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Review: Prednisone and Methotrexate

This review analyzes the effectiveness and drug interactions between Prednisone and Methotrexate. It is created by eHealthMe based on 25,734 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Mar, 31, 2014: 25,734 people who reported to have interactions when taking Prednisone, Methotrexate are studied

Trend of Prednisone, Methotrexate's drug interactions, side effects and effectiveness reports (4034694)

Drug combinations in study:
- Prednisone (prednisone)
- Methotrexate (methotrexate sodium)

eHealthMe real world results:

Most common interactions experienced by people in the use of Prednisone, Methotrexate:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Arthralgia (joint pain)5,454
Pyrexia (fever)5,227
Dyspnoea (difficult or laboured respiration)3,864
Pain3,124
Pneumonia3,001
Drug Ineffective2,970
Nausea (feeling of having an urge to vomit)2,862
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints)2,687
Fatigue (feeling of tiredness)2,574
Oedema Peripheral (superficial swelling)2,166

Most common interactions experienced by people in long term use of Prednisone, Methotrexate:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Pyrexia (fever)283
Asthenia (weakness)213
Pneumonia212
Diarrhoea204
Arthralgia (joint pain)187
Oedema Peripheral (superficial swelling)146
Weight Decreased144
Fatigue (feeling of tiredness)140
Nausea (feeling of having an urge to vomit)136
Pain121

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Prednisone0.00%14.81%48.15%24.07%12.96%
Methotrexate5.56%37.04%27.78%25.93%3.70%

Top conditions involved for these people * :

  1. Rheumatoid arthritis
  2. Acute lymphocytic leukaemia
  3. Hypertension
  4. Pain
  5. Crohn's disease

Top co-used drugs for these people * :

  1. Folic acid
  2. Humira
  3. Remicade
  4. Enbrel
  5. Golimumab

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Methotrexate, Prednisone

You can also:

Complete drug side effects:

On eHealthMe, Prednisone (prednisone) is often used to treat asthma. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (3 days ago):

  • Trying to determine if the timing of these drugs- especially the weekly mtx- should be staggered during the day to ensure they are appropriately absorbed. Periodic seizures continue- about once a quarter.

    Reply

  • From this study (3 weeks ago):

  • Do these drugs cause large lymph nodes and infected lymph nodes

    Reply

    Dshadel on Mar, 27, 2014:

    I am a 56 yo female newly dx with ra and more have been trying to stay well enough to be on methotrexate for at least a month to see if it works but this my second bout of bronchitis and need antibiotics so have to stop ra tx til its gone. The one big warning for ra drugs is enlarge lymph nodes because they all say lymphoma can be caused by their use. My dr had me see my gyn ay the start of tx and then regular mamograms. Thats the only way to detect a problem is occurring. Please get it checked out soon.

    Reply

  • From this study (3 weeks ago):

  • Wondering if last 6 months on Methotrexate and Prednisone has caused recent severe Cataract development ??

    Reply

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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