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Review: Naproxen and Tylenol W/ Codeine

Summary: drug interactions are reported among people who take Naproxen and Tylenol W/ Codeine together.

This review analyzes the effectiveness and drug interactions between Naproxen and Tylenol W/ Codeine. It is created by eHealthMe based on reports of 750 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Naproxen and Tylenol W/ Codeine >>>

What are the drugs

Naproxen has active ingredients of naproxen. It is often used in pain. (latest outcomes from Naproxen 21,930 users)

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. (latest outcomes from Tylenol w/ codeine 8,049 users)

On Dec, 15, 2014: 749 people who take Naproxen, Tylenol W/ Codeine are studied

Naproxen, Tylenol W/ Codeine outcomes

Drug combinations in study:
- Naproxen (naproxen)
- Tylenol W/ Codeine (acetaminophen; codeine phosphate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Naproxen is effective12.50%
(2 of 16 people)
(0 of 5 people)
(0 of 2 people)
(0 of 2 people)
(0 of 2 people)
(0 of 1 people)
(0 of 1 people)
(0 of 1 people)
Tylenol W/ Codeine is effective21.43%
(3 of 14 people)
(1 of 5 people)
(0 of 2 people)
(0 of 1 people)
(2 of 3 people)
(0 of 1 people)
(0 of 1 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Abdominal PainPregnancy On Oral ContraceptiveCoronary Artery StenosisDiarrhoeaInsomniaAnxietyUpper Gastrointestinal HaemorrhagePain
Duodenal UlcerMaternal Exposure During PregnancyNeurofibromatosisPainAnxietyInsomniaGastric UlcerDyspnoea
DizzinessPregnancyOsteoarthritisCholecystitis ChronicDepressionCholecystitis ChronicHaemoglobin DecreasedAnxiety
PallorCoronary Artery StenosisCellulitisGallbladder Non-functioningSuicidal IdeationGallbladder InjuryDizzinessHeadache
Gastrointestinal HaemorrhageGastrointestinal HaemorrhageEscherichia InfectionVomitingInflammatory PainAbdominal Pain UpperHaematemesisDizziness
LethargyAnaemiaInterstitial Lung DiseaseAppendicitis PerforatedDysarthriaDepressionMalaiseDepression
Lip SwellingOsteoarthritisRespiratory FailureDeep Vein ThrombosisSuicidal IdeationPainNausea
HaematemesisCellulitisExhaustion, Fatigue, Lethargy, Tiredness, WearinessPulmonary EmbolismFolate DeficiencyPollakiuriaArthralgia
Gastric UlcerExhaustion, Fatigue, Lethargy, Tiredness, WearinessDry MouthGallbladder CholesterolosisInterstitial Lung DiseaseDepressionChest Pain
Faeces DiscolouredLightheadednessDyspnoea ExertionalNauseaPulmonary FibrosisHepatotoxicityFall

Drug effectiveness by gender :

Naproxen is effective5.26%
(1 of 19 people)
(1 of 11 people)
Tylenol W/ Codeine is effective16.67%
(3 of 18 people)
(4 of 10 people)

Most common drug interactions by gender * :

DizzinessBone Disorder
AnxietyOral Disorder
Oedema PeripheralHeadache
MigraineWeight Decreased

Drug effectiveness by age :

Naproxen is effectiven/an/an/a14.29%
(1 of 7 people)
(0 of 7 people)
(0 of 12 people)
(0 of 9 people)
(1 of 11 people)
Tylenol W/ Codeine is effectiven/an/an/a14.29%
(1 of 7 people)
(3 of 7 people)
(0 of 12 people)
(3 of 8 people)
(0 of 7 people)

Most common drug interactions by age * :

n/aNeurofibromatosisPyrexiaPregnancy On Oral ContraceptiveAnxietyFallChest PainPain
Pulmonary EmbolismParaesthesiaPainOedema PeripheralDyspnoeaAnxiety
Abdominal Pain UpperDyspnoeaDepressionBack PainNauseaInjury
NauseaHypoaesthesiaDrug DependenceArthralgiaMalaiseHaemoglobin Decreased
VomitingSomnolenceHeadacheHeadacheMyalgiaBone Disorder
Completed SuicideMaternal Exposure During PregnancyAgitationPainDizzinessOral Disorder
PainSinus HeadacheHypertensionChest PainHeadacheGastrointestinal Haemorrhage
Cholecystitis ChronicPainful RespirationArthralgiaRashUpper Airway ObstructionDizziness
Lung DisorderNeuropathy PeripheralDizzinessFatigueHaematomaDyspnoea
Abdominal PainPruritusDrug Withdrawal SyndromeWeight IncreasedDiarrhoeaInfection

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Naproxen and Tylenol W/ Codeine?

You are not alone! Join a related mobile support group:
- support group for people who take Naproxen and Tylenol W/ Codeine
- support group for people who take Naproxen
- support group for people who take Tylenol W/ Codeine

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Can long-term methadone use cause or increase the risk of colon cancer?
    I had a two-level spinal fusion at L4-S1 in 2000 after being injuried at work in Sept. 24, 1997. I lost everything after...the unjury, ability to do my job, my wife and family (couldn't take the strain) my home, my sense of self and purpose, direction and rating and ability to pay my bills.
    After a long period of waiting to settle my workmens' comp. case, I returned home, from the Bat Area back to Arizona to take of my mother with a yet un dianosed case of moderate dementia.
    Then, in 2011 I had a 2nd surgery to relieve spinal stenosis btwn. L2-L4, just above the fusion site.
    I've been taking methadone since early 2004, a little over ten years, now. I've had high blood pressure since my injury.

    Now, I waiting to be scheduled for a colonoscopy, with my father having had polyps and the way I've been feeling..drained, tired all the time, and stomach pains ( in addition to my chronic low back pain), I...
    find myself wondering if there is any relationtionship between the methadone and other meds and cancer?
  • What can i do to lessen the diarrhea i get while taking naprosyn?
    I am already using probiotics and trying to eat yogurt once a day. I also make sure to take medication on a full stomach.
  • Does tylenol slow down my ileostomy
    I have an iloestomy and taking pain killers due back pain arthritis and fibro
  • Cranberry juice making percocet not show up in a uv test.
    Had gotting Kidney Stones and had been drinking about 3 gallons of cranberry juice and bunch of water and went in for a ut test and it came back neg for percocet. I always take my pills but don't alway take them at the right time cause sometimes i have to drive my niece so i wouldn't take them when i had to drive, i have alway drive cranberry juice and a lot of water cause i started a new diet millary diet and started losing wiegt i lose 30 to 35 pound also for the past year the head dr. has been changing my meds and for the pass 6 to 7 month i've being taking what i have list i'm really don't know was going on, i just know that i was taking my pain meds and know they have stoped them. I just hope them maybe someone on here might understand what's going on. Thanks to anyone for any help that you can give me.
  • Caffeine, anhydrous and sodium benzoate injection?
    A treatment has been prescribed but cannot be administered due to the decision by American Regent to not release their Caffeine and Sodium Benzoate Injection product (Caffeine, anhydrous (125 mg/mL) and Sodium benzoate (125 mg/mL)

    2 mL single-dose vial). Does anyone take this via injection or IV, and if so, can you identify the source of the Caffeine and Sodium Benzoate Injection product? Thank you!

More questions for: Naproxen, Tylenol W/ Codeine

You may be interested at these reviews (Write a review):

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    Taking naproxen for pain relief of mortons neuromas. 500 mg twice a day (cut in half) caused breathing problems. Now dose reduced to 125mg 2xdaily still causing intense jaw pain
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    I started getting eczema over the last year and recently decided it may be from the birth control as well, which I started taking @ 2 months before I got the eczema and skin started breaking out...weight gain, etc. I am on singulair, westcort cream, moisture/kenalog, exederm cream, cerevue wash, cetaphil moisturizer, and started using the black soap which is apparently helping. I started a vegetarian diet and eat mainly the same foods daily to monitor anything for allergies. I stopped taking the pill 3 days ago and I am optimistic. I am hoping others have had positive experiences.
  • Horrific nightmares taking naproxen
    I've Taking naproxen 500mg twice a day for 3 weeks on a course for 6 months, I've been having horrific dreams worse than horrer movies, the most recent is involving my ex & current partner where I had a psychotic stalker (my ex) switched around because in the dream I dump my partner for my ex, well the things that have been going on in my dreams are scary to the point I've woken up screaming/ crying, body is covered in sweat & it's stopping me from sleeping more, I get around 2 hours sleep a night off them..... I mean dripping, this dream was so horrific I had to post a review which I woke up around 15 mins ago, I have nightmares quiet often but never this bad
  • Pulse increase with tylenol w/ codeine/caffeine no. 3
    Knee arthroscopic surgery at 2pm

    Took one tablet with food at 2am that night (next morning actually) before going to bed.

    Pulse increased to 88-92 after about 20-30 min (taken for 15 secs and multiplied)(taken a few times)

    Possible interaction with chocolate milk???

    Next morning at 8am pulse was down to 68

    Pre surgery pulse (my normal) was 60

    Not on any other medication. Weight 220lbs. 5'10"

    Stopped use...pain not that significant.

More reviews for: Naproxen, Tylenol W/ Codeine

Comments from related studies:

  • From this study (6 months ago):

  • head/neck injury 17 days ago. post anterior cervical disc fusion december 2012. History of migraines.


  • From this study (1 year ago):

  • Angiedema induced by drugs or some food( suddenly and never had it before)


  • From this study (2 years ago):

  • i have systemic lupus and idiopathic thrombocytopenic purpura.Also lower back pain ,tingling sensation below the knee in both legs.possible prolapsed disc


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Naproxen (naproxen) is often used to treat pain. Tylenol W/ Codeine (acetaminophen; codeine phosphate) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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