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Review: Methadone and Amitriptyline

This review analyzes the effectiveness and drug interactions between Methadone and Amitriptyline. It is created by eHealthMe based on reports of 906 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Methadone and Amitriptyline >>>

What are the drugs

Methadone hydrochloride (latest outcomes from 2,819 users) has active ingredients of methadone hydrochloride. It is often used in pain.

Amitriptyline hydrochloride (latest outcomes from 7,109 users) has active ingredients of amitriptyline hydrochloride. It is often used in migraine.

On Sep, 12, 2014: 906 people who take Methadone Hydrochloride, Amitriptyline Hydrochloride are studied

Methadone Hydrochloride, Amitriptyline Hydrochloride outcomes

Drug combinations in study:
- Methadone Hydrochloride (methadone hydrochloride)
- Amitriptyline Hydrochloride (amitriptyline hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methadone Hydrochloride is effective25.00%
(1 of 4 people)
(2 of 6 people)
(1 of 3 people)
(0 of 1 people)
(2 of 3 people)
(1 of 4 people)
(1 of 3 people)
Amitriptyline Hydrochloride is effectiven/a8.33%
(1 of 12 people)
(1 of 1 people)
(0 of 3 people)
(0 of 3 people)
(0 of 2 people)
(1 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Blood Sodium DecreasedMultiple Drug Overdose AccidentalPainSeptic ShockMyocardial InfarctionHypotensionRed FacePain
ListlessMeningococcal InfectionPain In ExtremityHyperkalaemiaHepatic EncephalopathyNeutropeniaDry MouthAnxiety
Blood Potassium IncreasedHypotensionPeripheral Arterial Occlusive DiseaseTachycardiaPoor Peripheral CirculationDiarrhoeaWeight DecreasedNausea
Mental Status ChangesPneumoniaGangreneElectrocardiogram Qt ProlongedSuicide AttemptDehydrationVomitingBack Pain
OverdosePeripheral Arterial Occlusive DiseaseDrug Exposure During PregnancyNauseaAbdominal BloatingHaemoglobin DecreasedSicknessDizziness
MiosisTinnitusSomnolenceItchingPhantom PainWhite Blood Cell Count DecreasedAgitationPyrexia
LethargyPain In ExtremityOverdoseDizzinessParanoiaPain In ExtremityItchingBone Disorder
Depressed Level Of ConsciousnessPainPremature BabySupraventricular TachycardiaMood SwingsHaematocrit DecreasedParanoiaAsthenia
Palmar-plantar Erythrodysaesthesia SyndromeGangreneArterial Thrombosis LimbOedema PeripheralWeaknessPlatelet Count DecreasedConstipationWeight Decreased
FatigueArterial Thrombosis LimbMiosisCardiac DisorderLoss Of ConsciousnessBlood Sodium DecreasedWeaknessDyspnoea

Drug effectiveness by gender :

Methadone Hydrochloride is effective14.29%
(1 of 7 people)
(7 of 17 people)
Amitriptyline Hydrochloride is effective0.00%
(0 of 8 people)
(3 of 17 people)

Most common drug interactions by gender * :

AnxietyWeight Decreased
Bone DisorderConstipation
Pain In JawDepression
Back PainFatigue
Emotional DistressBack Pain
Osteonecrosis Of JawDyspnoea
InjuryDrug Ineffective

Drug effectiveness by age :

Methadone Hydrochloride is effectiven/an/an/a66.67%
(2 of 3 people)
(2 of 6 people)
(3 of 25 people)
(1 of 18 people)
(0 of 5 people)
Amitriptyline Hydrochloride is effectiven/an/an/a0.00%
(0 of 2 people)
(1 of 10 people)
(2 of 26 people)
(0 of 14 people)
(0 of 5 people)

Most common drug interactions by age * :

Developmental DelaySepsisn/aCardiac ArrestNauseaAstheniaPainPain
Drug Withdrawal Syndrome NeonatalCerebral InfarctionOverdoseCardiac ArrestWeight DecreasedAnxietyWeight Decreased
Drug Exposure During PregnancyCerebral HaemorrhageCompleted SuicideDyspnoeaBack PainBone DisorderOsteomyelitis
Neonatal DisorderRespiratory ArrestDeathConstipationPyrexiaBone Disorder
Congenital NystagmusRespiratory DepressionAnxietyDizzinessInsomniaBack Pain
StrabismusVomitingConvulsionFatigueArthralgiaImpaired Healing
NystagmusDrug AbuseHeadacheDepressionNauseaOsteoarthritis
Strabismus CongenitalInjection Site AbscessRespiratory ArrestPainFallTooth Extraction
Refraction DisorderUnresponsive To StimuliConstipationPyrexiaPain In JawRash
Maternal Drugs Affecting FoetusPyrexiaPainCompleted SuicideInjuryHypoaesthesia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methadone and Amitriptyline?

Get connected! Join a mobile support group:
- group for people who take Methadone and Amitriptyline
- group for people who take Amitriptyline Hydrochloride
- group for people who take Methadone Hydrochloride

Comments from related studies:

  • From this study (1 year ago):

  • My physician said to me when she started me on Zoloft 50mg a day, That there is some interaction between the zoloft and both Oxycodone 20mg / day and Methadone 20mg /day. I've noticed that my pain level seems to be higher than normal and for longer time periods than what I had been experiencing these past three or four months and also that when I use the oxycontin 5 mg for "break through pain it doesn't even come close to doing anything literally zero coverage if that's possible. I ifrst thought that mabye I got a bad batch of pills mabye ones that had expired perhaps?- or they are very nearly ready to expire as the effect from them was nonexistant.


    jimmy on Apr, 29, 2013:

    I do not believe they are supossed to give you oxycodone and methadone at the same time and 20mg a day is not very much, your doctor probably thinks he's passifying you! I am also told that the oxycontine is the management and the other breakethru. I dont really see the logic. you'ld think the stronger med is for when the weaker med fails. depending on your problem like mine I have to yake muscle relaxant with my meds or I just hurt worse!


    jimmy on Apr, 29, 2013:

    you probaby don't notice because oxycontin is the same as oxycodone. oxycodone (percocet) has acetaminophen (tylanol) where oxycontin is just the pain reliever but time release. If you are like me the pain meds by themselves cause cerebral hemraging (pressure increase in the cerebral and spinal fluid) same thing just hurts the most where the problem is! For instance, if you have had bad back problems. My case my brain feels like it is trying to explode out of my head! It also has become popular for doctors to imediatly say your hurtting because of depression! reflect back on your life very carefully and get a second oppinion from a very close friend, determine if you are depressed because of the pain or did the pain come out of a depressive streak? Be causious, I have tried every anti depressant out there just to passify the doctors with negative side effects from all of them. Never let them try you on cymbalta, after one and a half weeks I found myself picturing with sutch clarity that It felt real, I was going to go out and shoot myself then I realized I handed my life over to God and hadn't been on that trac until I had started the antidepressant. Not long after I visited a friend unknowing to me that his wife had just comitted suicide in her car and I was just intime to help him clean the car up so he could sell the memory away. Guess what I had learned she had been taking 'cymbalta'! She was a Christian as well and he didn't see it comming! So unless you actually have a problem with depression, be careful. If you don't have a chemical imbalance medications will create one. Find a church that has a Celebrate Recovery program and deal with the issues before you get to deep into medications. Don't just stop what you are taking because what I say, try the recovery program and weene yourself of those things if that works for you, there is always a chance someone there may have some good insite to your situation. Worth the try!


  • From this study (2 years ago):

  • Just started having headaches and evening body aches since started Methadone. Not sure if there's an interaction to drug i already take or if it just because of methadone. It really have helped with my back pain and neuropathy in my legs and feet so don't want to stop unless really need to.


  • From this study (4 years ago):

  • is methadone safe to use 79 yr old with heart problems, combined with morphine and amitripilyne


Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

  • I cannot get a direct answer from any of my drs.,is my sciatic pain caused by my interstitail cystitus?
    I have had interstitail cystitus for almost four years now.I have been on every kind of drug,other than pain pills.I will not take them,I don't believe in them they only mask the problem and cause addiction.of course,just my belief.I have had d.s.m.o. repetitively for first year and a half twice a w ...

  • Can methadone cause my aynurism to burst?
    A doctor is lowering my dose of Methadone I take for severe back pain due to my aneurysm because he said the Methadone could cause a stroke w/my aneurysm. Has anyone else heard of this? Thank you!!!

  • Does bcaa cause migraines?
    I took 3 capsules of BCAA and within the next hour I developed a very aggressive migraine. Believing the migraine may have been separate to the tablets, I took another 3 capsules the next day and again within 1 hour I developed a very aggressive migraines. Has anyone had a similar adverse reactio ...

More questions for: Amitriptyline Hydrochloride, Methadone Hydrochloride

You may be interested at these reviews (what is this?):

  • Androgel for secondary hypogonadism
    Severe swelling in legs, ankles and feet after being on my feet for more than one hour. Pain in calves and ankles. Feels like they're being squeezed or compressed. Pain dissipates after laying down for a few hours. Swelling never completely dissipates. Always some swelling in ankles.

  • Xanax bed wetting will it stop and do i wear diapers or die
    I am on the very edge of crazy. So starting this is pushing ne way over. I'm 49 for crap sakes. I am so tired of the pain in my body and I am just tired, this is the last slap I can't anymore. Naturally alcohol I am sure is just about the end game along with cuts. Just want to bleed out and not hur ...

  • Inflammation in leg and around pelvis
    I gave birth two years ago, in my birthing plan it only stated that i wished for gas & air ONlY. I was very confused what with all the gas & air.. So all i heared was midewife saying that she will order pethidine. Next minute i know midwife injects me with pethidine in right buttuck. Later that da ...

More reviews for: Amitriptyline Hydrochloride, Methadone Hydrochloride

Complete drug side effects:

On eHealthMe, Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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