eHealthMe - Personalized health information & community eHealthMe - Personalized health information & community

Personalized health information & community

  Tools   Community
All drugs: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
All conditions: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Check symptoms       Ask question       Write review       Answered/ Unanswered       Reviews       WellConnected

Review: Methadone and Amitriptyline





Summary: drug interactions are reported among people who take Methadone and Amitriptyline together.

This review analyzes the effectiveness and drug interactions between Methadone and Amitriptyline. It is created by eHealthMe based on reports of 906 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Methadone and Amitriptyline >>>

What are the drugs

Methadone Hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadone Hydrochloride 2,835 users)

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Amitriptyline hydrochloride 7,147 users)

On Nov, 27, 2014: 906 people who take Methadone Hydrochloride, Amitriptyline Hydrochloride are studied

Methadone Hydrochloride, Amitriptyline Hydrochloride outcomes

Drug combinations in study:
- Methadone Hydrochloride (methadone hydrochloride)
- Amitriptyline Hydrochloride (amitriptyline hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methadone Hydrochloride is effective25.00%
(1 of 4 people)
33.33%
(2 of 6 people)
33.33%
(1 of 3 people)
0.00%
(0 of 1 people)
66.67%
(2 of 3 people)
25.00%
(1 of 4 people)
33.33%
(1 of 3 people)
n/a
Amitriptyline Hydrochloride is effectiven/a8.33%
(1 of 12 people)
100.00%
(1 of 1 people)
0.00%
(0 of 3 people)
0.00%
(0 of 3 people)
0.00%
(0 of 2 people)
25.00%
(1 of 4 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Blood Sodium DecreasedMultiple Drug Overdose AccidentalPainSeptic ShockMyocardial InfarctionHypotensionRed FacePain
ListlessMeningococcal InfectionPain In ExtremityHyperkalaemiaHepatic EncephalopathyNeutropeniaDry MouthAnxiety
Blood Potassium IncreasedHypotensionPeripheral Arterial Occlusive DiseaseTachycardiaPoor Peripheral CirculationDiarrhoeaWeight DecreasedNausea
Mental Status ChangesPneumoniaGangreneElectrocardiogram Qt ProlongedSuicide AttemptDehydrationVomitingBack Pain
OverdosePeripheral Arterial Occlusive DiseaseDrug Exposure During PregnancyNauseaAbdominal BloatingHaemoglobin DecreasedSicknessDizziness
MiosisTinnitusSomnolenceItchingPhantom PainWhite Blood Cell Count DecreasedAgitationPyrexia
LethargyPain In ExtremityOverdoseDizzinessParanoiaPain In ExtremityItchingBone Disorder
Depressed Level Of ConsciousnessPainPremature BabySupraventricular TachycardiaMood SwingsHaematocrit DecreasedParanoiaAsthenia
Palmar-plantar Erythrodysaesthesia SyndromeGangreneArterial Thrombosis LimbOedema PeripheralWeaknessPlatelet Count DecreasedConstipationWeight Decreased
FatigueArterial Thrombosis LimbMiosisCardiac DisorderLoss Of ConsciousnessBlood Sodium DecreasedWeaknessDyspnoea

Drug effectiveness by gender :

FemaleMale
Methadone Hydrochloride is effective14.29%
(1 of 7 people)
41.18%
(7 of 17 people)
Amitriptyline Hydrochloride is effective0.00%
(0 of 8 people)
17.65%
(3 of 17 people)

Most common drug interactions by gender * :

FemaleMale
PainAsthenia
AnxietyWeight Decreased
NauseaDizziness
Bone DisorderConstipation
Pain In JawDepression
ArthralgiaPyrexia
Back PainFatigue
Emotional DistressBack Pain
Osteonecrosis Of JawDyspnoea
InjuryDrug Ineffective

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methadone Hydrochloride is effectiven/an/an/a66.67%
(2 of 3 people)
33.33%
(2 of 6 people)
12.00%
(3 of 25 people)
5.56%
(1 of 18 people)
0.00%
(0 of 5 people)
Amitriptyline Hydrochloride is effectiven/an/an/a0.00%
(0 of 2 people)
10.00%
(1 of 10 people)
7.69%
(2 of 26 people)
0.00%
(0 of 14 people)
0.00%
(0 of 5 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Developmental DelaySepsisn/aCardiac ArrestNauseaAstheniaPainPain
Drug Withdrawal Syndrome NeonatalCerebral InfarctionOverdoseCardiac ArrestWeight DecreasedAnxietyWeight Decreased
Drug Exposure During PregnancyCerebral HaemorrhageCompleted SuicideDyspnoeaBack PainBone DisorderOsteomyelitis
Neonatal DisorderRespiratory ArrestDeathConstipationPyrexiaBone Disorder
Congenital NystagmusRespiratory DepressionAnxietyDizzinessInsomniaBack Pain
StrabismusVomitingConvulsionFatigueArthralgiaImpaired Healing
NystagmusDrug AbuseHeadacheDepressionNauseaOsteoarthritis
Strabismus CongenitalInjection Site AbscessRespiratory ArrestPainFallTooth Extraction
Refraction DisorderUnresponsive To StimuliConstipationPyrexiaPain In JawRash
Maternal Drugs Affecting FoetusPyrexiaPainCompleted SuicideInjuryHypoaesthesia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methadone and Amitriptyline?

You are not alone! Join a related mobile support group:
- support group for people who take Methadone and Amitriptyline
- support group for people who take Amitriptyline Hydrochloride
- support group for people who take Methadone Hydrochloride

Can you answer these questions (Ask a question):

  • Does amitriptyline increase eye pressure when you have acute angle closure glaucoma
    Does taking Amitriptyline increase eye pressure in a case of someone who has had acute angle closure glaucoma for 12 years?
  • I take 20mg of amitriptyline each notgh to help me sleep. i have just been diagnosed with parkinsons and need to takae azilect, whihc is an mao-b inhibotor, can i take them together
    Can I take both these tables together? My consultant said it was ok to take both
    but the Amitriptyline instructions say do not take with MAO-B inhibitors, Azilect is an MAO-B inhibitors
  • Can long-term methadone use cause or increase the risk of colon cancer?
    I had a two-level spinal fusion at L4-S1 in 2000 after being injuried at work in Sept. 24, 1997. I lost everything after...the unjury, ability to do my job, my wife and family (couldn't take the strain) my home, my sense of self and purpose, direction and belonging...credit rating and ability to pay my bills.
    After a long period of waiting to settle my workmens' comp. case, I returned home, from the Bat Area back to Arizona to take of my mother with a yet un dianosed case of moderate dementia.
    Then, in 2011 I had a 2nd surgery to relieve spinal stenosis btwn. L2-L4, just above the fusion site.
    I've been taking methadone since early 2004, a little over ten years, now. I've had high blood pressure since my injury.

    Now, I waiting to be scheduled for a colonoscopy, with my father having had polyps and the way I've been feeling..drained, tired all the time, and stomach pains ( in addition to my chronic low back pain), I...
    find myself wondering if there is any relationtionship between the methadone and other meds and cancer?
  • I cannot get a direct answer from any of my drs.,is my sciatic pain caused by my interstitail cystitus? (1 answer)
    I have had interstitail cystitus for almost four years now.I have been on every kind of drug,other than pain pills.I will not take them,I don't believe in them they only mask the problem and cause addiction.of course,just my belief.I have had d.s.m.o. repetitively for first year and a half twice a week.I have tried physical therapy .I have had five hydrodistention.I just recently had my first hydrodistention with botox injections.nothing has kept me out of pain .even when I am doing good I can only seem to reach a six in my pain level.my frequency average is and has been 30-40Times a day.I am,or,was a chef kitchen manager.could not perform and lost two jobs because of this disease.my flanks,my lower back ,my legs,my arms all ways in pain.pelvic pain is constant.I'd rather not go into further details way too personal.but this has taken my life.I am 35.I have led a fairly healthy life.I have no life now.I am seeking disability .Every Dr. I go to has a different option about the sciatic part of my problem some Dr.s are very sure and as a matter of fact about how it is in conjunction with I.c..others look at me like I'm nuts?why do I limp?why can't I get in and out of a car,or bend down and touch my toes,pick heavy stuff up.just to laugh at times hurts.this is my life ,I gotta wonder ,is there any one else out there going through the same symptoms and no relief?
  • Can methadone cause my aynurism to burst?
    A doctor is lowering my dose of Methadone I take for severe back pain due to my aneurysm because he said the Methadone could cause a stroke w/my aneurysm. Has anyone else heard of this? Thank you!!!

More questions for: Amitriptyline Hydrochloride, Methadone Hydrochloride

You may be interested at these reviews (Write a review):

  • Amitriptyline involuntary eye movements
    I've began having sparatic involuntary eye movements a few days after I started taking amitriptyline. It's not faint either, it's like my eye is having a seizure, emabrassing. Just wanted to share.
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.
  • Androgel for secondary hypogonadism
    Severe swelling in legs, ankles and feet after being on my feet for more than one hour. Pain in calves and ankles. Feels like they're being squeezed or compressed. Pain dissipates after laying down for a few hours. Swelling never completely dissipates. Always some swelling in ankles.
  • Xanax bed wetting will it stop and do i wear diapers or die (1 response)
    I am on the very edge of crazy. So starting this is pushing ne way over. I'm 49 for crap sakes. I am so tired of the pain in my body and I am just tired, this is the last slap I can't anymore. Naturally alcohol I am sure is just about the end game along with cuts.
    Just want to bleed out and not hurt anymore and be so scared to leave my house or sleep. I just want to sleep forever.

More reviews for: Amitriptyline Hydrochloride, Methadone Hydrochloride

Comments from related studies:

  • From this study (2 years ago):

  • My physician said to me when she started me on Zoloft 50mg a day, That there is some interaction between the zoloft and both Oxycodone 20mg / day and Methadone 20mg /day. I've noticed that my pain level seems to be higher than normal and for longer time periods than what I had been experiencing these past three or four months and also that when I use the oxycontin 5 mg for "break through pain it doesn't even come close to doing anything literally zero coverage if that's possible. I ifrst thought that mabye I got a bad batch of pills mabye ones that had expired perhaps?- or they are very nearly ready to expire as the effect from them was nonexistant.

    Reply

    jimmy on Apr, 29, 2013:

    you probaby don't notice because oxycontin is the same as oxycodone. oxycodone (percocet) has acetaminophen (tylanol) where oxycontin is just the pain reliever but time release. If you are like me the pain meds by themselves cause cerebral hemraging (pressure increase in the cerebral and spinal fluid) same thing just hurts the most where the problem is! For instance, if you have had bad back problems. My case my brain feels like it is trying to explode out of my head! It also has become popular for doctors to imediatly say your hurtting because of depression! reflect back on your life very carefully and get a second oppinion from a very close friend, determine if you are depressed because of the pain or did the pain come out of a depressive streak? Be causious, I have tried every anti depressant out there just to passify the doctors with negative side effects from all of them. Never let them try you on cymbalta, after one and a half weeks I found myself picturing with sutch clarity that It felt real, I was going to go out and shoot myself then I realized I handed my life over to God and hadn't been on that trac until I had started the antidepressant. Not long after I visited a friend unknowing to me that his wife had just comitted suicide in her car and I was just intime to help him clean the car up so he could sell the memory away. Guess what I had learned she had been taking 'cymbalta'! She was a Christian as well and he didn't see it comming! So unless you actually have a problem with depression, be careful. If you don't have a chemical imbalance medications will create one. Find a church that has a Celebrate Recovery program and deal with the issues before you get to deep into medications. Don't just stop what you are taking because what I say, try the recovery program and weene yourself of those things if that works for you, there is always a chance someone there may have some good insite to your situation. Worth the try!

    Reply

    jimmy on Apr, 29, 2013:

    I do not believe they are supossed to give you oxycodone and methadone at the same time and 20mg a day is not very much, your doctor probably thinks he's passifying you! I am also told that the oxycontine is the management and the other breakethru. I dont really see the logic. you'ld think the stronger med is for when the weaker med fails. depending on your problem like mine I have to yake muscle relaxant with my meds or I just hurt worse!

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used to treat migraine. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

About - Terms of service - Privacy policy - Press - Testimonials - Contact us

 
© 2014 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.