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Review: taking Omeprazole and Synthroid together

Summary: drug interactions are reported among people who take Omeprazole and Synthroid together.

This review analyzes the effectiveness and drug interactions between Omeprazole and Synthroid. It is created by eHealthMe based on reports of 15,677 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Omeprazole and Synthroid >>>

On Mar, 27, 2015: 15,677 people who take Omeprazole, Synthroid are studied

Omeprazole, Synthroid outcomes

Drug combinations in study:
- Omeprazole (omeprazole)
- Synthroid (levothyroxine sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Omeprazole is effective30.00%
(9 of 30 people)
(26 of 63 people)
(18 of 45 people)
(39 of 77 people)
(77 of 123 people)
(63 of 98 people)
(30 of 49 people)
(1 of 4 people)
Synthroid is effective40.00%
(2 of 5 people)
(8 of 28 people)
(15 of 29 people)
(22 of 50 people)
(54 of 93 people)
(65 of 111 people)
(119 of 171 people)
(1 of 2 people)

Drug effectiveness by gender :

Omeprazole is effective53.23%
(214 of 402 people)
(48 of 86 people)
Synthroid is effective58.21%
(234 of 402 people)
(52 of 86 people)

Drug effectiveness by age :

Omeprazole is effectiven/an/a50.00%
(2 of 4 people)
(8 of 12 people)
(23 of 84 people)
(49 of 166 people)
(74 of 236 people)
(107 of 326 people)
Synthroid is effectiven/an/a0.00%
(0 of 2 people)
(6 of 11 people)
(25 of 77 people)
(48 of 172 people)
(81 of 217 people)
(126 of 333 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DiarrhoeaFatigueBack PainDizzinessFatigueFatigueDizzinessNausea
VomitingDizzinessFebrile NeutropeniaFatigueDyspepsiaOedema PeripheralFatigueDyspnoea
NauseaAbdominal PainRenal Failure AcuteAnxietyChest PainPulmonary EmbolismDepressionFatigue
HypotensionDiarrhoeaGenital HerpesPulmonary EmbolismNauseaDeep Vein ThrombosisInsomniaPain
DizzinessMyalgiaFatigueDyspnoeaDizzinessFebrile NeutropeniaHair LossAsthenia
PruritusHeart Rate IrregularPneumoniaPainHypertensionDizzinessDry MouthFall
HypersensitivityHypothyroidismNecrotising FasciitisNauseaCardiac Failure CongestiveNauseaExhaustion, Fatigue, Lethargy, Tiredness, WearinessDizziness
HypertensionSleep DisorderSyncopeDeep Vein ThrombosisGastrointestinal PerforationTirednessWeight IncreasedDiarrhoea
RashNauseaCardiac Failure CongestiveHeadacheSleep Apnoea SyndromePain In ExtremityLethargyVomiting
Respiratory FailureBack PainHeart Valve IncompetenceDepressionCoronary Artery DiseaseExhaustion, Fatigue, Lethargy, Tiredness, WearinessWeight GainDrug Ineffective

Most common drug interactions by gender * :

VomitingDrug Ineffective
Chest PainPneumonia

Most common drug interactions by age * :

DeathHypertensionCholecystitis ChronicPainPainNauseaNauseaNausea
ConvulsionDyskinesiaPainInjuryNauseaChest PainPainDyspnoea
Depressed Level Of ConsciousnessEye DischargeVomitingPyrexiaDepressionFatigueFatigueAsthenia
Upper Respiratory Tract InfectionCytomegalovirus ViraemiaAbdominal Pain UpperAnxietyAnxietyVomitingOedema PeripheralFall
Congenital Choroid Plexus CystUrine Output DecreasedDiarrhoeaBiliary DyskinesiaFatigueDiarrhoeaDyspnoeaFatigue
Blood Thyroid Stimulating Hormone IncreasedPneumonia AspirationGallbladder DisorderNauseaArthralgiaPyrexiaAnxietyDizziness
EpilepsyGastrointestinal HypermotilityOverdoseDeep Vein ThrombosisAbdominal PainDyspnoeaDrug IneffectivePain
Feeling ColdHyperkalaemiaBone DisorderDizzinessAstheniaWeight IncreasedHeadacheDiarrhoea
Heart Rate IncreasedHypotensionGastric UlcerAbdominal PainPruritusDepressionDizzinessHypotension
Cold SweatBronchitisTooth DisorderGeneral Physical Health DeteriorationSinusitisHeadacheVomitingVomiting

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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You are not alone! Join a related support group:
- support group for people who take Omeprazole
- support group for people who take Synthroid

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Omeprazole (omeprazole) is often used to treat gastroesophageal reflux disease. Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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