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Review: taking Synthroid and Melatonin together

Summary: drug interactions are reported among people who take Synthroid and Melatonin together.

This review analyzes the effectiveness and drug interactions between Synthroid and Melatonin. It is created by eHealthMe based on reports of 471 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 14, 2015: 452 people who take Synthroid, Melatonin are studied

Synthroid, Melatonin outcomes

Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Melatonin (melatonin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Synthroid is effectiven/a0.00%
(0 of 1 people)
(2 of 4 people)
(1 of 7 people)
(6 of 12 people)
(5 of 9 people)
(14 of 20 people)
Melatonin is effective0.00%
(0 of 4 people)
(3 of 11 people)
(0 of 3 people)
(3 of 9 people)
(7 of 13 people)
(2 of 6 people)
(1 of 3 people)

Drug effectiveness by gender :

Synthroid is effective56.25%
(27 of 48 people)
(1 of 5 people)
Melatonin is effective33.33%
(15 of 45 people)
(1 of 4 people)

Drug effectiveness by age :

Synthroid is effectiven/an/a0.00%
(0 of 1 people)
(3 of 19 people)
(2 of 9 people)
(5 of 10 people)
(7 of 24 people)
(11 of 42 people)
Melatonin is effectiven/an/a100.00%
(1 of 1 people)
(0 of 19 people)
(0 of 9 people)
(2 of 8 people)
(7 of 24 people)
(6 of 40 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PruritusAntepartum HaemorrhageHot FlashesVision BlurredOrgan FailureSkin Blushing/flushingInsomniaNausea
Antepartum HaemorrhageIrritabilityRheumatoid ArthritisMovement - UncoordinatedGallbladder DisorderAlopeciaDepressionHeadache
NasopharyngitisDizzinessBipolarHeadache NosOsteonecrosisHypersomnia - IdiopathicArthropathyFatigue
Rash Maculo-papularTremorHigh Blood PressureSupraventricular TachycardiaRashFibromyalgiaExercise Tolerance DecreasedDrug Ineffective
EffusionHypersomniaBrain NeoplasmDark Circles Under EyesCholecystitisSpondylolisthesisMood SwingsPain
DysphagiaGastrointestinal DiscomfortInsomniaLewy Body DementiaGallbladder CholesterolosisArthritisDrug IneffectiveInsomnia
Subchorionic HaemorrhageMouth UlcerationDry MouthDiarrhoea AggravatedDiarrhoea AggravatedAnxietyGastrooesophageal Reflux DiseaseFall
Vitamin D DeficiencyDeja VuDry EyesTeeth Grinding And ClenchingLewy Body DementiaFeeling AbnormalHigh Blood PressureDizziness
Fungal InfectionVaginal SloughingMuscle TwitchingInsomnia Related To Another Mental ConditionDystoniaStomach UpsetAlopeciaMalaise
HypertensionDiarrhoeaDystoniaUrethral PainMuscle TwitchingUrinary IncontinenceAnxietyConvulsion

Most common drug interactions by gender * :

NauseaRespiratory Failure
HeadacheMyelodysplastic Syndrome
FatigueMetastases To Bone
PainAnal Fistula
InsomniaCrohn's Disease
Drug IneffectiveConfusional State
MalaiseThyroid Cancer
ConvulsionBlood Creatinine Increased

Most common drug interactions by age * :

Respiratory DistressSkin HypertrophyAnal FistulaMuscle SpasmsHeadachePruritusDrug IneffectiveNausea
VasculitisCrohn's DiseaseHypothyroidismConvulsionAnxietyInsomniaFatigue
Abdominal PainHeadacheLymphopeniaEpilepsyFatigueFatigueFall
Pulmonary OedemaHaemorrhagic Cerebral InfarctionHyponatraemiaInjuryWeight IncreasedHeadacheAnxiety
Radiation InjuryConfusional StateHeadacheUrinary Tract InfectionNasopharyngitisDyspnoeaPain
Arterial Occlusive DiseaseSpastic DiplegiaDiplopiaPainDiarrhoeaGastrooesophageal Reflux DiseaseConfusional State
DehydrationPneumonia AspirationNeutropeniaDecreased AppetiteDyspepsiaRashDiarrhoea
Cerebrovascular AccidentTransverse Sinus ThrombosisHypocalcaemiaBalance DisorderDry MouthParaesthesiaDepression
DiarrhoeaConvulsionPyrexiaFluid RetentionSoft Tissue NecrosisNauseaDizziness
ScreamingPerirectal AbscessDiabetes MellitusDizzinessWound ComplicationMemory ImpairmentInsomnia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Do you take Synthroid and Melatonin?




You are not alone! Join a related mobile support group on :
- support group for people who take Melatonin
- support group for people who take Synthroid

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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