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Review: Synthroid and Savella





Summary: drug interactions are reported among people who take Synthroid and Savella together.

This review analyzes the effectiveness and drug interactions between Synthroid and Savella. It is created by eHealthMe based on reports of 404 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Synthroid and Savella >>>

What are the drugs

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from Synthroid 93,746 users)

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. (latest outcomes from Savella 3,389 users)

On Dec, 5, 2014: 404 people who take Synthroid, Savella are studied

Synthroid, Savella outcomes

Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Savella (milnacipran hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Synthroid is effective0.00%
(0 of 1 people)
33.33%
(1 of 3 people)
50.00%
(1 of 2 people)
0.00%
(0 of 1 people)
55.56%
(5 of 9 people)
71.43%
(5 of 7 people)
90.48%
(19 of 21 people)
n/a
Savella is effective0.00%
(0 of 7 people)
22.22%
(2 of 9 people)
22.22%
(2 of 9 people)
37.50%
(3 of 8 people)
66.67%
(2 of 3 people)
0.00%
(0 of 1 people)
n/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaNauseaTremorUrinary Tract InfectionSweating - ExcessiveWheezing AggravatedUrinary Tract InfectionNausea
HyperhidrosisDizzinessBlood Pressure IncreasedTeeth ClinchingDizzinessAnxiety AggravatedFatigue
InsomniaHeadacheMemory ImpairmentTeeth GrindingSwellingUrinary RetentionHeadache
DizzinessHyperhidrosisVomitingDry Eyes AggravatedBloody SputumEagles SyndromeHyperhidrosis
FatigueFlushingHypoaesthesiaNauseaBenign Positional VertigoPainful Red EyesInsomnia
HeadacheDecreased AppetiteNauseaDiscolored TeethFlushingJob ChangeDizziness
Blood Pressure IncreasedHeart Rate IncreasedMigraineJob ChangeHeadacheDry Eyes AggravatedVomiting
Heart Rate IncreasedAbdominal PainFibromyalgiaAcid RefluxExhaustion, Fatigue, Lethargy, Tiredness, WearinessTeeth ClinchingPain
VomitingHot FlushVision BlurredPainful Red EyesTinnitusTeeth GrindingBlood Pressure Increased
TremorTremorHeart Rate IncreasedEagles SyndromeCervicogenic HeadacheDiscolored TeethWeight Decreased

Drug effectiveness by gender :

FemaleMale
Synthroid is effective69.05%
(29 of 42 people)
100.00%
(2 of 2 people)
Savella is effective26.47%
(9 of 34 people)
0.00%
(0 of 3 people)

Most common drug interactions by gender * :

FemaleMale
NauseaInternational Normalised Ratio Increased
FatigueAnaemia
HeadacheSubcutaneous Haematoma
HyperhidrosisMuscle Haemorrhage
DizzinessWeight Decreased
InsomniaHaematoma
PainConvulsion
VomitingSmall Intestinal Obstruction
Blood Pressure IncreasedFlatulence
DyspnoeaAbdominal Distension

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Synthroid is effectiven/an/an/a0.00%
(0 of 2 people)
33.33%
(3 of 9 people)
57.89%
(11 of 19 people)
23.08%
(9 of 39 people)
47.06%
(8 of 17 people)
Savella is effectiven/an/an/a50.00%
(1 of 2 people)
12.50%
(1 of 8 people)
18.75%
(3 of 16 people)
5.41%
(2 of 37 people)
12.50%
(2 of 16 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/an/aPsychiatric DecompensationNauseaNauseaNauseaNausea
Weight IncreasedWeight DecreasedDiarrhoeaHeadacheHyperhidrosis
Heart Rate AbnormalPainDizzinessFatigueInsomnia
Abdominal PainHomicidal IdeationPainHyperhidrosisHeadache
Heart Rate IncreasedDehydrationTremorInsomniaFatigue
DyspnoeaVomitingMigraineDizzinessDizziness
Abnormal Loss Of WeightDizzinessAnxietyBlood Pressure IncreasedHot Flush
DystoniaChest PainBlood Pressure IncreasedDyspnoeaPain
Muscle SpasmsPanic AttackHyperhidrosisVomitingVomiting
Muscle TwitchingDrug Screen PositiveWeight DecreasedPalpitationsChills

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Synthroid and Savella?

You are not alone! Join a related mobile support group:
- support group for people who take Synthroid and Savella
- support group for people who take Savella
- support group for people who take Synthroid

Can you answer these questions (Ask a question):

More questions for: Savella, Synthroid

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    I have been on Savella for 6 months now and the nausea has increased with time and now I also have vomiting daily along with occasional diarrhea. I am currently weaning off of the Savella, cutting the dosage in half for two weeks and then one pill every other day for two weeks, following my dr.'s instructions. I have three weeks total left and still have the nausea and vomiting but hopeful that these will start to go away soon. Anyone else who has weaned off of it- how long until your symptoms subsided?

More reviews for: Savella, Synthroid

Comments from related studies:

  • From this study (2 months ago):

  • I have been experiencing reoccurring UTI's and now have symptoms of acid reflux. I started taking Savella about 2 years ago. So I am trying to determine if these symptoms could be being caused by the medications.

    Reply

  • From this study (7 months ago):

  • Have had a headache for three days

    Reply

  • From this study (7 months ago):

  • Been on MS ContinSR 100mg, Tizanadine(Zanaflex) 4mg for 10+years and it does not much at all to help, also MS Contin 15mgIR in between. Pain is severe, fatigue is extreme, lack of sleep is hardest. Just started Temazepam for sleep,insurance co's. wants huge co pay for Ambien so had to go with something old for sleeep. Savella, just started on..no idea yet if it's going to help.
    Due to fatigue, lack of sleep, extreme bone and muscle pain bones have turned in degenerative disc disease. Exercise is what is impossible to do due to pain,lack of sleep.

    Reply

    Linda on Jun, 9, 2014:

    Female, age 52, Fibro and Ankylosing Spondylitis. I took Ambien for one or two years. Either a) didn't work at all,
    b) worked too well and I was hung over the next day or
    c) made me walk in my sleep. Once I cleanly the whole house in my sleep, which was a nice surprise the next morning. But once I took a huge butcher knife and hid it under the bed.

    Reply

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Complete drug side effects:

On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Savella (milnacipran hydrochloride) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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