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Review: taking Wellbutrin and Zyrtec together

Summary: drug interactions are reported among people who take Wellbutrin and Zyrtec together. This review analyzes the effectiveness and drug interactions between Wellbutrin and Zyrtec. It is created by eHealthMe based on reports of 1,290 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>


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What are the drugs

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. (latest outcomes from 55,119 Wellbutrin users)

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. (latest outcomes from 29,990 Zyrtec users)

On May, 9, 2015: 1,290 people who take Wellbutrin, Zyrtec are studied

Wellbutrin, Zyrtec outcomes

Drug combinations in study:
- Wellbutrin (bupropion hydrochloride)
- Zyrtec (cetirizine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Wellbutrin is effective33.33%
(2 of 6 people)
(5 of 21 people)
(7 of 12 people)
(8 of 20 people)
(16 of 26 people)
(9 of 17 people)
(8 of 12 people)
(0 of 1 people)
Zyrtec is effective45.45%
(5 of 11 people)
(0 of 9 people)
(7 of 11 people)
(5 of 14 people)
(24 of 38 people)
(10 of 17 people)
(9 of 13 people)
(0 of 1 people)

Drug effectiveness by gender :

Wellbutrin is effective51.52%
(51 of 99 people)
(4 of 16 people)
Zyrtec is effective51.02%
(50 of 98 people)
(10 of 15 people)

Drug effectiveness by age :

Wellbutrin is effectiven/an/an/a33.33%
(13 of 39 people)
(8 of 60 people)
(21 of 50 people)
(8 of 26 people)
(5 of 29 people)
Zyrtec is effectiven/an/an/a31.58%
(12 of 38 people)
(15 of 61 people)
(16 of 49 people)
(13 of 27 people)
(4 of 12 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DepressionNauseaCondition AggravatedPulmonary EmbolismDepressionMemory ImpairmentHeadachePain
Drug IneffectiveHeadacheHeadacheInjuryIrritabilityFrequent HeadachesItchingAnxiety
InsomniaDizzinessCervical Root PainHeadacheInsomniaLibido DecreasedTemporomandibular Joint SyndromeNausea
FatigueVomitingConvulsionPremature BabyDyspepsiaDepressionParosmiaDepression
Congenital Cystic Kidney DiseaseHypertensionGallbladder DisorderAsthmaGastric UlcerLoss Of ConsciousnessLibido DecreasedFatigue
RashEye PainCholecystitis ChronicDrug Exposure During PregnancyBladder DisorderSuicidal IdeationGas - FlatulenceFall
DizzinessCongenital Cystic Kidney DiseaseEmotional DistressPre-eclampsiaHypertensionPanic DisorderEpistaxisBack Pain
Rash GeneralisedNeuralgiaCor Pulmonale ChronicDeliveryEmotional DistressNeck PainDry MouthDyspnoea
Suicidal IdeationHyperhidrosisFatigueInduced LabourChest PainBack PainSinus CongestionArthralgia
UrticariaRed Blood Cell Count DecreasedRenal Failure ChronicAnxietyLeft Ventricular FailureHallucinationArthralgiaConstipation

Most common drug interactions by gender * :

FatigueDrug Ineffective
Pain In ExtremityHeadache

Most common drug interactions by age * :

OrthopnoeaMuscle SpasmsSuicidal IdeationPainDepressionPainPainFatigue
Nervous System DisorderEye Movement DisorderWeight IncreasedInjuryAbdominal PainAnxietyAnxietyNausea
Pancreatitis AcuteDystoniaAnxietyCholelithiasisInsomniaNauseaHeadacheDrug Ineffective
PneumoniaDyskinesiaDiabetes MellitusCholecystitis AcuteFatigueBack PainDepressionFall
TremorDifficulty In WalkingVomitingNauseaConstipationHeadacheArthralgiaDyspnoea
Renal ImpairmentDysgeusiaDiabetes MellitusBronchitisAnaemiaNauseaPain
HypotensionConvulsionDiabetic KetoacidosisWeight IncreasedOsteonecrosis Of JawDizzinessPruritus
HyponatraemiaHeadacheCompleted SuicideGastrooesophageal Reflux DiseaseOedema PeripheralWeight DecreasedDepression
BradycardiaObesityAbdominal PainContusionConstipationFatigueMalaise
Cholecystitis ChronicAsthmaMetrorrhagiaBlood Pressure IncreasedDrug IneffectiveDyspnoeaHeadache

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Wellbutrin and Zyrtec on

Do you take Wellbutrin and Zyrtec?


You are not alone! Join a related support group:
- support group for people who take Wellbutrin
- support group for people who take Zyrtec

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Wellbutrin, Zyrtec

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More reviews for: Wellbutrin, Zyrtec

Comments from related studies:

  • From this study (4 months ago):

  • coolaero on Feb, 7, 2015:

    there wont be side effect other that DEATH


    peanuts on Mar, 31, 2010:

    my friend is suffering from rhumatory arthertis.and is currenty taking cocaine. oxy cotin,prestine, wellbutrim, predisone 10mg what side effects should she expect ?????


    mtntexas on May, 11, 2013:

    Just ask John Belushi


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Wellbutrin (bupropion hydrochloride) is often used to treat depression. Zyrtec (cetirizine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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