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Review: Plaquenil and Ibuprofen

This review analyzes the effectiveness and drug interactions between Plaquenil and Ibuprofen. It is created by eHealthMe based on reports of 747 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Plaquenil and Ibuprofen >>>

What are the drugs

Plaquenil (latest outcomes from 15,500 users) has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus.

Ibuprofen (latest outcomes from 61,569 users) has active ingredients of ibuprofen. It is often used in pain.

On Oct, 13, 2014: 747 people who take Plaquenil, Ibuprofen are studied

Plaquenil, Ibuprofen outcomes

Drug combinations in study:
- Plaquenil (hydroxychloroquine sulfate)
- Ibuprofen (ibuprofen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Plaquenil is effective0.00%
(0 of 1 people)
(0 of 6 people)
(1 of 4 people)
(0 of 3 people)
(2 of 8 people)
(1 of 3 people)
(0 of 2 people)
(0 of 1 people)
Ibuprofen is effective40.00%
(2 of 5 people)
(1 of 5 people)
(1 of 4 people)
(0 of 2 people)
(2 of 8 people)
(2 of 4 people)
(1 of 2 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Neonatal AspirationAtrial Septal DefectCleft PalatePathological GamblingShortness Of BreathMalignant Neoplasm Of ThoraxSynovitisNausea
Neonatal Respiratory Distress SyndromeNeonatal AspirationDysplasiaBronchitisPalpitationsGeneral Physical Health DeteriorationLethargyHeadache
Meningitis AsepticNeonatal Respiratory Distress SyndromeMyositisEustachian Tube DysfunctionLethargyDecreased AppetiteNauseaFatigue
Cleft PalateFatigueFebrile InfectionPharyngitisNauseaMusculoskeletal Chest PainPlatelet Count DecreasedPain
Atrial Septal DefectHeadacheGastrooesophageal Reflux DiseasePsychiatric SymptomWeight DecreasedMeningitis AsepticArthralgia
Vomiting NosLiver Transplant RejectionSepsis NeonatalTracheitisThrombosisHaemoglobin DecreasedFall
Cardiac DisorderEncephalopathyDrug Exposure During PregnancyRhinitis AllergicPulmonary EmbolismInfluenza Like IllnessDyspnoea
Drug Effect DecreasedPulmonary Artery Stenosis CongenitalCardiac DisorderOtitis Media AcuteDeep Vein ThrombosisLymphadenopathyDiarrhoea
HeadacheVomiting NosNauseaChest PainChest Wall MassSmall Cell Lung Cancer MetastaticInsomnia
Liver Transplant RejectionAtrial FibrillationMacular DegenerationDyspnoeaDeafnessOedema Peripheral

Drug effectiveness by gender :

Plaquenil is effective12.00%
(3 of 25 people)
(1 of 3 people)
Ibuprofen is effective25.00%
(7 of 28 people)
(2 of 3 people)

Most common drug interactions by gender * :

NauseaMyocardial Infarction
HeadacheOedema Peripheral
ArthralgiaChest Pain
RashCoronary Artery Disease

Drug effectiveness by age :

Plaquenil is effectiven/an/an/a16.67%
(1 of 6 people)
(0 of 8 people)
(1 of 6 people)
(2 of 16 people)
(0 of 6 people)
Ibuprofen is effectiven/an/an/a28.57%
(2 of 7 people)
(2 of 11 people)
(1 of 8 people)
(3 of 15 people)
(1 of 6 people)

Most common drug interactions by age * :

n/aPanniculitisMeningitis AsepticPainPainNauseaNauseaFall
PyrexiaLack Of Spontaneous SpeechInjuryFatiguePyrexiaHeadacheArthralgia
Status EpilepticusFeeling AbnormalCholecystitis ChronicAnxietyHeadachePainDiarrhoea
Transient Ischaemic AttackAnxietyMental DisorderStressNephrolithiasisDyspnoeaInsomnia
Migraine AggravatedMental Status ChangesCondition AggravatedEmotional DistressVomiting NosMuscular WeaknessDizziness
DysarthriaTremorEmotional DistressAnhedoniaFatigueFatigueMyocardial Infarction
Condition AggravatedAgitationMaternal Exposure During PregnancyInjuryMyalgiaInjection Site PainNausea
Csf Glucose DecreasedPancreatitis AcuteAnxietyInjection Site Reaction NosNeck PainOedema PeripheralBronchitis
Cerebral OedemaDrug IneffectiveAbdominal PainNauseaPainMusculoskeletal StiffnessContusion
Gastric UlcerChest PainAbortion Spontaneous NosDyspnoeaDizzinessFatigue

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Plaquenil and Ibuprofen?

Get connected! Join a related mobile support group:
- support group for people who take Plaquenil and Ibuprofen
- support group for people who take Ibuprofen
- support group for people who take Plaquenil

Comments from related studies:

  • From this study (2 years ago):

  • eosinophilia bowel problems with pain lethargic


  • From this study (2 years ago):

  • I found out I have svt heart conditions and was wondering if any of these drugs have an effect or cause any problems with it or cause you to get svt?


  • From this study (2 years ago):

  • Mirena put in January 2012 and removed July 2012. Started getting sick June 2012 and diagnosed with Kidney Stones, bone spurs, and Lupus since.


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Complete drug side effects:

On eHealthMe, Plaquenil (hydroxychloroquine sulfate) is often used to treat systemic lupus erythematosus. Ibuprofen (ibuprofen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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