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Review: Seroquel and Depakote





Summary: drug interactions are reported among people who take Seroquel and Depakote together.

This review analyzes the effectiveness and drug interactions between Seroquel and Depakote. It is created by eHealthMe based on reports of 5,152 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Seroquel and Depakote >>>

What are the drugs

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. (latest outcomes from Seroquel 79,098 users)

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote 30,928 users)

On Dec, 1, 2014: 5,152 people who take Seroquel, Depakote are studied

Seroquel, Depakote outcomes

Drug combinations in study:
- Seroquel (quetiapine fumarate)
- Depakote (divalproex sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Seroquel is effective36.84%
(7 of 19 people)
28.00%
(7 of 25 people)
35.71%
(5 of 14 people)
31.58%
(6 of 19 people)
38.46%
(10 of 26 people)
72.73%
(8 of 11 people)
33.33%
(1 of 3 people)
66.67%
(2 of 3 people)
Depakote is effective25.00%
(4 of 16 people)
25.00%
(7 of 28 people)
38.46%
(5 of 13 people)
41.67%
(5 of 12 people)
29.63%
(8 of 27 people)
70.00%
(7 of 10 people)
36.36%
(4 of 11 people)
50.00%
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes Mellitus
AggressionDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusType 2 Diabetes Mellitus
Type 2 Diabetes MellitusBlood Cholesterol IncreasedWeight IncreasedBlood Cholesterol IncreasedBlood Cholesterol IncreasedObesityObesityWeight Increased
Suicidal IdeationSuicidal IdeationObesityObesityObesityBlood Cholesterol IncreasedRenal FailureBlood Cholesterol Increased
SomnolenceWeight IncreasedBlood Cholesterol IncreasedHyperlipidaemiaHyperlipidaemiaHyperlipidaemiaConvulsionPancreatitis
DepressionDepressionBlood Triglycerides IncreasedNeuropathy PeripheralBlood Triglycerides IncreasedHyperglycaemiaNeuropathy PeripheralDiabetes Mellitus Inadequate Control
VomitingPancreatitisHyperglycaemiaWeight IncreasedDiabetic KetoacidosisBlood Triglycerides IncreasedDiabetes Mellitus Inadequate ControlObesity
ManiaBlood Triglycerides IncreasedFatigueDiabetic KetoacidosisDiabetes Mellitus Inadequate ControlDiabetes Mellitus Inadequate ControlDiabetic NeuropathyInsomnia
Confusional StateHyperglycaemiaDiabetic KetoacidosisDiabetic NeuropathyHypertensionBack PainWeight IncreasedHyperglycaemia
AgitationSomnolenceGastrooesophageal Reflux DiseaseBack PainDiabetic NeuropathyNeuropathy PeripheralDiabetic NephropathyDiabetic Ketoacidosis

Drug effectiveness by gender :

FemaleMale
Seroquel is effective40.35%
(23 of 57 people)
36.51%
(23 of 63 people)
Depakote is effective38.98%
(23 of 59 people)
30.00%
(18 of 60 people)

Most common drug interactions by gender * :

FemaleMale
Diabetes MellitusDiabetes Mellitus
Type 2 Diabetes MellitusType 2 Diabetes Mellitus
Weight IncreasedWeight Increased
Blood Cholesterol IncreasedBlood Cholesterol Increased
PancreatitisDiabetes Mellitus Inadequate Control
ObesityPancreatitis
DepressionDiabetic Ketoacidosis
InsomniaDiabetic Neuropathy
HyperglycaemiaHyperglycaemia
Diabetes Mellitus Inadequate ControlObesity

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Seroquel is effectiven/a0.00%
(0 of 1 people)
15.00%
(3 of 20 people)
36.36%
(12 of 33 people)
22.03%
(13 of 59 people)
35.48%
(11 of 31 people)
28.57%
(6 of 21 people)
5.56%
(1 of 18 people)
Depakote is effectiven/a0.00%
(0 of 1 people)
19.05%
(4 of 21 people)
30.00%
(9 of 30 people)
22.81%
(13 of 57 people)
17.65%
(6 of 34 people)
38.10%
(8 of 21 people)
5.56%
(1 of 18 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
PancreatitisOverdoseSuicidal IdeationDiabetes MellitusType 2 Diabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes Mellitus
ConvulsionDrug IneffectiveWeight IncreasedType 2 Diabetes MellitusDiabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes Mellitus
Type 2 Diabetes MellitusWeight IncreasedDiabetes MellitusWeight IncreasedWeight IncreasedBlood Cholesterol IncreasedInsomniaTremor
Diabetes MellitusSuicidal IdeationType 2 Diabetes MellitusDiabetic KetoacidosisObesityNeuropathy PeripheralSomnolenceConfusional State
NeutropeniaConvulsionAggressionBlood Cholesterol IncreasedBlood Cholesterol IncreasedDiabetes Mellitus Inadequate ControlWeight IncreasedFall
ThrombocytopeniaInsomniaAgitationPancreatitisDiabetes Mellitus Inadequate ControlDiabetic NeuropathyBlood Cholesterol IncreasedInsomnia
Cerebrovascular AccidentAggressionAbnormal BehaviourObesityPancreatitisWeight IncreasedHyperglycaemiaWeight Increased
HyperlipidaemiaSomnolenceDiabetic KetoacidosisSuicidal IdeationDiabetic NeuropathyBlood Triglycerides IncreasedTremorFatigue
Type 1 Diabetes MellitusHyperglycaemiaType 1 Diabetes MellitusType 1 Diabetes MellitusHypertensionChest PainDepressionDiarrhoea
AnaemiaPetit Mal EpilepsyWhite Blood Cell Count DecreasedHypertensionDiabetic KetoacidosisObesityAnxietyAnaemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Seroquel and Depakote?

You are not alone! Join a related mobile support group:
- support group for people who take Seroquel and Depakote
- support group for people who take Depakote
- support group for people who take Seroquel

Can you answer these questions (Ask a question):

More questions for: Depakote, Seroquel

You may be interested at these reviews (Write a review):

  • Bipolar patient extremely violent on seraquel
    I have been diagnosed bipolar for over 10 years. 3 years ago I was taken off of topamax and my seraquel was upped to 300 mg from 100 because I was pregnant. I was very violent! Punching, breaking stuff, in jail, in the psych ward. Yes pregnancy and bipolar are not a perfect combination. I too thought it was the hormones. My husband and split several times over me punching him. We moved to a state cross country so there was no more family drama. Nothing worked! Over the last 3 years my life has been hell! I happen to run out of my seroquel (tg) it took 2 weeks to arrive. In that time my body went thru horrible withdrawals. I vowed I wouldn't take it any longer. I've been seraquel free for 2 months. I'm now on gabapentin and proud to say I have no anger issues! Not 1 punch has
    been thrown. I feel like a totally different person.
  • Seroquel and iron deficiency?
    I've been taking Seroquel for about four year, I have been having symptoms similar to hypothyroidism, and just found out I have an iron deficiency. The doctor said my platelets are smaller than average, and it is possible that my grandmother is anemic. But in trying to study Seroquel I kept finding things that made me wonder if Seroquel could be linked to iron deficiency.
  • Transition from mirtazapine to cymbalta (bipolar ii) 6 week duration taken in conjunction with seroquel, propranalol and implanon
    In early September I approached my Psychiatrist to report that I was having sleep paralysis episodes as well as insatiable appetite. I had put on about 20lb in the space of 6 months since the sleep paralysis started.

    My Psychiatrist opted to wean me off the Mirtazapine and onto Cymbalta. I have now been on 60mg of Cymbalta for about 4 weeks and completely titrated off the Mirtazapine.

    I have noted that since switching to Cymbalta that I no longer have the insatiable appetite, nor have I had any further sleep paralysis episodes (though I have had a brain MRI to rule out any physiological issues - yet to receive results).

    I have noticed that I have had mild to moderate rolling nausea with the Cymbalta and that I now have food aversions. Food does not interest me as much anymore and I find that certain foods (mostly processed snacks) are no longer palatable. I also find that I become full after much smaller meal portions.

    I have found that I can no longer drink wine or spirits because they now taste awful however I can still tolerate certain brands of beer. I also no longer enjoy drinking cola.

    I am also on the Implanon Implant. I have had this implant inserted for about 12 months and my cycles have been rather regular. Since starting the Cymbalta I have had some breakthrough bleeding yet my periods have not been as painful, though they have been heavier and longer.

    My Psychiatrist will commence titrating me off the Seroquel in about two weeks and onto Topamax as it is his belief it will be less sedating than the Seroquel and that it will hopefully help as a mood stabiliser, treat my migraines and allow me to come off the Propranolol. he also hopes that I am able to loose some of the weight gained since the sleep paralysis episodes started.

    As a side note regarding the Propranolol, I have naturally low blood pressure and I find while Propranalol is generally an effective migraine prophylactic, (I do get some breakthrough migraines) it does make my blood pressure even lower which leads to dizziness and faintness when I stand up too quickly from a recumbent position.
  • Seizure patient was on depakote for 16 years now on keppra 1500 mg.
    I am 28 years old and been off depakote for 5 months. I started keppra to control my seizure disorder, which works great. But for the past year I have developed osteoarthritis in my thoracic, si joints, and lumbar. I get alot of muscle hypersensitivity and pain. Can any of this be due to long term effects of seizure meds?
  • Eczema and birth control-microgestin
    I started getting eczema over the last year and recently decided it may be from the birth control as well, which I started taking @ 2 months before I got the eczema and skin started breaking out...weight gain, etc. I am on singulair, westcort cream, moisture/kenalog, exederm cream, cerevue wash, cetaphil moisturizer, and started using the black soap which is apparently helping. I started a vegetarian diet and eat mainly the same foods daily to monitor anything for allergies. I stopped taking the pill 3 days ago and I am optimistic. I am hoping others have had positive experiences.

More reviews for: Depakote, Seroquel

Comments from related studies:

  • From this study (1 month ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!

    Reply

    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor

    Reply

    trust1983 on Dec, 3, 2012:

    Is it true in the states that a psych doc can up and just leave and refuse to treat you because you tried to kill yourself, especially if you didn't have a contact for life with you r doc?

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Seroquel (quetiapine fumarate) is often used to treat bipolar disorder. Depakote (divalproex sodium) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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