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Review: Valproate and Topiramate

This review analyzes the effectiveness and drug interactions between Valproate and Topiramate. It is created by eHealthMe based on 727 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 6, 2014: 727 people who reported to have interactions when taking Valproate Sodium, Topiramate are studied

Trend of Valproate Sodium, Topiramate's drug interactions, side effects and effectiveness reports (3131933)

Drug combinations in study:
- Valproate Sodium (valproate sodium)
- Topiramate (topiramate)

eHealthMe real world results:

Most common interactions experienced by people in the use of Valproate Sodium, Topiramate:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Drug Interaction177
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)176
Pyrexia (fever)157
Somnolence (a state of near-sleep, a strong desire for sleep)151
Drug Ineffective130
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)120
Renal Failure (kidney dysfunction)109
Grand Mal Convulsion (a type of generalized seizure that affects the entire brain)86
Weight Decreased86
Aggression80

Most common interactions experienced by people in long term use of Valproate Sodium, Topiramate:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Pyrexia (fever)33
Rash (redness)33
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)24
Memory Impairment24
Platelet Count Decreased24
Drug Rash With Eosinophilia And Systemic Symptoms (adverse drug reactions with rash)20
Thyroiditis (inflammation of thyroid gland)20
Myocarditis (inflammation of heart muscle myocardium)20
White Blood Cell Count Decreased16
Cardiomegaly (increased size of heart than normal)12

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Valproate Sodium0.00%50.00%0.00%50.00%0.00%
Topiramate0.00%0.00%100.00%0.00%0.00%

Top conditions involved for these people * :

  1. Epilepsy
  2. Convulsion
  3. Drug exposure during pregnancy
  4. Status epilepticus
  5. Partial seizures

Top co-used drugs for these people * :

  1. Topamax
  2. Lamotrigine
  3. Carbamazepine
  4. Lamictal
  5. Clonazepam

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Topiramate, Valproate Sodium

You can also:

Complete drug side effects:

On eHealthMe, Valproate Sodium (valproate sodium) is often used to treat epilepsy. Topiramate (topiramate) is often used to treat migraine. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (7 months ago):

  • Unable to concentrate for any length of time
    Unable to organise myself like I previously could
    Unable to think logically / sequence things or prioritise things
    Unable to remember anything short term
    Find it difficult to retain instructions


    Reply

Can you answer these questions (what is this?):

More questions for: Topiramate, Valproate Sodium

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More reviews for: Topiramate, Valproate Sodium

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Related studies

- Topiramate side effects
- Valproate Sodium side effects

 

 

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