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Review: taking Methotrexate and Tylenol together

Summary: drug interactions are reported among people who take Methotrexate and Tylenol together.

This review analyzes the effectiveness and drug interactions between Methotrexate and Tylenol. It is created by eHealthMe based on reports of 4,883 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

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What are the drugs

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,243 Methotrexate users)

Tylenol has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from 55,638 Tylenol users)

On Feb, 11, 2015: 4,883 people who take Methotrexate, Tylenol are studied

Methotrexate, Tylenol outcomes

Drug combinations in study:
- Methotrexate (methotrexate sodium)
- Tylenol (acetaminophen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methotrexate is effectiven/a0.00%
(0 of 5 people)
100.00%
(1 of 1 people)
50.00%
(1 of 2 people)
0.00%
(0 of 4 people)
14.29%
(1 of 7 people)
100.00%
(1 of 1 people)
n/a
Tylenol is effective50.00%
(1 of 2 people)
n/an/a0.00%
(0 of 4 people)
20.00%
(1 of 5 people)
25.00%
(1 of 4 people)
0.00%
(0 of 5 people)
100.00%
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaNauseaPneumonitisPneumoniaPneumoniaDeep Vein ThrombosisAstheniaPyrexia
NauseaPyrexiaPneumoniaPyrexiaPyrexiaThrombocytopeniaHeadacheNausea
HypotensionVomitingSepsisRespiratory FailureErysipelasNon-small Cell Lung Cancer Stage IiibAgranulocytosisDyspnoea
DehydrationPneumoniaLiver Function Test AbnormalMulti-organ FailureHerpes ZosterPyrexiaOedema PeripheralArthralgia
VomitingRheumatoid ArthritisInfectionSepsisPharyngitis StreptococcalBreast CancerChillsPain
Febrile NeutropeniaCondition AggravatedDehydrationGeneral Physical Health DeteriorationRheumatoid ArthritisVasculitisMyocardial InfarctionHeadache
HyperglycaemiaRashTuberculosisVomitingNauseaNauseaChest PainVomiting
DyspnoeaDyspnoeaWeight DecreasedLung DisorderDyspnoeaPneumoniaCandidiasisFatigue
Respiratory FailureHeadacheAlanine Aminotransferase IncreasedDisseminated TuberculosisFatigueMouth UlcerationPyrexiaOedema Peripheral
HypoalbuminaemiaColitisNauseaAnaemiaCoughPurpuraDehydrationDiarrhoea

Drug effectiveness by gender :

FemaleMale
Methotrexate is effective25.00%
(4 of 16 people)
0.00%
(0 of 4 people)
Tylenol is effective20.00%
(3 of 15 people)
25.00%
(1 of 4 people)

Most common drug interactions by gender * :

FemaleMale
NauseaPyrexia
PyrexiaNausea
HeadachePneumonia
DyspnoeaDyspnoea
PainFatigue
ArthralgiaArthralgia
VomitingVomiting
FatiguePain
DiarrhoeaHypotension
FallCough

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methotrexate is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
33.33%
(1 of 3 people)
9.09%
(2 of 22 people)
7.14%
(1 of 14 people)
Tylenol is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
0.00%
(0 of 3 people)
10.53%
(2 of 19 people)
13.33%
(2 of 15 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Central Line InfectionPyrexiaFebrile NeutropeniaPyrexiaDyspnoeaNauseaHeadachePyrexia
Bronchial HyperreactivityTremorMucosal InflammationPainPyrexiaHeadachePainDyspnoea
AscitesNauseaArthralgiaArthralgiaPruritusPyrexiaArthralgiaPneumonia
Staphylococcal InfectionTachycardiaVomitingHeadacheVomitingPainNauseaNausea
Acute Circulatory FailureDiarrhoeaCrohn's DiseaseNauseaHeadacheArthralgiaPyrexiaOedema Peripheral
Angioneurotic OedemaVomitingPyrexiaDizzinessNauseaDyspnoeaDyspnoeaAtrial Fibrillation
Respiratory DistressTracheobronchitisFebrile Bone Marrow AplasiaDyspnoeaDehydrationFatigueBack PainPain
Lobar PneumoniaAscitesMulti-organ FailureDiarrhoeaCoughVomitingDiarrhoeaArthralgia
Condition AggravatedRespiratory FailureMuscular WeaknessCrohn's DiseaseHyperglycaemiaOedema PeripheralVomitingFatigue
Bacteria Stool IdentifiedPseudomonal BacteraemiaPain In ExtremityInfusion Related ReactionDiarrhoeaChest PainAstheniaFall

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Methotrexate and Tylenol on

Do you take Methotrexate and Tylenol?

You are not alone! Join a related mobile support group:
- support group for people who take Methotrexate and Tylenol
- support group for people who take Methotrexate
- support group for people who take Tylenol

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Will a hiatal hernia swell or decrease or stay the same size?
    After taking Tylenol, my hiatal hernia is tender to the touch and seems to get bigger and protrudes more. Is this happening or do I just imagine it seems bigger?
  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
  • Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
    I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?
  • What does unmasking mean; and does it mean that i always had hight cholesterol and triglycerides, or did actemra increase them?
    I have failed many RA meds, and now receive actemera x's 10 months I have never had high cholesterol or triglycerides and did not get my cholesterol checked except for the baseline 2/2014 and 12/2014 I was 198 TChol and now am 245; my tri up 85 points. my MD said that now that my inflammation is normal it shows my true cholestorol. I don't understand.

More questions for: Methotrexate, Tylenol

You may be interested at these reviews (Write a review):

  • The dangers off fluoridation
    I live in an area where the water has been fluoridated for approximately 55 years and have been treated for an underactive thyroid since 1978. I have also suffered from urge incontinence since 1967 and for 4 years have also had the symptoms of skeletal fluorosis although I have not been able to get the tests to confirm this. About 2 years ago I read about the dangers of fluoride and stopped using the tap water for drinking and cooking but still had to use it for bathing and still swam in the local pool. Also I have always drunk about 3 pints of tea a day. Recently it was found that there might be a problem with my kidneys so I stopped drinking tea and swimming. I had been going to the toilet 16/17 times a day but after about 5 weeks this was down to 7/8 times and the urgency was gone. Also I was given a follow up kidney function test after 6 weeks and that was normal. A few weeks later I was shopping in an area where the water is not fluoridated and risked having tea in a cafe there and the irritable bladder symptoms came back almost immediately and lasted for several weeks.
  • Muscle weakness from methotrexate
    I'm 61 and have taken methotrexate for 25 yrs. I've always done well with my blood results etc. Lately I've been having problems pushing a grocery cart. My arm muscles are so weak!
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  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Bone pain localized to poison ivy rash
    I am having a moderate to strong reaction to poison ivy exposure. I have a localized rash with blistering, swelling and inflammation similar to cellulitis. The rash has been progressing for about a week. The blisters are not weeping or oozing. The area is cleaned daily with neem oil soap. Coincident with the rash, I have a persistent ache/pain in my lower forearm, wrist and hand that is responding weakly to Aleve and pretty much unresponsive to acetaminophen.

More reviews for: Methotrexate, Tylenol

Comments from related studies:

  • From this study (1 month ago):

  • recurring vertigo that lasts from an hour to a couple of days per episode

    Reply

  • From this study (7 months ago):

  • I've been diagnosed with sero-negative rheumatoid arthritis. I have only tested minimally positive on the anti-CCP test and had a slightly high SED rate. My most recent tests showed some slight elevation in some RA marker tests, but nothing really significant. My rheumatologist is now doubting whether I have RA or some other pain syndrome going on.

    Reply

    IHateRA on Jul, 22, 2014:

    My first RA Dr. put me on Plaquenil, it seemed to work for six months, then stopped - I thought the dose would be adjusted but it wasn't, so I went to another RA Doc - C-RP wasn't too high, sero neg. Was put on methotrexate - I ended up with a mouth sore the NEXT day, then bumps started appearing on my face, like zits, but NOT zits. I didn't touch them, but they ulcerated, left me full of scars on face, legs, etc - I have been OFF methotrexate for 5 years AND still have the same problem along with a daily fever (100+) and severe sweating - I knew the bumps were a sign of being allergic to Methotrexate, I quit it right away, called Dr. to get in - they told me 3 months (I was an established patient). In terms of fever and sweating, the ONLY thing I have in common with some of these posts and drug lists is METHOTREXATE - I wouldn't allow a pet to take it. I seem to have more in common with a friend who as MS - but my reg. doc doesn't listen to that. I can't take bio. drugs (live in "fungal" region), so I take pain medicine - as little as possible, I guess the Methotrexate is STILL messing with my body. I have a very good acupuncturist - when I told him that my Doc. wasn't "sure" about RA, he poked me (lightly) with his finger in two places and ask which hurt more. He confirmed the RA as it travels on certain meridians in Chinese medicine. Had I picked a different spot for hurting more, then we would have to figure out what I really had. My joints are deteriorating but now I'm afraid of the drugs for RA, so I just put up with and manage the pain (which is extreme) with pain meds, cold therapy (I love my cryo-cuff), and acupuncture. I wish that the side effects of RA drugs weren't as bad as they are! Leaving Cymbalta, Lyrica, Plaquenil and Methotrexate (all at different times) OUT of my body made me realize that they did affect me - I was "foggy" and sluggish mentally but didn't really notice it until I quit them.

    Reply

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Complete drug side effects:

On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Tylenol (acetaminophen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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