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Review: Methotrexate and Tylenol

This review analyzes the effectiveness and drug interactions between Methotrexate and Tylenol. It is created by eHealthMe based on reports of 4,881 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Methotrexate and Tylenol >>>

What are the drugs

Methotrexate (what 131,102 Methotrexate users reported?) has active ingredients of methotrexate sodium. It is used in rheumatoid arthritis.

Tylenol (what 55,595 Tylenol users reported?) has active ingredients of acetaminophen. It is used in pain.

On Aug, 11, 2014: 4,881 people who take Methotrexate, Tylenol are studied

Methotrexate, Tylenol outcomes

Drug combinations in study:
- Methotrexate (methotrexate sodium)
- Tylenol (acetaminophen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methotrexate is effectiven/a0.00%
(0 of 5 people)
100.00%
(1 of 1 people)
50.00%
(1 of 2 people)
0.00%
(0 of 4 people)
0.00%
(0 of 5 people)
100.00%
(1 of 1 people)
n/a
Tylenol is effective50.00%
(1 of 2 people)
n/an/a0.00%
(0 of 4 people)
20.00%
(1 of 5 people)
0.00%
(0 of 2 people)
0.00%
(0 of 5 people)
100.00%
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaNauseaPneumonitisPneumoniaPneumoniaDeep Vein ThrombosisAstheniaPyrexia
NauseaPyrexiaPneumoniaPyrexiaPyrexiaThrombocytopeniaHeadacheNausea
HypotensionVomitingSepsisRespiratory FailureErysipelasPyrexiaAgranulocytosisDyspnoea
DehydrationPneumoniaLiver Function Test AbnormalMulti-organ FailureHerpes ZosterNon-small Cell Lung Cancer Stage IiibOedema PeripheralArthralgia
VomitingRheumatoid ArthritisInfectionSepsisPharyngitis StreptococcalMouth UlcerationChillsPain
Febrile NeutropeniaCondition AggravatedDehydrationGeneral Physical Health DeteriorationRheumatoid ArthritisPurpuraMyocardial InfarctionHeadache
HyperglycaemiaRashTuberculosisVomitingNauseaCoughChest PainVomiting
DyspnoeaDyspnoeaWeight DecreasedLung DisorderDyspnoeaPancytopeniaCandidiasisFatigue
Respiratory FailureHeadacheAlanine Aminotransferase IncreasedDisseminated TuberculosisFatigueWeight DecreasedPyrexiaOedema Peripheral
HypoalbuminaemiaColitisNauseaAnaemiaCoughHeadacheDehydrationDiarrhoea

Drug effectiveness by gender :

FemaleMale
Methotrexate is effective20.00%
(3 of 15 people)
0.00%
(0 of 3 people)
Tylenol is effective14.29%
(2 of 14 people)
33.33%
(1 of 3 people)

Most common drug interactions by gender * :

FemaleMale
NauseaPyrexia
PyrexiaNausea
HeadachePneumonia
DyspnoeaDyspnoea
PainFatigue
ArthralgiaArthralgia
VomitingVomiting
FatiguePain
DiarrhoeaHypotension
FallCough

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methotrexate is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
50.00%
(1 of 2 people)
4.76%
(1 of 21 people)
7.14%
(1 of 14 people)
Tylenol is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
0.00%
(0 of 2 people)
5.56%
(1 of 18 people)
13.33%
(2 of 15 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Central Line InfectionPyrexiaFebrile NeutropeniaPyrexiaDyspnoeaNauseaHeadachePyrexia
Bronchial HyperreactivityTremorMucosal InflammationPainPyrexiaHeadachePainDyspnoea
AscitesNauseaArthralgiaArthralgiaPruritusPyrexiaArthralgiaPneumonia
Staphylococcal InfectionTachycardiaVomitingHeadacheVomitingPainNauseaNausea
Acute Circulatory FailureDiarrhoeaCrohn's DiseaseNauseaHeadacheArthralgiaPyrexiaOedema Peripheral
Angioneurotic OedemaVomitingPyrexiaDizzinessNauseaDyspnoeaDyspnoeaAtrial Fibrillation
Respiratory DistressTracheobronchitisFebrile Bone Marrow AplasiaDyspnoeaDehydrationFatigueBack PainPain
Lobar PneumoniaAscitesMulti-organ FailureDiarrhoeaCoughVomitingDiarrhoeaArthralgia
Condition AggravatedRespiratory FailureMuscular WeaknessCrohn's DiseaseHyperglycaemiaOedema PeripheralVomitingFatigue
Bacteria Stool IdentifiedPseudomonal BacteraemiaPain In ExtremityInfusion Related ReactionDiarrhoeaChest PainAstheniaFall

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group to help out with your experience or learn from others anytime and anywhere:
- group for people who take Methotrexate and Tylenol
- group for people who take Methotrexate
- group for people who take Tylenol

Comments from related studies:

  • From this study (3 weeks ago):

  • I've been diagnosed with sero-negative rheumatoid arthritis. I have only tested minimally positive on the anti-CCP test and had a slightly high SED rate. My most recent tests showed some slight elevation in some RA marker tests, but nothing really significant. My rheumatologist is now doubting whether I have RA or some other pain syndrome going on.

    Reply

    IHateRA on Jul, 22, 2014:

    My first RA Dr. put me on Plaquenil, it seemed to work for six months, then stopped - I thought the dose would be adjusted but it wasn't, so I went to another RA Doc - C-RP wasn't too high, sero neg. Was put on methotrexate - I ended up with a mouth sore the NEXT day, then bumps started appearing on my face, like zits, but NOT zits. I didn't touch them, but they ulcerated, left me full of scars on face, legs, etc - I have been OFF methotrexate for 5 years AND still have the same problem along with a daily fever (100+) and severe sweating - I knew the bumps were a sign of being allergic to Methotrexate, I quit it right away, called Dr. to get in - they told me 3 months (I was an established patient). In terms of fever and sweating, the ONLY thing I have in common with some of these posts and drug lists is METHOTREXATE - I wouldn't allow a pet to take it. I seem to have more in common with a friend who as MS - but my reg. doc doesn't listen to that. I can't take bio. drugs (live in "fungal" region), so I take pain medicine - as little as possible, I guess the Methotrexate is STILL messing with my body. I have a very good acupuncturist - when I told him that my Doc. wasn't "sure" about RA, he poked me (lightly) with his finger in two places and ask which hurt more. He confirmed the RA as it travels on certain meridians in Chinese medicine. Had I picked a different spot for hurting more, then we would have to figure out what I really had. My joints are deteriorating but now I'm afraid of the drugs for RA, so I just put up with and manage the pain (which is extreme) with pain meds, cold therapy (I love my cryo-cuff), and acupuncture. I wish that the side effects of RA drugs weren't as bad as they are! Leaving Cymbalta, Lyrica, Plaquenil and Methotrexate (all at different times) OUT of my body made me realize that they did affect me - I was "foggy" and sluggish mentally but didn't really notice it until I quit them.

    Reply

  • From this study (12 months ago):

  • I am having most of the symptoms of Hypothyroid, weight gain, very dry skin & hair, easily stressed, palpitations yet my doctor tells me my bloods are normal. No one seems to know why I am feeling so bad all the time.

    Reply

  • From this study (1 year ago):

  • I want to know if in fact there is a relation between these conditions and if there is any possibility that the adderall which he used for years before getting the other two conditions has anything to do with the two. Also if the chronic asthma medications he was exposed as a baby (proventyl, pulmicort and prednisone). Fyi child has allergy to amoxil. Thank you.

    Reply

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Complete drug side effects:

On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Tylenol (acetaminophen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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