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Review: taking Synthroid and Savella together

Summary: drug interactions are reported among people who take Synthroid and Savella together.

This review analyzes the effectiveness and drug interactions between Synthroid and Savella. It is created by eHealthMe based on reports of 405 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Synthroid and Savella >>>

On Mar, 20, 2015: 405 people who take Synthroid, Savella are studied

Synthroid, Savella outcomes

Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Savella (milnacipran hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Synthroid is effective0.00%
(0 of 1 people)
(1 of 3 people)
(1 of 2 people)
(0 of 2 people)
(5 of 9 people)
(5 of 7 people)
(19 of 21 people)
Savella is effective0.00%
(0 of 7 people)
(2 of 9 people)
(2 of 9 people)
(3 of 8 people)
(2 of 4 people)
(0 of 1 people)

Drug effectiveness by gender :

Synthroid is effective69.05%
(29 of 42 people)
(2 of 3 people)
Savella is effective26.47%
(9 of 34 people)
(0 of 4 people)

Drug effectiveness by age :

Synthroid is effectiven/an/an/a0.00%
(0 of 2 people)
(3 of 9 people)
(11 of 19 people)
(9 of 41 people)
(8 of 17 people)
Savella is effectiven/an/an/a50.00%
(1 of 2 people)
(1 of 8 people)
(3 of 16 people)
(2 of 38 people)
(2 of 16 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaNauseaTremorUrinary Tract InfectionSweating - ExcessiveWheezing AggravatedUrinary Tract InfectionNausea
HyperhidrosisDizzinessBlood Pressure IncreasedDry Eyes AggravatedSwellingAnxiety AggravatedFatigue
InsomniaHeadacheMemory ImpairmentTeeth ClinchingBenign Positional VertigoUrinary RetentionHeadache
DizzinessHyperhidrosisVomitingVision BlurredHair LossEagles SyndromeHyperhidrosis
FatigueFlushingHypoaesthesiaNauseaBloody SputumPainful Red EyesInsomnia
HeadacheDecreased AppetiteNauseaTeeth GrindingDizzinessJob ChangeDizziness
Blood Pressure IncreasedHeart Rate IncreasedMigraineJob ChangeHeadacheDry Eyes AggravatedVomiting
Heart Rate IncreasedAbdominal PainFibromyalgiaAcid RefluxCervicogenic HeadacheTeeth ClinchingPain
VomitingHot FlushVision BlurredPainful Red EyesExhaustion, Fatigue, Lethargy, Tiredness, WearinessTeeth GrindingBlood Pressure Increased
TremorTremorHeart Rate IncreasedMood AlteredTinnitusDiscolored TeethWeight Decreased

Most common drug interactions by gender * :

NauseaMuscle Haemorrhage
FatigueSubcutaneous Haematoma
HyperhidrosisInternational Normalised Ratio Increased
InsomniaWeight Decreased
VomitingAbdominal Distension
Blood Pressure IncreasedVisual Acuity Reduced

Most common drug interactions by age * :

n/an/an/aPsychiatric DecompensationNauseaNauseaNauseaNausea
Weight IncreasedWeight DecreasedDiarrhoeaHeadacheHyperhidrosis
Heart Rate AbnormalPainDizzinessFatigueInsomnia
Abdominal PainHomicidal IdeationPainHyperhidrosisHeadache
Heart Rate IncreasedDehydrationTremorDizzinessFatigue
Abnormal Loss Of WeightDizzinessAnxietyBlood Pressure IncreasedHot Flush
DystoniaChest PainBlood Pressure IncreasedDyspnoeaPain
Muscle SpasmsPanic AttackHyperhidrosisAstheniaVomiting
Muscle TwitchingDrug Screen PositiveWeight DecreasedVomitingChills

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Synthroid and Savella?




You are not alone! Join a related mobile support group on :
- support group for people who take Savella
- support group for people who take Synthroid

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Savella (milnacipran hydrochloride) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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