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Review: Wellbutrin and Vicodin

Summary: drug interactions are reported among people who take Wellbutrin and Vicodin together.

This review analyzes the effectiveness and drug interactions between Wellbutrin and Vicodin. It is created by eHealthMe based on reports of 3,624 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Wellbutrin and Vicodin >>>

What are the drugs

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. (view latest outcomes from 54,972 users)

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. (latest outcomes from Vicodin 35,316 users)

On Nov, 28, 2014: 3,623 people who take Wellbutrin, Vicodin are studied

Wellbutrin, Vicodin outcomes

Drug combinations in study:
- Wellbutrin (bupropion hydrochloride)
- Vicodin (acetaminophen; hydrocodone bitartrate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Wellbutrin is effective6.90%
(2 of 29 people)
(18 of 39 people)
(11 of 33 people)
(11 of 35 people)
(12 of 60 people)
(20 of 38 people)
(17 of 32 people)
(1 of 3 people)
Vicodin is effective44.90%
(22 of 49 people)
(10 of 35 people)
(5 of 14 people)
(21 of 52 people)
(28 of 60 people)
(15 of 30 people)
(7 of 20 people)
(7 of 9 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
IrritabilityDepressionDrug IneffectiveAnxietyDepressionDepressionDepressionPain
AmnesiaPainHaemorrhagic StrokeInjurySuicide AttemptNauseaExhaustion, Fatigue, Lethargy, Tiredness, WearinessDepression
Chest PainDrug IneffectiveDepressionPainPainInsomniaInsomniaNausea
Pain In ExtremityOedema PeripheralFatigueGeneral Physical Health DeteriorationSuicidal IdeationPainShort-term Memory LossBack Pain
Loss Of ConsciousnessArthralgiaDiabetes MellitusEmotional DistressHeadacheLoss Of ConsciousnessIntentional OverdoseDyspnoea
AnxietyAnxietyPainDeep Vein ThrombosisHypertensionFallFatigueFall
Respiratory FailureNauseaCholecystitis ChronicConvulsionRenal FailureFatigueBack PainFatigue
Suicidal IdeationCataractNauseaDrug IneffectiveEmotional DistressHeadacheCoughHeadache
Impaired Driving AbilityVomitingBlood Triglycerides IncreasedHaemorrhagic StrokeSleep Apnoea SyndromeTremorAbdominal PainArthralgia

Drug effectiveness by gender :

Wellbutrin is effective35.15%
(71 of 202 people)
(21 of 67 people)
Vicodin is effective41.67%
(85 of 204 people)
(30 of 64 people)

Most common drug interactions by gender * :

Back PainBack Pain
FallWeight Decreased
Pain In ExtremityFatigue

Drug effectiveness by age :

Wellbutrin is effectiven/an/a100.00%
(2 of 2 people)
(14 of 56 people)
(19 of 130 people)
(27 of 186 people)
(23 of 125 people)
(7 of 27 people)
Vicodin is effectiven/an/a100.00%
(2 of 2 people)
(17 of 50 people)
(21 of 128 people)
(33 of 170 people)
(32 of 126 people)
(10 of 32 people)

Most common drug interactions by age * :

Type 2 Diabetes MellitusUpper Respiratory Tract InfectionCholecystitis ChronicAnxietyDepressionPainPainAnxiety
Suicide AttemptWhite Blood Cell Count DecreasedPainPulmonary EmbolismAnxietyDepressionAnxietyNausea
FallRhinorrhoeaGallbladder DisorderPainPainAnxietyNauseaPneumonia
HaematocheziaHeart Rate IncreasedAbdominal Pain UpperChest PainWeight IncreasedNauseaDepressionArthralgia
Hepatitis CBlood Pressure DecreasedVomitingDeep Vein ThrombosisType 2 Diabetes MellitusDyspnoeaInsomniaFall
Deep Vein ThrombosisAccidental ExposureCholelithiasisDepressionNauseaBack PainAnaemiaPain
Systemic Lupus ErythematosusCholecystitisCholecystitis ChronicBack PainChest PainHeadacheFatigue
Pulmonary EmbolismInjuryAbdominal Pain UpperDiabetes MellitusHeadacheFallDepression
Drug Exposure Via Breast MilkAnxietyConstipationPain In ExtremityFatigueDiarrhoeaDyspnoea
Neuroleptic Malignant SyndromeDeep Vein ThrombosisMuscle SpasmsSuicidal IdeationOedema PeripheralBack PainVomiting

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Wellbutrin and Vicodin?

You are not alone! Join a related mobile support group:
- support group for people who take Wellbutrin and Vicodin
- support group for people who take Vicodin
- support group for people who take Wellbutrin

Can you answer these questions (Ask a question):

More questions for: Vicodin, Wellbutrin

You may be interested at these reviews (Write a review):

  • Intrsoccular pressure increase associated with wellbutrin
    I was given a prescription for Wellbutrin in approximately 1998. I had has my ocular pressure checked a year prior to this and it was okay. At the time, I only needed to wear reading glasses, common in people over 45. I took the drug at the full prescribed dosage for two weeks. Immediately prior to the narrow angle glaucoma episode, my vision had actually seemed to improve. For one day, prior, I could read without reading glasses. The following night, I was watching tv, and things suddenly became foggy. It was actually as if a fog had enveloped the room. I could not see anything except to discern between light and dark areas. I had to have emergency laser surgery the next morning. I mentioned to the doctor that Iwas taking Wellbutrin to stop smoking, and asked if it could have caused the ocular pressure increase. he consulted the PDR, and said there was no mention of it causing increases in ocular pressure. One year later my primary care doctor again insisted that I stop smoking, and again I mentioned that I thought it might increase ocular pressure. She told me to take a half dose, I did, and I took it one week, at which time I again experienced another episode of narrow angle glaucoma. When I go to the doctor's office my pressure in my left eye was 72, and 68 in my right eye. I was then referred on a triage basis to another doctor. I spent the rest of the day in his office having drops administered every fifteen minutes(extremely painful). I had extensive laser surgery the next morning.It required over fifty shots from the laser machine into each eye, (also extremely painful). I had lost considerable peripheral AND CENTRAL VISION in my left eye, and a good deal in my right. As a result of having to have such extensive laser surgery I also had cataracts that began at 50% maturity. I was advised by the surgeon that I should wait to have the cataracts removed "until my vision and quality of life was so poor that I was ready to commit suicide" because having the cataracts removed would cause the pressure in my eyes to become very difficult to control, and that more than likely I would end up being black blind. I would never use Wellbutrin under any circumstances, and I always check to make sure that any new meds I may be put on don't have anything to do with an increase in ocular pressure. If they do, I refuse to take them. The surgeon said he was surprised that I didn't lose more vision than I did, and I am grateful that I didn't, and that he was a good surgen. He wrote an article concerning this case for a medical journal since he said he had been seeing a recent increase of narrow angle glaucoma.
  • Librium 25mg and wellbutrin 300mg for >1 month
    I've been taking librium twice daily, morning and night, for about 3 months now along with wellbutrin XL in the morning. I've basically had the mood of "I don't care" and a great boost in confidence.
  • Bedwetting with paxil and wellbutrin
    I have been using both of these drugs and now have bedwetting issues 5 times a week on average. I would rate the bedwetting as moderate about a6/10 but my wife and I can live with this as she had made the comment " you are back to the man I married ". I started taking these due to depression about work and anxiety about work. We both think we can live with the bedwetting as no one needs to know about it
  • Wellbutrin caused my trigeminal neurlagia
    So I'm writing this to hopefully shed light to other users in the same position I was in. I had taken Wellbutrin for about 4 years. The pain experienced in my face was excruciatingly painful. It was just on one side of my face between my temple and upper lip. All the symptoms reflected Trigeminal Neuralgia. But even with an MRI nothing could be found. I suffered for 3 of those years with pain coming and going, not understanding what was going on. Finally one day I decided hell with Wellbutrin and just stopped taking it. It's been 6 months now and I have yet to have a single shred of pain. Coincidence? I doubt it.
  • Lorazepam nearly killed me during cancer treatment
    Day 31 of cold turkey and I want to die. It is a roller coaster from body tics and sweats to rage and crying in one day. I felt so good the 4h day of c/t. It was like before my cancer diagnosis. My bowels are better off Lorazepam. I threw up during bowel movements from the pain. Off Lorazepam first normal bowel movement in over 2 years. Stomach so damaged by Lorazepam that I have absolutely no appetite. I force myself to eat. Neuropathy in hands nearly gone. Feet are better but slower. Lymphedema that appeared after one year on Lorazepam is now gone. I have full range of motion.

More reviews for: Vicodin, Wellbutrin

Comments from related studies:

  • From this study (4 weeks ago):

  • peanuts on Mar, 31, 2010:

    my friend is suffering from rhumatory arthertis.and is currenty taking cocaine. oxy cotin,prestine, wellbutrim, predisone 10mg what side effects should she expect ?????


    mtntexas on May, 11, 2013:

    Just ask John Belushi


    2cents on Mar, 6, 2013:

    I'll second that!


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Complete drug side effects:

On eHealthMe, Wellbutrin (bupropion hydrochloride) is often used to treat depression. Vicodin (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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