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Review: Suboxone and Methadone





Summary: drug interactions are reported among people who take Suboxone and Methadone together.

This review analyzes the effectiveness and drug interactions between Suboxone and Methadone. It is created by eHealthMe based on reports of 105 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Suboxone and Methadone >>>

What are the drugs

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. (latest outcomes from Suboxone 8,267 users)

Methadone Hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadone Hydrochloride 2,835 users)

On Nov, 25, 2014: 105 people who take Suboxone, Methadone Hydrochloride are studied

Suboxone, Methadone Hydrochloride outcomes

Drug combinations in study:
- Suboxone (buprenorphine hydrochloride; naloxone hydrochloride)
- Methadone Hydrochloride (methadone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Suboxone is effective0.00%
(0 of 1 people)
66.67%
(2 of 3 people)
n/an/an/an/an/an/a
Methadone Hydrochloride is effective0.00%
(0 of 2 people)
n/an/a0.00%
(0 of 1 people)
n/an/a0.00%
(0 of 1 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Drug Exposure During PregnancyDrug Exposure During PregnancyDrug Exposure During PregnancyIntentional OverdoseConvulsionHeart Rate Irregularn/aDrug Withdrawal Syndrome
InsomniaDrug Withdrawal Syndrome NeonatalPremature BabyCompleted SuicideAppetite DisorderMigraineOverdose
MalaiseIntentional OverdoseMaternal Exposure During PregnancyMaternal Exposure During PregnancyDrug Withdrawal SyndromeRib FractureInsomnia
Premature BabyDrug Withdrawal SyndromeAbortion SpontaneousSuppressed LactationHeadacheVomitingMalaise
NephrolithiasisHeadacheDepressionPneumoniaFatigueDrug Abuse
Drug Withdrawal SyndromePneumoniaFatigueInsomniaComaDrug Exposure During Pregnancy
PainCompleted SuicideNervous System DisorderElevated MoodCardiac ArrestVomiting
NauseaDehydrationDrug DependenceHepatosplenomegalyCardiac Failure CongestivePain
Vomiting In PregnancyBack PainSubstance AbuseAmnesiaCardiac Valve DiseaseConfusional State
Premature Separation Of PlacentaCholelithiasisPremature DeliveryRespiratory ArrestChest PainCardiac Arrest

Drug effectiveness by gender :

FemaleMale
Suboxone is effective50.00%
(1 of 2 people)
50.00%
(1 of 2 people)
Methadone Hydrochloride is effective0.00%
(0 of 3 people)
0.00%
(0 of 1 people)

Most common drug interactions by gender * :

FemaleMale
Drug Exposure During PregnancyDrug Withdrawal Syndrome
Drug Withdrawal SyndromeDrug Abuse
InsomniaOverdose
Substance AbuseConvulsion
NauseaMalaise
Confusional StateInsomnia
Maternal Exposure During PregnancyAmnesia
OverdosePain
PneumoniaCardiac Arrest
AnxietyTremor

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Suboxone is effectiven/an/an/a50.00%
(1 of 2 people)
n/a50.00%
(1 of 2 people)
n/an/a
Methadone Hydrochloride is effectiven/an/an/a0.00%
(0 of 2 people)
0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
n/an/a

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Drug Exposure During Pregnancyn/aDrug ToxicityDrug AbuseDrug Exposure During PregnancyOverdoseDehydrationDrug Withdrawal Syndrome
Drug Withdrawal Syndrome NeonatalBrain OedemaRespiratory ArrestDrug Withdrawal SyndromeInsomniaPainElectrocardiogram Qt Prolonged
Accidental OverdoseCardiac ArrestFatigueSomnolenceMalaiseDepression
PapilloedemaPulmonary EmbolismSubstance AbuseSubstance AbuseInsomniaDrug Dependence
HeadacheWeight DecreasedVomitingTooth DisorderDrug Withdrawal SyndromeNervous System Disorder
Vision BlurredGallbladder PainPremature LabourSuicidal IdeationFeeling ColdIntentional Overdose
Drug Screen PositiveAbdominal PainDrug IneffectiveMemory ImpairmentDiarrhoeaFatigue
Gallbladder DisorderChest PainAnxietyFeeling HotBlindness Transient
Decreased AppetiteComaDrug DependenceCold SweatBlood Pressure Increased
Maternal Exposure During PregnancyCardiac Valve DiseaseHypersomniaEye DisorderSurgery

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Suboxone and Methadone?

You are not alone! Join a related mobile support group:
- support group for people who take Suboxone and Methadone
- support group for people who take Methadone Hydrochloride
- support group for people who take Suboxone

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Is it okay to take 15mg. of remeron also known as mirtazapine
    is it safe to take suboxone with remeron because I am having a panic attack
  • Can long-term methadone use cause or increase the risk of colon cancer?
    I had a two-level spinal fusion at L4-S1 in 2000 after being injuried at work in Sept. 24, 1997. I lost everything after...the unjury, ability to do my job, my wife and family (couldn't take the strain) my home, my sense of self and purpose, direction and belonging...credit rating and ability to pay my bills.
    After a long period of waiting to settle my workmens' comp. case, I returned home, from the Bat Area back to Arizona to take of my mother with a yet un dianosed case of moderate dementia.
    Then, in 2011 I had a 2nd surgery to relieve spinal stenosis btwn. L2-L4, just above the fusion site.
    I've been taking methadone since early 2004, a little over ten years, now. I've had high blood pressure since my injury.

    Now, I waiting to be scheduled for a colonoscopy, with my father having had polyps and the way I've been feeling..drained, tired all the time, and stomach pains ( in addition to my chronic low back pain), I...
    find myself wondering if there is any relationtionship between the methadone and other meds and cancer?
  • What side effects from nuvigil and cymbalta creating seretonin syndrome? (2 answers)
    My dr thinks that all the drugs I'm on are causing sedition syndrome. But I have t seen where a symptom was red flushed skin?
  • Have been on suboxone strips almost a year. i have just recently since yesterday got sick i have strep throat and my throat is really hurting and i can't even speak today. can i still take my strips? (1 answer)
    I just wonder if it will be ok today to go ahead and use my suboxone strips or will it do more damage than good? It's never bothered my throat before but my throat is so bad right now that I don't know if it will hurt or help? I'm supposed to take 2 8mg strips a day? Help!!!!???
  • Why are my medications making me look bloated (1 answer)
    In 2008 I started the Suboxone Program. I Started on 16mg since then, I have been up and down on my doses. I was put on this drug as a result of my addiction to to over the counter opiates. I was also prescribed Seroquel, I stopped taking the Seroquel it wasn't helping me in anyway and I gained so much weight. In 2012 I was diagnosed with Bipolar and my psychiatrist put me on 300Mg Effexor, 20Mg Olanzipane and 1000Mg of Valpro. After 10 months I was able to stop taking the Valpro and Olanzipane. No matter how much weight I lose, I always appear so puffy and bloated in the face, especially under my eyes, they look like I haven't slept for weeks. I have very low self esteem as it is, this is making me feel miserable. I should also mention, that i got down 1MG of the Suboxone, after various stresses I went right back up to 18Mg. I have finally started to turn a corner and I am now reducing my dose at the right pace. It would make me feel so much better if I knew if even one more person was having this experience. Any feedback would be so appreciated. I send this with love from Australia :)

More questions for: Methadone Hydrochloride, Suboxone

You may be interested at these reviews (Write a review):

  • Ulcerative colitis from suboxone?
    Anyone else out there experiencing ulcerative colitis after multiple yearprescribed Suboxone? Suboxone stole a large portion of my life, and now I am considering going on a full-agonist analgesic until the buprenorphine bond has broken, and no more presence of it in my plasma. Insane!
  • Suboxone treatment may have caused my trichotillomania
    It's a long story of how I became addicted to opiates after 15+ years of chronic pain, but I decided to give up pain killers and try suboxone/subutex treatment. Shortly thereafter, I began pulling hair. First from my head, then when the bald spots became too obvious I started pulling from all over. It seemed to be triggered by stress or anxiety but not always. I did not make an association until recently, when I finally stopped the suboxone. It was two weeks of miserable withdrawal, much worse than from pain killers themselves, but I am finally out of the haze I'd be in all of that time, and I have no urge to pull hair whatsoever. I don't know how often the association of suboxone use and trichotillomania has been examined, but I wanted to share my experience in case anyone else is in a similar situation. Also, if you are considering starting suboxone treatment, don't. Withdrawal from opiates will lead to a few pretty rough days, but that's nothing compared to what you'll go through during suboxone withdrawal.
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Pacemaker experience
    I had a pacemaker installed about 5 weeks ago. I went to the doctors because I was feeling fatigue, shortness of breath, I felt as if someone was holding my heart in their hand and I had some confusion and dizziness.

    To get to the point, after my first visit with my PCP I decided to go directly to emergency via 911 since my PCP was basically ignoring, or better put, had no sense of urgency regarding how I was feeling even though she knew my heart rate had dropped and was steady at 44 bpm, my normal rate 62 bpm.

    The night I was in observation at the hospital I dropped to 20 bpm, next day I had a pacemaker installed, had I not taken the initiative to call the hospital I don't know if I would have continued dropping until I was dead, I don't know enough about the science behind this to draw that conclusion but common sense tells me yes.

    I have explained this in another post but I cannot find it, not sure what I am doing wrong, so I am writing another post because I have more to add after a couple of weeks since my last post.

    The issue I have is I am still tired after more than a month after the installation of the pacemaker. I had the bpm (beats per minute) on my pacemaker increased from 60, the factory settings, to somewhere in the mid 60's.......so I thought. I went to the hospital twice to have my pacemaker "tweaked" but when I met with the cardiologist for my "one week" follow up, which took almost three weeks to see him due to his heavy schedule, he told me there were never any changes made to my pacemaker, I was still at 60 bpm. How could this be since I was told twice it had been increased? I had the wand on my chest and the nurse made the changes which were made due to my complaining about being exhausted still, the reason I went to the PCP in the first place five weeks ago.
    Was she playing mind games, thinking the power of suggestion would make me feel better? If so I am disgusted to think she would feel I was faking my feelings of exhaustion, what she did had absolutely no effect on how poorly I was feeling.

    To get to the point, I finally had my first meeting with the surgeon, he raised my bpm to 75 from 60, was going to go to 80 but changed his mind. The moment he made the change to 75 bpm from my original 60 he asked if I was feeling better, feeling better after 60 seconds of changing the bpm, how is that possible? I told him no, kind of too soon to tell. His reply was "it looks like we have done everything we can on our end, your heart was not significantly damaged, your pacemaker is working as it should, therefore there must be something else making you feel so poorly so I suggest you see an internal medicine specialist." My brain had a big WHAT sign flashing, I couldn't believe what he was saying, basically beat it and move on, I don't have the time to deal with you anymore. Lets see, the appointment lasted 25 minutes and he does not have the time to work with me anymore, sorry but that irritates the hell out of me.

    He was washing his hands of me, nothing else he could do so spend time and money finding out what the problem is with an internest, it is not my heart according to the cardiologist. The appointment ended and I left wondering how I was going to find out what is causing my issues.

    To my great fortune a nurse with 20 years experience teaching doctors and nurses how to use the pacemaker computer asked me to come into her office after my appointment with the cardiologist, she asked me this prior to seeing the doctor. Thank God she did as the doctor did not do a thorough job adjusting the pacemaker, she adjusted what the doctor had, tweaked the pacemaker a bit, had me walk for 10 minutes and come back to the office and did a bit more tweaking, I slowly started feeling a touch better. She asked me to come back in two weeks and she would see if the pacemaker needed to be tweaked a bit more. I was walking on air, still not close to my "normal", thrilled I was not just a number being tossed in the heap of unfixed people. I am feeling 70% better than how I felt prior to the doctor and her tweaking the pacemaker. Had she not been there that day and had the opportunity to do this I would be on a never ending search for what is making me feel so exhausted and!
    dizzy.

    There is a moral to this which I will let you draw your own conclusion. In my mind it is trust God will intervene, he certainly did when the nurse asked me to see her after the appointment with the surgeon. The reason I feel this way is because she was there and is only there on Fridays, the day I had my appointment. I never would have gone back again after my meeting with the doctor and I would have been spending needless hours and money looking through the wrong box for what ales me. Now it is obvious it was my pacemaker settings, my heart rate was set too low and the pacemaker was not fine tuned properly with the proper slope and other settings.

    Don't let these doctors do what mine tried doing with me, be aggressive and insist on more adjustments if you have issues similar to mine.

    AS I sit here I am still tired, I could easily take a nap but I am better than I was yesterday, significantly.

    Best of luck to all. Your comments will be very much appreciated.
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More reviews for: Methadone Hydrochloride, Suboxone

Complete drug side effects:

On eHealthMe, Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) is often used to treat opiate withdrawal. Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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