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Review: taking Seroquel and Depakote together

Summary: drug interactions are reported among people who take Seroquel and Depakote together. This review analyzes the effectiveness and drug interactions between Seroquel and Depakote. It is created by eHealthMe based on reports of 5,157 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>


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What are the drugs

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. (latest outcomes from 79,174 Seroquel users)

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from 30,964 Depakote users)

On May, 10, 2015: 5,157 people who take Seroquel, Depakote are studied

Seroquel, Depakote outcomes

Drug combinations in study:
- Seroquel (quetiapine fumarate)
- Depakote (divalproex sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Seroquel is effective38.10%
(8 of 21 people)
(7 of 26 people)
(5 of 14 people)
(6 of 19 people)
(10 of 26 people)
(8 of 11 people)
(1 of 4 people)
(2 of 3 people)
Depakote is effective22.22%
(4 of 18 people)
(7 of 29 people)
(5 of 13 people)
(5 of 12 people)
(8 of 27 people)
(7 of 10 people)
(4 of 12 people)
(1 of 2 people)

Drug effectiveness by gender :

Seroquel is effective40.00%
(24 of 60 people)
(23 of 64 people)
Depakote is effective37.10%
(23 of 62 people)
(18 of 61 people)

Drug effectiveness by age :

Seroquel is effectiven/a0.00%
(0 of 1 people)
(3 of 20 people)
(13 of 34 people)
(13 of 70 people)
(11 of 31 people)
(6 of 26 people)
(1 of 18 people)
Depakote is effectiven/a0.00%
(0 of 1 people)
(4 of 21 people)
(9 of 31 people)
(13 of 68 people)
(6 of 34 people)
(8 of 26 people)
(1 of 18 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes Mellitus
Type 2 Diabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusType 2 Diabetes Mellitus
AggressionBlood Cholesterol IncreasedWeight IncreasedBlood Cholesterol IncreasedBlood Cholesterol IncreasedObesityObesityWeight Increased
Suicidal IdeationSuicidal IdeationObesityObesityObesityBlood Cholesterol IncreasedRenal FailureBlood Cholesterol Increased
SomnolenceWeight IncreasedBlood Cholesterol IncreasedHyperlipidaemiaHyperlipidaemiaHyperlipidaemiaConvulsionPancreatitis
DepressionDepressionBlood Triglycerides IncreasedNeuropathy PeripheralBlood Triglycerides IncreasedHyperglycaemiaDiabetes Mellitus Inadequate ControlDiabetes Mellitus Inadequate Control
VomitingPancreatitisHyperglycaemiaWeight IncreasedDiabetic KetoacidosisBlood Triglycerides IncreasedNeuropathy PeripheralObesity
AgitationBlood Triglycerides IncreasedFatigueDiabetic KetoacidosisDiabetes Mellitus Inadequate ControlDiabetes Mellitus Inadequate ControlDiabetic NeuropathyInsomnia
Loss Of ConsciousnessHyperglycaemiaDiabetic KetoacidosisDiabetic NeuropathyHypertensionBack PainDiabetic NephropathyHyperglycaemia
Confusional StateSomnolenceGastrooesophageal Reflux DiseaseBack PainDiabetic NeuropathyNeuropathy PeripheralWeight IncreasedDiabetic Ketoacidosis

Most common drug interactions by gender * :

Diabetes MellitusDiabetes Mellitus
Type 2 Diabetes MellitusType 2 Diabetes Mellitus
Weight IncreasedWeight Increased
Blood Cholesterol IncreasedBlood Cholesterol Increased
ObesityDiabetes Mellitus Inadequate Control
DepressionDiabetic Ketoacidosis
InsomniaDiabetic Neuropathy
Diabetes Mellitus Inadequate ControlHyperglycaemia

Most common drug interactions by age * :

PancreatitisOverdoseSuicidal IdeationDiabetes MellitusType 2 Diabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes Mellitus
ConvulsionDrug IneffectiveWeight IncreasedType 2 Diabetes MellitusDiabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes Mellitus
Type 2 Diabetes MellitusWeight IncreasedDiabetes MellitusWeight IncreasedWeight IncreasedBlood Cholesterol IncreasedInsomniaTremor
Diabetes MellitusSuicidal IdeationType 2 Diabetes MellitusDiabetic KetoacidosisObesityNeuropathy PeripheralSomnolenceConfusional State
NeutropeniaConvulsionAggressionBlood Cholesterol IncreasedBlood Cholesterol IncreasedDiabetes Mellitus Inadequate ControlWeight IncreasedFall
ThrombocytopeniaInsomniaAgitationPancreatitisDiabetes Mellitus Inadequate ControlDiabetic NeuropathyBlood Cholesterol IncreasedInsomnia
Cerebrovascular AccidentAggressionAbnormal BehaviourObesityPancreatitisWeight IncreasedHyperglycaemiaWeight Increased
HyperlipidaemiaSomnolenceDiabetic KetoacidosisSuicidal IdeationDiabetic NeuropathyBlood Triglycerides IncreasedTremorFatigue
Type 1 Diabetes MellitusHyperglycaemiaType 1 Diabetes MellitusType 1 Diabetes MellitusHypertensionChest PainDepressionDiarrhoea
AnaemiaPetit Mal EpilepsyWhite Blood Cell Count DecreasedHypertensionDiabetic KetoacidosisObesityAnxietyAnaemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Seroquel and Depakote on

Do you take Seroquel and Depakote?


You are not alone! Join a related support group:
- support group for people who take Depakote
- support group for people who take Seroquel

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Depakote, Seroquel

You may be interested at these reviews (Write a review):

  • Do not take lamictal or seroquel while pregnant.
    I had a miscarriage at around 8 weeks. I am a healthy 20 year old with absolutely no health conditions besides bipolar disorder. No one in my family has ever had a miscarriage in my family, and I'm convinced it was the drugs. Ladies, do NOT take these while pregnant.
  • Results on seroquel (quetiapine-genric ) (1 response)
    Have been on Quetiapine-genric name (seroquel) 25mg since March 16 for hot flashes and have not had any since then. It is working for me. This is a blessing for me and no side effects yet
  • Seroquel horrible for someone with a pacemaker
    My husband had a severe convulsion? His eyes rolled back in his head about 15 minutes after he took what his nurse prescribed
    - his nurse never took or asked for his medical can not take seroquel with a pacemaker

    It will kill you.

  • 13yr old autistic daughter diagnosed with cerebral palsy after taking seroquel (1 response)
    My beautiful 13yrold daughter who was diagnosed with Autism at 2 yrs old, never suffered from ANY physical disabilities prior to being put on a very large dose of SEROQUEL at age 11. Within less than a year, she went from running and jumping on her trampoline to being diagnosed with Cerebral Palsy! ...
  • Terrible excessive sweating from hydrochlorothiazide
    I guess I fit the profile of who gets excessive sweating from HCTZ. I am a 65 year old female and suffered from excessive sweating for two years. With just very little exertion, I would pour sweat from the top of my head. It would run into my face and all over my hair. My hair would be ringing wet. ...

More reviews for: Depakote, Seroquel

Comments from related studies:

  • From this study (2 months ago):

  • I had emergency surgery for small bowel blockage due to lesions from a previous stomach surgery. After I made a complaint of sitting in my own diahrrea for 2 hours, my head nurse, Dan took acception to my complaining and he then,along with a few other young nurses and apprenticing Dr's proceeded to give me morphine which myself, a caregiver and daughter asked them not to give me.that in turn caused NMS!!!


  • From this study (5 months ago):

  • Can't remember last week events. Sometimes it's like a blackout. I remember bits and pieces.


  • From this study (7 months ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Seroquel (quetiapine fumarate) is often used to treat bipolar disorder. Depakote (divalproex sodium) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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