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Review: taking Tramadol and Ambien together

Summary: drug interactions are reported among people who take Tramadol and Ambien together.

This review analyzes the effectiveness and drug interactions between Tramadol and Ambien. It is created by eHealthMe based on reports of 3,193 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 15, 2015: 3,193 people who take Tramadol, Ambien are studied

Tramadol, Ambien outcomes

Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- Ambien (zolpidem tartrate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tramadol is effective11.76%
(2 of 17 people)
(7 of 46 people)
(4 of 19 people)
(4 of 27 people)
(10 of 30 people)
(7 of 20 people)
(3 of 11 people)
Ambien is effective9.09%
(1 of 11 people)
(16 of 33 people)
(10 of 19 people)
(19 of 30 people)
(22 of 43 people)
(13 of 23 people)
(10 of 14 people)

Drug effectiveness by gender :

Tramadol is effective23.66%
(31 of 131 people)
(6 of 39 people)
Ambien is effective54.14%
(72 of 133 people)
(19 of 39 people)

Drug effectiveness by age :

Tramadol is effectiven/an/a0.00%
(0 of 2 people)
(2 of 25 people)
(9 of 64 people)
(2 of 71 people)
(17 of 135 people)
(7 of 45 people)
Ambien is effectiven/an/a0.00%
(0 of 2 people)
(11 of 25 people)
(19 of 67 people)
(16 of 67 people)
(29 of 139 people)
(16 of 44 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Drug Rash With Eosinophilia And Systemic SymptomsPainDepressionDizzinessFatigueFatigueInsomnia ExacerbatedPain
Liver InjuryAbdominal PainDizzinessAnxietyDepressionPainLipidsNausea
NeutropeniaDepressionFatigueInjuryLoss Of ConsciousnessDependenceNeuromaAnxiety
RashPain In ExtremityChest PainMyocardial InfarctionTooth InjuryDrug AbuseRectal BleedingDyspnoea
DiarrhoeaDiabetes Mellitus Inadequate ControlMitral Valve IncompetenceDepressionPetit Mal EpilepsyBursitisTired EyesFatigue
Confusional StateAbnormal BehaviourHallucination, AuditoryAstheniaFallBack PainMental Status ChangesFall
DeathNauseaOverdoseMitral Valve IncompetenceUrinary Tract InfectionDrug IneffectiveNasal UlcerBack Pain
Febrile NeutropeniaMaternal Exposure During PregnancyMyocardial InfarctionNauseaPyrexiaDrug Withdrawal SyndromeDermatitis ExfoliativeArthralgia
Back PainMuscle TightnessInsomniaDeep Vein ThrombosisAbdominal PainHallucinationNasal InflammationDiarrhoea
Dermatitis ExfoliativeOedema PeripheralSomnolenceLacerationAbdominal Pain UpperImpaired Driving AbilityFatigueHeadache

Most common drug interactions by gender * :

ArthralgiaChest Pain
Back PainPain
Pain In ExtremityDrug Ineffective

Most common drug interactions by age * :

Patellofemoral Pain Syndromen/aNauseaTorsade De PointesArthralgiaNauseaNauseaDyspnoea
OsteoarthritisAbdominal PainCardiac ArrestNauseaFatiguePainPain
Stress FractureVomitingPainPainChest PainAnxietyFall
Type 2 Diabetes MellitusHeadacheAbdominal Pain UpperDrug DependencePainArthralgiaFatigue
TalipesCholecystitis ChronicLoss Of ConsciousnessHeadacheBack PainDepressionAnxiety
Drug Exposure During PregnancyFatigueNauseaDepressionDepressionOedema PeripheralBack Pain
LeiomyomaIll-defined DisorderVentricular FibrillationDrug Withdrawal SyndromeHeadacheFatigueNausea
Diabetes MellitusSystemic Lupus ErythematosusComaHypertensionGastrooesophageal Reflux DiseaseDiarrhoeaAnaemia
Transient Ischaemic AttackTendonitisInsomniaBack PainDizzinessHeadacheAsthenia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Ambien (zolpidem tartrate) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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