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Review: taking Norflex and Ibuprofen together

Summary: drug interactions are reported among people who take Norflex and Ibuprofen together. This review analyzes the effectiveness and drug interactions between Norflex and Ibuprofen. It is created by eHealthMe based on reports of 138 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>


You are not alone: join a support group for people who take Norflex and Ibuprofen >>>

What are the drugs

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. (latest outcomes from 904 Norflex users)

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. (latest outcomes from 61,663 Ibuprofen users)

On May, 17, 2015: 138 people who take Norflex, Ibuprofen are studied

Norflex, Ibuprofen outcomes

Drug combinations in study:
- Norflex (orphenadrine citrate)
- Ibuprofen (ibuprofen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Norflex is effective33.33%
(2 of 6 people)
(0 of 2 people)
(0 of 1 people)
Ibuprofen is effective0.00%
(0 of 4 people)
(0 of 1 people)
(0 of 1 people)
(0 of 2 people)
(1 of 1 people)
(0 of 1 people)

Drug effectiveness by gender :

Norflex is effective14.29%
(1 of 7 people)
(1 of 2 people)
Ibuprofen is effective12.50%
(1 of 8 people)
(0 of 2 people)

Drug effectiveness by age :

Norflex is effectiven/an/an/a20.00%
(1 of 5 people)
(0 of 2 people)
(1 of 2 people)
(0 of 2 people)
Ibuprofen is effectiven/an/an/a0.00%
(0 of 5 people)
(1 of 1 people)
(0 of 2 people)
(0 of 2 people)
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Hallucination, AuditoryPain - Legn/an/aHypoaesthesiaGallbladder DisorderPain - LegPain
Suicide AttemptLibido DecreasedInjuryHeadache
Disturbance In AttentionIntervertebral Disc DegenerationInsomnia
DepressionBone DisorderBack Pain
Abdominal PainErythemaTremor
Back PainPyrexiaDyspnoea
PainPain In Extremity

Most common drug interactions by gender * :

Back PainIrritability
Pain In ExtremityFall
TremorEmotional Distress
OsteoarthritisBack Pain

Most common drug interactions by age * :

n/an/aCholelithiasisPainEmotional DistressDepressionHeadacheContusion
InjuryGallbladder DisorderAnxietyInsomniaTremorMyocardial Infarction
Gallbladder DisorderSuicide AttemptPainAnxietyAnxietyDepression
Pseudofolliculitis BarbaeHypertensionDyspnoeaBack PainInsomniaLoss Of Consciousness
PhotophobiaMajor DepressionDeep Vein ThrombosisPainBack PainDiarrhoea
Nail Fungal Infection NosBronchitisRoad Traffic AccidentEmotional DistressDiarrhoeaPalpitations
Sinusitis Chronic NosBlood Cholesterol IncreasedOverdoseNauseaWeight DecreasedConfusional State
Osteomyelitis NosMigrainePalpitationsSuicidal IdeationPainArthralgia
Tooth LossObesityChest PainOsteoarthritisPain In ExtremityFatigue
Weight IncreasedUpper Respiratory Tract InfectionPyrexiaTremorArthralgiaPhotosensitivity Reaction

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Norflex and Ibuprofen on

Do you take Norflex and Ibuprofen?


You are not alone! Join a related support group:
- support group for people who take Ibuprofen
- support group for people who take Norflex

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Ibuprofen, Norflex

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More reviews for: Ibuprofen, Norflex

Comments from related studies:

  • From this study (9 months ago):

  • pain and heaviness in arms and legs, comes and goes. relieved by heat but gets worse immediately once heat is removed.


  • From this study (5 years ago):

  • Wake up sometimes in am sweaty and hot and then become anxious.


Complete drug side effects:

On eHealthMe, Norflex (orphenadrine citrate) is often used to treat muscle spasms. Ibuprofen (ibuprofen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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