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Review: Tramadol and Methotrexate





Summary: drug interactions are reported among people who take Tramadol and Methotrexate together.

This review analyzes the effectiveness and drug interactions between Tramadol and Methotrexate. It is created by eHealthMe based on reports of 3,219 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Tramadol and Methotrexate >>>

What are the drugs

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (view latest outcomes from 41,501 users)

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (view latest outcomes from 131,201 users)

On Dec, 14, 2014: 3,219 people who take Tramadol, Methotrexate are studied

Tramadol, Methotrexate outcomes

Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tramadol is effective50.00%
(1 of 2 people)
33.33%
(3 of 9 people)
25.00%
(2 of 8 people)
20.00%
(2 of 10 people)
28.57%
(4 of 14 people)
11.11%
(1 of 9 people)
100.00%
(1 of 1 people)
0.00%
(0 of 1 people)
Methotrexate is effective0.00%
(0 of 3 people)
25.00%
(3 of 12 people)
16.67%
(1 of 6 people)
11.11%
(1 of 9 people)
26.67%
(4 of 15 people)
0.00%
(0 of 4 people)
50.00%
(2 of 4 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Febrile NeutropeniaDyspnoeaNauseaCerebrovascular AccidentPulmonary EmbolismArthritis BacterialCellulitisNausea
Mucosal InflammationAnaemiaEmbolismHaematomaCoronary Artery EmbolismSystemic Lupus ErythematosusHip FractureArthralgia
ThrombocytopeniaVomitingCoronary Artery EmbolismLumbar Spinal StenosisEmbolismAkathisiaImpaired HealingPain
Weight DecreasedLeukopeniaPulmonary EmbolismGeneral Physical Health DeteriorationLower Respiratory Tract InfectionAffect LabilityPancytopeniaHeadache
Febrile Bone Marrow AplasiaPneumoniaArterial ThrombosisBasal Cell CarcinomaAstheniaHypertensionSepsisVomiting
LeukopeniaNauseaVomitingPneumonia NosArterial ThrombosisGastrointestinal InflammationLung Cancer MetastaticPyrexia
PneumoniaPleural EffusionHepatitis BDrug IneffectiveAlanine Aminotransferase IncreasedLung Neoplasm MalignantOedema PeripheralFatigue
VomitingJaundiceDehydrationPancreatitisBone CystEnterocolitis HaemorrhagicFallDyspnoea
FatigueGamma-glutamyltransferase IncreasedHepatitis B PositivePulmonary TuberculosisPneumoniaCytomegalovirus Test PositiveBack PainPneumonia
Renal Failure AcuteDecreased AppetiteHepatic FailureAlcohol PoisoningNauseaLower Gastrointestinal HaemorrhagePyrexiaDiarrhoea

Drug effectiveness by gender :

FemaleMale
Tramadol is effective22.73%
(10 of 44 people)
40.00%
(4 of 10 people)
Methotrexate is effective18.18%
(8 of 44 people)
33.33%
(3 of 9 people)

Most common drug interactions by gender * :

FemaleMale
NauseaPneumonia
ArthralgiaDyspnoea
PainPyrexia
VomitingArthralgia
HeadacheHeadache
FatigueNausea
DiarrhoeaRheumatoid Arthritis
FallDrug Ineffective
PyrexiaDizziness
AstheniaAnaemia

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Tramadol is effectiven/an/a33.33%
(1 of 3 people)
0.00%
(0 of 5 people)
18.75%
(3 of 16 people)
7.41%
(2 of 27 people)
22.73%
(5 of 22 people)
20.00%
(3 of 15 people)
Methotrexate is effectiven/an/a0.00%
(0 of 3 people)
20.00%
(1 of 5 people)
13.33%
(2 of 15 people)
8.33%
(2 of 24 people)
13.04%
(3 of 23 people)
20.00%
(3 of 15 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Limb Reduction DefectSomnolenceWeight DecreasedHeadacheFatigueNauseaArthralgiaPain
Complications Of Maternal Exposure To Therapeutic DrugsAbdominal PainVomitingNauseaNauseaArthralgiaNauseaFall
Bone Development AbnormalGraft Versus Host DiseaseFebrile NeutropeniaArthralgiaHeadacheHeadachePainArthralgia
SepsisFebrile Bone Marrow AplasiaPyrexiaVomitingRectal HaemorrhageDiarrhoeaDrug Ineffective
Vision BlurredMucosal InflammationBack PainDizzinessChest PainVomitingPneumonia
IrritabilityPyrexiaVomitingArthralgiaPneumoniaHeadacheAsthenia
Depressed Level Of ConsciousnessDehydrationPainCoughPainDyspnoeaAnaemia
TachycardiaDecreased AppetiteMulti-organ FailureMyalgiaAstheniaAbdominal PainAtrial Fibrillation
AgitationPregnancyAbdominal PainFallFatiguePyrexiaNausea
Partial SeizuresPulmonary OedemaParaesthesiaAbdominal Pain UpperPyrexiaPain In ExtremityPyrexia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Tramadol and Methotrexate?

You are not alone! Join a related mobile support group:
- support group for people who take Tramadol and Methotrexate
- support group for people who take Methotrexate
- support group for people who take Tramadol

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • In having a-fib, can one use xarelto along with temador for brain tumor treatment
    Both drugs lower platelets, is using Xarelto unwise
  • Can i take diclofenac sodium mispoprostol with tramadol hcl?
    I have bad arthritis in my hips - very painful and affecting my quality of life. My doctor like to prescribe pills. He has given me Diclofenac Sodium Mispoprostal and Tramadol HCL. I have experienced minimal side effects i.e.: drowsiness but thats about it. I just want to be sure that I can take these drugs together.
  • Is it safe to take demerol while taking tramadol hydrochloride and hydroxychloroquine (2 answers)
    I am experiencing acute, debilitating pain due to the Chikungunya virus, which has reintroduced all of the previous painful symptoms I have,ongoing and in the past, from Fibromyalgia, Arthritis, tendonitis and severe headaches. It's in its 38th day and I am basically crippled from neck to feet. Have to sleep propped up as arms throb with pain when horizontal. The only thing that has subdued the pain slightly are Oxycocet and Ibuprofen, but the pain never goes away. My hands and feet are so inflammed it's difficult to perform even the smallest tasks of personal hygiene and housekeeping. I have difficulty controlling my bladder and often don't make it to the washroom in time. Just started on Demerol today so will no longer take the Oxycocet, but am concerned of the interactions with Demerol, Hydroxychloroquine and Tramadol Hydrochloride extended release tablets that I take daily for the Fibromyalgia and Arthritis. I have dealt with a great deal of pain through the years, but I now have the pain of every serious illness I have had in my lifetime, all at the same time. I honestly didn't think a person could deal with this much pain at once. I have tried and am still taking several vitamins and herbal supplements as well as drinking tons of water and eating really well. Lots of berries, dark vegetables, apples, yogurt and minimal meat. Taking turmeric, papaya leaf, ginger, cinnamon and boswellia for the inflammation. Taking minimal wheat products, sugar and no alcohol. Also, drinking green, fennel and nettle tea daily. I know this is a lot of information, but I really need help and wonder if anyone has any suggestions! Thanking you in advance!!!
  • Does anyone experience heart palpitations causedby their acid reflux ?
    I have had acid reflux/Gerd for 4 years + Was not believed that symptoms were real for a while as had no heartburn and a diagnosis of Fibromyalgia which even now some medics think is imaginary...it's NOT!!! Following a demeester score of 45 ( very high confirmation of acid reflux) and discovery of a large hiatal hernia, ( a classic physical cause of acid reflux) I had hernia repair operation and LINX anti reflux surgery. Throughout the four years a major symptom of my acid reflux were heart palpatations. They started at the same time I started with reflux and cleared up after the surgery. I have been reflux free palpitation free and antacid free for four months. then I was put on Gabapentin for back spasm and the reflux returned along with the palpitations. Medics keep insisting this is just anxiety yet eat a food that gives me reflux also starts the palps which is the indicator of the reflux as I do not have heartburn. Comes on when relaxing and eating watching tv ( no anxiety present) and when I am sleeping peacefully ( no anxiety present) my heart wakes me up and fires off into tachycardia. Recently a doctor has said it is now known that acid reflux irritates the nerves in the solar plexus area and that triggers the palps. Anyone else experienced this? Are there any studies on it at all? Thanks all.
  • I have been having a horrible reaction to tramadol now from the er doctor. what do i do now for pain . i've tried the shots made things even worse. so many trials it's hurts 2 try to gr better ? (3 answers)
    Tramadol so been making me so sick from the ER doctor 2 c my doctor if I can hold on. It's a shame ! So many things they keep trying . It's pain not the knew in thing of treating fibromyalgia. Disk problems nerve sciatic. Anxiety u wouldn't believe. I've talked to the FDA
    I don't feel safe at all anymore and want to get better . My family gets so upset and we all have lives to live but mine has been on hold 4-5yrs. Just to do the simple things then I have to rest. It's sad . I've always been active . And watch out for Savella !! My god all I would like is to fel better. I can't believe all the things I've read about tramadol it makes me mad that an ER doctor gave it to me first and I told doctors and pain management It wsnt helping. Can't sleep anger horrible thoughts.please I can't do those shots they made things even worse and they don't help me.

More questions for: Methotrexate, Tramadol

You may be interested at these reviews (Write a review):

  • No noticeable effects
    No noticeable effects when used together. Tramadol dose 50-100 mg's four times a day.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • I wish i had never taken ambien
    Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered Ambien and since I had obviously needed the help sleeping I took it. For the next 10 years I suffered incredible depression. For example I remember laying in bed staring at the ceiling with tears rolling into my ears but I was too tired to wipe them away and realizing that I wanted to die so badly but there was no way I could have done anything about it. The worst effects were the loss of consciousness and the verbal abuse that I heaped on my husband and son. An example of each : I actually had sex with my husband that I could not remember amd hundreds of other actions and discussions. My husband started asking every morning what I remembered of the night before. He could usually tell when I was Ambien-awake (his name for it) he said my eyes would get glassy and my voice cadence would be off. Unfortunately my oldest son was going from infant to 8 years old at this time and any ifraction or even without provocation I would scream horrible things in his face. I don't remember much of it but what I do remember causes me enormous regret. He went from a happy and active toddler to a terrified amd anxious pre-teen. We are still working through the effects of this behavior. Finally, after a surprise pregnancy (see example above) My baby was placed in NICU and I stayed at the Ronald McDonald House and my son and husband visited when they could. Somehow my Ambien prescription was stopped and so I began going through withdrawal but I had no idea what was going on. My vision became so blurred thqt I couldn't identify items unless they were very large and then only by colors. When I visited my son those several days in the NICU I couldn't walk straight and would try to aim myself toward my goal until I hit a wall and I would correct course. These things didn't bother me at all but the nurses in the NICU were with me nearly the entire day because they were afraid I would have a stroke or who knew. Finally, after discussing these symptoms we decided to gradually stop the medication. Thankfully, i didn't have any withdrawal symptoms then. I did feel like an incredibly heavy and black blanket had been lifted away. Ever since I have had very little trouble with depression despite the continuation of sleep disturbance and pain. On a scale from one to 10 for depression with 10 being committing suicide I think my 10 years on the medicine was probably an 8.5 (I desperately wanted to die) and since stopping the medication I don't think it has gone above a 4 and is usually a 2 or 3. I will spend the rest of my life trying to repair the damage my verbal abuse caused my oldest son and my husband. For 10 years they lived in fear of my rages if I had a bad episode with Ambien.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.

More reviews for: Methotrexate, Tramadol

Comments from related studies:

  • From this study (8 months ago):

  • The abnormal dreams & mild hallucinations came only after starting the methylprednisolone a few days ago. They happen primarily when I am sleeping. I woke up last night with very unusual dreams & head/brain pain, and was quite concerned. I had taken 1 methylprednisolone & 1 cymbalta before bed. Earlier in the day, I had taken 2 methylprednisolone & 2 tramadol before a nap, and had similar, though not as severe issues. Trying to figure out what the interaction problem is. I did not take the muscle relaxant (cyclopenzaprine) before bed since I started the cortico steroid pack.

    Reply

    britsarmymom on Apr, 26, 2014:

    Mother just survived near brush with respiratory arrest. Hallucinated at night on Tramadol, argumentative with RN who reported her to MD. He planned to ADD Seroquel 25 mg to Tramadol, Neurontin, Remeron and Ativan in rehab facility. She declined Tramadol and Seroquel and was still so sedated her pulse ox went down to 84 with long periods of apnea and need for constant obs with frequent rousing for airway. MAJOR struggle with RN to get 02 and MD agreed to no more Tramodol at night and absolutely no Seroquel. How many elderly are lost this way?

    Reply

  • From this study (10 months ago):

  • suspicious lung nodule seen in x-ray, going in for a cat scan

    Reply

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Complete drug side effects:

On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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