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Review: taking Prednisone and Methotrexate together

Summary: drug interactions are reported among people who take Prednisone and Methotrexate together.

This review analyzes the effectiveness and drug interactions between Prednisone and Methotrexate. It is created by eHealthMe based on reports of 25,949 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

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What are the drugs

Prednisone has active ingredients of prednisone. It is often used in rheumatoid arthritis. (latest outcomes from 150,120 Prednisone users)

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,243 Methotrexate users)

On Feb, 26, 2015: 25,949 people who take Prednisone, Methotrexate are studied

Prednisone, Methotrexate outcomes

Drug combinations in study:
- Prednisone (prednisone)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Prednisone is effective27.59%
(8 of 29 people)
33.90%
(20 of 59 people)
33.33%
(11 of 33 people)
51.22%
(21 of 41 people)
45.95%
(17 of 37 people)
55.00%
(22 of 40 people)
62.50%
(15 of 24 people)
100.00%
(1 of 1 people)
Methotrexate is effective4.55%
(1 of 22 people)
19.72%
(14 of 71 people)
17.86%
(5 of 28 people)
38.46%
(15 of 39 people)
24.39%
(10 of 41 people)
40.00%
(12 of 30 people)
45.00%
(9 of 20 people)
0.00%
(0 of 2 people)

Drug effectiveness by gender :

FemaleMale
Prednisone is effective43.90%
(90 of 205 people)
42.37%
(25 of 59 people)
Methotrexate is effective23.00%
(46 of 200 people)
37.74%
(20 of 53 people)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Prednisone is effectiven/a100.00%
(2 of 2 people)
20.00%
(2 of 10 people)
25.00%
(3 of 12 people)
20.90%
(14 of 67 people)
25.56%
(23 of 90 people)
27.40%
(40 of 146 people)
33.33%
(31 of 93 people)
Methotrexate is effectiven/a100.00%
(2 of 2 people)
11.11%
(1 of 9 people)
15.38%
(2 of 13 people)
7.35%
(5 of 68 people)
9.09%
(8 of 88 people)
24.32%
(27 of 111 people)
23.60%
(21 of 89 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaPyrexiaPneumoniaPneumoniaDiarrhoeaPyrexiaOedema PeripheralPyrexia
Febrile NeutropeniaPneumoniaPneumonitisPyrexiaFatigueWeight DecreasedAstheniaArthralgia
PneumoniaAnaemiaNauseaNauseaPneumoniaDeathPyrexiaDrug Ineffective
NauseaCellulitisCellulitisArthralgiaSepsisFatigueCoughNausea
HypotensionNauseaDrug IneffectiveRespiratory FailureNauseaAnaemiaHeadacheRheumatoid Arthritis
VomitingCardio-respiratory ArrestUrinary Tract InfectionRheumatoid ArthritisWeight DecreasedPancytopeniaChest PainPain
DiarrhoeaWeight DecreasedAnaemiaRenal FailureRheumatoid ArthritisPneumoniaLung DisorderPneumonia
DyspnoeaRenal Failure AcuteWeight DecreasedFatigueImpaired HealingNauseaCerebrovascular AccidentFatigue
HeadacheFebrile NeutropeniaPulmonary FibrosisVomitingChest PainMalaiseChillsDyspnoea
HypertensionSepsisDyspnoeaSepsisDepressionGastric DisorderArthralgiaAsthenia

Most common drug interactions by gender * :

FemaleMale
ArthralgiaPyrexia
PyrexiaPneumonia
NauseaDrug Ineffective
Drug IneffectiveArthralgia
PainRheumatoid Arthritis
Rheumatoid ArthritisNausea
FatigueAsthenia
PneumoniaPain
DyspnoeaFatigue
HeadacheDyspnoea

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
NeutropeniaPyrexiaCrohn's DiseasePyrexiaPyrexiaPyrexiaArthralgiaPneumonia
Gamma-glutamyltransferase IncreasedDrug ToxicityPyrexiaArthralgiaNauseaArthralgiaPyrexiaPyrexia
Respiratory Syncytial Virus InfectionPneumoniaHypotensionNauseaArthralgiaDrug IneffectiveNauseaArthralgia
DiarrhoeaFebrile NeutropeniaNeutropeniaHeadacheDrug IneffectiveNauseaPainDrug Ineffective
StomatitisConvulsionAbdominal PainDyspnoeaVomitingRheumatoid ArthritisDrug IneffectiveNausea
PyrexiaMucosal InflammationVomitingDrug IneffectiveInjection Site Reaction NosPainFatigueAsthenia
ThrombocytopeniaNeutropeniaHyperglycaemiaPainHeadacheHeadacheOedema PeripheralRheumatoid Arthritis
Pain In ExtremityVomitingHyperbilirubinaemiaChest PainRheumatoid ArthritisFatigueRheumatoid ArthritisFatigue
Normochromic Normocytic AnaemiaAlanine Aminotransferase IncreasedHeadacheRheumatoid ArthritisInjection Site HaemorrhageOedema PeripheralDiarrhoeaDyspnoea
Molluscum ContagiosumAbdominal PainNauseaWeight DecreasedDiarrhoeaInjection Site Reaction NosHeadacheFall

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Prednisone and Methotrexate on

Do you take Prednisone and Methotrexate?

You are not alone! Join a related mobile support group:
- support group for people who take Prednisone and Methotrexate
- support group for people who take Methotrexate
- support group for people who take Prednisone

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Methotrexate, Prednisone

You may be interested at these reviews (Write a review):

  • Prednisone relieves anosmia
    Having had anosmia for 15 years now the only thing that ever relieves it, albeit temporarily, is prednisone. I have done 2 surgeries to remove polyps (and won't do it again, waste of time and money - the polyps returned within a year), every herb and other "guaranteed cure" (bogus) on the Internet and the only thing that gives me my smell back is prednisone. Have also done allergy injections, nebulizers, neti-pots, Flonase, etc. None of these things work.
    Being without smell is subtly debilitating. It takes away your drive, your pleasures of life and leads to depression. I wish the medical community would apply as much effort here as they do to the loss of hearing or sight since this is in many ways just as debilitating although in more subtle ways.
  • Muscle weakness from methotrexate
    I'm 61 and have taken methotrexate for 25 yrs. I've always done well with my blood results etc. Lately I've been having problems pushing a grocery cart. My arm muscles are so weak!
  • Having leg cramps after 2 years on enbrel
    Started having leg cramps after using Enbrel for almsot 2 years. They start the day I give the injection and have lasted 1-3 days waking me several time in the middle of the night.
  • Adverse reaction to prednisone
    Severe allergic reaction. Given prednisone for angioedema attributed to Lisinopril. Within 24 hours, severe red skin on face, bp +200/+100 spikes, shortness of breath, chest pain snd severe heart palpitations. Went to ER. Given another IV cocktail of sulomedrol, Bdnadryl snd Zantac, told to double my prednisone pills to 20 mg twice a day. On fifth day, znother similar reaction but worse. Went in ambulance to ER. Put on oxygen and atavan. Sent home with six day tapering dose. No appetite. Nausea. After last pill, blood pressure spikes, flushing, chills, fatigue, blood sugar crashes, especially at night. Had to eat every two hours. Severe skin pain and itching, going on still after six weeks of stopping meds. This drug has HORRIBLE side effects. None of the drs czn tell me how long this will last, or evdn if it will go away. Eating organic, taking soothing baths, detoxing, taking adrenal, vitamin and mineral suppldments, drinking water and detoxing teas. Some symptoms are a bit better but skin is driving me crazy. How czn this drug be prescribed when drs really don 't know all it does nor how to counteract the horrible side effects!?!?
  • My finger tendons broke on prednisone
    Twelve years ago I was put on prednisone for sudden hearing loss. The prednisone helped the hearing loss (for as long as I took the drug; hearing loss returned after I stopped the prednisone.) But I kept getting ruptured tendons in my fingers, which I had to splint to use. I couldn't figure out why in heck this was happening. My doctor(s) didn't have a clue. I suspected the ruptures might have to do with prednisone. Now I know they were caused by it. When I stopped the prednisone, the tendon-ruptures stopped, too. This should be Must Tell information for any doctor who prescribes this dangerous drug.

More reviews for: Methotrexate, Prednisone

Comments from related studies:

  • From this study (2 weeks ago):

  • I had the flu for two weeks it has been gone two weeks but I stayed fatigued with dry cough. I had my infusion of Simponi Aria 10 days ago. My Methotrexate injection is due tomorrow.

    Reply

  • From this study (1 month ago):

  • My jaw cracks,pops,grinds when I try to move it. Cant open hardly at all and pain is radiating throw my ear and temple.

    Reply

  • From this study (1 month ago):

  • My chest begin after walking or cycling at a heart rate of 90-95 bpm for 5 minutes
    and increase in intensity for 10 minutes and a heart rate 100-105. The chest pains
    subside gradually and disappear after 5 more minutes of continued walking or cycling.

    I had the same condition before taking Folic acid and Methotrexate.

    Reply

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Complete drug side effects:

On eHealthMe, Prednisone (prednisone) is often used to treat rheumatoid arthritis. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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