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Review: Methotrexate and Tylenol





Summary: drug interactions are reported among people who take Methotrexate and Tylenol together.

This review analyzes the effectiveness and drug interactions between Methotrexate and Tylenol. It is created by eHealthMe based on reports of 4,881 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Methotrexate and Tylenol >>>

What are the drugs

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (view latest outcomes from 131,201 users)

Tylenol has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from Tylenol 55,615 users)

On Dec, 13, 2014: 4,881 people who take Methotrexate, Tylenol are studied

Methotrexate, Tylenol outcomes

Drug combinations in study:
- Methotrexate (methotrexate sodium)
- Tylenol (acetaminophen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methotrexate is effectiven/a0.00%
(0 of 5 people)
100.00%
(1 of 1 people)
50.00%
(1 of 2 people)
0.00%
(0 of 4 people)
0.00%
(0 of 5 people)
100.00%
(1 of 1 people)
n/a
Tylenol is effective50.00%
(1 of 2 people)
n/an/a0.00%
(0 of 4 people)
20.00%
(1 of 5 people)
0.00%
(0 of 2 people)
0.00%
(0 of 5 people)
100.00%
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaNauseaPneumonitisPneumoniaPneumoniaDeep Vein ThrombosisAstheniaPyrexia
NauseaPyrexiaPneumoniaPyrexiaPyrexiaThrombocytopeniaHeadacheNausea
HypotensionVomitingSepsisRespiratory FailureErysipelasPyrexiaAgranulocytosisDyspnoea
DehydrationPneumoniaLiver Function Test AbnormalMulti-organ FailureHerpes ZosterNon-small Cell Lung Cancer Stage IiibOedema PeripheralArthralgia
VomitingRheumatoid ArthritisInfectionSepsisPharyngitis StreptococcalMouth UlcerationChillsPain
Febrile NeutropeniaCondition AggravatedDehydrationGeneral Physical Health DeteriorationRheumatoid ArthritisPurpuraMyocardial InfarctionHeadache
HyperglycaemiaRashTuberculosisVomitingNauseaCoughChest PainVomiting
DyspnoeaDyspnoeaWeight DecreasedLung DisorderDyspnoeaPancytopeniaCandidiasisFatigue
Respiratory FailureHeadacheAlanine Aminotransferase IncreasedDisseminated TuberculosisFatigueWeight DecreasedPyrexiaOedema Peripheral
HypoalbuminaemiaColitisNauseaAnaemiaCoughHeadacheDehydrationDiarrhoea

Drug effectiveness by gender :

FemaleMale
Methotrexate is effective20.00%
(3 of 15 people)
0.00%
(0 of 3 people)
Tylenol is effective14.29%
(2 of 14 people)
33.33%
(1 of 3 people)

Most common drug interactions by gender * :

FemaleMale
NauseaPyrexia
PyrexiaNausea
HeadachePneumonia
DyspnoeaDyspnoea
PainFatigue
ArthralgiaArthralgia
VomitingVomiting
FatiguePain
DiarrhoeaHypotension
FallCough

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methotrexate is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
50.00%
(1 of 2 people)
4.76%
(1 of 21 people)
7.14%
(1 of 14 people)
Tylenol is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
0.00%
(0 of 2 people)
5.56%
(1 of 18 people)
13.33%
(2 of 15 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Central Line InfectionPyrexiaFebrile NeutropeniaPyrexiaDyspnoeaNauseaHeadachePyrexia
Bronchial HyperreactivityTremorMucosal InflammationPainPyrexiaHeadachePainDyspnoea
AscitesNauseaArthralgiaArthralgiaPruritusPyrexiaArthralgiaPneumonia
Staphylococcal InfectionTachycardiaVomitingHeadacheVomitingPainNauseaNausea
Acute Circulatory FailureDiarrhoeaCrohn's DiseaseNauseaHeadacheArthralgiaPyrexiaOedema Peripheral
Angioneurotic OedemaVomitingPyrexiaDizzinessNauseaDyspnoeaDyspnoeaAtrial Fibrillation
Respiratory DistressTracheobronchitisFebrile Bone Marrow AplasiaDyspnoeaDehydrationFatigueBack PainPain
Lobar PneumoniaAscitesMulti-organ FailureDiarrhoeaCoughVomitingDiarrhoeaArthralgia
Condition AggravatedRespiratory FailureMuscular WeaknessCrohn's DiseaseHyperglycaemiaOedema PeripheralVomitingFatigue
Bacteria Stool IdentifiedPseudomonal BacteraemiaPain In ExtremityInfusion Related ReactionDiarrhoeaChest PainAstheniaFall

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methotrexate and Tylenol?

You are not alone! Join a related mobile support group:
- support group for people who take Methotrexate and Tylenol
- support group for people who take Methotrexate
- support group for people who take Tylenol

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Can a drug test result return positive for amphetamine using 500mg tylenol extra strength
    Can a drug test result return positive for amphetamine using 500mg tylenol extra strength?
  • Can unexplained hypertension be cause by a partial thyroidectomy?
    Doc is trying to figure out why the BP suddenly spiked. I started an exercise regimen after a stress test. I had to be on Metoprolol just to pass the test. Results were no heart-related issues. Lost 6lbs. since starting exercise and don't know if this is Thyroidal or not. No discussion with the doc yet of whether this is related to the thyroidectomy of the past.
  • Does zoloft cause ringing in the ears, like tinnitus? i've been on it for a month and noticed the ringing in the ears about a week ago, and it's just constant ringing and it's driving me insane. (1 answer)
    I've been on most of the medications for more than a year and it hasn't been that bad getting used to them. But I've been on Zoloft and ambien for about a month now, and I've been noticing a lot of side effects. The one I just recently noticed and that has been driving me completely insane, is the ringing in the ears. It's been about a week now and I just don't know what to do anymore. If it is the Zoloft then I can finally just stop taking it and make this stop. If anyone has an answer or knows what to do, PLEASE help. I'm at my wits end.
  • Hlab27 antigen and unexplained scratches caused by accutane
    Guinea pig user of Accutane 1982. Experimental drug (told at that time) when a woman hits menopause we are not sure what will happen. I have hit early menopause 42 to be exact. Conjunctivitis, unexplained swelling in fingers, toes, kness, pseudogout (not normal according to my rheumatologist) unexplained scratches in same location, forearms, lower thigh (by knee) fingers. Scratches always are in a line with a break in the line. When a woman hits menopause hormones cease and when this happens the path that Accutane takes to cease sebaceous gland function, skin proliferation ceases. Therefore, my friends the HLA B27 (abnormal antigen targeted for skin proliferation does not know where to go so it randomly attacks whatever organ it chooses. Accutane if I remember correctly and I do have proof, permanently alters DNA. There is no other way orally ingesting a retinolic acid it could control skin, hormonal cesessation. I have only been diagnosed thus far with psoriatic arthritis with no other explanations for these other symptoms. I wonder why this is and I also wonder why dermatologists refuse to take a biopsy of my skin to rule out cell skin proliferation dysfunction. What will this damaging drug attack next. Do no be fooled by Dr.s who tell you that you took this drug so long ago how could this be. Well folks, it is because it has already changed your DNA to the HLAB27 antigen. My question also is, what was supposed to be where this abnormal DNA antigen is and how come this antigen only shows up at menopause. My disease (autoimmune) is progressive) and has already attacked nervous, muscle, skin, joints etc. Interesting
  • Can long-term methadone use cause or increase the risk of colon cancer?
    I had a two-level spinal fusion at L4-S1 in 2000 after being injuried at work in Sept. 24, 1997. I lost everything after...the unjury, ability to do my job, my wife and family (couldn't take the strain) my home, my sense of self and purpose, direction and belonging...credit rating and ability to pay my bills.
    After a long period of waiting to settle my workmens' comp. case, I returned home, from the Bat Area back to Arizona to take of my mother with a yet un dianosed case of moderate dementia.
    Then, in 2011 I had a 2nd surgery to relieve spinal stenosis btwn. L2-L4, just above the fusion site.
    I've been taking methadone since early 2004, a little over ten years, now. I've had high blood pressure since my injury.

    Now, I waiting to be scheduled for a colonoscopy, with my father having had polyps and the way I've been feeling..drained, tired all the time, and stomach pains ( in addition to my chronic low back pain), I...
    find myself wondering if there is any relationtionship between the methadone and other meds and cancer?

More questions for: Methotrexate, Tylenol

You may be interested at these reviews (Write a review):

  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Bone pain localized to poison ivy rash
    I am having a moderate to strong reaction to poison ivy exposure. I have a localized rash with blistering, swelling and inflammation similar to cellulitis. The rash has been progressing for about a week. The blisters are not weeping or oozing. The area is cleaned daily with neem oil soap. Coincident with the rash, I have a persistent ache/pain in my lower forearm, wrist and hand that is responding weakly to Aleve and pretty much unresponsive to acetaminophen.
  • Xanax bed wetting will it stop and do i wear diapers or die (1 response)
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    Just want to bleed out and not hurt anymore and be so scared to leave my house or sleep. I just want to sleep forever.
  • Penicillin vk induced drowsiness
    I have been taking Penicillin VK and Acetaminophen for a severe pain I had been feeling in my ear. It's been 48 hours since I started taking them. Within the first 24 hours the pain had calmed down and I was feeling normal. However, since day 2 started, I have been feeling really drowsy. I keep falling asleep with no reason or desire to sleep. I just wanted to put this side effect out there for anyone else who might be feeling the same.
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  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
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    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine

More reviews for: Methotrexate, Tylenol

Comments from related studies:

  • From this study (5 months ago):

  • I've been diagnosed with sero-negative rheumatoid arthritis. I have only tested minimally positive on the anti-CCP test and had a slightly high SED rate. My most recent tests showed some slight elevation in some RA marker tests, but nothing really significant. My rheumatologist is now doubting whether I have RA or some other pain syndrome going on.

    Reply

    IHateRA on Jul, 22, 2014:

    My first RA Dr. put me on Plaquenil, it seemed to work for six months, then stopped - I thought the dose would be adjusted but it wasn't, so I went to another RA Doc - C-RP wasn't too high, sero neg. Was put on methotrexate - I ended up with a mouth sore the NEXT day, then bumps started appearing on my face, like zits, but NOT zits. I didn't touch them, but they ulcerated, left me full of scars on face, legs, etc - I have been OFF methotrexate for 5 years AND still have the same problem along with a daily fever (100+) and severe sweating - I knew the bumps were a sign of being allergic to Methotrexate, I quit it right away, called Dr. to get in - they told me 3 months (I was an established patient). In terms of fever and sweating, the ONLY thing I have in common with some of these posts and drug lists is METHOTREXATE - I wouldn't allow a pet to take it. I seem to have more in common with a friend who as MS - but my reg. doc doesn't listen to that. I can't take bio. drugs (live in "fungal" region), so I take pain medicine - as little as possible, I guess the Methotrexate is STILL messing with my body. I have a very good acupuncturist - when I told him that my Doc. wasn't "sure" about RA, he poked me (lightly) with his finger in two places and ask which hurt more. He confirmed the RA as it travels on certain meridians in Chinese medicine. Had I picked a different spot for hurting more, then we would have to figure out what I really had. My joints are deteriorating but now I'm afraid of the drugs for RA, so I just put up with and manage the pain (which is extreme) with pain meds, cold therapy (I love my cryo-cuff), and acupuncture. I wish that the side effects of RA drugs weren't as bad as they are! Leaving Cymbalta, Lyrica, Plaquenil and Methotrexate (all at different times) OUT of my body made me realize that they did affect me - I was "foggy" and sluggish mentally but didn't really notice it until I quit them.

    Reply

  • From this study (1 year ago):

  • I am having most of the symptoms of Hypothyroid, weight gain, very dry skin & hair, easily stressed, palpitations yet my doctor tells me my bloods are normal. No one seems to know why I am feeling so bad all the time.

    Reply

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Complete drug side effects:

On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Tylenol (acetaminophen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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