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Review: Spironolactone and Benadryl

This review analyzes the effectiveness and drug interactions between Spironolactone and Benadryl. It is created by eHealthMe based on reports of 572 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Spironolactone and Benadryl >>>

What are the drugs

Spironolactone (latest outcomes from 26,408 users) has active ingredients of spironolactone. It is often used in acne.

Benadryl (latest outcomes from 29,335 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

On Sep, 12, 2014: 572 people who take Spironolactone, Benadryl are studied

Spironolactone, Benadryl outcomes

Drug combinations in study:
- Spironolactone (spironolactone)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Spironolactone is effective0.00%
(0 of 1 people)
(3 of 5 people)
(1 of 3 people)
(1 of 2 people)
Benadryl is effective50.00%
(1 of 2 people)
(0 of 1 people)
(0 of 3 people)
(3 of 4 people)
(1 of 3 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Orthostatic HypotensionArthralgiaNauseaBipolar Ii DisorderSeromaErectile Dysfunctionn/aNausea
HyponatraemiaCryingLoss Of AppetiteHypomaniaSleep Disorder Due To General Medical Condition, Insomnia TypeDyspnoea
HypersensitivityDepressionLack Of Strength, Muscle Weakness, WeaknessGender Identity DisorderPain
LethargyCardiomyopathyOrgasmic DysfunctionOrgasmic Sensation DecreasedFatigue
AstheniaCardiac Failure CongestiveOrgasmic Sensation DecreasedOrgasmic DysfunctionCardiac Failure Congestive
DiarrhoeaAngerApathyLoss Of AppetiteVomiting
Dermatitis AcneiformAnxietySuicide AttemptLack Of Strength, Muscle Weakness, WeaknessAnxiety
SyncopeInsomniaAstheniaBreathing - Slowed Or StoppedPneumonia
JaundiceSleep Apnoea SyndromeAnorgasmiaTachycardiaOedema Peripheral
PyrexiaMyocardial InfarctionLoss Of LibidoPanic AttacksAsthenia

Drug effectiveness by gender :

Spironolactone is effective50.00%
(4 of 8 people)
(1 of 3 people)
Benadryl is effective45.45%
(5 of 11 people)
(1 of 3 people)

Most common drug interactions by gender * :

PainCardiac Failure Congestive
Oedema PeripheralOedema Peripheral
Urinary Tract InfectionBack Pain

Drug effectiveness by age :

Spironolactone is effectiven/an/an/a2.86%
(1 of 35 people)
(1 of 1 people)
(2 of 6 people)
(0 of 2 people)
(1 of 2 people)
Benadryl is effectiven/an/an/a5.71%
(2 of 35 people)
(2 of 14 people)
(1 of 12 people)
(1 of 2 people)
(0 of 2 people)

Most common drug interactions by age * :

TachycardiaTracheobronchitisDyspnoea ExertionalInsomniaNauseaAnxietyCardiac Failure CongestiveAsthenia
WheezingGastroenteritis ViralFatigueUrinary Tract InfectionChest PainPainDyspnoeaNausea
PyrexiaPseudomonal BacteraemiaNauseaNauseaCholelithiasisBack PainPainHypotension
Cardio-respiratory ArrestFallAbdominal DistensionPericardial EffusionDiarrhoeaDepressionHepatic FailureFatigue
Respiratory DistressUpper Limb FracturePalpitationsInfluenza Like IllnessHypertensionOedema PeripheralAnxietyAnaemia
VomitingStaphylococcal InfectionChest Pain AggravatedBronchitisGallbladder DisorderDyspnoeaCholelithiasisVomiting
InfectionCentral Line InfectionCardiac ArrestCholecystitisAbdominal Pain UpperArthralgiaCoughDyspnoea
DiarrhoeaRetchingDizzinessCardiac Failure CongestiveBlood Bilirubin IncreasedEar PainDeep Vein ThrombosisCardiac Failure Congestive
CyanosisHeart Rate IncreasedImplant Site InfectionCerebral IschaemiaInjuryCardiac Failure CongestiveAzotaemiaThrombocytopenia
ConvulsionTremorPulmonary HaemorrhageSinusitisHeadacheAspartate Aminotransferase IncreasedNauseaDizziness

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Spironolactone and Benadryl?

Get connected! Join a mobile support group:
- group for people who take Spironolactone and Benadryl
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- group for people who take Spironolactone

Comments from related studies:

  • From this study (2 years ago):

  • Overall: Diabetes stays under 120, testosterone levels remain low for age (48, but testosterone levels of 90 year old man). Atypically small penis, testes often recede so that the scrotum is flat and tight. Bi-sexual with periodic gender issues (desire to be feminine). Married, two children and no family issues to include sexual oddities, wife is supportive.

    I am reluctant to bring up sexual and gender issues to Doctor, but have the feeling that gender drift (feelings), small penis and receding testicles and attraction to both sexes (including transgendered males with feminine qualities and penis). I know that all of this makes me rather unusual in terms of societal norms, but this is an honest assessment to the best of my ability. I started becoming sexually active at 13 years old with males first and later (15) with females. I desire only a relationship with a female or shemale (preferable but not realistic so I don't dwell on it).

    Despite gender struggles from 14 to present I joined the US Army and went Airborne and Special Forces, spending a majority of my adult life (even unitl present) as an operator in Special Forces (albeit my age is making that more and more difficult).

    I'm looking for a medical opinion that takes in current health conditions and issues, sexual history and other factors that are tell tale signs of a condition that I am unaware of.


    Me on Jan, 4, 2013:

    Forgot to mention that I have one son who has only one testicle but is not infertile. He was operated on at 3 to determine is it was an undescended testicle, however no trace of a second testicle was found. In his 20s he fathered a female child and still no trace of second testicle.


  • From this study (4 years ago):

  • I always panic when they change my meds. just making sure all my meds can work together.


Can you answer these questions (what is this?):

More questions for: Benadryl, Spironolactone

You may be interested at these reviews (what is this?):

  • Abnormal orgasm after likely caused by taking spironolactone
    I was taking Spironolactone to assist with hairloss for approx 7 years. Although the drug did help to stop hair falling out it also caused abnormal orgasm and after 12 months of not taking the drug I am still unable to climax normally. My doctor cannot give me a full explanation for this.

  • Ovary pain disappeared
    I have been taking Spironolactone 50mg for over a year that was prescribed by my dermatologist for acne. Prior to this I had daily pain in my right ovary for the previous 2 years with laproscopic surgery for tubal ligation the gyn did not see anything on this ovary to cause the pain, but my pain is ...

  • Breast enlargement and tenderness
    starting taking spironolactone approximately one year ago to help with chronic kidney failure. Soon experienced enlargement of both breast and tenderness. Stopped taking the med and enlargement returned to normal but soreness continues. Some days are worse than others.

More reviews for: Benadryl, Spironolactone

Complete drug side effects:

On eHealthMe, Spironolactone (spironolactone) is often used to treat acne. Benadryl (diphenhydramine hydrochloride) is often used to treat allergen. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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