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Review: taking Wellbutrin and Vicodin together

Summary: drug interactions are reported among people who take Wellbutrin and Vicodin together.

This review analyzes the effectiveness and drug interactions between Wellbutrin and Vicodin. It is created by eHealthMe based on reports of 3,630 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 3, 2015: 3,629 people who take Wellbutrin, Vicodin are studied

Wellbutrin, Vicodin outcomes

Drug combinations in study:
- Wellbutrin (bupropion hydrochloride)
- Vicodin (acetaminophen; hydrocodone bitartrate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Wellbutrin is effective6.90%
(2 of 29 people)
(18 of 39 people)
(11 of 34 people)
(11 of 36 people)
(12 of 60 people)
(22 of 42 people)
(17 of 32 people)
(1 of 3 people)
Vicodin is effective44.00%
(22 of 50 people)
(10 of 35 people)
(5 of 14 people)
(21 of 52 people)
(29 of 61 people)
(16 of 31 people)
(9 of 22 people)
(8 of 10 people)

Drug effectiveness by gender :

Wellbutrin is effective35.10%
(73 of 208 people)
(21 of 67 people)
Vicodin is effective42.86%
(90 of 210 people)
(30 of 64 people)

Drug effectiveness by age :

Wellbutrin is effectiven/an/a100.00%
(2 of 2 people)
(15 of 65 people)
(19 of 130 people)
(28 of 187 people)
(23 of 129 people)
(7 of 31 people)
Vicodin is effectiven/an/a100.00%
(2 of 2 people)
(18 of 59 people)
(21 of 128 people)
(34 of 171 people)
(34 of 130 people)
(11 of 36 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
IrritabilityDepressionDrug IneffectiveAnxietyDepressionDepressionDepressionPain
DeliriumHeadacheAnxietyDepressionAnxietyAnxietyExhaustion, Fatigue, Lethargy, Tiredness, WearinessAnxiety
AmnesiaPainDepressionInjurySuicide AttemptNauseaFatigueDepression
Chest PainDrug IneffectiveHaemorrhagic StrokePainPainInsomniaPainNausea
Pain In ExtremityOedema PeripheralDiabetes MellitusEmotional DistressSuicidal IdeationPainShort-term Memory LossBack Pain
Loss Of ConsciousnessArthralgiaFatigueDrug IneffectiveHeadacheHeadacheWeight GainDyspnoea
AnxietyAnxietyBlood Triglycerides IncreasedDeep Vein ThrombosisHypertensionBack PainInsomniaFall
Respiratory FailureNauseaPainConvulsionRenal FailureLoss Of ConsciousnessSuicide AttemptFatigue
Suicidal IdeationCataractCholecystitis ChronicGeneral Physical Health DeteriorationEmotional DistressFatigueLibido DecreasedHeadache
Impaired Driving AbilityVomitingNauseaType 2 Diabetes MellitusSleep Apnoea SyndromeFallIntentional OverdoseArthralgia

Most common drug interactions by gender * :

Back PainBack Pain
FallWeight Decreased
Pain In ExtremityFatigue

Most common drug interactions by age * :

Type 2 Diabetes MellitusUpper Respiratory Tract InfectionCholecystitis ChronicAnxietyDepressionPainPainAnxiety
Suicide AttemptWhite Blood Cell Count DecreasedPainPulmonary EmbolismAnxietyAnxietyAnxietyNausea
FallRhinorrhoeaGallbladder DisorderPainPainDepressionNauseaPneumonia
HaematocheziaHeart Rate IncreasedAbdominal Pain UpperDeep Vein ThrombosisWeight IncreasedNauseaDepressionArthralgia
Hepatitis CBlood Pressure DecreasedVomitingChest PainType 2 Diabetes MellitusDyspnoeaInsomniaFall
Deep Vein ThrombosisAccidental ExposureCholelithiasisDepressionNauseaBack PainAnaemiaPain
Systemic Lupus ErythematosusCholecystitisCholecystitis ChronicBack PainChest PainHeadacheFatigue
Pulmonary EmbolismInjuryAbdominal Pain UpperDiabetes MellitusHeadacheFallDepression
Drug Exposure Via Breast MilkAnxietyMuscle SpasmsPain In ExtremityFatigueDiarrhoeaDyspnoea
Neuroleptic Malignant SyndromeDeep Vein ThrombosisCompleted SuicideSuicidal IdeationFallBack PainVomiting

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Vicodin
- support group for people who take Wellbutrin

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Wellbutrin (bupropion hydrochloride) is often used to treat depression. Vicodin (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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