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Review: taking Spironolactone and Benadryl together

Summary: drug interactions are reported among people who take Spironolactone and Benadryl together.

This review analyzes the effectiveness and drug interactions between Spironolactone and Benadryl. It is created by eHealthMe based on reports of 572 people who take the same drugs from FDA and social media, and is updated regularly.


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On Feb, 28, 2015: 572 people who take Spironolactone, Benadryl are studied

Spironolactone, Benadryl outcomes

Drug combinations in study:
- Spironolactone (spironolactone)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Spironolactone is effective0.00%
(0 of 1 people)
(3 of 5 people)
(1 of 3 people)
(1 of 2 people)
Benadryl is effective50.00%
(1 of 2 people)
(0 of 1 people)
(0 of 3 people)
(3 of 4 people)
(1 of 3 people)
(1 of 1 people)

Drug effectiveness by gender :

Spironolactone is effective50.00%
(4 of 8 people)
(1 of 3 people)
Benadryl is effective45.45%
(5 of 11 people)
(1 of 3 people)

Drug effectiveness by age :

Spironolactone is effectiven/an/an/a2.86%
(1 of 35 people)
(1 of 1 people)
(2 of 6 people)
(0 of 2 people)
(1 of 2 people)
Benadryl is effectiven/an/an/a5.71%
(2 of 35 people)
(2 of 14 people)
(1 of 12 people)
(1 of 2 people)
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Orthostatic HypotensionArthralgiaNauseaBipolar Ii DisorderSeromaErectile Dysfunctionn/aNausea
HyponatraemiaCryingLoss Of AppetiteHypomaniaSleep Disorder Due To General Medical Condition, Insomnia TypeDyspnoea
HypersensitivityDepressionLack Of Strength, Muscle Weakness, WeaknessGender Identity DisorderPain
LethargyCardiomyopathyOrgasmic DysfunctionOrgasmic Sensation DecreasedFatigue
AstheniaCardiac Failure CongestiveOrgasmic Sensation DecreasedOrgasmic DysfunctionCardiac Failure Congestive
DiarrhoeaAngerApathyLoss Of AppetiteVomiting
Dermatitis AcneiformAnxietySuicide AttemptLack Of Strength, Muscle Weakness, WeaknessAnxiety
SyncopeInsomniaAstheniaBreathing - Slowed Or StoppedPneumonia
JaundiceSleep Apnoea SyndromeAnorgasmiaTachycardiaOedema Peripheral
PyrexiaMyocardial InfarctionLoss Of LibidoPanic AttacksAsthenia

Most common drug interactions by gender * :

PainCardiac Failure Congestive
Oedema PeripheralOedema Peripheral
Urinary Tract InfectionBack Pain

Most common drug interactions by age * :

TachycardiaTracheobronchitisDyspnoea ExertionalInsomniaNauseaAnxietyCardiac Failure CongestiveAsthenia
WheezingGastroenteritis ViralFatigueUrinary Tract InfectionChest PainPainDyspnoeaNausea
PyrexiaPseudomonal BacteraemiaNauseaNauseaCholelithiasisBack PainPainHypotension
Cardio-respiratory ArrestFallAbdominal DistensionPericardial EffusionDiarrhoeaDepressionHepatic FailureFatigue
Respiratory DistressUpper Limb FracturePalpitationsInfluenza Like IllnessHypertensionOedema PeripheralAnxietyAnaemia
VomitingStaphylococcal InfectionChest Pain AggravatedBronchitisGallbladder DisorderDyspnoeaCholelithiasisVomiting
InfectionCentral Line InfectionCardiac ArrestCholecystitisAbdominal Pain UpperArthralgiaCoughDyspnoea
DiarrhoeaRetchingDizzinessCardiac Failure CongestiveBlood Bilirubin IncreasedEar PainDeep Vein ThrombosisCardiac Failure Congestive
CyanosisHeart Rate IncreasedImplant Site InfectionCerebral IschaemiaInjuryCardiac Failure CongestiveAzotaemiaThrombocytopenia
ConvulsionTremorPulmonary HaemorrhageSinusitisHeadacheAspartate Aminotransferase IncreasedNauseaDizziness

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Spironolactone and Benadryl?




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- support group for people who take Benadryl
- support group for people who take Spironolactone

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Spironolactone (spironolactone) is often used to treat acne. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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