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Review: Spironolactone and Benadryl

This review analyzes the effectiveness and drug interactions between Spironolactone and Benadryl. It is created by eHealthMe based on 554 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Mar, 31, 2014: 554 people who reported to have interactions when taking Spironolactone, Benadryl are studied

Trend of Spironolactone, Benadryl's drug interactions, side effects and effectiveness reports (3400400)

Drug combinations in study:
- Spironolactone (spironolactone)
- Benadryl (diphenhydramine hydrochloride)

eHealthMe real world results:

Most common interactions experienced by people in the use of Spironolactone, Benadryl:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Dyspnoea (difficult or laboured respiration)388
Anxiety319
Vomiting311
Nausea (feeling of having an urge to vomit)270
Pain257
Pneumonia239
Fatigue (feeling of tiredness)236
Cardiac Failure Congestive226
Oedema Peripheral (superficial swelling)200
Dizziness171

Most common interactions experienced by people in long term use of Spironolactone, Benadryl:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Erectile Dysfunction2
Sleep Disorder Due To General Medical Condition, Insomnia Type (conditions that prevent a person from getting restful sleep due to mental condition of not getting sleep)2
Oxymetazoline Rebound2
Zolpidem, Memory Loss, Hangover2
Alprazolam, Rebound, Addiction2

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Spironolactone0.00%0.00%0.00%100.00%0.00%
Benadryl0.00%0.00%100.00%0.00%0.00%

Top conditions involved for these people * :

  1. Ill-defined disorder
  2. Premedication
  3. Hypertension
  4. Pain
  5. Breast cancer metastatic

Top co-used drugs for these people * :

  1. Lasix
  2. Aldactone
  3. Aspirin
  4. Digoxin
  5. Heparin sodium injection

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Benadryl, Spironolactone

You can also:

Complete drug side effects:

On eHealthMe, Spironolactone (spironolactone) is often used to treat acne. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (1 year ago):

  • Overall: Diabetes stays under 120, testosterone levels remain low for age (48, but testosterone levels of 90 year old man). Atypically small penis, testes often recede so that the scrotum is flat and tight. Bi-sexual with periodic gender issues (desire to be feminine). Married, two children and no family issues to include sexual oddities, wife is supportive.

    I am reluctant to bring up sexual and gender issues to Doctor, but have the feeling that gender drift (feelings), small penis and receding testicles and attraction to both sexes (including transgendered males with feminine qualities and penis). I know that all of this makes me rather unusual in terms of societal norms, but this is an honest assessment to the best of my ability. I started becoming sexually active at 13 years old with males first and later (15) with females. I desire only a relationship with a female or shemale (preferable but not realistic so I don't dwell on it).

    Despite gender struggles from 14 to present I joined the US Army and went Airborne and Special Forces, spending a majority of my adult life (even unitl present) as an operator in Special Forces (albeit my age is making that more and more difficult).

    I'm looking for a medical opinion that takes in current health conditions and issues, sexual history and other factors that are tell tale signs of a condition that I am unaware of.

    Reply

    Me on Jan, 4, 2013:

    Forgot to mention that I have one son who has only one testicle but is not infertile. He was operated on at 3 to determine is it was an undescended testicle, however no trace of a second testicle was found. In his 20s he fathered a female child and still no trace of second testicle.

    Reply

  • From this study (3 years ago):

  • I always panic when they change my meds. just making sure all my meds can work together.

    Reply

Can you answer these questions (what is this?):

More questions for: Benadryl, Spironolactone

You may be interested at these reviews (what is this?):

  • Ovary pain disappeared
    I have been taking Spironolactone 50mg for over a year that was prescribed by my dermatologist for acne. Prior to this I had daily pain in my right ovary for the previous 2 years with laproscopic surgery for tubal ligation the gyn did not see anything on this ovary to cause the pain, but my pain is ...

  • Breast enlargement and tenderness
    starting taking spironolactone approximately one year ago to help with chronic kidney failure. Soon experienced enlargement of both breast and tenderness. Stopped taking the med and enlargement returned to normal but soreness continues. Some days are worse than others.

  • Allopurinol and muscle cramps
    Approximately 5 years ago I developed gout and my physician prescribed allopurinol. After a period of time I began to have muscle spasms in the calves of my legs at night. My doctor gave me a prescription for restless leg syndrome, which helped for a short time. I was then given a different presc ...

More reviews for: Benadryl, Spironolactone

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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