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Review: taking Synthroid and Savella together

Summary: drug interactions are reported among people who take Synthroid and Savella together.

This review analyzes the effectiveness and drug interactions between Synthroid and Savella. It is created by eHealthMe based on reports of 405 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Synthroid and Savella >>>

What are the drugs

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from 93,791 Synthroid users)

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. (latest outcomes from 3,391 Savella users)

On Jan, 14, 2015: 405 people who take Synthroid, Savella are studied

Synthroid, Savella outcomes

Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Savella (milnacipran hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Synthroid is effective0.00%
(0 of 1 people)
33.33%
(1 of 3 people)
50.00%
(1 of 2 people)
0.00%
(0 of 2 people)
55.56%
(5 of 9 people)
71.43%
(5 of 7 people)
90.48%
(19 of 21 people)
n/a
Savella is effective0.00%
(0 of 7 people)
22.22%
(2 of 9 people)
22.22%
(2 of 9 people)
37.50%
(3 of 8 people)
50.00%
(2 of 4 people)
0.00%
(0 of 1 people)
n/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaNauseaTremorUrinary Tract InfectionSweating - ExcessiveWheezing AggravatedUrinary Tract InfectionNausea
HyperhidrosisDizzinessBlood Pressure IncreasedDry Eyes AggravatedSwellingAnxiety AggravatedFatigue
InsomniaHeadacheMemory ImpairmentTeeth ClinchingBenign Positional VertigoUrinary RetentionHeadache
DizzinessHyperhidrosisVomitingVision BlurredHair LossEagles SyndromeHyperhidrosis
FatigueFlushingHypoaesthesiaNauseaBloody SputumPainful Red EyesInsomnia
HeadacheDecreased AppetiteNauseaTeeth GrindingDizzinessJob ChangeDizziness
Blood Pressure IncreasedHeart Rate IncreasedMigraineJob ChangeHeadacheDry Eyes AggravatedVomiting
Heart Rate IncreasedAbdominal PainFibromyalgiaAcid RefluxCervicogenic HeadacheTeeth ClinchingPain
VomitingHot FlushVision BlurredPainful Red EyesExhaustion, Fatigue, Lethargy, Tiredness, WearinessTeeth GrindingBlood Pressure Increased
TremorTremorHeart Rate IncreasedMood AlteredTinnitusDiscolored TeethWeight Decreased

Drug effectiveness by gender :

FemaleMale
Synthroid is effective69.05%
(29 of 42 people)
66.67%
(2 of 3 people)
Savella is effective26.47%
(9 of 34 people)
0.00%
(0 of 4 people)

Most common drug interactions by gender * :

FemaleMale
NauseaMuscle Haemorrhage
FatigueSubcutaneous Haematoma
HeadacheAnaemia
HyperhidrosisInternational Normalised Ratio Increased
DizzinessHaematoma
InsomniaWeight Decreased
PainConvulsion
VomitingAbdominal Distension
Blood Pressure IncreasedVisual Acuity Reduced
DyspnoeaFlatulence

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Synthroid is effectiven/an/an/a0.00%
(0 of 2 people)
33.33%
(3 of 9 people)
57.89%
(11 of 19 people)
21.95%
(9 of 41 people)
47.06%
(8 of 17 people)
Savella is effectiven/an/an/a50.00%
(1 of 2 people)
12.50%
(1 of 8 people)
18.75%
(3 of 16 people)
5.26%
(2 of 38 people)
12.50%
(2 of 16 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/an/aPsychiatric DecompensationNauseaNauseaNauseaNausea
Weight IncreasedWeight DecreasedDiarrhoeaHeadacheHyperhidrosis
Heart Rate AbnormalPainDizzinessFatigueInsomnia
Abdominal PainHomicidal IdeationPainHyperhidrosisHeadache
Heart Rate IncreasedDehydrationTremorDizzinessFatigue
DyspnoeaVomitingMigraineInsomniaDizziness
Abnormal Loss Of WeightDizzinessAnxietyBlood Pressure IncreasedHot Flush
DystoniaChest PainBlood Pressure IncreasedDyspnoeaPain
Muscle SpasmsPanic AttackHyperhidrosisAstheniaVomiting
Muscle TwitchingDrug Screen PositiveWeight DecreasedVomitingChills

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Synthroid and Savella?

You are not alone! Join a related mobile support group:
- support group for people who take Synthroid and Savella
- support group for people who take Savella
- support group for people who take Synthroid

Can you answer these questions (Ask a question):

More questions for: Savella, Synthroid

You may be interested at these reviews (Write a review):

  • Syntroid and pruritus
    I have been on levothyroxine for more than ten years and have had two episodes, each lasting over several months of unbearable itching. Doctors seem to deny any connection but are also unable identify the cause of the itching. None of the tests pick anything. Antihistamines are not much of a help. I am still in the throes of the second episode and life is plain, simple miserable.
  • Thrush while on prograf
    I am a health provider at an emergency room and had a patient come in because of a food bolus and when i examined his oral/pharynx I noticed he had thrush. Patient stated it has been their for a while. Patient also stated he has been having progressive difficulty in swallowing. Pt is a kidney transplant patient and has been worked up for other causes of his thrush (including HIV, as per patient results neg) and everything came back negative. I can only conclude that maybe the prograf which is a immunosupressent can possible be the cause
  • Cardio version caused fingernail abnormalities
    Right hip fracture. When prepping for surgery AFIB was found. Surgery was cancelled and they attempted to get AFIB under control. Finally, cardioversion was performed. When my nails started to grow out they all had two horizontal lines that cause the nail to break when it grows out to that point.
  • Drug interractions savella. amoxicillin
    Sudden ache, pain and neuropathy in right hand and wrist within 8 hours of sterting Amoxicillin.
  • Synthroid and breast enlargement
    I have went from a B-C cup size to a D cup in the past 8-9 months.

More reviews for: Savella, Synthroid

Comments from related studies:

  • From this study (4 months ago):

  • I have been experiencing reoccurring UTI's and now have symptoms of acid reflux. I started taking Savella about 2 years ago. So I am trying to determine if these symptoms could be being caused by the medications.

    Reply

  • From this study (8 months ago):

  • Have had a headache for three days

    Reply

  • From this study (8 months ago):

  • Been on MS ContinSR 100mg, Tizanadine(Zanaflex) 4mg for 10+years and it does not much at all to help, also MS Contin 15mgIR in between. Pain is severe, fatigue is extreme, lack of sleep is hardest. Just started Temazepam for sleep,insurance co's. wants huge co pay for Ambien so had to go with something old for sleeep. Savella, just started on..no idea yet if it's going to help.
    Due to fatigue, lack of sleep, extreme bone and muscle pain bones have turned in degenerative disc disease. Exercise is what is impossible to do due to pain,lack of sleep.

    Reply

    Linda on Jun, 9, 2014:

    Female, age 52, Fibro and Ankylosing Spondylitis. I took Ambien for one or two years. Either a) didn't work at all,
    b) worked too well and I was hung over the next day or
    c) made me walk in my sleep. Once I cleanly the whole house in my sleep, which was a nice surprise the next morning. But once I took a huge butcher knife and hid it under the bed.

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Savella (milnacipran hydrochloride) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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