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Review: Synthroid and Savella

This review analyzes the effectiveness and drug interactions between Synthroid and Savella. It is created by eHealthMe based on 370 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Mar, 31, 2014: 370 people who reported to have interactions when taking Synthroid, Savella are studied

Trend of Synthroid, Savella's drug interactions, side effects and effectiveness reports (8538159)

Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Savella (milnacipran hydrochloride)

eHealthMe real world results:

Most common interactions experienced by people in the use of Synthroid, Savella:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Nausea (feeling of having an urge to vomit)220
Fatigue (feeling of tiredness)129
Vomiting114
Headache (pain in head)109
Blood Pressure Increased104
Dizziness99
Hyperhidrosis (abnormally increased sweating)97
Insomnia (sleeplessness)90
Pain78
Weight Decreased70

Most common interactions experienced by people in long term use of Synthroid, Savella:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Sweating - Excessive (abnormally increased sweating)9
Renal Failure (kidney dysfunction)6
Anxiety Aggravated5
Urinary Retention (the inability to completely or partially empty the bladder)4
Overdose4
Dizziness4
Flushing (the warm, red condition of human skin)3
Wheezing Aggravated (a high-pitched whistling sound made while you breathe)2
Headache (pain in head)2
Swelling2

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Synthroid0.00%14.29%14.29%28.57%42.86%
Savella7.69%15.38%61.54%15.38%0.00%

Top conditions involved for these people * :

  1. Fibromyalgia
  2. Pain
  3. Rheumatoid arthritis
  4. Hypothyroidism
  5. Depression

Top co-used drugs for these people * :

  1. Lyrica
  2. Humira
  3. Nexium
  4. Xanax
  5. Ambien

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Savella, Synthroid

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Complete drug side effects:

On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Savella (milnacipran hydrochloride) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (13 months ago):

  • Please help if you are able.
    Background: Very Healthy, active 115 lb. 70 year old female. Worked out, lifted weights, 40 minute walk, 40 deep knee bends, 20 push ups, all daily activities until 8 months ago when became profoundly fatigued, with severe (incapacitating) muscle pain, literally overnight. Had to quit job, as too fatigued to work. Currently: No muscle pain. Debilitating fatigue persists.
    Current Meds:
    200 Tramadol daily, Chronic Severe Bursitis
    8 mgs. Prednisone daily, fatigue
    50 mcs. Synthroid daily, Hypothyroidism
    300 mgs. Gabapentin daily, Post Herpetic Neuralgia (Shingles)
    Savella Dose pack prescribed. Details below.

    Current Problem:
    Recently prescribed Savella dose pack to treat unremitting fatigue. Dx: PMR NOS. Also taking Tramadol 200 mgs. daily, 3 years for Severe Chronic Bursitis.
    After 12.5 msg Savella twice daily for three days, nothing different noted.
    Dose pack increase: 25 mgs twice daily for four days. After three days, noted moderate increase in energy. Dose pack increase to 50 mgs. twice daily. After three to four days felt increasingly worse: fatigued, weak, unsteady on my feet, heart rate 104 (typically 70-74). Fatigue much worse than before started Savella. Quit Savella.
    Question: I read Savella interacts badly with Tramadol, but how seriously for my body, and at what dose? Savella at lower dose (25 mgs twice daily,) was such a welcome therapeutic difference in fatigue symptoms. If possible, would like to restart Savella at 25 mgs twice daily. Would I notice if an interaction with Tramadol at that dose of Savella, and would it preclude taking them together? Looking forward to your report on others experiencing these interactions and symptoms.

    Reply

  • From this study (1 year ago):

  • have been overwhelmed by rash/hives since July '12, was on long term prednisone for polymyalgia rheumatica/inflammatory arthritis ending in 4/12. Started on Lyrica in June--on for 3 weeks then off d/t excessive drowsiness. Biopsy of rash indicated RX hypersensitivity and d/c'd all RX except: synthroid, lasix, zolpidem. increased SOB has indicated use of Xopenex nebulizer txs q 4 hrs x 2days. Prescribed Prednisone for rash. Has cleared everytime except this one. Currently on day 2 of 40mg and have facial rash (slightly worse this round--first occurred with last round) and body rash is NOT clearing! Any info is welcomed!

    Reply

  • From this study (1 year ago):

  • have been diagnosed with high blood pressure, also have had an operation fusing l5/s1 vertebra after which got restless leg syndrome and many leg cramps and pain, have anxiety and depression for many year, recently have been diagnosed with fybromyalgia through process of elimination

    Reply

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More questions for: Savella, Synthroid

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