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Review: taking Methadone and Amitriptyline together

Summary: drug interactions are reported among people who take Methadone and Amitriptyline together.

This review analyzes the effectiveness and drug interactions between Methadone and Amitriptyline. It is created by eHealthMe based on reports of 907 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from 2,848 Methadone hydrochloride users)

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. (latest outcomes from 7,179 Amitriptyline hydrochloride users)

On Feb, 26, 2015: 907 people who take Methadone Hydrochloride, Amitriptyline Hydrochloride are studied

Methadone Hydrochloride, Amitriptyline Hydrochloride outcomes

Drug combinations in study:
- Methadone Hydrochloride (methadone hydrochloride)
- Amitriptyline Hydrochloride (amitriptyline hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methadone Hydrochloride is effective25.00%
(1 of 4 people)
(2 of 6 people)
(1 of 3 people)
(0 of 1 people)
(2 of 3 people)
(2 of 5 people)
(1 of 3 people)
Amitriptyline Hydrochloride is effectiven/a8.33%
(1 of 12 people)
(1 of 1 people)
(0 of 3 people)
(0 of 3 people)
(0 of 2 people)
(2 of 5 people)

Drug effectiveness by gender :

Methadone Hydrochloride is effective25.00%
(2 of 8 people)
(7 of 17 people)
Amitriptyline Hydrochloride is effective11.11%
(1 of 9 people)
(3 of 17 people)

Drug effectiveness by age :

Methadone Hydrochloride is effectiven/an/an/a66.67%
(2 of 3 people)
(2 of 6 people)
(3 of 25 people)
(2 of 19 people)
(0 of 5 people)
Amitriptyline Hydrochloride is effectiven/an/an/a0.00%
(0 of 2 people)
(1 of 10 people)
(2 of 26 people)
(1 of 15 people)
(0 of 5 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Blood Sodium DecreasedMultiple Drug Overdose AccidentalPainSeptic ShockMyocardial InfarctionHypotensionVomitingPain
ListlessMeningococcal InfectionPain In ExtremityHyperkalaemiaHepatic EncephalopathyNeutropeniaRed FaceAnxiety
Blood Potassium IncreasedHypotensionPeripheral Arterial Occlusive DiseaseTachycardiaPoor Peripheral CirculationDehydrationDry MouthNausea
Mental Status ChangesPneumoniaGangreneElectrocardiogram Qt ProlongedSuicide AttemptDiarrhoeaSicknessBack Pain
OverdosePeripheral Arterial Occlusive DiseaseDrug Exposure During PregnancyNauseaAbdominal BloatingHaemoglobin DecreasedParanoiaDizziness
MiosisTinnitusSomnolenceItchingPhantom PainHaematocrit DecreasedUrinary Bladder PolypPyrexia
LethargyPain In ExtremityOverdoseDizzinessParanoiaPain In ExtremityAgitationBone Disorder
Depressed Level Of ConsciousnessPainPremature BabySupraventricular TachycardiaMood SwingsWhite Blood Cell Count DecreasedItchingAsthenia
Palmar-plantar Erythrodysaesthesia SyndromeGangreneArterial Thrombosis LimbOedema PeripheralWeaknessPlatelet Count DecreasedWeight DecreasedWeight Decreased
FatigueArterial Thrombosis LimbMiosisCardiac DisorderLoss Of ConsciousnessDizzinessConstipationDyspnoea

Most common drug interactions by gender * :

AnxietyWeight Decreased
Bone DisorderConstipation
Pain In JawDepression
Back PainFatigue
Emotional DistressBack Pain
Osteonecrosis Of JawDyspnoea
InjuryDrug Ineffective

Most common drug interactions by age * :

Developmental DelaySepsisn/aCardiac ArrestNauseaAstheniaPainPain
Drug Withdrawal Syndrome NeonatalCerebral InfarctionOverdoseCardiac ArrestWeight DecreasedAnxietyWeight Decreased
Drug Exposure During PregnancyCerebral HaemorrhageCompleted SuicideDyspnoeaBack PainPyrexiaOsteomyelitis
Neonatal DisorderRespiratory ArrestDeathConstipationBone DisorderBone Disorder
Congenital NystagmusRespiratory DepressionAnxietyDizzinessInsomniaBack Pain
StrabismusVomitingConvulsionFatigueArthralgiaImpaired Healing
NystagmusDrug AbuseHeadacheDepressionNauseaOsteoarthritis
Strabismus CongenitalInjection Site AbscessRespiratory ArrestPainPain In JawTooth Extraction
Refraction DisorderUnresponsive To StimuliConstipationPyrexiaFallRash
Maternal Drugs Affecting FoetusPyrexiaPainCompleted SuicideInjuryHypoaesthesia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Methadone and Amitriptyline on

Do you take Methadone and Amitriptyline?

You are not alone! Join a related mobile support group:
- support group for people who take Methadone and Amitriptyline
- support group for people who take Amitriptyline Hydrochloride
- support group for people who take Methadone Hydrochloride

Can you answer these questions (Ask a question):

  • Why is restoril showing poaitive in my urin when i never took this drug (2 answers)
    I have been ill for 15 years, taking Methadone all the while along with Soma and Hydrocodone for break thru pain. I now include Lyrica daily.I have had 2 back surgeries, one detailing rod and cage around L4 L5 in 2007. Most recent Nov 2013 at the Laser Spine Institute for spine decompression in that same area. Diagnosed w/ Arachnoiditis 15 yrs ago when working full time and since Methadone seems to be my only safe bet to take so that I can function. 4 years on Hizentra IVG home treatment every week. Lorazapam was prescribed for panic. Tried Diazapam more than 8-9 months ago, however that drug seems to back up in my system therefore I get no immediate relief but sort of a knock out sleep 8 hours later so we went back to Lorazapam. I am now unfortunately disabled, mostly homebound and 60 yrs old. Since this past August my urin specimen has come back positive for Restoril. This past month Restoril is still positive and described as habitual use. I am staring down a discharge from my physician who I care for, respect and admire, I never ever thought this would happen. We just took another test I offered to get another different Lab test she told me to wait so I am but its killing me. I never took a sleeping other than Unisom OTC in my Entire life. Never been prescribed Restoril, no offense but would never take it on top of what I already take and Lord knows how I would react to this drug. If I am awake all night that's just the way it is and I live with it. Why is this foreign drug showing up in my system? Please help. Thank you kindly, Louise
  • Is there a relationship between charcot leyden crystals and groin pain or urinary symptoms?
    Patient has severe dyspepsia, RUQ pain, nausea, and also occasional groin pain. Went to Infectious Disease specialist and was found to have Charcot Leyden Crystal, but no parasites were found. Is there a connections between the Charcot Leyden Crystals and his abdominal symptoms or his urological symptoms?
  • What are the side effects of taking methadone and cefdinir
    I know there are some antibiotics that do not go well with methadone. I need to know if anyone has ever had these two together and how well it worked or not
  • Can i take ketorolac if i am already taking methadone everyday?
    I take methadone everyday and I have a tooth ache so can I take ketorolac with methadone?
  • What are the effect of taking amatripline an premarin at the same time
    I am on amitriptyline. To help with depression an to help me to pain from five surgery.I am on preparing an medroxyprogesterone for hot flashes I only take the medroxyprogesterone ten days a month.

More questions for: Amitriptyline Hydrochloride, Methadone Hydrochloride

You may be interested at these reviews (Write a review):

  • Are you mental on methadone
    My doctor changed my pain medication back in May of 2014 . I was pleased with how well it handle my back pain and was pleased with how inexpensive it was. My husband had been using the same drug with great results. It wasn't until about a month later I started to notice just feelings of sadness. I didn't think too much of it but then I would get such strong feelings of despair really bad that I would just cry. I also started getting a lot of panic attacks I had so much anxiety at times it prevented me from doing things. At one point I really thought I was having some sort of break down, but the feelings would have highs and lows and sometimes I would have a day with out them. Eventually after being on them for 7 months I went to my doctor and asked if it were possible I was experiencing these feelings from the Methadone. He wasn't sure but with it all happening right after I started taking them he decided to put me on something else. It's been about three weeks and even though the feelings are still there they are not as strong and seem to be passing. I hope as time goes I will feel like myself again and hope never to have to experience something like that again.
  • Methadone and forgetting basic things.
    I have been in MMT (Methadone Maintenance Treatment) for around 7 1/2 years for chronic pain. I have gotten to where I forget things that I never would or did before and the longer in time the worse it has gotten I am currently looking at some different meds for treatment. The loss of memory is everything from childhood memories to what I did yesterday I may pay something and if I dont write it diwn I will forget it things I have known all my life I have forgotten. I can't say 100% it is from the MMT or not however I will sag I had no such problems before and I am at age 38 so I believe I am much too young to have severe memory loss that I am currently experiencing and whats scary is what if it never comes back and continues to decline?
  • Amitriptyline involuntary eye movements
    I've began having sparatic involuntary eye movements a few days after I started taking amitriptyline. It's not faint either, it's like my eye is having a seizure, emabrassing. Just wanted to share.
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.

More reviews for: Amitriptyline Hydrochloride, Methadone Hydrochloride

Comments from related studies:

  • From this study (1 month ago):

  • I have a spinal cord injury and have frequent UTIs. In July of 2014 I began to have urinary leaking around my foley catheter for the first time in 35 years. I am having a problem with antibiotics not touching the current bacteria in my urine. I was prescribed Keflex 5 days before the initial leaking [back in July as stated above] and I do not know whether it is from taking the Keflex or not. My urologist wants to prescribe it again but after reading about bladder and urethral damage, I am scared to death to do so. I have taken many antibiotics over 35 years with no problems except for Levaquin for a UTI that caused EXTREME deep muscle and joint pain.


  • From this study (2 years ago):

  • My physician said to me when she started me on Zoloft 50mg a day, That there is some interaction between the zoloft and both Oxycodone 20mg / day and Methadone 20mg /day. I've noticed that my pain level seems to be higher than normal and for longer time periods than what I had been experiencing these past three or four months and also that when I use the oxycontin 5 mg for "break through pain it doesn't even come close to doing anything literally zero coverage if that's possible. I ifrst thought that mabye I got a bad batch of pills mabye ones that had expired perhaps?- or they are very nearly ready to expire as the effect from them was nonexistant.


    jimmy on Apr, 29, 2013:

    you probaby don't notice because oxycontin is the same as oxycodone. oxycodone (percocet) has acetaminophen (tylanol) where oxycontin is just the pain reliever but time release. If you are like me the pain meds by themselves cause cerebral hemraging (pressure increase in the cerebral and spinal fluid) same thing just hurts the most where the problem is! For instance, if you have had bad back problems. My case my brain feels like it is trying to explode out of my head! It also has become popular for doctors to imediatly say your hurtting because of depression! reflect back on your life very carefully and get a second oppinion from a very close friend, determine if you are depressed because of the pain or did the pain come out of a depressive streak? Be causious, I have tried every anti depressant out there just to passify the doctors with negative side effects from all of them. Never let them try you on cymbalta, after one and a half weeks I found myself picturing with sutch clarity that It felt real, I was going to go out and shoot myself then I realized I handed my life over to God and hadn't been on that trac until I had started the antidepressant. Not long after I visited a friend unknowing to me that his wife had just comitted suicide in her car and I was just intime to help him clean the car up so he could sell the memory away. Guess what I had learned she had been taking 'cymbalta'! She was a Christian as well and he didn't see it comming! So unless you actually have a problem with depression, be careful. If you don't have a chemical imbalance medications will create one. Find a church that has a Celebrate Recovery program and deal with the issues before you get to deep into medications. Don't just stop what you are taking because what I say, try the recovery program and weene yourself of those things if that works for you, there is always a chance someone there may have some good insite to your situation. Worth the try!


    jimmy on Apr, 29, 2013:

    I do not believe they are supossed to give you oxycodone and methadone at the same time and 20mg a day is not very much, your doctor probably thinks he's passifying you! I am also told that the oxycontine is the management and the other breakethru. I dont really see the logic. you'ld think the stronger med is for when the weaker med fails. depending on your problem like mine I have to yake muscle relaxant with my meds or I just hurt worse!


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Complete drug side effects:

On eHealthMe, Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used to treat migraine. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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