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Review: Prednisone and Methotrexate

This review analyzes the effectiveness and drug interactions between Prednisone and Methotrexate. It is created by eHealthMe based on reports of 25,918 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Prednisone and Methotrexate >>>

What are the drugs

Prednisone (latest outcomes from 149,848 users) has active ingredients of prednisone. It is often used in rheumatoid arthritis.

Methotrexate (latest outcomes from 131,070 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

On Jul, 14, 2014: 25,918 people who take Prednisone, Methotrexate are studied

Prednisone, Methotrexate outcomes

Drug combinations in study:
- Prednisone (prednisone)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Prednisone is effective25.93%
(7 of 27 people)
36.36%
(20 of 55 people)
31.03%
(9 of 29 people)
51.28%
(20 of 39 people)
51.52%
(17 of 33 people)
54.55%
(18 of 33 people)
62.50%
(15 of 24 people)
100.00%
(1 of 1 people)
Methotrexate is effective4.76%
(1 of 21 people)
20.31%
(13 of 64 people)
19.23%
(5 of 26 people)
37.14%
(13 of 35 people)
27.03%
(10 of 37 people)
37.50%
(9 of 24 people)
45.00%
(9 of 20 people)
0.00%
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaPyrexiaPneumoniaPneumoniaDiarrhoeaPyrexiaOedema PeripheralPyrexia
Febrile NeutropeniaPneumoniaPneumonitisPyrexiaPneumoniaWeight DecreasedAstheniaArthralgia
PneumoniaAnaemiaNauseaNauseaFatigueDeathPyrexiaDrug Ineffective
NauseaCellulitisCellulitisArthralgiaSepsisFatigueCoughNausea
HypotensionNauseaDrug IneffectiveRespiratory FailureNauseaAnaemiaHeadacheRheumatoid Arthritis
DiarrhoeaCardio-respiratory ArrestAnaemiaRheumatoid ArthritisWeight DecreasedNauseaChest PainPain
VomitingRenal Failure AcuteUrinary Tract InfectionFatigueRheumatoid ArthritisPancytopeniaLung DisorderPneumonia
DyspnoeaWeight DecreasedPulmonary FibrosisRenal FailureImpaired HealingPneumoniaCerebrovascular AccidentFatigue
HeadacheSepsisDyspnoeaSepsisInsomniaMalaiseChillsDyspnoea
HypertensionFebrile NeutropeniaWeight DecreasedVomitingChest PainPleural EffusionArthralgiaAsthenia

Drug effectiveness by gender :

FemaleMale
Prednisone is effective44.62%
(83 of 186 people)
43.64%
(24 of 55 people)
Methotrexate is effective22.78%
(41 of 180 people)
38.78%
(19 of 49 people)

Most common drug interactions by gender * :

FemaleMale
ArthralgiaPyrexia
PyrexiaPneumonia
NauseaDrug Ineffective
Drug IneffectiveArthralgia
PainRheumatoid Arthritis
Rheumatoid ArthritisNausea
FatigueAsthenia
PneumoniaPain
DyspnoeaFatigue
HeadacheDyspnoea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Prednisone is effectiven/a100.00%
(2 of 2 people)
20.00%
(2 of 10 people)
18.18%
(2 of 11 people)
23.64%
(13 of 55 people)
26.19%
(22 of 84 people)
28.15%
(38 of 135 people)
34.57%
(28 of 81 people)
Methotrexate is effectiven/a100.00%
(2 of 2 people)
11.11%
(1 of 9 people)
9.09%
(1 of 11 people)
7.41%
(4 of 54 people)
9.76%
(8 of 82 people)
26.00%
(26 of 100 people)
23.38%
(18 of 77 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
NeutropeniaPyrexiaCrohn's DiseasePyrexiaPyrexiaPyrexiaArthralgiaPneumonia
Gamma-glutamyltransferase IncreasedDrug ToxicityPyrexiaArthralgiaNauseaArthralgiaPyrexiaPyrexia
Respiratory Syncytial Virus InfectionPneumoniaHypotensionNauseaArthralgiaDrug IneffectiveNauseaArthralgia
DiarrhoeaFebrile NeutropeniaNeutropeniaHeadacheDrug IneffectiveNauseaPainDrug Ineffective
StomatitisConvulsionAbdominal PainDrug IneffectiveVomitingRheumatoid ArthritisDrug IneffectiveNausea
PyrexiaMucosal InflammationVomitingDyspnoeaInjection Site Reaction NosPainFatigueAsthenia
ThrombocytopeniaNeutropeniaHyperglycaemiaPainHeadacheHeadacheOedema PeripheralRheumatoid Arthritis
Pain In ExtremityVomitingHyperbilirubinaemiaChest PainRheumatoid ArthritisFatigueRheumatoid ArthritisFatigue
Normochromic Normocytic AnaemiaAlanine Aminotransferase IncreasedHeadacheRheumatoid ArthritisInjection Site HaemorrhageOedema PeripheralDiarrhoeaDyspnoea
Molluscum ContagiosumAbdominal PainNauseaWeight DecreasedDiarrhoeaInjection Site Reaction NosHeadacheFall

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Prednisone and Methotrexate
- group for people who take Methotrexate
- group for people who take Prednisone

Comments from related studies:

  • From this study (1 day ago):

  • Our 6 year old was diagnosed 4 years ago, polyarticular JRA. She did about 1 year of sulfasalazine combined with prednisone. Then the next year was prednisone and methotrexate. We came of off prednisone in March and remain on 7.5mg of methotrexate once a week.

    She is extremely hyper. She NEVER sits still and is constantly bouncing around. She can't even sit down/sit still long enough to eat a meal.

    We thought that she would calm down a few months after coming off of prednisone since she was on it for 2 years, but that didn't happen. Now we are curious as to whether the hyperness is a result of the methotrexate or a permanent result of the prednisone. Any guidance is appreciated.

    Thank you

    Reply

  • From this study (2 days ago):

  • Have also been on the following medications on and off: Tramadol\Acet, Lyrica,
    Vitamin D, and Lanzap.
    Patient also suffers from rheumatoid arthritis.

    Reply

  • From this study (3 months ago):

  • All lesions necrosis
    Painful granulomas
    I live in chronic pain and fatigue

    Reply

Post a new comment    OR    Read more comments

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Complete drug side effects:

On eHealthMe, Prednisone (prednisone) is often used to treat rheumatoid arthritis. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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