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Review: taking Prednisone and Methotrexate together

Summary: drug interactions are reported among people who take Prednisone and Methotrexate together.

This review analyzes the effectiveness and drug interactions between Prednisone and Methotrexate. It is created by eHealthMe based on reports of 25,946 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Prednisone and Methotrexate >>>

What are the drugs

Prednisone has active ingredients of prednisone. It is often used in rheumatoid arthritis. (latest outcomes from 150,066 Prednisone users)

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,224 Methotrexate users)

On Jan, 26, 2015: 25,946 people who take Prednisone, Methotrexate are studied

Prednisone, Methotrexate outcomes

Drug combinations in study:
- Prednisone (prednisone)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Prednisone is effective27.59%
(8 of 29 people)
33.90%
(20 of 59 people)
34.38%
(11 of 32 people)
51.22%
(21 of 41 people)
47.22%
(17 of 36 people)
56.41%
(22 of 39 people)
62.50%
(15 of 24 people)
100.00%
(1 of 1 people)
Methotrexate is effective4.55%
(1 of 22 people)
20.00%
(14 of 70 people)
17.86%
(5 of 28 people)
38.46%
(15 of 39 people)
25.00%
(10 of 40 people)
41.38%
(12 of 29 people)
45.00%
(9 of 20 people)
0.00%
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaPyrexiaPneumoniaPneumoniaDiarrhoeaPyrexiaOedema PeripheralPyrexia
Febrile NeutropeniaPneumoniaPneumonitisPyrexiaPneumoniaWeight DecreasedAstheniaArthralgia
PneumoniaAnaemiaNauseaNauseaFatigueDeathPyrexiaDrug Ineffective
NauseaCellulitisCellulitisArthralgiaSepsisFatigueCoughNausea
HypotensionNauseaDrug IneffectiveRespiratory FailureNauseaAnaemiaHeadacheRheumatoid Arthritis
VomitingCardio-respiratory ArrestUrinary Tract InfectionRheumatoid ArthritisWeight DecreasedNauseaChest PainPain
DiarrhoeaWeight DecreasedAnaemiaRenal FailureRheumatoid ArthritisPancytopeniaLung DisorderPneumonia
DyspnoeaRenal Failure AcuteWeight DecreasedFatigueImpaired HealingPneumoniaCerebrovascular AccidentFatigue
HeadacheFebrile NeutropeniaPulmonary FibrosisVomitingChest PainPleural EffusionChillsDyspnoea
HypertensionSepsisDyspnoeaSepsisDepressionGastric DisorderArthralgiaAsthenia

Drug effectiveness by gender :

FemaleMale
Prednisone is effective44.55%
(90 of 202 people)
42.37%
(25 of 59 people)
Methotrexate is effective23.35%
(46 of 197 people)
37.74%
(20 of 53 people)

Most common drug interactions by gender * :

FemaleMale
ArthralgiaPyrexia
PyrexiaPneumonia
NauseaDrug Ineffective
Drug IneffectiveArthralgia
PainRheumatoid Arthritis
Rheumatoid ArthritisNausea
FatigueAsthenia
PneumoniaPain
DyspnoeaFatigue
HeadacheDyspnoea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Prednisone is effectiven/a100.00%
(2 of 2 people)
20.00%
(2 of 10 people)
25.00%
(3 of 12 people)
20.90%
(14 of 67 people)
25.56%
(23 of 90 people)
27.59%
(40 of 145 people)
36.05%
(31 of 86 people)
Methotrexate is effectiven/a100.00%
(2 of 2 people)
11.11%
(1 of 9 people)
15.38%
(2 of 13 people)
7.35%
(5 of 68 people)
9.09%
(8 of 88 people)
24.55%
(27 of 110 people)
25.61%
(21 of 82 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
NeutropeniaPyrexiaCrohn's DiseasePyrexiaPyrexiaPyrexiaArthralgiaPneumonia
Gamma-glutamyltransferase IncreasedDrug ToxicityPyrexiaArthralgiaNauseaArthralgiaPyrexiaPyrexia
Respiratory Syncytial Virus InfectionPneumoniaHypotensionNauseaArthralgiaDrug IneffectiveNauseaArthralgia
DiarrhoeaFebrile NeutropeniaNeutropeniaHeadacheDrug IneffectiveNauseaPainDrug Ineffective
StomatitisConvulsionAbdominal PainDyspnoeaVomitingRheumatoid ArthritisDrug IneffectiveNausea
PyrexiaMucosal InflammationVomitingDrug IneffectiveInjection Site Reaction NosPainFatigueAsthenia
ThrombocytopeniaNeutropeniaHyperglycaemiaPainHeadacheHeadacheOedema PeripheralRheumatoid Arthritis
Pain In ExtremityVomitingHyperbilirubinaemiaChest PainRheumatoid ArthritisFatigueRheumatoid ArthritisFatigue
Normochromic Normocytic AnaemiaAlanine Aminotransferase IncreasedHeadacheRheumatoid ArthritisInjection Site HaemorrhageOedema PeripheralDiarrhoeaDyspnoea
Molluscum ContagiosumAbdominal PainNauseaWeight DecreasedDiarrhoeaInjection Site Reaction NosHeadacheFall

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Prednisone and Methotrexate?

You are not alone! Join a related mobile support group:
- support group for people who take Prednisone and Methotrexate
- support group for people who take Methotrexate
- support group for people who take Prednisone

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Can i use a lidocaine patch for back pain if i am taking prograf for anti-rejection post lung transplant?
    Transplant was 6 years ago.
    Has suffered from PTLD on several occasions before.
    Recently hospitalized for Periodic Fever Syndrome.
    Received Interleukin 6 blocker last week and fevers have resolved, but back pain is still present
  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
  • What can i do about a really slow heart rate because i can barely feel my pulse at all ?
    Dizzy, not feeling good at all, wakes me up at night a lot too
  • Is cataract surgery possible w/pulmonary fibrosis & constant oxygen? (1 answer)
    Is it possible to have catateract surgery while on oxygen?

More questions for: Methotrexate, Prednisone

You may be interested at these reviews (Write a review):

  • Adverse reaction to prednisone
    Severe allergic reaction. Given prednisone for angioedema attributed to Lisinopril. Within 24 hours, severe red skin on face, bp +200/+100 spikes, shortness of breath, chest pain snd severe heart palpitations. Went to ER. Given another IV cocktail of sulomedrol, Bdnadryl snd Zantac, told to double my prednisone pills to 20 mg twice a day. On fifth day, znother similar reaction but worse. Went in ambulance to ER. Put on oxygen and atavan. Sent home with six day tapering dose. No appetite. Nausea. After last pill, blood pressure spikes, flushing, chills, fatigue, blood sugar crashes, especially at night. Had to eat every two hours. Severe skin pain and itching, going on still after six weeks of stopping meds. This drug has HORRIBLE side effects. None of the drs czn tell me how long this will last, or evdn if it will go away. Eating organic, taking soothing baths, detoxing, taking adrenal, vitamin and mineral suppldments, drinking water and detoxing teas. Some symptoms are a bit better but skin is driving me crazy. How czn this drug be prescribed when drs really don 't know all it does nor how to counteract the horrible side effects!?!?
  • My finger tendons broke on prednisone
    Twelve years ago I was put on prednisone for sudden hearing loss. The prednisone helped the hearing loss (for as long as I took the drug; hearing loss returned after I stopped the prednisone.) But I kept getting ruptured tendons in my fingers, which I had to splint to use. I couldn't figure out why in heck this was happening. My doctor(s) didn't have a clue. I suspected the ruptures might have to do with prednisone. Now I know they were caused by it. When I stopped the prednisone, the tendon-ruptures stopped, too. This should be Must Tell information for any doctor who prescribes this dangerous drug.
  • Prednisone rx 3,3,2,2,1,1 plan suicidal haunts all day
    I came home from the Hospitol with a 3,3,2,2,1,1 Rx.
    I took (3) and spent the rest of the day contenplating Suicide.
    The rest of the Rx went in the Toilet by 7:pm.
    I wonder how many this Killed.
  • Prednisone induced cushing's syndrome
    Prescribed Prednisone 20mg twice daily. Took for six weeks and developed weaken muscles and swollen face. Was hospitalized and informed I had severe Cushing's Syndrome. Host of problems included glucose over 400, inflammed pancreas, triglycerides over 4,000 and vision problems. Muscles were wasted and weak so fell several times. Had to regain strength and learn to walk again with physical therapy. Left with foggy thinking, fatigue, muscle myopathy and peripheral neuropathy. Also developed osteopenia. Afterwards was placed on hydrocortisone and Lyrica for pain. Later found liver damage.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.

More reviews for: Methotrexate, Prednisone

Comments from related studies:

  • From this study (2 weeks ago):

  • My jaw cracks,pops,grinds when I try to move it. Cant open hardly at all and pain is radiating throw my ear and temple.

    Reply

  • From this study (2 weeks ago):

  • My chest begin after walking or cycling at a heart rate of 90-95 bpm for 5 minutes
    and increase in intensity for 10 minutes and a heart rate 100-105. The chest pains
    subside gradually and disappear after 5 more minutes of continued walking or cycling.

    I had the same condition before taking Folic acid and Methotrexate.

    Reply

  • From this study (3 weeks ago):

  • recurring vertigo that lasts from an hour to a couple of days per episode

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Prednisone (prednisone) is often used to treat rheumatoid arthritis. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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