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Review: taking Rituxan and Benadryl together

Summary: drug interactions are reported among people who take Rituxan and Benadryl together.

This review analyzes the effectiveness and drug interactions between Rituxan and Benadryl. It is created by eHealthMe based on reports of 701 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 16, 2015: 701 people who take Rituxan, Benadryl are studied

Rituxan, Benadryl outcomes

Drug combinations in study:
- Rituxan (rituximab)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Rituxan is effectiven/an/a0.00%
(0 of 1 people)
Benadryl is effectiven/a0.00%
(0 of 1 people)

Drug effectiveness by gender :

Rituxan is effective0.00%
(0 of 1 people)
Benadryl is effective0.00%
(0 of 1 people)

Drug effectiveness by age :

Rituxan is effectiven/an/an/an/an/a0.00%
(0 of 1 people)
Benadryl is effectiven/an/an/an/an/a0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaPneumoniaHypotensionLower Respiratory Tract InfectionSquamous Cell Carcinoman/aVision BlurredDyspnoea
PyrexiaFebrile NeutropeniaRenal Failure AcuteSjogren's SyndromeAnaemiaHyperglycaemiaEmotional Distress
Infusion Related ReactionDyspnoeaNeoplasm MalignantSepsis SyndromeDizzinessHypotensionPyrexia
Blood Pressure DecreasedSepsisPneumoniaFebrile NeutropeniaPneumonitisFluid RetentionBlood Pressure Increased
ChillsFatigueImmunodeficiencyAtrial FibrillationPyrexiaNausea
Chest PainPlatelet Count DecreasedPain In ExtremityHerniaHypotension
FatiguePulmonary EmbolismRespiratory FailureLarge Intestine PerforationAnxiety Nec
NauseaInfectionFlushingIntraocular Pressure IncreasedPain Nos
VomitingAcute Respiratory Distress SyndromeNauseaEpistaxisCerebrovascular Accident Nos
AstheniaHaemoglobin DecreasedChillsLethargyAsthenia

Most common drug interactions by gender * :

NauseaEmotional Distress
DyspnoeaBlood Pressure Increased
PyrexiaAnxiety Nec
HypotensionPain Nos
AstheniaCerebrovascular Accident Nos
Febrile NeutropeniaPneumonia

Most common drug interactions by age * :

NystagmusHeart Rate IncreasedDyspnoeaNauseaNauseaFebrile NeutropeniaHypotensionDyspnoea
Lobar PneumoniaMoraxella InfectionInfusion Related ReactionUrinary Tract InfectionPyrexiaThrombocytopeniaPyrexiaHypotension
Parainfluenzae Virus InfectionGastroenteritis ViralSystemic Lupus ErythematosusConjunctivitis ViralHepatitisStomatitisNauseaPyrexia
Respiratory DistressCatheter Related InfectionFeeling HotAnaemiaInfusion Related ReactionVomitingVomitingAsthenia
Staphylococcal InfectionPseudomonas InfectionDizzinessDeep Vein ThrombosisVomitingNauseaChest PainThrombocytopenia
Eyelid DisorderRespiratory DistressPallorAstheniaPulmonary EmbolismRigorsTremorDehydration
Enterobacter InfectionTracheobronchitisFlushingGastritisLymphopeniaPyrexiaRigorsNausea
Bronchial HyperreactivityRetchingWheezingInsomniaDyspnoeaAspartate Aminotransferase IncreasedPulmonary EmbolismPleural Effusion
Bacteria Stool IdentifiedMonocyte Percentage DecreasedHyperhidrosisVomitingDeathAnaemiaDyspnoeaAnaemia
Catheter Related InfectionLymphocyte Percentage DecreasedNephrotic SyndromeHerpes ZosterDizzinessMenorrhagiaDizzinessFebrile Neutropenia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Benadryl
- support group for people who take Rituxan

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Rituxan (rituximab) is often used to treat rheumatoid arthritis. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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