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Review: taking Trazodone and Prozac together

Summary: drug interactions are reported among people who take Trazodone and Prozac together. This review analyzes the effectiveness and drug interactions between Trazodone and Prozac. It is created by eHealthMe based on reports of 3,420 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Trazodone hydrochloride has active ingredients of trazodone hydrochloride. It is often used in insomnia. (latest outcomes from 6,694 Trazodone hydrochloride users)

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. (latest outcomes from 42,370 Prozac users)

On May, 21, 2015: 3,419 people who take Trazodone Hydrochloride, Prozac are studied

Trazodone Hydrochloride, Prozac outcomes

Drug combinations in study:
- Trazodone Hydrochloride (trazodone hydrochloride)
- Prozac (fluoxetine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Trazodone Hydrochloride is effective19.05%
(4 of 21 people)
(8 of 21 people)
(10 of 19 people)
(9 of 21 people)
(16 of 28 people)
(12 of 22 people)
(12 of 16 people)
Prozac is effective12.50%
(2 of 16 people)
(6 of 23 people)
(5 of 18 people)
(8 of 21 people)
(11 of 25 people)
(8 of 20 people)
(13 of 30 people)

Drug effectiveness by gender :

Trazodone Hydrochloride is effective51.38%
(56 of 109 people)
(15 of 39 people)
Prozac is effective39.29%
(44 of 112 people)
(9 of 40 people)

Drug effectiveness by age :

Trazodone Hydrochloride is effectiven/a0.00%
(0 of 2 people)
(1 of 3 people)
(10 of 52 people)
(17 of 46 people)
(19 of 83 people)
(16 of 57 people)
(8 of 33 people)
Prozac is effectiven/a0.00%
(0 of 2 people)
(1 of 15 people)
(8 of 58 people)
(12 of 47 people)
(13 of 80 people)
(14 of 57 people)
(5 of 36 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
ArthralgiaType 2 Diabetes MellitusNauseaDiabetes MellitusObesityType 2 Diabetes MellitusDepressionNausea
DepressionNauseaType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusWeight IncreasedFatigueType 2 Diabetes Mellitus
Disturbance In AttentionBack PainBlood Triglycerides IncreasedPainBlood Cholesterol IncreasedDiabetes MellitusDepressed MoodDiabetes Mellitus
InsomniaObesityDiabetic NeuropathyBlood Cholesterol IncreasedBlood Triglycerides IncreasedDepressionMemory ImpairmentDepression
NauseaAgitationStillbirthObesityChest PainDiabetes Mellitus Inadequate ControlTremorAnxiety
MalaisePainDrug Exposure During PregnancyBladder DisorderWeight IncreasedAnxietyVictim Of CrimePain
Pharyngolaryngeal PainDiabetic KetoacidosisBack PainBlood Triglycerides IncreasedDepressionInfluenzaPanic AttackFatigue
AngerMuscle SpasmsArthralgiaDepressionOsteoporosisTardive DyskinesiaVision BlurredHeadache
Blood Creatine Phosphokinase IncreasedWeight IncreasedHypercholesterolaemiaHysterectomyRib FractureNasopharyngitisSomnolenceDyspnoea
Neuropathy PeripheralHyperglycaemiaMultiple AllergiesInflammationRespiratory DistressEar PainStressFall

Most common drug interactions by gender * :

Type 2 Diabetes MellitusType 2 Diabetes Mellitus
Diabetes MellitusDiabetes Mellitus
FatigueSuicidal Ideation
Weight IncreasedFall

Most common drug interactions by age * :

Diabetes MellitusElectrocardiogram Qt ProlongedAggressionDiabetes MellitusType 2 Diabetes MellitusDiabetes MellitusNauseaPain
AggressionBipolar DisorderSuicidal IdeationType 2 Diabetes MellitusDiabetes MellitusType 2 Diabetes MellitusDepressionFatigue
Tardive DyskinesiaRespiratory Failure (excl Neonatal)Suicide AttemptDizzinessNauseaNauseaType 2 Diabetes MellitusAnxiety
PancreatitisPulse AbsentWeight IncreasedVomitingAnxietyHeadacheFallAsthenia
Congenital Diaphragmatic HerniaInsomniaNauseaAbdominal Pain UpperDepressionDyspnoeaHeadacheFall
ConvulsionLeft Ventricular HypertrophyPersonality ChangeDepressionWeight IncreasedFatiguePainDiarrhoea
Lung Disorder NosAggressionAngerDyspnoeaDrug Withdrawal SyndromeDepressionAnxietyDyspnoea
Peritoneal EffusionSedationAgitationSuicidal IdeationPainChest PainPain In ExtremityHeadache
Pleural EffusionWeight IncreasedScreamingWeight IncreasedDrug DependenceAnxietyFatigueConstipation
Pelvic Fluid CollectionDrug IneffectivePsychomotor HyperactivityPancreatitisHeadacheWeight IncreasedDiabetes MellitusDepression

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Trazodone and Prozac on

Do you take Trazodone and Prozac?


You are not alone! Join a related support group:
- support group for people who take Prozac
- support group for people who take Trazodone Hydrochloride

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Prozac, Trazodone Hydrochloride

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    No side effects, works wonders, taking for two years and weaning off.
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More reviews for: Prozac, Trazodone Hydrochloride

Comments from related studies:

  • From this study (2 weeks ago):

  • been taking antabuse since February, had these symptoms on sunday only. has not stopped taking any of the above mentioned drugs since this but symptoms have subsided


  • From this study (2 months ago):

  • General lack of hope and motivation. Do not experience joy or looking forward to things I once enjoyed. Do not leave my bed because I don't have a reason to. Don't get dressed or shower same reason above. Feel exhausted and burnt out all the time.


  • From this study (4 months ago):

  • Hemoglobin low. Reading 9.5


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Prozac (fluoxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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