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Review: Tramadol and Methotrexate

This review analyzes the effectiveness and drug interactions between Tramadol and Methotrexate. It is created by eHealthMe based on reports of 3,219 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Tramadol and Methotrexate >>>

What are the drugs

Tramadol (latest outcomes from 41,469 users) has active ingredients of tramadol hydrochloride. It is often used in pain.

Methotrexate (latest outcomes from 131,165 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

On Oct, 13, 2014: 3,219 people who take Tramadol, Methotrexate are studied

Tramadol, Methotrexate outcomes

Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tramadol is effective50.00%
(1 of 2 people)
33.33%
(3 of 9 people)
25.00%
(2 of 8 people)
20.00%
(2 of 10 people)
28.57%
(4 of 14 people)
11.11%
(1 of 9 people)
100.00%
(1 of 1 people)
0.00%
(0 of 1 people)
Methotrexate is effective0.00%
(0 of 3 people)
25.00%
(3 of 12 people)
16.67%
(1 of 6 people)
11.11%
(1 of 9 people)
26.67%
(4 of 15 people)
0.00%
(0 of 4 people)
50.00%
(2 of 4 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Febrile NeutropeniaDyspnoeaNauseaCerebrovascular AccidentPulmonary EmbolismArthritis BacterialCellulitisNausea
Mucosal InflammationAnaemiaEmbolismHaematomaCoronary Artery EmbolismSystemic Lupus ErythematosusHip FractureArthralgia
ThrombocytopeniaVomitingCoronary Artery EmbolismLumbar Spinal StenosisEmbolismAkathisiaImpaired HealingPain
Weight DecreasedLeukopeniaPulmonary EmbolismGeneral Physical Health DeteriorationLower Respiratory Tract InfectionAffect LabilityPancytopeniaHeadache
Febrile Bone Marrow AplasiaPneumoniaArterial ThrombosisBasal Cell CarcinomaAstheniaHypertensionSepsisVomiting
LeukopeniaNauseaVomitingPneumonia NosArterial ThrombosisGastrointestinal InflammationLung Cancer MetastaticPyrexia
PneumoniaPleural EffusionHepatitis BDrug IneffectiveAlanine Aminotransferase IncreasedLung Neoplasm MalignantOedema PeripheralFatigue
VomitingJaundiceDehydrationPancreatitisBone CystEnterocolitis HaemorrhagicFallDyspnoea
FatigueGamma-glutamyltransferase IncreasedHepatitis B PositivePulmonary TuberculosisPneumoniaCytomegalovirus Test PositiveBack PainPneumonia
Renal Failure AcuteDecreased AppetiteHepatic FailureAlcohol PoisoningNauseaLower Gastrointestinal HaemorrhagePyrexiaDiarrhoea

Drug effectiveness by gender :

FemaleMale
Tramadol is effective22.73%
(10 of 44 people)
40.00%
(4 of 10 people)
Methotrexate is effective18.18%
(8 of 44 people)
33.33%
(3 of 9 people)

Most common drug interactions by gender * :

FemaleMale
NauseaPneumonia
ArthralgiaDyspnoea
PainPyrexia
VomitingArthralgia
HeadacheHeadache
FatigueNausea
DiarrhoeaRheumatoid Arthritis
FallDrug Ineffective
PyrexiaDizziness
AstheniaAnaemia

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Tramadol is effectiven/an/a33.33%
(1 of 3 people)
0.00%
(0 of 5 people)
18.75%
(3 of 16 people)
7.41%
(2 of 27 people)
22.73%
(5 of 22 people)
20.00%
(3 of 15 people)
Methotrexate is effectiven/an/a0.00%
(0 of 3 people)
20.00%
(1 of 5 people)
13.33%
(2 of 15 people)
8.33%
(2 of 24 people)
13.04%
(3 of 23 people)
20.00%
(3 of 15 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Limb Reduction DefectSomnolenceWeight DecreasedHeadacheFatigueNauseaArthralgiaPain
Complications Of Maternal Exposure To Therapeutic DrugsAbdominal PainVomitingNauseaNauseaArthralgiaNauseaFall
Bone Development AbnormalGraft Versus Host DiseaseFebrile NeutropeniaArthralgiaHeadacheHeadachePainArthralgia
SepsisFebrile Bone Marrow AplasiaPyrexiaVomitingRectal HaemorrhageDiarrhoeaDrug Ineffective
Vision BlurredMucosal InflammationBack PainDizzinessChest PainVomitingPneumonia
IrritabilityPyrexiaVomitingArthralgiaPneumoniaHeadacheAsthenia
Depressed Level Of ConsciousnessDehydrationPainCoughPainDyspnoeaAnaemia
TachycardiaDecreased AppetiteMulti-organ FailureMyalgiaAstheniaAbdominal PainAtrial Fibrillation
AgitationPregnancyAbdominal PainFallFatiguePyrexiaNausea
Partial SeizuresPulmonary OedemaParaesthesiaAbdominal Pain UpperPyrexiaPain In ExtremityPyrexia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Tramadol and Methotrexate?

Get connected! Join a related mobile support group:
- support group for people who take Tramadol and Methotrexate
- support group for people who take Methotrexate
- support group for people who take Tramadol

Comments from related studies:

  • From this study (6 months ago):

  • The abnormal dreams & mild hallucinations came only after starting the methylprednisolone a few days ago. They happen primarily when I am sleeping. I woke up last night with very unusual dreams & head/brain pain, and was quite concerned. I had taken 1 methylprednisolone & 1 cymbalta before bed. Earlier in the day, I had taken 2 methylprednisolone & 2 tramadol before a nap, and had similar, though not as severe issues. Trying to figure out what the interaction problem is. I did not take the muscle relaxant (cyclopenzaprine) before bed since I started the cortico steroid pack.

    Reply

    britsarmymom on Apr, 26, 2014:

    Mother just survived near brush with respiratory arrest. Hallucinated at night on Tramadol, argumentative with RN who reported her to MD. He planned to ADD Seroquel 25 mg to Tramadol, Neurontin, Remeron and Ativan in rehab facility. She declined Tramadol and Seroquel and was still so sedated her pulse ox went down to 84 with long periods of apnea and need for constant obs with frequent rousing for airway. MAJOR struggle with RN to get 02 and MD agreed to no more Tramodol at night and absolutely no Seroquel. How many elderly are lost this way?

    Reply

  • From this study (7 months ago):

  • suspicious lung nodule seen in x-ray, going in for a cat scan

    Reply

  • From this study (8 months ago):

  • Trying to figure out if my sudden non stop menstruation is due to medication or a health concern.

    Reply

Post a new comment    OR    Read more comments

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Complete drug side effects:

On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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