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Review: taking Pristiq and Buspar together

Summary: drug interactions are reported among people who take Pristiq and Buspar together.

This review analyzes the effectiveness and drug interactions between Pristiq and Buspar. It is created by eHealthMe based on reports of 129 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 14, 2015: 129 people who take Pristiq, Buspar are studied

Pristiq, Buspar outcomes

Drug combinations in study:
- Pristiq (desvenlafaxine succinate)
- Buspar (buspirone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Pristiq is effectiven/a20.00%
(2 of 10 people)
(2 of 6 people)
(2 of 7 people)
(1 of 2 people)
(1 of 1 people)
Buspar is effective0.00%
(0 of 2 people)
(1 of 9 people)
(1 of 6 people)
(1 of 5 people)
(2 of 3 people)
(1 of 2 people)
(0 of 2 people)

Drug effectiveness by gender :

Pristiq is effective28.57%
(6 of 21 people)
(2 of 5 people)
Buspar is effective22.73%
(5 of 22 people)
(1 of 7 people)

Drug effectiveness by age :

Pristiq is effectiven/an/a25.00%
(1 of 4 people)
(1 of 4 people)
(2 of 15 people)
(2 of 7 people)
(1 of 5 people)
(1 of 3 people)
Buspar is effectiven/an/a0.00%
(0 of 4 people)
(1 of 5 people)
(4 of 17 people)
(1 of 7 people)
(0 of 5 people)
(0 of 5 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Suicide AttemptAnxietyAstheniaGait DisturbanceAngerDizzinessn/aNausea
Intentional OverdoseHeadacheDrug IneffectiveDrug Withdrawal SyndromeFatigueAnxiety
Weight IncreasedAggression AggravatedMetabolic DisorderDizzinessIrritabilityDrug Ineffective
Decreased AppetiteAkathisiaParadoxical Drug ReactionHypoaesthesiaSexual DysfunctionHeadache
DiarrhoeaAngerFatigueParanoiaHeadache - TensionFatigue
FatigueNauseaDrug Effect DecreasedNauseaShopliftingNervousness
DizzinessInsomnia ExacerbatedTremorFallDizziness
Drug Effect DecreasedFatigueWeight Gain - UnintentionalConvulsionHypertension
Self Esteem DecreasedBlood Glucose IncreasedConvulsionHead DiscomfortPain
Obsessive ThoughtsDrug IneffectiveDrug Withdrawal SyndromeDizzinessWeight Increased

Most common drug interactions by gender * :

AnxietyDrug Ineffective
Suicide AttemptAnger
Drug IneffectiveGastrooesophageal Reflux Disease
Intentional OverdoseDizziness
Weight IncreasedAbdominal Pain
Decreased AppetiteFatigue

Most common drug interactions by age * :

n/an/aOcdMalaiseSuicide AttemptWeight IncreasedPainAnxiety
InsomniaAbdominal DiscomfortIntentional OverdoseFatigueNauseaNervousness
AnxietyFeeling AbnormalNauseaDecreased AppetiteAngerNausea
Heart RateMood SwingsHeadacheSuicidal IdeationHypertensionHeadache
DiarrhoeaAngerNightmareHeart Rate IncreasedCondition Aggravated
HeadacheDecreased AppetiteDrug Effect DecreasedTremorDrug Ineffective
MigraineAggression AggravatedSelf Esteem DecreasedDiarrhoeaBlood Triglycerides Increased
Neck PainAkathisiaObsessive ThoughtsParaesthesiaConstipation
Drug HypersensitivityIrritabilityPsychotic DisorderDroolingBlood Cholesterol Increased
InsomniaInsomnia ExacerbatedRash ErythematousBack InjuryParaesthesia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Buspar
- support group for people who take Pristiq

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Pristiq (desvenlafaxine succinate) is often used to treat depression. Buspar (buspirone hydrochloride) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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