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Review: taking Rituxan and Benadryl together

Summary: drug interactions are reported among people who take Rituxan and Benadryl together.

This review analyzes the effectiveness and drug interactions between Rituxan and Benadryl. It is created by eHealthMe based on reports of 701 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Rituxan and Benadryl >>>

What are the drugs

Rituxan has active ingredients of rituximab. It is often used in rheumatoid arthritis. (latest outcomes from 10,312 Rituxan users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,380 Benadryl users)

On Jan, 27, 2015: 701 people who take Rituxan, Benadryl are studied

Rituxan, Benadryl outcomes

Drug combinations in study:
- Rituxan (rituximab)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Rituxan is effectiven/an/a0.00%
(0 of 1 people)
Benadryl is effectiven/a0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaPneumoniaHypotensionLower Respiratory Tract InfectionSquamous Cell Carcinoman/aVision BlurredDyspnoea
PyrexiaFebrile NeutropeniaRenal Failure AcuteSjogren's SyndromeAnaemiaHyperglycaemiaEmotional Distress
Infusion Related ReactionDyspnoeaNeoplasm MalignantSepsis SyndromeDizzinessHypotensionPyrexia
Blood Pressure DecreasedSepsisPneumoniaFebrile NeutropeniaPneumonitisFluid RetentionBlood Pressure Increased
ChillsFatigueImmunodeficiencyAtrial FibrillationPyrexiaNausea
Chest PainPlatelet Count DecreasedPain In ExtremityHerniaHypotension
FatiguePulmonary EmbolismRespiratory FailureLarge Intestine PerforationAnxiety Nec
NauseaInfectionFlushingIntraocular Pressure IncreasedPain Nos
VomitingAcute Respiratory Distress SyndromeNauseaEpistaxisCerebrovascular Accident Nos
AstheniaHaemoglobin DecreasedChillsLethargyAsthenia

Drug effectiveness by gender :

Rituxan is effective0.00%
(0 of 1 people)
Benadryl is effective0.00%
(0 of 1 people)

Most common drug interactions by gender * :

NauseaEmotional Distress
DyspnoeaBlood Pressure Increased
PyrexiaAnxiety Nec
HypotensionPain Nos
AstheniaCerebrovascular Accident Nos
Febrile NeutropeniaPneumonia

Drug effectiveness by age :

Rituxan is effectiven/an/an/an/an/a0.00%
(0 of 1 people)
Benadryl is effectiven/an/an/an/an/a0.00%
(0 of 1 people)

Most common drug interactions by age * :

NystagmusHeart Rate IncreasedDyspnoeaNauseaNauseaFebrile NeutropeniaHypotensionDyspnoea
Lobar PneumoniaMoraxella InfectionInfusion Related ReactionUrinary Tract InfectionPyrexiaThrombocytopeniaPyrexiaHypotension
Parainfluenzae Virus InfectionGastroenteritis ViralSystemic Lupus ErythematosusConjunctivitis ViralHepatitisStomatitisNauseaPyrexia
Respiratory DistressCatheter Related InfectionFeeling HotAnaemiaInfusion Related ReactionVomitingVomitingAsthenia
Staphylococcal InfectionPseudomonas InfectionDizzinessDeep Vein ThrombosisVomitingNauseaChest PainThrombocytopenia
Eyelid DisorderRespiratory DistressPallorAstheniaPulmonary EmbolismRigorsTremorDehydration
Enterobacter InfectionTracheobronchitisFlushingGastritisLymphopeniaPyrexiaRigorsNausea
Bronchial HyperreactivityRetchingWheezingInsomniaDyspnoeaAspartate Aminotransferase IncreasedPulmonary EmbolismPleural Effusion
Bacteria Stool IdentifiedMonocyte Percentage DecreasedHyperhidrosisVomitingDeathAnaemiaDyspnoeaAnaemia
Catheter Related InfectionLymphocyte Percentage DecreasedNephrotic SyndromeHerpes ZosterDizzinessMenorrhagiaDizzinessFebrile Neutropenia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Rituxan and Benadryl?

You are not alone! Join a related mobile support group:
- support group for people who take Rituxan and Benadryl
- support group for people who take Benadryl
- support group for people who take Rituxan

Can you answer these questions (Ask a question):

More questions for: Benadryl, Rituxan

You may be interested at these reviews (Write a review):

  • Complement c3 elevated after taking rituxan
    I had 2 infusions of Rituxan 1000 mg. My labs came back with see rate .85, CRP 3.39 and complement c3 167. This is worse then highest rates tested earlier. Despite elevated rates pain level lowest it has been in 4 years.
  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
  • Benadryl completed suicide 50 year old
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.

More reviews for: Benadryl, Rituxan

Comments from related studies:

Complete drug side effects:

On eHealthMe, Rituxan (rituximab) is often used to treat rheumatoid arthritis. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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