrence of my vertigo but I STILL FEEL DRUNK 24/7!!!! Thanks Toperimate and it's makers, and the doctor that gave it to me. It was supposedly a "conservative approach" to my back pain, but the question is......will I ever feel normal again? If I do heal from this, I will try to remember to update this webpage again. Good luck to anyone who experiences this problem.
  • Are you mental on methadone
    My doctor changed my pain medication back in May of 2014 . I was pleased with how well it handle my back pain and was pleased with how inexpensive it was. My husband had been using the same drug with great results. It wasn't until about a month later I started to notice just feelings of sadness. I didn't think too much of it but then I would get such strong feelings of despair really bad that I would just cry. I also started getting a lot of panic attacks I had so much anxiety at times it prevented me from doing things. At one point I really thought I was having some sort of break down, but the feelings would have highs and lows and sometimes I would have a day with out them. Eventually after being on them for 7 months I went to my doctor and asked if it were possible I was experiencing these feelings from the Methadone. He wasn't sure but with it all happening right after I started taking them he decided to put me on something else. It's been about three weeks and even though the feelings are still there they are not as strong and seem to be passing. I hope as time goes I will feel like myself again and hope never to have to experience something like that again.
  • Methadone and forgetting basic things.
    I have been in MMT (Methadone Maintenance Treatment) for around 7 1/2 years for chronic pain. I have gotten to where I forget things that I never would or did before and the longer in time the worse it has gotten I am currently looking at some different meds for treatment. The loss of memory is everything from childhood memories to what I did yesterday I may pay something and if I dont write it diwn I will forget it things I have known all my life I have forgotten. I can't say 100% it is from the MMT or not however I will sag I had no such problems before and I am at age 38 so I believe I am much too young to have severe memory loss that I am currently experiencing and whats scary is what if it never comes back and continues to decline?
  • Urea urine increased while taking topamax
    I was on Topamax to lose weight. It worked for me, I lost weight but my blood urea increased. I have to stop taking it.
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.

More reviews for: Methadone Hydrochloride, Topiramate

Comments from related studies:

  • From this study (4 months ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!

    Reply

    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor

    Reply

    trust1983 on Dec, 3, 2012:

    Is it true in the states that a psych doc can up and just leave and refuse to treat you because you tried to kill yourself, especially if you didn't have a contact for life with you r doc?

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Topiramate (topiramate) is often used to treat migraine. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

About - Terms of service - Privacy policy - Press - Testimonials - Contact us

 
© 2015 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.