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Review: Synthroid and Savella

This review analyzes the effectiveness and drug interactions between Synthroid and Savella. It is created by eHealthMe based on reports of 401 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Synthroid and Savella >>>

What are the drugs

Synthroid (latest outcomes from 93,627 users) has active ingredients of levothyroxine sodium. It is used in hypothyroidism.

Savella (latest outcomes from 3,377 users) has active ingredients of milnacipran hydrochloride. It is used in fibromyalgia.

On Aug, 13, 2014: 401 people who take Synthroid, Savella are studied

Synthroid, Savella outcomes

Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Savella (milnacipran hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Synthroid is effective0.00%
(0 of 1 people)
33.33%
(1 of 3 people)
50.00%
(1 of 2 people)
0.00%
(0 of 1 people)
55.56%
(5 of 9 people)
71.43%
(5 of 7 people)
89.47%
(17 of 19 people)
n/a
Savella is effective0.00%
(0 of 7 people)
22.22%
(2 of 9 people)
12.50%
(1 of 8 people)
28.57%
(2 of 7 people)
66.67%
(2 of 3 people)
0.00%
(0 of 1 people)
n/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaNauseaTremorDry Eyes AggravatedSweating - ExcessiveWheezing AggravatedAnxiety AggravatedNausea
HyperhidrosisDizzinessBlood Pressure IncreasedTeeth ClinchingDizzinessUrinary RetentionFatigue
InsomniaHeadacheMemory ImpairmentVision BlurredSwellingEagles SyndromeHeadache
DizzinessHyperhidrosisVomitingNauseaBloody SputumUrinary Tract InfectionHyperhidrosis
FatigueFlushingHypoaesthesiaTeeth GrindingBenign Positional VertigoPainful Red EyesInsomnia
HeadacheDecreased AppetiteNauseaDiscolored TeethFlushingJob ChangeDizziness
Blood Pressure IncreasedHeart Rate IncreasedMigrainePainful Red EyesHeadacheDry Eyes AggravatedVomiting
Heart Rate IncreasedAbdominal PainFibromyalgiaUrinary Tract InfectionExhaustion, Fatigue, Lethargy, Tiredness, WearinessTeeth ClinchingBlood Pressure Increased
VomitingHot FlushVision BlurredJob ChangeTinnitusTeeth GrindingPain
TremorTremorHeart Rate IncreasedEagles SyndromeCervicogenic HeadacheDiscolored TeethWeight Decreased

Drug effectiveness by gender :

FemaleMale
Synthroid is effective67.50%
(27 of 40 people)
100.00%
(2 of 2 people)
Savella is effective21.88%
(7 of 32 people)
0.00%
(0 of 3 people)

Most common drug interactions by gender * :

FemaleMale
NauseaInternational Normalised Ratio Increased
FatigueAnaemia
HeadacheSubcutaneous Haematoma
HyperhidrosisMuscle Haemorrhage
DizzinessWeight Decreased
InsomniaHaematoma
VomitingConvulsion
Blood Pressure IncreasedSmall Intestinal Obstruction
PainFlatulence
DyspnoeaAbdominal Distension

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Synthroid is effectiven/an/an/a0.00%
(0 of 2 people)
33.33%
(3 of 9 people)
58.82%
(10 of 17 people)
23.08%
(9 of 39 people)
43.75%
(7 of 16 people)
Savella is effectiven/an/an/a50.00%
(1 of 2 people)
12.50%
(1 of 8 people)
14.29%
(2 of 14 people)
5.41%
(2 of 37 people)
6.67%
(1 of 15 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/an/aPsychiatric DecompensationNauseaNauseaNauseaNausea
Weight IncreasedWeight DecreasedDiarrhoeaHeadacheHyperhidrosis
Heart Rate AbnormalPainDizzinessFatigueInsomnia
Abdominal PainHomicidal IdeationTremorHyperhidrosisHeadache
Heart Rate IncreasedDehydrationHyperhidrosisInsomniaFatigue
DyspnoeaVomitingBlood Pressure IncreasedDizzinessDizziness
Abnormal Loss Of WeightDizzinessAnxietyBlood Pressure IncreasedHot Flush
DystoniaChest PainMigraineDyspnoeaPain
Muscle SpasmsPanic AttackPainVomitingVomiting
Muscle TwitchingDrug Screen PositiveDermatitis ExfoliativePalpitationsChills

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Synthroid and Savella
- group for people who take Savella
- group for people who take Synthroid

Comments from related studies:

  • From this study (2 months ago):

  • Have had a headache for three days

    Reply

  • From this study (3 months ago):

  • Been on MS ContinSR 100mg, Tizanadine(Zanaflex) 4mg for 10+years and it does not much at all to help, also MS Contin 15mgIR in between. Pain is severe, fatigue is extreme, lack of sleep is hardest. Just started Temazepam for sleep,insurance co's. wants huge co pay for Ambien so had to go with something old for sleeep. Savella, just started on..no idea yet if it's going to help.
    Due to fatigue, lack of sleep, extreme bone and muscle pain bones have turned in degenerative disc disease. Exercise is what is impossible to do due to pain,lack of sleep.

    Reply

    Linda on Jun, 9, 2014:

    Female, age 52, Fibro and Ankylosing Spondylitis. I took Ambien for one or two years. Either a) didn't work at all,
    b) worked too well and I was hung over the next day or
    c) made me walk in my sleep. Once I cleanly the whole house in my sleep, which was a nice surprise the next morning. But once I took a huge butcher knife and hid it under the bed.

    Reply

  • From this study (1 year ago):

  • Please help if you are able.
    Background: Very Healthy, active 115 lb. 70 year old female. Worked out, lifted weights, 40 minute walk, 40 deep knee bends, 20 push ups, all daily activities until 8 months ago when became profoundly fatigued, with severe (incapacitating) muscle pain, literally overnight. Had to quit job, as too fatigued to work. Currently: No muscle pain. Debilitating fatigue persists.
    Current Meds:
    200 Tramadol daily, Chronic Severe Bursitis
    8 mgs. Prednisone daily, fatigue
    50 mcs. Synthroid daily, Hypothyroidism
    300 mgs. Gabapentin daily, Post Herpetic Neuralgia (Shingles)
    Savella Dose pack prescribed. Details below.

    Current Problem:
    Recently prescribed Savella dose pack to treat unremitting fatigue. Dx: PMR NOS. Also taking Tramadol 200 mgs. daily, 3 years for Severe Chronic Bursitis.
    After 12.5 msg Savella twice daily for three days, nothing different noted.
    Dose pack increase: 25 mgs twice daily for four days. After three days, noted moderate increase in energy. Dose pack increase to 50 mgs. twice daily. After three to four days felt increasingly worse: fatigued, weak, unsteady on my feet, heart rate 104 (typically 70-74). Fatigue much worse than before started Savella. Quit Savella.
    Question: I read Savella interacts badly with Tramadol, but how seriously for my body, and at what dose? Savella at lower dose (25 mgs twice daily,) was such a welcome therapeutic difference in fatigue symptoms. If possible, would like to restart Savella at 25 mgs twice daily. Would I notice if an interaction with Tramadol at that dose of Savella, and would it preclude taking them together? Looking forward to your report on others experiencing these interactions and symptoms.

    Reply

Post a new comment    OR    Read more comments

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    I was taking about 5 to 15 mg of Percocet a day and wanted to get off them. If I don't take suboxone at night I get EXTREME discomfort down my left leg & can not sleep due to pressure on my lower back (that's why I had to take Percocet). I have tried NUMEROUS meds over the past 20 yrs & nothing work ...

More questions for: Savella, Synthroid

You may be interested at these reviews (what is this?):

  • Shortness of breath after taking levothyroxine for 8-10 yrs.
    I have been experiencing shortness of breath lately when taking the levothyroxine. If I stop taking it for a couple of days my shortness of breath is pretty much gone.

  • I wish i had never taken ambien
    Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered A ...

  • Bone infections involving my teeth crohns and prednisone over the past 12 years
    Dentist [2] tell me the abscesses are in the bones and I've had several root canals, bridges, bone surgeries that last 3 years, teeth became so mobile after the bone economy I had them pulled and now a partial one month ago. Bone loss etc. I don't have the ridges in my mouth that most Crohn patients ...

More reviews for: Savella, Synthroid

Complete drug side effects:

On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Savella (milnacipran hydrochloride) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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