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Review: Methadone and Methotrexate

This review analyzes the effectiveness and drug interactions between Methadone and Methotrexate. It is created by eHealthMe based on 270 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 9, 2014: 270 people who take Methadone Hydrochloride, Methotrexate are studied

Methadone Hydrochloride, Methotrexate outcomes

Drug combinations in study:
- Methadone Hydrochloride (methadone hydrochloride)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Methadone Hydrochloride is effectiven/an/an/an/a100.00%
(3 of 3 people)
0.00%
(0 of 6 people)
n/a
Methotrexate is effective0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
n/an/a0.00%
(0 of 6 people)
n/an/a

Drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Common drug interactions Blood Bilirubin Increased
(7 reports)

Acute Respiratory Distress Syndrome
(7 reports)

Pneumonitis
(7 reports)

Hypernatraemia
(7 reports)

Hypotension
(7 reports)

Asthenia
(2 reports)

Tuberculosis
(2 reports)

Memory Impairment
(2 reports)

Hypersomnia
(2 reports)

Gait Disturbance
(2 reports)

Herpes Zoster
(2 reports)

Arthralgia
(2 reports)

Oedema Peripheral
(2 reports)

Myocardial Infarction
(2 reports)

Pain
(2 reports)

Withdrawal Syndrome
(2 reports)

Malaise
(1 report)

Non-small Cell Lung Cancer
(1 report)

Feeling Hot
(1 report)

Alopecia
(1 report)

Abortion Spontaneous
(1 report)

Psoriasis
(1 report)

Pain
(1 report)

Arthralgia
(1 report)

Urinary Tract Infection
(1 report)

Memory Impairment
(1 report)

Dizziness Aggravated
(1 report)

Dizziness Postural
(1 report)

Hyperglycaemia
(1 report)

Nodules
(1 report)

n/a

Drug effectiveness by gender :

FemaleMale
Methadone Hydrochloride is effective33.33%
(3 of 9 people)
n/a
Methotrexate is effective0.00%
(0 of 8 people)
n/a

Drug interactions by gender * :

FemaleMale
Common drug interactions Pain
(68 reports)

Arthralgia
(45 reports)

Anaemia
(36 reports)

Oedema Peripheral
(36 reports)

Nausea
(34 reports)

Dehydration
(76 reports)

Oedema Peripheral
(59 reports)

Dizziness
(54 reports)

Vision Blurred
(50 reports)

Hyperhidrosis
(48 reports)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methadone Hydrochloride is effectiven/an/an/an/an/a100.00%
(3 of 3 people)
0.00%
(0 of 6 people)
n/a
Methotrexate is effectiven/an/an/an/an/a0.00%
(0 of 2 people)
0.00%
(0 of 6 people)
n/a

Drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Common drug interactions n/aHodgkin's Disease
(4 reports)

Pneumatosis Intestinalis
(3 reports)

Acute Graft Versus Host Disease
(3 reports)

Pneumoperitoneum
(3 reports)

Partial Seizures
(2 reports)

Hodgkin's Disease
(21 reports)

Hypernatraemia
(15 reports)

Pneumonitis
(15 reports)

Hypotension
(15 reports)

Acute Respiratory Distress Syndrome
(15 reports)

Ejection Fraction Abnormal
(6 reports)

Influenza Like Illness
(4 reports)

Oedema Lower Limb
(4 reports)

Hypokinesia
(4 reports)

Glossodynia
(4 reports)

Hyperglycaemia
(50 reports)

Dehydration
(48 reports)

Pain In Extremity
(28 reports)

Anorexia
(26 reports)

Oedema Peripheral
(26 reports)

Pain
(59 reports)

Oedema Peripheral
(52 reports)

Fibromyalgia
(40 reports)

Cataract
(38 reports)

Herpes Zoster
(38 reports)

Arthralgia
(29 reports)

Back Pain
(15 reports)

Pain
(14 reports)

Drug Ineffective
(12 reports)

Musculoskeletal Stiffness
(10 reports)

Pneumonia
(18 reports)

Pain
(14 reports)

Hypoaesthesia
(14 reports)

Hyperhidrosis
(12 reports)

Chest Pain
(12 reports)

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Methadone Hydrochloride, Methotrexate

You can also:

Complete drug side effects:

On eHealthMe, Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

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  • I take methotexate weekly.. After a day of taking them, I have terrible chest pain that radiates to my neck, and down my sides

    Reply

  • From this study (1 year ago):

  • just want to know what drugs are safe to take with methadone for arthritis?

    Reply

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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