Drug interactions between Nuvigil and Percocet
This is a real world study of Nuvigil and Percocet drug interactions. The study is created by eHealthMe based on 92 reports from FDA.
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What are the drugs
Nuvigil has active ingredients of armodafinil. It is used in narcolepsy, fatigue, drowsiness, sleep apnea, chronic fatigue syndrome, sleep disorder.
Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is used in pain, back pain - low, back pain, surgery, fibromyalgia, pain in extremity.
On May, 23, 2013: 92 people who reported to have interactions when taking Nuvigil, Percocet are studied

Drug combinations in study:
- Nuvigil (armodafinil)
- Percocet (acetaminophen; oxycodone hydrochloride)
Most common interactions experienced by people in the use of Nuvigil, Percocet:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Anxiety | 37 |
| 2 | Oedema Peripheral | 23 |
| 3 | Pain | 21 |
| 4 | Osteonecrosis Of Jaw | 18 |
| 5 | Gait Disturbance | 17 |
| 6 | Headache | 17 |
| 7 | Back Pain | 17 |
| 8 | Pain In Jaw | 16 |
| 9 | Osteopenia | 15 |
| 10 | Injury | 15 |
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Most common interactions experienced by people in long term use of Nuvigil, Percocet:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Dyspnoea | 1 |
| 2 | Dysphonia | 1 |
| 3 | Oedema Peripheral | 1 |
| 4 | Muscle Spasms | 1 |
| 5 | Pulse Abnormal | 1 |
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Top conditions involved for these people * :
- Pain
- Fatigue
- Depression
- Sleep disorder
- Fibromyalgia
Top co-used drugs for these people * :
- Cymbalta
- Zometa
- Lyrica
- Oxycontin
- Lasix
* Approximation only. Some reports may have incomplete information.
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Side effects in real world:
On eHealthMe, Nuvigil (armodafinil) is often used to treat narcolepsy. Percocet (acetaminophen; oxycodone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
Other drugs that are used to treat the same conditions:
Comments from related studies:
From this study (5 days ago):
From this study (9 months ago):
From this study (2 years ago):
Started taking Nuvigil at first did not help me stay awake. After starting Xyrem the Nuvigil was causing severe anxiety and dysphoria. After 6 weeks I told my doctor I could not take this medication any longer. I stopped the Nuvigil and a week later resumed my Vyvanse. I was taking Vyvanse 60mg daily since I was now on Xyrem my doctor and decided to start at 40mg since I was taking the Xyrem and getting the sleep I wasn't getting before. 40mg of Vyvanse is enough to get me through my day without and sleep attacks.
First day of Nuvigil, and immediately having hiccups after first taking it, as well as during short periods throughout the day. Wondering if this will go away?
Nausea not noted until I started taking Nuvigil 150mg this morning with my Oxycodone-Acetaminophen 5-325.
Recent related drug studies:
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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
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