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Review: taking Naproxen and Omeprazole together

Summary: drug interactions are reported among people who take Naproxen and Omeprazole together.

This review analyzes the effectiveness and drug interactions between Naproxen and Omeprazole. It is created by eHealthMe based on reports of 2,681 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 5, 2015: 2,679 people who take Naproxen, Omeprazole are studied

Naproxen, Omeprazole outcomes

Drug combinations in study:
- Naproxen (naproxen)
- Omeprazole (omeprazole)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Naproxen is effective35.71%
(5 of 14 people)
(5 of 15 people)
(3 of 12 people)
(3 of 14 people)
(6 of 16 people)
(1 of 3 people)
(5 of 8 people)
(0 of 2 people)
Omeprazole is effective50.00%
(3 of 6 people)
(8 of 17 people)
(4 of 7 people)
(8 of 17 people)
(20 of 23 people)
(4 of 7 people)
(5 of 7 people)
(0 of 1 people)

Drug effectiveness by gender :

Naproxen is effective32.14%
(18 of 56 people)
(10 of 28 people)
Omeprazole is effective60.34%
(35 of 58 people)
(17 of 27 people)

Drug effectiveness by age :

Naproxen is effectiven/an/an/a22.22%
(4 of 18 people)
(1 of 45 people)
(10 of 65 people)
(5 of 56 people)
(8 of 42 people)
Omeprazole is effectiven/an/an/a22.22%
(4 of 18 people)
(5 of 45 people)
(14 of 85 people)
(13 of 56 people)
(16 of 42 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Renal Failure AcuteAbdominal PainPainPulmonary EmbolismAnxietyAnxietyDisease ProgressionPain
DiarrhoeaSelf-injurious IdeationRib FractureInjuryPulmonary EmbolismDepressionSpondylosisNausea
Stevens-johnson SyndromeDepression SuicidalStress FracturePainHeadachePainDegenerative Joint DiseaseAnxiety
Lip SwellingGastrointestinal HaemorrhageBone Density DecreasedDizzinessChest PainEmotional DistressOsteoarthritisArthralgia
MyalgiaAnaemiaHip FractureDeep Vein ThrombosisDyspnoeaHaemorrhagic StrokeFibromyalgiaDyspnoea
AnuriaDuodenal UlcerOsteopeniaAbdominal DiscomfortDepressionHypertensionHeadache NosFatigue
Acute Generalised Exanthematous PustulosisHaematemesisDiarrhoeaOesophagitisGastrointestinal DisorderHeart Rate IrregularVertigoFall
Abdominal PainMyalgiaVomitingAnxiety DisorderGeneral Physical Health DeteriorationHiatus HerniaRash GeneralisedAnaemia
DyspnoeaChange Of Bowel HabitFallPortal Vein ThrombosisEmotional DistressSubdural HaemorrhageDizzinessBack Pain
Confusional StateMelaenaNauseaSplenic Vein ThrombosisPainInjuryEar CongestionInjury

Most common drug interactions by gender * :

FallBack Pain
Urinary Tract InfectionArthralgia
Back PainOsteonecrosis Of Jaw

Most common drug interactions by age * :

PalpitationsOsteosclerosisArthralgiaGallbladder DisorderAbdominal Pain UpperChest PainPainPain
OsteoporosisErythemaPyrexiaFatigueCholecystitis ChronicPainArthralgiaNausea
ArthritisTransaminases IncreasedDrug Rash With Eosinophilia And Systemic SymptomsCholecystitis ChronicCholelithiasisNauseaAnxietyDyspnoea
Rash GeneralisedHepatitis AcuteMulti-organ FailurePainHyperglycaemiaDiabetes MellitusFatigueAnxiety
TachycardiaConstipationDisseminated Intravascular CoagulationAbdominal PainNauseaDepressionOsteoarthritisFall
Type 2 Diabetes MellitusHaematocheziaBalance DisorderVomitingDeep Vein ThrombosisBack PainOsteonecrosis Of JawDiarrhoea
Transient Ischaemic AttackBone PainBrain OedemaInjuryDyspepsiaHeadacheBack PainAnaemia
HypertensionOsteomyelitisRashAnxietyOedema PeripheralDizzinessNauseaDizziness
Menstrual DisorderFeeling HotPainCholelithiasisChest PainDyspnoeaAnaemiaVomiting
ConvulsionChillsCholecystitis ChronicCoughPainArthralgiaConstipationAsthenia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Naproxen
- support group for people who take Omeprazole

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Naproxen (naproxen) is often used to treat pain. Omeprazole (omeprazole) is often used to treat gastroesophageal reflux disease. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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