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Review: Prednisone and Methotrexate





Summary: drug interactions are reported among people who take Prednisone and Methotrexate together.

This review analyzes the effectiveness and drug interactions between Prednisone and Methotrexate. It is created by eHealthMe based on reports of 25,934 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Prednisone and Methotrexate >>>

What are the drugs

Prednisone has active ingredients of prednisone. It is often used in rheumatoid arthritis. (view latest outcomes from 150,015 users)

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (view latest outcomes from 131,201 users)

On Nov, 26, 2014: 25,934 people who take Prednisone, Methotrexate are studied

Prednisone, Methotrexate outcomes

Drug combinations in study:
- Prednisone (prednisone)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Prednisone is effective27.59%
(8 of 29 people)
35.09%
(20 of 57 people)
32.26%
(10 of 31 people)
50.00%
(20 of 40 people)
50.00%
(17 of 34 people)
55.26%
(21 of 38 people)
62.50%
(15 of 24 people)
100.00%
(1 of 1 people)
Methotrexate is effective4.55%
(1 of 22 people)
19.12%
(13 of 68 people)
19.23%
(5 of 26 people)
36.84%
(14 of 38 people)
26.32%
(10 of 38 people)
39.29%
(11 of 28 people)
45.00%
(9 of 20 people)
0.00%
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaPyrexiaPneumoniaPneumoniaDiarrhoeaPyrexiaOedema PeripheralPyrexia
Febrile NeutropeniaPneumoniaPneumonitisPyrexiaPneumoniaWeight DecreasedAstheniaArthralgia
PneumoniaAnaemiaNauseaNauseaFatigueDeathPyrexiaDrug Ineffective
NauseaCellulitisCellulitisRespiratory FailureSepsisFatigueCoughNausea
HypotensionNauseaDrug IneffectiveArthralgiaNauseaAnaemiaHeadacheRheumatoid Arthritis
VomitingCardio-respiratory ArrestAnaemiaRheumatoid ArthritisWeight DecreasedPneumoniaChest PainPain
DiarrhoeaRenal Failure AcuteUrinary Tract InfectionFatigueRheumatoid ArthritisPancytopeniaLung DisorderPneumonia
DyspnoeaWeight DecreasedVomitingRenal FailureImpaired HealingNauseaCerebrovascular AccidentFatigue
HeadacheFebrile NeutropeniaDyspnoeaVomitingChest PainPleural EffusionChillsDyspnoea
HypertensionPainWeight DecreasedSepsisDepressionMalaiseArthralgiaAsthenia

Drug effectiveness by gender :

FemaleMale
Prednisone is effective44.67%
(88 of 197 people)
42.11%
(24 of 57 people)
Methotrexate is effective23.04%
(44 of 191 people)
37.25%
(19 of 51 people)

Most common drug interactions by gender * :

FemaleMale
ArthralgiaPyrexia
PyrexiaPneumonia
NauseaDrug Ineffective
Drug IneffectiveArthralgia
PainRheumatoid Arthritis
Rheumatoid ArthritisNausea
FatigueAsthenia
PneumoniaPain
DyspnoeaFatigue
HeadacheDyspnoea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Prednisone is effectiven/a100.00%
(2 of 2 people)
20.00%
(2 of 10 people)
25.00%
(3 of 12 people)
21.88%
(14 of 64 people)
25.00%
(22 of 88 people)
27.27%
(39 of 143 people)
35.29%
(30 of 85 people)
Methotrexate is effectiven/a100.00%
(2 of 2 people)
11.11%
(1 of 9 people)
8.33%
(1 of 12 people)
7.94%
(5 of 63 people)
9.30%
(8 of 86 people)
24.07%
(26 of 108 people)
24.69%
(20 of 81 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
NeutropeniaPyrexiaCrohn's DiseasePyrexiaPyrexiaPyrexiaArthralgiaPneumonia
Gamma-glutamyltransferase IncreasedDrug ToxicityPyrexiaArthralgiaNauseaArthralgiaPyrexiaPyrexia
Respiratory Syncytial Virus InfectionPneumoniaHypotensionNauseaArthralgiaDrug IneffectiveNauseaArthralgia
DiarrhoeaFebrile NeutropeniaNeutropeniaHeadacheDrug IneffectiveNauseaPainDrug Ineffective
StomatitisConvulsionAbdominal PainDrug IneffectiveVomitingRheumatoid ArthritisDrug IneffectiveNausea
PyrexiaMucosal InflammationVomitingDyspnoeaInjection Site Reaction NosPainFatigueAsthenia
ThrombocytopeniaNeutropeniaHyperglycaemiaPainHeadacheHeadacheOedema PeripheralRheumatoid Arthritis
Pain In ExtremityVomitingHyperbilirubinaemiaChest PainRheumatoid ArthritisFatigueRheumatoid ArthritisFatigue
Normochromic Normocytic AnaemiaAlanine Aminotransferase IncreasedHeadacheRheumatoid ArthritisInjection Site HaemorrhageOedema PeripheralDiarrhoeaDyspnoea
Molluscum ContagiosumAbdominal PainNauseaWeight DecreasedDiarrhoeaInjection Site Reaction NosHeadacheFall

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Prednisone and Methotrexate?

You are not alone! Join a related mobile support group:
- support group for people who take Prednisone and Methotrexate
- support group for people who take Methotrexate
- support group for people who take Prednisone

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Can i continue taking lysine while taking prednisone? (5 day prescription)
    I am on a 5 day prescription of prednisone for my allergies/ear blockage. Is it safe for me during this time to continue taking my Lysine supplement?
  • Does zoloft cause ringing in the ears, like tinnitus? i've been on it for a month and noticed the ringing in the ears about a week ago, and it's just constant ringing and it's driving me insane. (1 answer)
    I've been on most of the medications for more than a year and it hasn't been that bad getting used to them. But I've been on Zoloft and ambien for about a month now, and I've been noticing a lot of side effects. The one I just recently noticed and that has been driving me completely insane, is the ringing in the ears. It's been about a week now and I just don't know what to do anymore. If it is the Zoloft then I can finally just stop taking it and make this stop. If anyone has an answer or knows what to do, PLEASE help. I'm at my wits end.
  • Hlab27 antigen and unexplained scratches caused by accutane
    Guinea pig user of Accutane 1982. Experimental drug (told at that time) when a woman hits menopause we are not sure what will happen. I have hit early menopause 42 to be exact. Conjunctivitis, unexplained swelling in fingers, toes, kness, pseudogout (not normal according to my rheumatologist) unexplained scratches in same location, forearms, lower thigh (by knee) fingers. Scratches always are in a line with a break in the line. When a woman hits menopause hormones cease and when this happens the path that Accutane takes to cease sebaceous gland function, skin proliferation ceases. Therefore, my friends the HLA B27 (abnormal antigen targeted for skin proliferation does not know where to go so it randomly attacks whatever organ it chooses. Accutane if I remember correctly and I do have proof, permanently alters DNA. There is no other way orally ingesting a retinolic acid it could control skin, hormonal cesessation. I have only been diagnosed thus far with psoriatic arthritis with no other explanations for these other symptoms. I wonder why this is and I also wonder why dermatologists refuse to take a biopsy of my skin to rule out cell skin proliferation dysfunction. What will this damaging drug attack next. Do no be fooled by Dr.s who tell you that you took this drug so long ago how could this be. Well folks, it is because it has already changed your DNA to the HLAB27 antigen. My question also is, what was supposed to be where this abnormal DNA antigen is and how come this antigen only shows up at menopause. My disease (autoimmune) is progressive) and has already attacked nervous, muscle, skin, joints etc. Interesting
  • Has anyone with autoimmune hepatitis tried alpha lipoic acid, milk thistle and selenium (1 answer)
    Has anyone tried alpha lipoic , selenium and silybum marianum? I read an article that synergically they have anti inflammatory impact on the liver.
  • Has anybody had multi lobar pneumonia from reaction to methotrexate?
    Bilateral multilobar pneumonia - rheumatologist considers it was caused by a reaction to methotrexate I was taking for ankylosing spondylitis and I was lucky to survive. Anyone have this and later shown to have scarring of the lungs?

More questions for: Methotrexate, Prednisone

You may be interested at these reviews (Write a review):

  • Prednisone rx 3,3,2,2,1,1 plan suicidal haunts all day
    I came home from the Hospitol with a 3,3,2,2,1,1 Rx.
    I took (3) and spent the rest of the day contenplating Suicide.
    The rest of the Rx went in the Toilet by 7:pm.
    I wonder how many this Killed.
  • Prednisone induced cushing's syndrome
    Prescribed Prednisone 20mg twice daily. Took for six weeks and developed weaken muscles and swollen face. Was hospitalized and informed I had severe Cushing's Syndrome. Host of problems included glucose over 400, inflammed pancreas, triglycerides over 4,000 and vision problems. Muscles were wasted and weak so fell several times. Had to regain strength and learn to walk again with physical therapy. Left with foggy thinking, fatigue, muscle myopathy and peripheral neuropathy. Also developed osteopenia. Afterwards was placed on hydrocortisone and Lyrica for pain. Later found liver damage.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Prednisone side effect: hiccups
    I am taking prednisone for an allergic reaction to a bee sting. 20mg for 5 days, then 10mg for 5 days. Starting the second day, I have fairly consistent hiccups, which become more severe at night. I have also previously taken prednisone to tame a severe poison ivy rash and have had the same reaction.

    Any remedies? All I found, that works sometimes, is a scoop of peanut butter, didn't work last night though...
  • Prednisone mixed results-it lets me breath
    have been on prednisone now for 3 years straight. Am taking 30mg a day just to breath. every time i have tried to taper off i have ended up in the emergency room unable to breath. That has been 7 times in the last year. I am 49 years old and was in good health 3-4 years ago. got a cough and it has been down hill.Prednisone worked great at first but then it starts to destroy the body.Had nasal passage surgery(waste of time)have broken many ribs from coughing.painful.when you are on prednisone your body takes 3-5 times longer to heal.craked tailbone from a slip. have seen over 12 doctors.reasonable gueswork. My best doc which is mine says do you want to suffocate to death or let your body try and fix itself if it can. im not for suffocation at all. Just a good medicine to counter the angriness of the steroid. Any ideas i am all ears. oh ya my eyes are starting to go and my joints as well

More reviews for: Methotrexate, Prednisone

Comments from related studies:

  • From this study (1 month ago):

  • Also take Vitamin D, Actonel,Calcium, B-12, Folic acid

    Reply

  • From this study (2 months ago):

  • I find I can read something but have a difficult time relating what I have just read to another person. Although I understand what I have read, I just seem to have great difficulty putting it into words to relate

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  • From this study (2 months ago):

  • Going blind and nothing seems to be helping

    Reply

    kss40 on Oct, 4, 2014:

    What do u mean going blind? Do u have RP and CME that is why u r on Diamox? U neec someone to talk to?

    Reply

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Complete drug side effects:

On eHealthMe, Prednisone (prednisone) is often used to treat rheumatoid arthritis. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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