Review: taking Seroquel and Depakote together
Summary: drug interactions are reported among people who take Seroquel and Depakote together.
This review analyzes the effectiveness and drug interactions between Seroquel and Depakote. It is created by eHealthMe based on reports of 5,152 people who take the same drugs from FDA and social media, and is updated regularly.
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Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. (latest outcomes from 79,125 Seroquel users) Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from 30,936 Depakote users)
What are the drugs
Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. (latest outcomes from 79,125 Seroquel users)
Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from 30,936 Depakote users)
On Dec, 31, 2014: 5,152 people who take Seroquel, Depakote are studied
Drug combinations in study:
- Seroquel (quetiapine fumarate)
- Depakote (divalproex sodium)
Drug effectiveness over time :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Seroquel is effective||36.84%|
(7 of 19 people)
(7 of 25 people)
(5 of 14 people)
(6 of 19 people)
(10 of 26 people)
(8 of 11 people)
(1 of 3 people)
(2 of 3 people)
|Depakote is effective||25.00%|
(4 of 16 people)
(7 of 28 people)
(5 of 13 people)
(5 of 12 people)
(8 of 27 people)
(7 of 10 people)
(4 of 11 people)
(1 of 2 people)
Most common drug interactions over time * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Diabetes Mellitus||Type 2 Diabetes Mellitus||Type 2 Diabetes Mellitus||Type 2 Diabetes Mellitus||Type 2 Diabetes Mellitus||Type 2 Diabetes Mellitus||Type 2 Diabetes Mellitus||Diabetes Mellitus|
|Aggression||Diabetes Mellitus||Diabetes Mellitus||Diabetes Mellitus||Diabetes Mellitus||Diabetes Mellitus||Diabetes Mellitus||Type 2 Diabetes Mellitus|
|Type 2 Diabetes Mellitus||Blood Cholesterol Increased||Weight Increased||Blood Cholesterol Increased||Blood Cholesterol Increased||Obesity||Obesity||Weight Increased|
|Suicidal Ideation||Suicidal Ideation||Obesity||Obesity||Obesity||Blood Cholesterol Increased||Renal Failure||Blood Cholesterol Increased|
|Somnolence||Weight Increased||Blood Cholesterol Increased||Hyperlipidaemia||Hyperlipidaemia||Hyperlipidaemia||Convulsion||Pancreatitis|
|Depression||Depression||Blood Triglycerides Increased||Neuropathy Peripheral||Blood Triglycerides Increased||Hyperglycaemia||Neuropathy Peripheral||Diabetes Mellitus Inadequate Control|
|Vomiting||Pancreatitis||Hyperglycaemia||Weight Increased||Diabetic Ketoacidosis||Blood Triglycerides Increased||Diabetes Mellitus Inadequate Control||Obesity|
|Mania||Blood Triglycerides Increased||Fatigue||Diabetic Ketoacidosis||Diabetes Mellitus Inadequate Control||Diabetes Mellitus Inadequate Control||Diabetic Neuropathy||Insomnia|
|Confusional State||Hyperglycaemia||Diabetic Ketoacidosis||Diabetic Neuropathy||Hypertension||Back Pain||Weight Increased||Hyperglycaemia|
|Agitation||Somnolence||Gastrooesophageal Reflux Disease||Back Pain||Diabetic Neuropathy||Neuropathy Peripheral||Diabetic Nephropathy||Diabetic Ketoacidosis|
Drug effectiveness by gender :
|Seroquel is effective||40.35%|
(23 of 57 people)
(23 of 63 people)
|Depakote is effective||38.98%|
(23 of 59 people)
(18 of 60 people)
Most common drug interactions by gender * :
|Diabetes Mellitus||Diabetes Mellitus|
|Type 2 Diabetes Mellitus||Type 2 Diabetes Mellitus|
|Weight Increased||Weight Increased|
|Blood Cholesterol Increased||Blood Cholesterol Increased|
|Pancreatitis||Diabetes Mellitus Inadequate Control|
|Diabetes Mellitus Inadequate Control||Obesity|
Drug effectiveness by age :
|Seroquel is effective||n/a||0.00%|
(0 of 1 people)
(3 of 20 people)
(12 of 33 people)
(13 of 59 people)
(11 of 31 people)
(6 of 21 people)
(1 of 18 people)
|Depakote is effective||n/a||0.00%|
(0 of 1 people)
(4 of 21 people)
(9 of 30 people)
(13 of 57 people)
(6 of 34 people)
(8 of 21 people)
(1 of 18 people)
Most common drug interactions by age * :
|Pancreatitis||Overdose||Suicidal Ideation||Diabetes Mellitus||Type 2 Diabetes Mellitus||Diabetes Mellitus||Diabetes Mellitus||Diabetes Mellitus|
|Convulsion||Drug Ineffective||Weight Increased||Type 2 Diabetes Mellitus||Diabetes Mellitus||Type 2 Diabetes Mellitus||Type 2 Diabetes Mellitus||Type 2 Diabetes Mellitus|
|Type 2 Diabetes Mellitus||Weight Increased||Diabetes Mellitus||Weight Increased||Weight Increased||Blood Cholesterol Increased||Insomnia||Tremor|
|Diabetes Mellitus||Suicidal Ideation||Type 2 Diabetes Mellitus||Diabetic Ketoacidosis||Obesity||Neuropathy Peripheral||Somnolence||Confusional State|
|Neutropenia||Convulsion||Aggression||Blood Cholesterol Increased||Blood Cholesterol Increased||Diabetes Mellitus Inadequate Control||Weight Increased||Fall|
|Thrombocytopenia||Insomnia||Agitation||Pancreatitis||Diabetes Mellitus Inadequate Control||Diabetic Neuropathy||Blood Cholesterol Increased||Insomnia|
|Cerebrovascular Accident||Aggression||Abnormal Behaviour||Obesity||Pancreatitis||Weight Increased||Hyperglycaemia||Weight Increased|
|Hyperlipidaemia||Somnolence||Diabetic Ketoacidosis||Suicidal Ideation||Diabetic Neuropathy||Blood Triglycerides Increased||Tremor||Fatigue|
|Type 1 Diabetes Mellitus||Hyperglycaemia||Type 1 Diabetes Mellitus||Type 1 Diabetes Mellitus||Hypertension||Chest Pain||Depression||Diarrhoea|
|Anaemia||Petit Mal Epilepsy||White Blood Cell Count Decreased||Hypertension||Diabetic Ketoacidosis||Obesity||Anxiety||Anaemia|
* Some reports may have incomplete information.
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- support group for people who take Seroquel and Depakote
- support group for people who take Depakote
- support group for people who take Seroquel
Can you answer these questions (Ask a question):
- I tested positive for methadone, i have never taken this drug (1 answer)
I tested positive for methadone, I have never taken this drug. My Dr said I had to have taken it because it was there and that a false positive is out of the question. Could my meds cause methadone to show up on a urine drug test
- Bipolar 2 since 1975. recently d/c'd lithium. looking for a treatment that will not make glaucoma condition worse (1 answer)
I am trying to determine which medication to use now that my 40 year successful run with Lithium is over. (The kdneys say it's time to quit). However, I do not want to increase intraocular pressure by using a medication known to increase said pressure. Most importantly, I do not want to lose my livelihood or cause my family and friends unforeseen difficulty due to ineffective medications. I have little faith in the alternatives and see Depakote, Geodon, and Lamictal as poor seconds at
best. Any suggestions???
- Can clyndamican cause a seizure while taking depakote
I am currently taking Depakote Extended Realease 1000mgs at bedtime with Clyndamican an antibiotic. I have been feeling dizzy, fatigue, headaches, body aches, sore throat, and pain and pressure in my chest. I would like to know if these two medications mixed together are causing me these problems, and if it can cause me a seizure.
- Requip cause dysphagia
an increase caused me not to be able to swallow at all
- What is the reaction to vivitrol and ritalin?
25 year old client in early recovery from opioid dependence takes ritalin and seroquel and wants to add vivitrol. What are the risks and side effects?
You may be interested at these reviews (Write a review):
- Terrible excessive sweating from hydrochlorothiazide
I guess I fit the profile of who gets excessive sweating from HCTZ. I am a 65 year old female and suffered from excessive sweating for two years. With just very little exertion, I would pour sweat from the top of my head. It would run into my face and all over my hair. My hair would be ringing wet. I had heavy perspiration in the groin area and down my back also. I had to change clothing 2-3 times a day and wash up or shower that many times also. The doctor tried changing my Cymbalta and put me on Wellbutrin instead. It did absolutely no good. I went off the wellbutrin and back onto the Cymbalta. I did some research and saw that HCTZ could cause excessive sweating. Both my doctor and my pharmacist said that they had never heard of that. I went off the HCTZ, and my sweating stopped almost immediately. My doctor and my pharmacist were very surprised. I'm one of those people who frequently have different reactions to drugs than are typical. If you're having excessive perspiration and are on HCTZ, try going off of it. It just may be the culprit!
- Bipolar patient extremely violent on seraquel
I have been diagnosed bipolar for over 10 years. 3 years ago I was taken off of topamax and my seraquel was upped to 300 mg from 100 because I was pregnant. I was very violent! Punching, breaking stuff, in jail, in the psych ward. Yes pregnancy and bipolar are not a perfect combination. I too thought it was the hormones. My husband and split several times over me punching him. We moved to a state cross country so there was no more family drama. Nothing worked! Over the last 3 years my life has been hell! I happen to run out of my seroquel (tg) it took 2 weeks to arrive. In that time my body went thru horrible withdrawals. I vowed I wouldn't take it any longer. I've been seraquel free for 2 months. I'm now on gabapentin and proud to say I have no anger issues! Not 1 punch has
been thrown. I feel like a totally different person.
- Seroquel and iron deficiency?
I've been taking Seroquel for about four year, I have been having symptoms similar to hypothyroidism, and just found out I have an iron deficiency. The doctor said my platelets are smaller than average, and it is possible that my grandmother is anemic. But in trying to study Seroquel I kept finding things that made me wonder if Seroquel could be linked to iron deficiency.
- Transition from mirtazapine to cymbalta (bipolar ii) 6 week duration taken in conjunction with seroquel, propranalol and implanon
In early September I approached my Psychiatrist to report that I was having sleep paralysis episodes as well as insatiable appetite. I had put on about 20lb in the space of 6 months since the sleep paralysis started.
My Psychiatrist opted to wean me off the Mirtazapine and onto Cymbalta. I have now been on 60mg of Cymbalta for about 4 weeks and completely titrated off the Mirtazapine.
I have noted that since switching to Cymbalta that I no longer have the insatiable appetite, nor have I had any further sleep paralysis episodes (though I have had a brain MRI to rule out any physiological issues - yet to receive results).
I have noticed that I have had mild to moderate rolling nausea with the Cymbalta and that I now have food aversions. Food does not interest me as much anymore and I find that certain foods (mostly processed snacks) are no longer palatable. I also find that I become full after much smaller meal portions.
I have found that I can no longer drink wine or spirits because they now taste awful however I can still tolerate certain brands of beer. I also no longer enjoy drinking cola.
I am also on the Implanon Implant. I have had this implant inserted for about 12 months and my cycles have been rather regular. Since starting the Cymbalta I have had some breakthrough bleeding yet my periods have not been as painful, though they have been heavier and longer.
My Psychiatrist will commence titrating me off the Seroquel in about two weeks and onto Topamax as it is his belief it will be less sedating than the Seroquel and that it will hopefully help as a mood stabiliser, treat my migraines and allow me to come off the Propranolol. he also hopes that I am able to loose some of the weight gained since the sleep paralysis episodes started.
As a side note regarding the Propranolol, I have naturally low blood pressure and I find while Propranalol is generally an effective migraine prophylactic, (I do get some breakthrough migraines) it does make my blood pressure even lower which leads to dizziness and faintness when I stand up too quickly from a recumbent position.
- Seizure patient was on depakote for 16 years now on keppra 1500 mg.
I am 28 years old and been off depakote for 5 months. I started keppra to control my seizure disorder, which works great. But for the past year I have developed osteoarthritis in my thoracic, si joints, and lumbar. I get alot of muscle hypersensitivity and pain. Can any of this be due to long term effects of seizure meds?
Comments from related studies:
From this study (1 week ago):
From this study (3 months ago):
Can't remember last week events. Sometimes it's like a blackout. I remember bits and pieces.
doc moc on Apr, 25, 2013:
BREAK down FOOL!
Rhs on Oct, 13, 2012:
Get your medical records
and consult w/your doctor
Complete drug side effects:
On eHealthMe, Seroquel (quetiapine fumarate) is often used to treat bipolar disorder. Depakote (divalproex sodium) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
- Seroquel is used in:
- Depakote is used in:
Other drugs that are used to treat the same conditions:
- Seroquel alternatives:
- Depakote alternatives:
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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