Drug interactions between Methadone Hydrochloride and Methotrexate
This is a real world study of Methadone Hydrochloride and Methotrexate drug interactions. The study is created by eHealthMe based on 259 reports from FDA.
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What are the drugs
Methadone hydrochloride has active ingredients of methadone hydrochloride. It is used in pain, drug abuse and dependence, addiction, opiate withdrawal, back pain - low, drug abuse.
Methotrexate has active ingredients of methotrexate sodium. It is used in rheumatoid arthritis, psoriatic arthritis, arthritis, psoriasis, systemic lupus erythematosus, psoriatic arthropathy.
On Apr, 27, 2013: 259 people who reported to have interactions when taking Methotrexate, Methadone Hydrochloride are studied
Drug combinations in study:
- Methotrexate (methotrexate sodium)
- Methadone Hydrochloride (methadone hydrochloride)
Most common interactions experienced by people in the use of Methotrexate, Methadone Hydrochloride:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Arthralgia | 62 |
| 2 | Dyspnoea | 55 |
| 3 | Pyrexia | 54 |
| 4 | Pain | 52 |
| 5 | Oedema Peripheral | 39 |
| 6 | Anaemia | 36 |
| 7 | Dehydration | 34 |
| 8 | Weight Decreased | 29 |
| 9 | Chest Pain | 26 |
| 10 | Bone Disorder | 26 |
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Most common interactions experienced by people in long term use of Methotrexate, Methadone Hydrochloride:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Non-small Cell Lung Cancer | 4 |
| 2 | Alopecia | 2 |
| 3 | Withdrawal Syndrome | 2 |
| 4 | Arthralgia | 2 |
| 5 | Abortion Spontaneous | 1 |
| 6 | Malaise | 1 |
| 7 | Nausea | 1 |
| 8 | Psoriasis | 1 |
| 9 | Urinary Tract Infection | 1 |
| 10 | Pain | 1 |
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Top conditions involved for these people * :
- Rheumatoid arthritis
- Juvenile arthritis
- Pain
- Acute lymphocytic leukaemia
- Sedation
Top co-used drugs for these people * :
- Methadone hcl
- Folic acid
- Humira
- Prednisone
- Remicade
* Approximation only. Some reports may have incomplete information.
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Side effects in real world:
On eHealthMe, Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
Other drugs that are used to treat the same conditions:
Comments from related studies:
From this study (6 months ago):
just want to know what drugs are safe to take with methadone for arthritis?
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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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