Drug interactions between Synthroid and Savella
This is a real world study of Synthroid and Savella drug interactions. The study is created by eHealthMe based on 335 reports from FDA.
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What are the drugs
Synthroid has active ingredients of levothyroxine sodium. It is used in hypothyroidism, thyroid function tests, thyroid diseases, chronic thyroiditis, hyperthyroidism, primary hypothyroidism.
Savella has active ingredients of milnacipran hydrochloride. It is used in fibromyalgia, pain, depression, muscle aches, chronic gouty arthritis, migraine.
On May, 11, 2013: 335 people who reported to have interactions when taking Savella, Synthroid are studied
Drug combinations in study:
- Savella (milnacipran hydrochloride)
- Synthroid (levothyroxine sodium)
Most common interactions experienced by people in the use of Savella, Synthroid:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Nausea | 71 |
| 2 | Vomiting | 52 |
| 3 | Blood Pressure Increased | 47 |
| 4 | Fatigue | 42 |
| 5 | Headache | 38 |
| 6 | Dizziness | 36 |
| 7 | Hyperhidrosis | 36 |
| 8 | Insomnia | 31 |
| 9 | Pain | 23 |
| 10 | Weight Decreased | 22 |
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Most common interactions experienced by people in long term use of Savella, Synthroid:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Renal Failure | 1 |
| 2 | Overdose | 1 |
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Top conditions involved for these people * :
- Fibromyalgia
- Pain
- Rheumatoid arthritis
- Depression
- Hypothyroidism
Top co-used drugs for these people * :
- Humira
- Lyrica
- Nexium
- Xanax
- Ambien
* Approximation only. Some reports may have incomplete information.
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Side effects in real world:
On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Savella (milnacipran hydrochloride) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
Other drugs that are used to treat the same conditions:
Comments from related studies:
From this study (1 month ago):
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Please help if you are able.
Background: Very Healthy, active 115 lb. 70 year old female. Worked out, lifted weights, 40 minute walk, 40 deep knee bends, 20 push ups, all daily activities until 8 months ago when became profoundly fatigued, with severe (incapacitating) muscle pain, literally overnight. Had to quit job, as too fatigued to work. Currently: No muscle pain. Debilitating fatigue persists.
Current Meds:
200 Tramadol daily, Chronic Severe Bursitis
8 mgs. Prednisone daily, fatigue
50 mcs. Synthroid daily, Hypothyroidism
300 mgs. Gabapentin daily, Post Herpetic Neuralgia (Shingles)
Savella Dose pack prescribed. Details below.
Current Problem:
Recently prescribed Savella dose pack to treat unremitting fatigue. Dx: PMR NOS. Also taking Tramadol 200 mgs. daily, 3 years for Severe Chronic Bursitis.
After 12.5 msg Savella twice daily for three days, nothing different noted.
Dose pack increase: 25 mgs twice daily for four days. After three days, noted moderate increase in energy. Dose pack increase to 50 mgs. twice daily. After three to four days felt increasingly worse: fatigued, weak, unsteady on my feet, heart rate 104 (typically 70-74). Fatigue much worse than before started Savella. Quit Savella.
Question: I read Savella interacts badly with Tramadol, but how seriously for my body, and at what dose? Savella at lower dose (25 mgs twice daily,) was such a welcome therapeutic difference in fatigue symptoms. If possible, would like to restart Savella at 25 mgs twice daily. Would I notice if an interaction with Tramadol at that dose of Savella, and would it preclude taking them together? Looking forward to your report on others experiencing these interactions and symptoms.
have been overwhelmed by rash/hives since July '12, was on long term prednisone for polymyalgia rheumatica/inflammatory arthritis ending in 4/12. Started on Lyrica in June--on for 3 weeks then off d/t excessive drowsiness. Biopsy of rash indicated RX hypersensitivity and d/c'd all RX except: synthroid, lasix, zolpidem. increased SOB has indicated use of Xopenex nebulizer txs q 4 hrs x 2days. Prescribed Prednisone for rash. Has cleared everytime except this one. Currently on day 2 of 40mg and have facial rash (slightly worse this round--first occurred with last round) and body rash is NOT clearing! Any info is welcomed!
have been diagnosed with high blood pressure, also have had an operation fusing l5/s1 vertebra after which got restless leg syndrome and many leg cramps and pain, have anxiety and depression for many year, recently have been diagnosed with fybromyalgia through process of elimination
The Doctor changed me to Nucynta 10 days ago, I began having adverse effects day five. Nausea, diarrhea, chills and hot feeling all at the same time, & headache.
Medications improved fibromyalgia for about 1.5 years until side effects began to outweigh benefits. Tremor & myoclonic jerking seemed linked to build up of SINGULAIR, Cymbalta, SAVELLA, Elavil & Lyrica. Tremor, jerking and mood problems lessened when SINGULAIR was discontinued. Cognition improved slightly when Elavil was discontinued. Urinary retention lessened when Cymbalta dose was lowered to 40mg.
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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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