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Review: taking Wellbutrin and Zyrtec together

Summary: drug interactions are reported among people who take Wellbutrin and Zyrtec together.

This review analyzes the effectiveness and drug interactions between Wellbutrin and Zyrtec. It is created by eHealthMe based on reports of 1,288 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 5, 2015: 1,288 people who take Wellbutrin, Zyrtec are studied

Wellbutrin, Zyrtec outcomes

Drug combinations in study:
- Wellbutrin (bupropion hydrochloride)
- Zyrtec (cetirizine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Wellbutrin is effective33.33%
(2 of 6 people)
(5 of 21 people)
(6 of 11 people)
(8 of 20 people)
(15 of 25 people)
(9 of 17 people)
(8 of 12 people)
(0 of 1 people)
Zyrtec is effective45.45%
(5 of 11 people)
(0 of 8 people)
(7 of 11 people)
(5 of 14 people)
(24 of 37 people)
(10 of 17 people)
(9 of 13 people)
(0 of 1 people)

Drug effectiveness by gender :

Wellbutrin is effective51.02%
(50 of 98 people)
(3 of 15 people)
Zyrtec is effective51.55%
(50 of 97 people)
(10 of 14 people)

Drug effectiveness by age :

Wellbutrin is effectiven/an/an/a33.33%
(13 of 39 people)
(6 of 56 people)
(21 of 50 people)
(8 of 26 people)
(5 of 29 people)
Zyrtec is effectiven/an/an/a31.58%
(12 of 38 people)
(15 of 57 people)
(16 of 49 people)
(13 of 27 people)
(4 of 12 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DepressionNauseaCondition AggravatedPulmonary EmbolismDepressionMemory ImpairmentHeadachePain
Drug IneffectiveHeadacheHeadacheInjuryIrritabilityFrequent HeadachesItchingAnxiety
InsomniaDizzinessCervical Root PainHeadacheInsomniaLibido DecreasedTemporomandibular Joint SyndromeNausea
FatigueVomitingConvulsionPremature BabyDyspepsiaDepressionParosmiaDepression
Congenital Cystic Kidney DiseaseHypertensionGallbladder DisorderAsthmaGastric UlcerLoss Of ConsciousnessLibido DecreasedFatigue
RashEye PainCholecystitis ChronicDrug Exposure During PregnancyBladder DisorderSuicidal IdeationGas - FlatulenceFall
DizzinessCongenital Cystic Kidney DiseaseEmotional DistressPre-eclampsiaHypertensionPanic DisorderEpistaxisBack Pain
Rash GeneralisedNeuralgiaCor Pulmonale ChronicDeliveryEmotional DistressNeck PainDry MouthDyspnoea
Suicidal IdeationHyperhidrosisFatigueInduced LabourChest PainBack PainSinus CongestionArthralgia
UrticariaRed Blood Cell Count DecreasedRenal Failure ChronicAnxietyLeft Ventricular FailureHallucinationArthralgiaConstipation

Most common drug interactions by gender * :

FatigueDrug Ineffective
Pain In ExtremityNausea
DyspnoeaChest Pain

Most common drug interactions by age * :

OrthopnoeaMuscle SpasmsSuicidal IdeationPainDepressionPainPainFatigue
Nervous System DisorderEye Movement DisorderWeight IncreasedInjuryAbdominal PainAnxietyAnxietyNausea
Pancreatitis AcuteDystoniaAnxietyCholelithiasisInsomniaNauseaHeadacheDrug Ineffective
PneumoniaDyskinesiaDiabetes MellitusCholecystitis AcuteFatigueBack PainDepressionFall
TremorDifficulty In WalkingVomitingNauseaConstipationHeadacheArthralgiaDyspnoea
Renal ImpairmentDysgeusiaDiabetes MellitusWeight IncreasedAnaemiaNauseaPain
HypotensionConvulsionDiabetic KetoacidosisBronchitisOsteonecrosis Of JawDizzinessPruritus
HyponatraemiaHeadacheCompleted SuicideGastrooesophageal Reflux DiseaseOedema PeripheralWeight DecreasedDepression
BradycardiaObesityAbdominal PainContusionConstipationFatigueMalaise
Cholecystitis ChronicAsthmaMetrorrhagiaBlood Pressure IncreasedDrug IneffectiveDyspnoeaHeadache

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Wellbutrin
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Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Wellbutrin (bupropion hydrochloride) is often used to treat depression. Zyrtec (cetirizine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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