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Review: taking Tussionex Pennkinetic and Benadryl together

Summary: drug interactions are reported among people who take Tussionex Pennkinetic and Benadryl together. This review analyzes the effectiveness and drug interactions between Tussionex Pennkinetic and Benadryl. It is created by eHealthMe based on reports of 116 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>


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What are the drugs

Tussionex pennkinetic has active ingredients of chlorpheniramine polistirex; hydrocodone polistirex. It is often used in cough. (latest outcomes from 192 Tussionex pennkinetic users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,405 Benadryl users)

On May, 1, 2015: 116 people who take Tussionex Pennkinetic, Benadryl are studied

Tussionex Pennkinetic, Benadryl outcomes

Drug combinations in study:
- Tussionex Pennkinetic (chlorpheniramine polistirex; hydrocodone polistirex)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tussionex Pennkinetic is effective0.00%
(0 of 1 people)
Benadryl is effective0.00%
(0 of 1 people)

Drug effectiveness by gender :

Tussionex Pennkinetic is effectiven/a0.00%
(0 of 1 people)
Benadryl is effectiven/a0.00%
(0 of 1 people)

Drug effectiveness by age :

Tussionex Pennkinetic is effectiven/an/an/an/a0.00%
(0 of 1 people)
Benadryl is effectiven/an/an/an/a0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Malignant Neoplasm Progressionn/an/an/aHeadacheAbdominal Pain Uppern/aAnaemia
VomitingMuscle CrampsGeneral Physical Health DeteriorationBack Pain
NauseaMuscle PainParaesthesiaFall
Speech DisorderSinusitis
Emotional DistressArthralgia
ClumsinessAbdominal Pain Upper
InjuryGait Disturbance
Biliary ColicPain

Most common drug interactions by gender * :

FallBack Pain
AnaemiaFlank Pain
Gait DisturbanceDecreased Appetite
Back PainCrohn's Disease
HeadacheGroin Pain
FatiguePain In Extremity
ContusionMulti-organ Disorder
AnxietyIrritable Bowel Syndrome

Most common drug interactions by age * :

n/an/aUrinary Tract InfectionPain In ExtremityMycosis FungoidesAbdominal Pain UpperPainMalignant Neoplasm Progression
Staphylococcal InfectionChest PainJoint SwellingGallbladder DisorderHeadacheRenal Failure Acute
Visual DisturbanceCardiac DisorderFallMigraineAnxietyCoronary Artery Stenosis
Weight DecreasedGastrointestinal DisorderBronchitisApraxiaDizzinessCoronary Artery Occlusion
Weight IncreasedFlank PainContusionCerebral InfarctionSinusitisProthrombin Level Decreased
InfluenzaDecreased AppetitePruritusInjuryDehydrationDiarrhoea Nos
Hepatic CirrhosisCrohn's DiseaseSkin LesionBiliary ColicAnaemiaDilatation Ventricular
CystitisGroin PainPhotopheresisAnxietyEating DisorderCulture Positive
CoughIleitisAcneMuscular WeaknessAnhedoniaCoronary Artery Disease
DehydrationMulti-organ DisorderSkin UlcerEmotional DistressBack PainLeft Ventricular End-diastolic Pressure Increased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Tussionex Pennkinetic and Benadryl?


You are not alone! Join a related support group:
- support group for people who take Benadryl
- support group for people who take Tussionex Pennkinetic

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Benadryl, Tussionex Pennkinetic

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Complete drug side effects:

On eHealthMe, Tussionex Pennkinetic (chlorpheniramine polistirex; hydrocodone polistirex) is often used to treat cough. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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