Review: Synthroid and Savella drug interactions
This review analyzes the interactions between Synthroid and Savella. It is created by eHealthMe based on 373 people who have drug interactions while taking the drugs. The review uses reports from FDA and social media, and is updated regularly.
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What are the drugs
Synthroid (latest outcomes from 93,377 users) has active ingredients of levothyroxine sodium. It is often used in hypothyroidism.
Savella (latest outcomes from 3,359 users) has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia.
On Mar, 1, 2014: 373 people who reported to have interactions when taking Synthroid, Savella are studied
Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Savella (milnacipran hydrochloride)
Most common interactions experienced by people in the use of Synthroid, Savella:(click on each outcome to view in-depth analysis, incl. how people recovered)
|Interaction||Number of reports|
|Nausea (feeling of having an urge to vomit)||74|
|Blood Pressure Increased||49|
|Fatigue (feeling of tiredness)||43|
|Headache (pain in head)||40|
|Hyperhidrosis (abnormally increased sweating)||39|
Most common interactions experienced by people in long term use of Synthroid, Savella:(click on each outcome to view in-depth analysis, incl. how people recovered)
|Interaction||Number of reports|
|Sweating - Excessive (abnormally increased sweating)||6|
|Teeth Grinding (habitual grinding of the teeth, typically during sleep)||3|
|Teeth Clinching (habitual grinding of the teeth, typically during sleep)||3|
|Loss Of Weight||2|
|Urinary Retention (the inability to completely or partially empty the bladder)||2|
|Mood Altered (changes in mood)||2|
|Dry Eyes Aggravated (lack of adequate tears)||1|
How effective are the drugs:
|not at all||somewhat||moderate||high||very high|
Top conditions involved for these people * :
- Rheumatoid arthritis
Top co-used drugs for these people * :
* Approximation only. Some reports may have incomplete information.
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Complete drug side effects:
On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Savella (milnacipran hydrochloride) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
- Synthroid is used in:
- Savella is used in:
Other drugs that are used to treat the same conditions:
- Synthroid alternatives:
- Savella alternatives:
Comments from related studies:
From this study (12 months ago):
From this study (1 year ago):
From this study (1 year ago):
Please help if you are able.
Background: Very Healthy, active 115 lb. 70 year old female. Worked out, lifted weights, 40 minute walk, 40 deep knee bends, 20 push ups, all daily activities until 8 months ago when became profoundly fatigued, with severe (incapacitating) muscle pain, literally overnight. Had to quit job, as too fatigued to work. Currently: No muscle pain. Debilitating fatigue persists.
200 Tramadol daily, Chronic Severe Bursitis
8 mgs. Prednisone daily, fatigue
50 mcs. Synthroid daily, Hypothyroidism
300 mgs. Gabapentin daily, Post Herpetic Neuralgia (Shingles)
Savella Dose pack prescribed. Details below.
Recently prescribed Savella dose pack to treat unremitting fatigue. Dx: PMR NOS. Also taking Tramadol 200 mgs. daily, 3 years for Severe Chronic Bursitis.
After 12.5 msg Savella twice daily for three days, nothing different noted.
Dose pack increase: 25 mgs twice daily for four days. After three days, noted moderate increase in energy. Dose pack increase to 50 mgs. twice daily. After three to four days felt increasingly worse: fatigued, weak, unsteady on my feet, heart rate 104 (typically 70-74). Fatigue much worse than before started Savella. Quit Savella.
Question: I read Savella interacts badly with Tramadol, but how seriously for my body, and at what dose? Savella at lower dose (25 mgs twice daily,) was such a welcome therapeutic difference in fatigue symptoms. If possible, would like to restart Savella at 25 mgs twice daily. Would I notice if an interaction with Tramadol at that dose of Savella, and would it preclude taking them together? Looking forward to your report on others experiencing these interactions and symptoms.
have been overwhelmed by rash/hives since July '12, was on long term prednisone for polymyalgia rheumatica/inflammatory arthritis ending in 4/12. Started on Lyrica in June--on for 3 weeks then off d/t excessive drowsiness. Biopsy of rash indicated RX hypersensitivity and d/c'd all RX except: synthroid, lasix, zolpidem. increased SOB has indicated use of Xopenex nebulizer txs q 4 hrs x 2days. Prescribed Prednisone for rash. Has cleared everytime except this one. Currently on day 2 of 40mg and have facial rash (slightly worse this round--first occurred with last round) and body rash is NOT clearing! Any info is welcomed!
have been diagnosed with high blood pressure, also have had an operation fusing l5/s1 vertebra after which got restless leg syndrome and many leg cramps and pain, have anxiety and depression for many year, recently have been diagnosed with fybromyalgia through process of elimination
Can you answer these questions (what is this?):
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- Has anyone had negative experiences with simvastin or with omerprazole?
I have been diagnosed as having diabetes but at this point I am not taking any meds for it, my numbers are excellent. I was not on a cholestral or blood pressure med until I was diagnosed with diabetes.
- To know whether drugs for hypothyroidism have side effects
hypertension range 130-140/90-95 for 2 mths. No previous history
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Recent related drug studies:
- A study of drug interactions between Tramadol, Synthroid, Savella, Gabapentin, Prednisone for a patient with Bursitis, Hypothyroidism, Fatigue, Post Herpetic Neuralgia. The patient has Fatigue Much Worse At Higher Dose (50 Mgs Twice Daily) Of Savella. Much More Fatigue. Weak. Unsteady On Feet.
- A study of drug interactions between Lisinopril, Furosemide, Klor-con, Montelukast Sodium, Plaquenil, Vitamin A - EQ 50,000 UNITS BASE, Zolpidem Tartrate, Levalbuterol Hydrochloride, Allopurinol, Synthroid, Savella, Cyclobenzaprine Hydrochloride for a patient with Hypertension, Edema - Peripheral, Peripheral Edema, Metabolic Syndrome, Asthma Exacerbation Prophylaxis, Myalgia, Fibromyalgia, Asthmatic Crisis, Chronic Gouty Arthritis, Thyroid Cancer, Polymyalgia Rheumatica.
- A study of drug interactions between Savella, Kariva, Synthroid, Tekturna Hct, Pramipexole Dihydrochloride, Alprazolam, Alprazolam, Klor-con M20, Vitamin D, Biotin, Magnesium Sulfate In Plastic Container for a patient with Fibromyalgia, Birth Control And Family Planning, Hypothyroidism, High Blood Pressure, Restless Leg Syndrome, Stress And Anxiety, Insomnia, Recurrent Leg Pain And Cramping, Depressed Mood, Hair Loss In Women. The patient has Bone Loss, Swollen Tongue
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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