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Review: taking Wellbutrin and Cannabis together

Summary: drug interactions are reported among people who take Wellbutrin and Cannabis together.

This review analyzes the effectiveness and drug interactions between Wellbutrin and Cannabis. It is created by eHealthMe based on reports of 117 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 26, 2015: 117 people who take Wellbutrin, Cannabis are studied

Wellbutrin, Cannabis outcomes

Drug combinations in study:
- Wellbutrin (bupropion hydrochloride)
- Cannabis (marijuana)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Wellbutrin is effectiven/a20.00%
(1 of 5 people)
(1 of 1 people)
(1 of 2 people)
(2 of 7 people)
(2 of 3 people)
Cannabis is effective100.00%
(2 of 2 people)
(3 of 5 people)
(1 of 1 people)
(3 of 4 people)
(1 of 1 people)
(3 of 5 people)

Drug effectiveness by gender :

Wellbutrin is effective45.45%
(5 of 11 people)
(2 of 7 people)
Cannabis is effective72.73%
(8 of 11 people)
(5 of 7 people)

Drug effectiveness by age :

Wellbutrin is effectiven/an/a66.67%
(2 of 3 people)
(1 of 10 people)
(4 of 15 people)
Cannabis is effectiven/an/a33.33%
(1 of 3 people)
(5 of 9 people)
(6 of 15 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Angular CheilitisDiplopiaHeadachen/aAngular CheilitisDepression SuicidalPancreatitisAnxiety
Tongue IrritationDepressionHypoglycemiaHair LossDiabetes MellitusBone Disorder
DiplopiaBreathlessnessTongue IrritationTardive DyskinesiaDepression
DepressionPain Threshold DecreasedNightmareHair LossPain
InsomniaInsomniaDepression SuicidalInsomniaOsteonecrosis Of Jaw
Pain Threshold DecreasedNightmareFatigueLethargyChest Pain
Swallowing DifficultyFall
Pain - BackNausea
Pain - JointsBone Lesion
Common ColdPain In Extremity

Most common drug interactions by gender * :

PainDecreased Interest
Urinary IncontinenceDental Caries
DiarrhoeaGeneral Physical Health Deterioration
FatiguePain In Jaw
LacerationVentricular Tachycardia

Most common drug interactions by age * :

n/an/aPleural EffusionCompleted SuicideOsteomyelitisAnxietyPyrexiaRenal Failure
Pulmonary HaemorrhageDrug ToxicityAnxietyChest PainAnxiety
Sinus TachycardiaConvulsionPyrexiaSuicidal IdeationLaceration
Ventricular FibrillationDeliriumImpaired HealingAbdominal Pain UpperInsomnia
Circulatory CollapseHypotensionLeft Ventricular HypertrophyDyspepsiaFatigue
Ventricular TachycardiaBody Temperature IncreasedGeneral Physical Health DeteriorationNauseaAnaemia
Cardiac ArrestRespiratory ArrestHallucinationDepressionPollakiuria
Acute Respiratory Distress SyndromeDeath Of RelativeFlushingBlood Cholesterol IncreasedDyspnoea Exertional
ConvulsionMultiple Drug OverdoseHeadacheStressUrinary Incontinence
ComaOptic NeuritisDrug Screen PositiveGastrooesophageal Reflux DiseaseVomiting

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Cannabis
- support group for people who take Wellbutrin

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Wellbutrin (bupropion hydrochloride) is often used to treat depression. Cannabis (marijuana) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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