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Review: taking Methadone and Methotrexate together

Summary: drug interactions are reported among people who take Methadone and Methotrexate together.

This review analyzes the effectiveness and drug interactions between Methadone and Methotrexate. It is created by eHealthMe based on reports of 271 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Methadone and Methotrexate >>>

What are the drugs

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from 2,842 Methadone hydrochloride users)

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,233 Methotrexate users)

On Jan, 29, 2015: 271 people who take Methadone Hydrochloride, Methotrexate are studied

Methadone Hydrochloride, Methotrexate outcomes

Drug combinations in study:
- Methadone Hydrochloride (methadone hydrochloride)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methadone Hydrochloride is effectiven/an/an/an/a100.00%
(3 of 3 people)
50.00%
(1 of 2 people)
n/an/a
Methotrexate is effective0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
n/an/a0.00%
(0 of 1 people)
n/an/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Blood Bilirubin IncreasedChest PainHerpes ZosterWithdrawal SyndromeAbortion SpontaneousSkin Fissuresn/aPain
Acute Respiratory Distress SyndromeGait DisturbanceArthralgiaMalaisePsoriasisEye PainOedema Peripheral
PneumonitisOxygen Saturation DecreasedOedema PeripheralNon-small Cell Lung CancerPainEar PainAnaemia
HypernatraemiaHypersomniaMyocardial InfarctionFeeling HotArthralgiaSkin SensitisationDehydration
HypotensionBlood Potassium IncreasedPainAlopeciaUrinary Tract InfectionSkin Discoloration - BluishArthralgia
Pneumonia Respiratory Syncytial ViralTherapeutic Agent ToxicityFibromyalgiaPneumoniaNauseaMouth UlcerationWeight Decreased
HypoxiaSimilar Reaction On Previous Exposure To DrugImmune System DisorderInsomniaDizziness AggravatedPain - JointsDyspnoea
Cerebrovascular AccidentRenal Failure AcuteThyroid NeoplasmNodulesHot FlashesBone Disorder
PainPancytopeniaJoint SwellingAbnormal DreamsSkin Burning SensationChest Pain
Pain In ExtremityMemory ImpairmentCataractHyperglycaemiaSkin NecrosisPyrexia

Drug effectiveness by gender :

FemaleMale
Methadone Hydrochloride is effective80.00%
(4 of 5 people)
n/a
Methotrexate is effective0.00%
(0 of 3 people)
n/a

Most common drug interactions by gender * :

FemaleMale
PainDehydration
ArthralgiaOedema Peripheral
AnaemiaDizziness
NauseaVision Blurred
Oedema PeripheralPain
Drug IneffectiveHyperhidrosis
FatigueBlood Calcium Decreased
DyspnoeaChest Pain
Hodgkin's DiseaseBack Pain
VomitingDepression

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methadone Hydrochloride is effectiven/an/an/an/an/a100.00%
(3 of 3 people)
3.12%
(1 of 32 people)
n/a
Methotrexate is effectiven/an/an/an/an/a0.00%
(0 of 2 people)
0.00%
(0 of 6 people)
n/a

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aHodgkin's DiseaseHodgkin's DiseaseCardiomyopathy NosHyperglycaemiaPainArthralgiaPneumonia
SomnolenceAnaphylactic ReactionDyspnoea NosDehydrationOedema PeripheralBack PainHypoaesthesia
Septic ShockPneumonia Respiratory Syncytial ViralEjection Fraction AbnormalPain In ExtremityFibromyalgiaPainPain
Partial SeizuresHypernatraemiaGlossodyniaFatigueOsteonecrosis Of JawDrug IneffectiveChest Pain
NystagmusBlood Bilirubin IncreasedHypokinesiaOedema PeripheralCataractMusculoskeletal StiffnessNausea
TachycardiaHypotensionOedema Lower LimbArthralgiaHerpes ZosterHeadacheTooth Extraction
Vision BlurredAcute Respiratory Distress SyndromeDyspnoea ExertionalCoughAnaemiaAnaemiaAnaemia
PneumoperitoneumPneumonitisHeadacheHaemoptysisWeight DecreasedPain In ExtremityHyperhidrosis
Pneumatosis IntestinalisHodgkin's Disease Stage IiCardiac Failure CongestiveDyspnoeaConstipationAlopeciaVomiting
Acute Graft Versus Host DiseaseDrug IneffectiveDepressionDizzinessBone PainHaemoglobin DecreasedDry Mouth

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methadone and Methotrexate?

You are not alone! Join a related mobile support group:
- support group for people who take Methadone and Methotrexate
- support group for people who take Methadone Hydrochloride
- support group for people who take Methotrexate

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Can i take ketorolac if i am already taking methadone everyday?
    I take methadone everyday and I have a tooth ache so can I take ketorolac with methadone?
  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
  • Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
    I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?
  • What does unmasking mean; and does it mean that i always had hight cholesterol and triglycerides, or did actemra increase them?
    I have failed many RA meds, and now receive actemera x's 10 months I have never had high cholesterol or triglycerides and did not get my cholesterol checked except for the baseline 2/2014 and 12/2014 I was 198 TChol and now am 245; my tri up 85 points. my MD said that now that my inflammation is normal it shows my true cholestorol. I don't understand.

More questions for: Methadone Hydrochloride, Methotrexate

You may be interested at these reviews (Write a review):

  • Are you mental on methadone
    My doctor changed my pain medication back in May of 2014 . I was pleased with how well it handle my back pain and was pleased with how inexpensive it was. My husband had been using the same drug with great results. It wasn't until about a month later I started to notice just feelings of sadness. I didn't think too much of it but then I would get such strong feelings of despair really bad that I would just cry. I also started getting a lot of panic attacks I had so much anxiety at times it prevented me from doing things. At one point I really thought I was having some sort of break down, but the feelings would have highs and lows and sometimes I would have a day with out them. Eventually after being on them for 7 months I went to my doctor and asked if it were possible I was experiencing these feelings from the Methadone. He wasn't sure but with it all happening right after I started taking them he decided to put me on something else. It's been about three weeks and even though the feelings are still there they are not as strong and seem to be passing. I hope as time goes I will feel like myself again and hope never to have to experience something like that again.
  • Methadone and forgetting basic things.
    I have been in MMT (Methadone Maintenance Treatment) for around 7 1/2 years for chronic pain. I have gotten to where I forget things that I never would or did before and the longer in time the worse it has gotten I am currently looking at some different meds for treatment. The loss of memory is everything from childhood memories to what I did yesterday I may pay something and if I dont write it diwn I will forget it things I have known all my life I have forgotten. I can't say 100% it is from the MMT or not however I will sag I had no such problems before and I am at age 38 so I believe I am much too young to have severe memory loss that I am currently experiencing and whats scary is what if it never comes back and continues to decline?
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.

More reviews for: Methadone Hydrochloride, Methotrexate

Comments from related studies:

  • From this study (5 months ago):

  • All lesions necrosis
    Painful granulomas
    I live in chronic pain and fatigue

    Reply

    Lisa on Sep, 4, 2014:

    Female 55 I have bechets. Diagnosed at 39. I take every medication on that list except I dropped methotrexate. I worse since I dropped it. And I have every symptom including ganglion cyst which needs to be surgically removed to the throat lesion. I can barely function. The only 5hing I dont have is the allergic cough. I did have mrsa phenomia once. Oh most recently plursey. I have been ivig dependent for 13 years.

    Reply

  • From this study (1 year ago):

  • I take methotexate weekly.. After a day of taking them, I have terrible chest pain that radiates to my neck, and down my sides

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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