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Review: taking Wellbutrin and Zyrtec together

Summary: drug interactions are reported among people who take Wellbutrin and Zyrtec together.

This review analyzes the effectiveness and drug interactions between Wellbutrin and Zyrtec. It is created by eHealthMe based on reports of 1,287 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Wellbutrin and Zyrtec >>>

What are the drugs

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. (latest outcomes from 55,029 Wellbutrin users)

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. (latest outcomes from 29,951 Zyrtec users)

On Jan, 3, 2015: 1,287 people who take Wellbutrin, Zyrtec are studied

Wellbutrin, Zyrtec outcomes

Drug combinations in study:
- Wellbutrin (bupropion hydrochloride)
- Zyrtec (cetirizine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Wellbutrin is effective33.33%
(2 of 6 people)
(5 of 21 people)
(6 of 11 people)
(8 of 20 people)
(15 of 25 people)
(9 of 16 people)
(8 of 12 people)
(0 of 1 people)
Zyrtec is effective45.45%
(5 of 11 people)
(0 of 8 people)
(7 of 11 people)
(5 of 14 people)
(23 of 36 people)
(10 of 17 people)
(9 of 13 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DepressionNauseaCondition AggravatedPulmonary EmbolismDepressionMemory ImpairmentHeadachePain
Drug IneffectiveHeadacheHeadacheInjuryIrritabilityFrequent HeadachesItchingAnxiety
InsomniaDizzinessCervical Root PainHeadacheInsomniaLibido DecreasedTemporomandibular Joint SyndromeNausea
FatigueVomitingConvulsionPremature BabyDyspepsiaDepressionParosmiaDepression
Congenital Cystic Kidney DiseaseHypertensionGallbladder DisorderAsthmaGastric UlcerLoss Of ConsciousnessLibido DecreasedFatigue
RashEye PainCholecystitis ChronicDrug Exposure During PregnancyBladder DisorderSuicidal IdeationGas - FlatulenceFall
DizzinessCongenital Cystic Kidney DiseaseEmotional DistressPre-eclampsiaHypertensionPanic DisorderEpistaxisBack Pain
Rash GeneralisedNeuralgiaCor Pulmonale ChronicDeliveryEmotional DistressNeck PainDry MouthDyspnoea
Suicidal IdeationHyperhidrosisFatigueInduced LabourChest PainBack PainSinus CongestionArthralgia
UrticariaRed Blood Cell Count DecreasedRenal Failure ChronicAnxietyLeft Ventricular FailureHallucinationArthralgiaConstipation

Drug effectiveness by gender :

Wellbutrin is effective51.55%
(50 of 97 people)
(3 of 15 people)
Zyrtec is effective51.04%
(49 of 96 people)
(10 of 14 people)

Most common drug interactions by gender * :

FatigueDrug Ineffective
Pain In ExtremityNausea
DyspnoeaChest Pain

Drug effectiveness by age :

Wellbutrin is effectiven/an/an/a33.33%
(13 of 39 people)
(6 of 56 people)
(21 of 50 people)
(8 of 25 people)
(5 of 29 people)
Zyrtec is effectiven/an/an/a31.58%
(12 of 38 people)
(15 of 57 people)
(16 of 49 people)
(12 of 26 people)
(4 of 12 people)

Most common drug interactions by age * :

OrthopnoeaMuscle SpasmsSuicidal IdeationPainDepressionPainPainFatigue
Nervous System DisorderEye Movement DisorderWeight IncreasedInjuryAbdominal PainAnxietyAnxietyNausea
Pancreatitis AcuteDystoniaAnxietyCholelithiasisInsomniaNauseaHeadacheDrug Ineffective
PneumoniaDyskinesiaDiabetes MellitusCholecystitis AcuteFatigueBack PainDepressionFall
TremorDifficulty In WalkingVomitingNauseaConstipationHeadacheArthralgiaDyspnoea
Renal ImpairmentDysgeusiaDiabetes MellitusWeight IncreasedAnaemiaNauseaPain
HypotensionConvulsionDiabetic KetoacidosisBronchitisOsteonecrosis Of JawDizzinessPruritus
HyponatraemiaHeadacheCompleted SuicideGastrooesophageal Reflux DiseaseOedema PeripheralWeight DecreasedDepression
BradycardiaObesityAbdominal PainContusionConstipationFatigueMalaise
Cholecystitis ChronicAsthmaMetrorrhagiaBlood Pressure IncreasedDrug IneffectiveDyspnoeaHeadache

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Wellbutrin and Zyrtec?

You are not alone! Join a related mobile support group:
- support group for people who take Wellbutrin and Zyrtec
- support group for people who take Wellbutrin
- support group for people who take Zyrtec

Can you answer these questions (Ask a question):

More questions for: Wellbutrin, Zyrtec

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    I was given a prescription for Wellbutrin in approximately 1998. I had has my ocular pressure checked a year prior to this and it was okay. At the time, I only needed to wear reading glasses, common in people over 45. I took the drug at the full prescribed dosage for two weeks. Immediately prior to the narrow angle glaucoma episode, my vision had actually seemed to improve. For one day, prior, I could read without reading glasses. The following night, I was watching tv, and things suddenly became foggy. It was actually as if a fog had enveloped the room. I could not see anything except to discern between light and dark areas. I had to have emergency laser surgery the next morning. I mentioned to the doctor that Iwas taking Wellbutrin to stop smoking, and asked if it could have caused the ocular pressure increase. he consulted the PDR, and said there was no mention of it causing increases in ocular pressure. One year later my primary care doctor again insisted that I stop smoking, and again I mentioned that I thought it might increase ocular pressure. She told me to take a half dose, I did, and I took it one week, at which time I again experienced another episode of narrow angle glaucoma. When I go to the doctor's office my pressure in my left eye was 72, and 68 in my right eye. I was then referred on a triage basis to another doctor. I spent the rest of the day in his office having drops administered every fifteen minutes(extremely painful). I had extensive laser surgery the next morning.It required over fifty shots from the laser machine into each eye, (also extremely painful). I had lost considerable peripheral AND CENTRAL VISION in my left eye, and a good deal in my right. As a result of having to have such extensive laser surgery I also had cataracts that began at 50% maturity. I was advised by the surgeon that I should wait to have the cataracts removed "until my vision and quality of life was so poor that I was ready to commit suicide" because having the cataracts removed would cause the pressure in my eyes to become very difficult to control, and that more than likely I would end up being black blind. I would never use Wellbutrin under any circumstances, and I always check to make sure that any new meds I may be put on don't have anything to do with an increase in ocular pressure. If they do, I refuse to take them. The surgeon said he was surprised that I didn't lose more vision than I did, and I am grateful that I didn't, and that he was a good surgen. He wrote an article concerning this case for a medical journal since he said he had been seeing a recent increase of narrow angle glaucoma.
  • Librium 25mg and wellbutrin 300mg for >1 month
    I've been taking librium twice daily, morning and night, for about 3 months now along with wellbutrin XL in the morning. I've basically had the mood of "I don't care" and a great boost in confidence.
  • Bedwetting with paxil and wellbutrin
    I have been using both of these drugs and now have bedwetting issues 5 times a week on average. I would rate the bedwetting as moderate about a6/10 but my wife and I can live with this as she had made the comment " you are back to the man I married ". I started taking these due to depression about work and anxiety about work. We both think we can live with the bedwetting as no one needs to know about it
  • Wellbutrin caused my trigeminal neurlagia
    So I'm writing this to hopefully shed light to other users in the same position I was in. I had taken Wellbutrin for about 4 years. The pain experienced in my face was excruciatingly painful. It was just on one side of my face between my temple and upper lip. All the symptoms reflected Trigeminal Neuralgia. But even with an MRI nothing could be found. I suffered for 3 of those years with pain coming and going, not understanding what was going on. Finally one day I decided hell with Wellbutrin and just stopped taking it. It's been 6 months now and I have yet to have a single shred of pain. Coincidence? I doubt it.

More reviews for: Wellbutrin, Zyrtec

Comments from related studies:

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  • Urination is minimal, pain in area of left ovary.


  • From this study (3 months ago):

  • peanuts on Mar, 31, 2010:

    my friend is suffering from rhumatory arthertis.and is currenty taking cocaine. oxy cotin,prestine, wellbutrim, predisone 10mg what side effects should she expect ?????


    mtntexas on May, 11, 2013:

    Just ask John Belushi


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Complete drug side effects:

On eHealthMe, Wellbutrin (bupropion hydrochloride) is often used to treat depression. Zyrtec (cetirizine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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