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Related topic: Amitriptyline Hydrochloride, Methadone Hydrochloride

Review: Methadone and Amitriptyline

This review analyzes the effectiveness and drug interactions between Methadone and Amitriptyline. It is created by eHealthMe based on 892 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Mar, 30, 2014: 892 people who reported to have interactions when taking Methadone Hydrochloride, Amitriptyline Hydrochloride are studied

Trend of Methadone Hydrochloride, Amitriptyline Hydrochloride's drug interactions, side effects and effectiveness reports (4113518)

Drug combinations in study:
- Methadone Hydrochloride (methadone hydrochloride)
- Amitriptyline Hydrochloride (amitriptyline hydrochloride)

eHealthMe real world results:

Most common interactions experienced by people in the use of Methadone Hydrochloride, Amitriptyline Hydrochloride:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Anxiety592
Asthenia (weakness)521
Pyrexia (fever)495
Dyspnoea (difficult or laboured respiration)483
Pain471
Nausea (feeling of having an urge to vomit)376
Bone Disorder326
Back Pain322
Dizziness313
Osteonecrosis Of Jaw (death of bone of jaw)312

Most common interactions experienced by people in long term use of Methadone Hydrochloride, Amitriptyline Hydrochloride:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Diarrhoea15
Neutropenia (an abnormally low number of neutrophils)15
Pain In Extremity12
Hypotension (abnormally low blood pressure)10
Haemoglobin Decreased10
Dehydration (dryness resulting from the removal of water)10
Dizziness8
Blood Sodium Decreased8
Haematocrit Decreased8
Chest Pain8

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Methadone Hydrochloride10.00%30.00%40.00%10.00%10.00%
Amitriptyline Hydrochloride0.00%57.14%28.57%14.29%0.00%

Top conditions involved for these people * :

  1. Pain
  2. Multiple myeloma
  3. Depression
  4. Anxiety
  5. Hypertension

Top co-used drugs for these people * :

  1. Methadone hcl
  2. Amitriptyline hcl
  3. Elavil
  4. Gabapentin
  5. Neurontin

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Complete drug side effects:

On eHealthMe, Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used to treat migraine. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (13 months ago):

  • My physician said to me when she started me on Zoloft 50mg a day, That there is some interaction between the zoloft and both Oxycodone 20mg / day and Methadone 20mg /day. I've noticed that my pain level seems to be higher than normal and for longer time periods than what I had been experiencing these past three or four months and also that when I use the oxycontin 5 mg for "break through pain it doesn't even come close to doing anything literally zero coverage if that's possible. I ifrst thought that mabye I got a bad batch of pills mabye ones that had expired perhaps?- or they are very nearly ready to expire as the effect from them was nonexistant.

    Reply

    jimmy on Apr, 29, 2013:

    I do not believe they are supossed to give you oxycodone and methadone at the same time and 20mg a day is not very much, your doctor probably thinks he's passifying you! I am also told that the oxycontine is the management and the other breakethru. I dont really see the logic. you'ld think the stronger med is for when the weaker med fails. depending on your problem like mine I have to yake muscle relaxant with my meds or I just hurt worse!

    Reply

    jimmy on Apr, 29, 2013:

    you probaby don't notice because oxycontin is the same as oxycodone. oxycodone (percocet) has acetaminophen (tylanol) where oxycontin is just the pain reliever but time release. If you are like me the pain meds by themselves cause cerebral hemraging (pressure increase in the cerebral and spinal fluid) same thing just hurts the most where the problem is! For instance, if you have had bad back problems. My case my brain feels like it is trying to explode out of my head! It also has become popular for doctors to imediatly say your hurtting because of depression! reflect back on your life very carefully and get a second oppinion from a very close friend, determine if you are depressed because of the pain or did the pain come out of a depressive streak? Be causious, I have tried every anti depressant out there just to passify the doctors with negative side effects from all of them. Never let them try you on cymbalta, after one and a half weeks I found myself picturing with sutch clarity that It felt real, I was going to go out and shoot myself then I realized I handed my life over to God and hadn't been on that trac until I had started the antidepressant. Not long after I visited a friend unknowing to me that his wife had just comitted suicide in her car and I was just intime to help him clean the car up so he could sell the memory away. Guess what I had learned she had been taking 'cymbalta'! She was a Christian as well and he didn't see it comming! So unless you actually have a problem with depression, be careful. If you don't have a chemical imbalance medications will create one. Find a church that has a Celebrate Recovery program and deal with the issues before you get to deep into medications. Don't just stop what you are taking because what I say, try the recovery program and weene yourself of those things if that works for you, there is always a chance someone there may have some good insite to your situation. Worth the try!

    Reply

  • From this study (2 years ago):

  • Just started having headaches and evening body aches since started Methadone. Not sure if there's an interaction to drug i already take or if it just because of methadone. It really have helped with my back pain and neuropathy in my legs and feet so don't want to stop unless really need to.

    Reply

  • From this study (4 years ago):

  • is methadone safe to use 79 yr old with heart problems, combined with morphine and amitripilyne

    Reply

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