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Review: taking Nexium and Imodium together

Summary: drug interactions are reported among people who take Nexium and Imodium together.

This review analyzes the effectiveness and drug interactions between Nexium and Imodium. It is created by eHealthMe based on reports of 965 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 3, 2015: 965 people who take Nexium, Imodium are studied

Nexium, Imodium outcomes

Drug combinations in study:
- Nexium (esomeprazole magnesium)
- Imodium (loperamide hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Nexium is effective50.00%
(1 of 2 people)
(0 of 1 people)
(1 of 2 people)
(1 of 3 people)
Imodium is effective50.00%
(2 of 4 people)
(0 of 1 people)
(1 of 1 people)
(1 of 1 people)

Drug effectiveness by gender :

Nexium is effective50.00%
(2 of 4 people)
(1 of 4 people)
Imodium is effective75.00%
(3 of 4 people)
(1 of 3 people)

Drug effectiveness by age :

Nexium is effectiven/an/an/a50.00%
(1 of 2 people)
(0 of 2 people)
(2 of 16 people)
Imodium is effectiven/an/an/a0.00%
(0 of 1 people)
(1 of 2 people)
(3 of 16 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
ThrombocytopeniaDeathGeneralised OedemaDeathHeadacheGallbladder DisorderIrritable Bowel Syndrome AggravatedDiarrhoea
Pleural EffusionNeutropeniaDeathAbdominal Pain UpperEmotional DistressAbdominal DiscomfortDehydration
DiarrhoeaMyocardial InfarctionVitreous HaemorrhageGastrooesophageal Reflux DiseaseCalcium DeficiencyAnal CandidiasisNausea
Complications Of Transplanted KidneyDiarrhoeaPneumothoraxVomitingUrinary Frequency AggravatedItchinessAnaemia
VomitingHypertensionRetinal Vascular ThrombosisProcedural PainVitamin D DeficiencyUrinary Frequency AggravatedVomiting
Anastomotic HaemorrhageGastrointestinal InfectionHypertensionNauseaSkin CancerNausea AggravatedPyrexia
Escherichia SepsisAgranulocytosisMyocardial InfarctionChest PainOsteoporosisExternal Ear PainAsthenia
Renal ImpairmentThrombocytopeniaBlindnessCholecystitis ChronicOsteopeniaBlepharitisFatigue
Cardiac Failure CongestiveMulti-organ FailureHepatic Neoplasm MalignantBiliary ColicDepressionSensitivity Of TeethRenal Failure
Renal Tubular NecrosisAcidosisVisual Acuity ReducedFatiguePainHalitosisPneumonia

Most common drug interactions by gender * :

DehydrationRenal Failure Acute

Most common drug interactions by age * :

HypomagnesaemiaMydriasisFebrile NeutropeniaRenal FailureDyspnoeaDehydrationDiarrhoeaDiarrhoea
HypertensionAspergillosisLactic AcidosisElectrolyte ImbalanceDiarrhoeaGastrointestinal HaemorrhageAsthenia
NauseaAplastic AnaemiaKlebsiella BacteraemiaHypotensionAbdominal PainRenal Failure AcuteDehydration
TachycardiaVomitingSeptic ShockCellulitisDyspnoeaNauseaNausea
TremorImmunosuppressionHepatic FailureConvulsionRenal Failure AcutePneumoniaVomiting
HallucinationPancytopeniaClostridium Difficile ColitisPneumoniaColitisVomitingFall
ConvulsionBiliary DyskinesiaMental Status ChangesSleep Apnoea SyndromeHypokalaemiaThrombocytopeniaFatigue
Accidental Drug Intake By ChildGallbladder DisorderBacterial InfectionGraft ThrombosisAnaemiaDehydrationAnaemia
AgitationCholecystitis ChronicMulti-organ FailureHip FractureHypotensionPyrexiaRenal Failure
AtaxiaProtein Total AbnormalAbdominal Compartment SyndromeNephrogenic Systemic FibrosisNauseaAnaemiaHypertension

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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You are not alone! Join a related support group:
- support group for people who take Imodium
- support group for people who take Nexium

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Nexium (esomeprazole magnesium) is often used to treat gastroesophageal reflux disease. Imodium (loperamide hydrochloride) is often used to treat diarrhea. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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