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Review: Valproate and Topiramate

This review analyzes the effectiveness and drug interactions between Valproate and Topiramate. It is created by eHealthMe based on reports of 734 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Valproate and Topiramate >>>

What are the drugs

Valproate sodium (latest outcomes from 12,628 users) has active ingredients of valproate sodium. It is often used in epilepsy.

Topiramate (latest outcomes from 8,357 users) has active ingredients of topiramate. It is often used in migraine.

On Sep, 21, 2014: 734 people who take Valproate Sodium, Topiramate are studied

Valproate Sodium, Topiramate outcomes

Drug combinations in study:
- Valproate Sodium (valproate sodium)
- Topiramate (topiramate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Valproate Sodium is effectiven/a0.00%
(0 of 2 people)
(0 of 1 people)
(1 of 1 people)
(1 of 2 people)
(2 of 3 people)
Topiramate is effectiven/a0.00%
(0 of 1 people)
(3 of 4 people)
(1 of 2 people)
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
ConvulsionConvulsionPyrexiaHypothyroidismMemory ImpairmentPyrexiaMetabolic EncephalopathyConvulsion
SomnolenceCytomegalovirus InfectionMyocarditisPyrexiaPsychotic DisorderInfluenza A Virus Test PositiveHepatosplenomegalyDrug Ineffective
Drug IneffectiveStatus EpilepticusDrug Rash With Eosinophilia And Systemic SymptomsThyroiditisHeadacheC-reactive Protein IncreasedHepatic SteatosisStatus Epilepticus
Psychotic DisorderHiv InfectionThyroiditisRashLoss Of ConsciousnessWhite Blood Cell Count DecreasedPleural EffusionSomnolence
BradycardiaDrug IneffectiveRashMyocarditisDisturbance In AttentionPlatelet Count DecreasedPyrexiaWeight Decreased
Ammonia IncreasedIntentional Self-injuryBlood Creatine Phosphokinase IncreasedDrug Rash With Eosinophilia And Systemic SymptomsVisual ImpairmentElectroencephalogram AbnormalDisseminated Intravascular CoagulationGrand Mal Convulsion
Thyroiditis SubacuteGamma-glutamyltransferase IncreasedCardiomegalyVentricular FibrillationDeafnessPain In ExtremityCerebral HaemorrhagePyrexia
Respiratory Failure (excl Neonatal)SomnolenceHepatic Function AbnormalPancytopeniaScotomaDrug Effect DecreasedHepatic FailureCondition Aggravated
Cerebral OedemaTraumatic Liver InjuryVomitingCardiac FailureTransverse Sinus ThrombosisSleep Phase Rhythm DisturbanceExanthemDrug Exposure During Pregnancy
DepressionLoss Of ConsciousnessHypothyroidismHyperthyroidismJugular Vein ThrombosisFoetal Valproate SyndromeCholestasisHyperammonaemia

Drug effectiveness by gender :

Valproate Sodium is effective42.86%
(3 of 7 people)
(1 of 2 people)
Topiramate is effective42.86%
(3 of 7 people)
(1 of 1 people)

Most common drug interactions by gender * :

Drug IneffectiveConvulsion
Status EpilepticusSomnolence
ConvulsionDrug Ineffective
Grand Mal ConvulsionPyrexia
Condition AggravatedSepsis
Drug Exposure During PregnancyWeight Decreased
IrritabilityBlood Glucose Increased
Weight IncreasedRenal Failure
Memory ImpairmentPsychotic Disorder

Drug effectiveness by age :

Valproate Sodium is effective100.00%
(1 of 1 people)
(1 of 1 people)
(0 of 1 people)
(2 of 3 people)
(0 of 3 people)
(0 of 1 people)
(0 of 1 people)
Topiramate is effective0.00%
(0 of 1 people)
(1 of 1 people)
(0 of 1 people)
(3 of 4 people)
(0 of 3 people)
(0 of 1 people)

Most common drug interactions by age * :

Depressed Level Of ConsciousnessPyrexiaConvulsionAggressionPsychotic DisorderWeight DecreasedDyspnoeaAgitation
Drug Exposure During PregnancyStatus EpilepticusDrug IneffectiveAbnormal BehaviourConvulsionSomnolenceHemiparesisIleus
ConvulsionHyperammonaemiaEpilepsyDisturbance In AttentionDrug IneffectiveFatigueAnticonvulsant Drug Level IncreasedSomnolence
Plasmodium Falciparum InfectionDrug IneffectiveSomnolenceImpulse-control DisorderMental DisorderMemory ImpairmentConvulsionBlood Creatinine Increased
IrritabilityAnorexiaUnresponsive To StimuliSudden Unexplained Death In EpilepsyHallucination, AuditoryBlood Glucose IncreasedCondition AggravatedAggression
Foetal Anticonvulsant SyndromeRashVomitingGrand Mal ConvulsionBlood Cholesterol IncreasedWeight IncreasedGait DisturbanceCardiac Arrest
Cleft PalateErythemaStevens Johnson SyndromeConvulsionWeight DecreasedBlood Cholesterol IncreasedPain In ExtremityMyocardial Infarction
PyrexiaCondition AggravatedLoss Of ConsciousnessConfusional StateMalaiseHeadache NosEpilepsy AggravatedElectroencephalogram Abnormal
Atrial Septal DefectAstheniaGrand Mal ConvulsionMood AlteredBlood Glucose IncreasedStuporPeripheral Neuropathy NecMania
Disease RecurrenceHepatic FailureDizzinessWeight DecreasedDecreased AppetiteMetabolic AcidosisAlopeciaAbdominal Distension

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Valproate and Topiramate?

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More reviews for: Topiramate, Valproate Sodium

Complete drug side effects:

On eHealthMe, Valproate Sodium (valproate sodium) is often used to treat epilepsy. Topiramate (topiramate) is often used to treat migraine. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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