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Review: taking Seroquel and Depakote together

Summary: drug interactions are reported among people who take Seroquel and Depakote together.

This review analyzes the effectiveness and drug interactions between Seroquel and Depakote. It is created by eHealthMe based on reports of 5,157 people who take the same drugs from FDA and social media, and is updated regularly.

 

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On Apr, 9, 2015: 5,157 people who take Seroquel, Depakote are studied

Seroquel, Depakote outcomes

Drug combinations in study:
- Seroquel (quetiapine fumarate)
- Depakote (divalproex sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Seroquel is effective38.10%
(8 of 21 people)
26.92%
(7 of 26 people)
35.71%
(5 of 14 people)
31.58%
(6 of 19 people)
38.46%
(10 of 26 people)
72.73%
(8 of 11 people)
25.00%
(1 of 4 people)
66.67%
(2 of 3 people)
Depakote is effective22.22%
(4 of 18 people)
24.14%
(7 of 29 people)
38.46%
(5 of 13 people)
41.67%
(5 of 12 people)
29.63%
(8 of 27 people)
70.00%
(7 of 10 people)
33.33%
(4 of 12 people)
50.00%
(1 of 2 people)

Drug effectiveness by gender :

FemaleMale
Seroquel is effective40.00%
(24 of 60 people)
35.94%
(23 of 64 people)
Depakote is effective37.10%
(23 of 62 people)
29.51%
(18 of 61 people)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Seroquel is effectiven/a0.00%
(0 of 1 people)
15.00%
(3 of 20 people)
38.24%
(13 of 34 people)
18.57%
(13 of 70 people)
35.48%
(11 of 31 people)
23.08%
(6 of 26 people)
5.56%
(1 of 18 people)
Depakote is effectiven/a0.00%
(0 of 1 people)
19.05%
(4 of 21 people)
29.03%
(9 of 31 people)
19.12%
(13 of 68 people)
17.65%
(6 of 34 people)
30.77%
(8 of 26 people)
5.56%
(1 of 18 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes Mellitus
Type 2 Diabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusType 2 Diabetes Mellitus
AggressionBlood Cholesterol IncreasedWeight IncreasedBlood Cholesterol IncreasedBlood Cholesterol IncreasedObesityObesityWeight Increased
Suicidal IdeationSuicidal IdeationObesityObesityObesityBlood Cholesterol IncreasedRenal FailureBlood Cholesterol Increased
SomnolenceWeight IncreasedBlood Cholesterol IncreasedHyperlipidaemiaHyperlipidaemiaHyperlipidaemiaConvulsionPancreatitis
DepressionDepressionBlood Triglycerides IncreasedNeuropathy PeripheralBlood Triglycerides IncreasedHyperglycaemiaDiabetes Mellitus Inadequate ControlDiabetes Mellitus Inadequate Control
VomitingPancreatitisHyperglycaemiaWeight IncreasedDiabetic KetoacidosisBlood Triglycerides IncreasedNeuropathy PeripheralObesity
AgitationBlood Triglycerides IncreasedFatigueDiabetic KetoacidosisDiabetes Mellitus Inadequate ControlDiabetes Mellitus Inadequate ControlDiabetic NeuropathyInsomnia
Loss Of ConsciousnessHyperglycaemiaDiabetic KetoacidosisDiabetic NeuropathyHypertensionBack PainDiabetic NephropathyHyperglycaemia
Confusional StateSomnolenceGastrooesophageal Reflux DiseaseBack PainDiabetic NeuropathyNeuropathy PeripheralWeight IncreasedDiabetic Ketoacidosis

Most common drug interactions by gender * :

FemaleMale
Diabetes MellitusDiabetes Mellitus
Type 2 Diabetes MellitusType 2 Diabetes Mellitus
Weight IncreasedWeight Increased
Blood Cholesterol IncreasedBlood Cholesterol Increased
ObesityDiabetes Mellitus Inadequate Control
PancreatitisPancreatitis
DepressionDiabetic Ketoacidosis
InsomniaDiabetic Neuropathy
Diabetes Mellitus Inadequate ControlHyperglycaemia
HyperglycaemiaObesity

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
PancreatitisOverdoseSuicidal IdeationDiabetes MellitusType 2 Diabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes Mellitus
ConvulsionDrug IneffectiveWeight IncreasedType 2 Diabetes MellitusDiabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes Mellitus
Type 2 Diabetes MellitusWeight IncreasedDiabetes MellitusWeight IncreasedWeight IncreasedBlood Cholesterol IncreasedInsomniaTremor
Diabetes MellitusSuicidal IdeationType 2 Diabetes MellitusDiabetic KetoacidosisObesityNeuropathy PeripheralSomnolenceConfusional State
NeutropeniaConvulsionAggressionBlood Cholesterol IncreasedBlood Cholesterol IncreasedDiabetes Mellitus Inadequate ControlWeight IncreasedFall
ThrombocytopeniaInsomniaAgitationPancreatitisDiabetes Mellitus Inadequate ControlDiabetic NeuropathyBlood Cholesterol IncreasedInsomnia
Cerebrovascular AccidentAggressionAbnormal BehaviourObesityPancreatitisWeight IncreasedHyperglycaemiaWeight Increased
HyperlipidaemiaSomnolenceDiabetic KetoacidosisSuicidal IdeationDiabetic NeuropathyBlood Triglycerides IncreasedTremorFatigue
Type 1 Diabetes MellitusHyperglycaemiaType 1 Diabetes MellitusType 1 Diabetes MellitusHypertensionChest PainDepressionDiarrhoea
AnaemiaPetit Mal EpilepsyWhite Blood Cell Count DecreasedHypertensionDiabetic KetoacidosisObesityAnxietyAnaemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Seroquel and Depakote on

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You are not alone! Join a related support group:
- support group for people who take Depakote
- support group for people who take Seroquel

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Seroquel (quetiapine fumarate) is often used to treat bipolar disorder. Depakote (divalproex sodium) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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