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Review: taking Opana and Xanax together

Summary: drug interactions are reported among people who take Opana and Xanax together.

This review analyzes the effectiveness and drug interactions between Opana and Xanax. It is created by eHealthMe based on reports of 277 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Opana and Xanax >>>

On Apr, 17, 2015: 277 people who take Opana, Xanax are studied

Opana, Xanax outcomes

Drug combinations in study:
- Opana (oxymorphone hydrochloride)
- Xanax (alprazolam)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Opana is effective25.00%
(2 of 8 people)
(0 of 5 people)
(3 of 6 people)
(1 of 4 people)
Xanax is effective50.00%
(1 of 2 people)
(0 of 1 people)
(4 of 6 people)
(3 of 8 people)
(3 of 5 people)
(0 of 1 people)

Drug effectiveness by gender :

Opana is effective25.00%
(4 of 16 people)
(2 of 7 people)
Xanax is effective60.00%
(9 of 15 people)
(2 of 8 people)

Drug effectiveness by age :

Opana is effectiven/an/an/a0.00%
(0 of 9 people)
(0 of 11 people)
(2 of 10 people)
(1 of 17 people)
(3 of 8 people)
Xanax is effectiven/an/an/a11.11%
(1 of 9 people)
(1 of 10 people)
(3 of 10 people)
(3 of 16 people)
(3 of 8 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Drug AbuseFeeling AbnormalUrinary Tract Infection FungalCardiac ArrestPsoriasisInsomnian/aDrug Abuse
Drug ToxicityDisorientationDeathChest PainFeeling AbnormalChronic PainVomiting
Feeling AbnormalVomitingMultiple Drug Overdose AccidentalLoss Of ConsciousnessBrain InjuryBipolar DisorderLoss Of Consciousness
ParanoiaHypersomniaDepressed Level Of ConsciousnessMultiple Drug Overdose AccidentalPanic Disorder With AgoraphobiaDepressionUnresponsive To Stimuli
DiscomfortTherapeutic Response DecreasedClostridium Difficile ColitisUnresponsive To StimuliDepressionPsoriasisNausea
Hallucination, AuditoryConstipationBlastocystis InfectionOverdoseDizzinessPanic Disorder With AgoraphobiaPain
DizzinessAbdominal PainClostridium Difficile ColitisRinging In The EarsHypertension AggravatedCardiac Arrest
Drug DiversionFatigueBlastocystis InfectionFatigueIrritabilityOverdose
Sweating - ExcessiveConfusional StateUrinary Tract InfectionChronic PainSweating - ExcessiveOedema Peripheral
IrritabilitySedationPupil FixedBipolar DisorderDizzinessDyspnoea

Most common drug interactions by gender * :

VomitingDrug Abuse
NauseaRespiratory Arrest
Loss Of ConsciousnessUnresponsive To Stimuli
Drug AbuseDeath
Oedema PeripheralPulmonary Congestion
MalaiseAccidental Death
DyspnoeaDrug Toxicity
Unresponsive To StimuliAccidental Overdose
Cardiac ArrestCardiac Arrest

Most common drug interactions by age * :

n/an/aDrug AbuseUnresponsive To StimuliOedema PeripheralVomitingCardiac ArrestNausea
Drug DiversionDrug AbuseParaesthesiaNauseaChest PainDizziness
Drug ToxicityOverdoseDrug ToxicityTremorMultiple Drug Overdose AccidentalVomiting
Loss Of ConsciousnessPulmonary CongestionHeadacheMalaiseDepressionDisturbance In Attention
Pulmonary OedemaAccidental DeathSwelling FaceConstipationUnresponsive To StimuliTachycardia
Respiratory ArrestDeathVomitingAnxietyClostridium Difficile ColitisLigament Pain
Pulmonary CongestionPulmonary OedemaWeight IncreasedOedema PeripheralAbnormal DreamsInfluenza Like Illness
Accidental DeathThymus DisorderPainPainBlastocystis InfectionDental Caries
Accidental OverdosePetechiaeAccidental DeathFeeling AbnormalMood AlteredFibromyalgia
Multiple Drug OverdoseMultiple Drug Overdose AccidentalChest PainPyrexiaDeathDisorientation

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Opana
- support group for people who take Xanax

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Opana (oxymorphone hydrochloride) is often used to treat pain. Xanax (alprazolam) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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