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Review: taking Clonidine and Zoloft together

Summary: drug interactions are reported among people who take Clonidine and Zoloft together. This review analyzes the effectiveness and drug interactions between Clonidine and Zoloft. It is created by eHealthMe based on reports of 705 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>

 

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What are the drugs

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. (latest outcomes from 9,699 Clonidine users)

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from 78,429 Zoloft users)

On Apr, 28, 2015: 705 people who take Clonidine, Zoloft are studied

Clonidine, Zoloft outcomes

Drug combinations in study:
- Clonidine (clonidine)
- Zoloft (sertraline hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Clonidine is effective0.00%
(0 of 2 people)
33.33%
(1 of 3 people)
25.00%
(1 of 4 people)
100.00%
(1 of 1 people)
0.00%
(0 of 3 people)
71.43%
(5 of 7 people)
n/a50.00%
(1 of 2 people)
Zoloft is effective0.00%
(0 of 1 people)
16.67%
(1 of 6 people)
0.00%
(0 of 6 people)
100.00%
(1 of 1 people)
33.33%
(1 of 3 people)
33.33%
(1 of 3 people)
100.00%
(3 of 3 people)
n/a

Drug effectiveness by gender :

FemaleMale
Clonidine is effective36.36%
(4 of 11 people)
45.45%
(5 of 11 people)
Zoloft is effective25.00%
(3 of 12 people)
36.36%
(4 of 11 people)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Clonidine is effectiven/a0.00%
(0 of 1 people)
26.67%
(4 of 15 people)
0.00%
(0 of 4 people)
0.00%
(0 of 1 people)
25.00%
(1 of 4 people)
44.44%
(4 of 9 people)
0.00%
(0 of 6 people)
Zoloft is effectiven/a0.00%
(0 of 1 people)
14.29%
(2 of 14 people)
11.11%
(1 of 9 people)
0.00%
(0 of 1 people)
25.00%
(1 of 4 people)
33.33%
(3 of 9 people)
0.00%
(0 of 6 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
SepsisSomnolenceType 2 Diabetes MellitusPriapismBreast Cancer FemaleExhaustion, Fatigue, Lethargy, Tiredness, WearinessExhaustion, Fatigue, Lethargy, Tiredness, WearinessAnxiety
NeutropeniaHyperhidrosisBlood Cholesterol IncreasedChronic PainBreast CystDiverticulumLose WeightPain
AcidosisExtrapyramidal DisorderObesityPostoperative Wound ComplicationDuodenitisWeight IncreasedDyspnoea
Multi-organ FailureEnuresisHyperlipidaemiaFatigueGastritis ErosiveAllergiesDepression
ThrombocytopeniaTachypnoeaBlood Triglycerides IncreasedPainCoronary Artery DiseaseHyperkalaemiaNausea
Respiratory FailureVomitingStress And AnxietyMental DisorderCataractImpotenceInjury
Cerebrovascular AccidentThrombocytopeniaIrritabilityGallbladder InjuryCardiac Failure CongestiveEjaculation DelayedFatigue
AnhedoniaSepsisCraniocerebral InjuryCholecystitis ChronicGastrointestinal HaemorrhageAutism Spectrum DisorderHeadache
FearWithdrawal SyndromeDyslipidaemiaEmotional DistressColitisConstipationVomiting
DepressionWeight IncreasedGlaucomaMusculoskeletal DiscomfortHypertonic BladderDiabetic KetoacidosisAsthenia

Most common drug interactions by gender * :

FemaleMale
PainAnxiety
AnxietyDizziness
DepressionPain
NauseaBack Pain
DyspnoeaHeadache
InjuryBronchitis
Pain In ExtremitySomnolence
ArthralgiaTremor
Muscular WeaknessDyspnoea
HypoaesthesiaCardiac Failure Congestive

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Pancreatitis AcuteWeight IncreasedAggressionRenal Failure AcuteAnxietyPainPainHypotension
DyspnoeaDiabetic KetoacidosisCerebrovascular AccidentHypertensionAnxietyOedema PeripheralVomiting
SomnolencePancreatitisAnxietyType 2 Diabetes MellitusDepressionAnxietyNausea
TachypnoeaAbnormal BehaviourVomitingBack PainPain In ExtremityDepressionDehydration
VomitingAnxietyMalaiseHeadacheNeuropathy PeripheralMobility DecreasedAsthenia
Cardio-respiratory ArrestIrritabilityAbdominal PainDyspnoeaInjuryNauseaDiarrhoea
Blood Pressure DecreasedSuicidal IdeationDepressionPainDyspnoeaFallPain
DystoniaType 1 Diabetes MellitusConvulsionPanic AttackSpinal OsteoarthritisArthralgiaPneumonia
EnuresisDeathChest PainChest PainArthralgiaDyspnoeaDizziness
HyperhidrosisGynaecomastiaBlood Pressure FluctuationEmotional DistressOsteonecrosis Of JawDeformityHypertension

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Clonidine and Zoloft on

Do you take Clonidine and Zoloft?

 

You are not alone! Join a related support group:
- support group for people who take Clonidine
- support group for people who take Zoloft

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Clonidine, Zoloft

You may be interested at these reviews (Write a review):

  • Clonidine is a no-go
    I was prescribed this drug to help knock me out as I was having a lot of trouble sleeping and for the first week, it didn't do much. After that first week, it helped put me to sleep right away for a few weeks and then it stopped working again so my psychiatrist doubled the dose to 2mg. That started ...
  • Can depression really be the cause of a chemical inbalance (1 response)
    During my experience with these antidepressants that i took, Which were ssri they don't exactly work. At the start , you will feel headaches during the beginning of the pill popping which is usually taken in the morning. the more of these antidepressants you take the more you begin to feel the tole ...
  • Compulsive hair pulling on zoloft
    Ive been on Zoloft for 2.5 months and started hair pulling after about a month. The medication is working well for me so Im going to stay on it for the time being.
  • Took buspirone once and got a blister
    Took Buspirone 5mg once and a few minutes later felt a bubble on my lip. The next morning I check and sure enough it's a blister on my top lip. Called a nurse and she said I had an allergic reaction.
  • Fluoxetine with hypnagogic hallucinations
    Was taking fluoxetine until recently for a depressive episode (suffered from depression pretty much my whole life). Strange hypnagogic hallucinations and bizarre thoughts, sometimes coupled with feeling faint. Also strong feelings of numbness for the first two weeks or so, headaches and dry mouth. S ...

More reviews for: Clonidine, Zoloft

Comments from related studies:

  • From this study (11 months ago):

  • Upon taking the Clonidine & melatonin before bedtime, this 4 year old develops severe knee clicking which seems to hurt her upon falling asleep. If she gets angry during the day she can involuntarily start the knee clicking. She is very double jointed.

    Reply

  • From this study (1 year ago):

  • Vyvanse is my most recently prescribed ADD medication, but I have been on various other prescriptions since the age of 9. (Adderall at first for a short time [< 1 month], stopped because it caused severe panic attacks; Concerta in increasing doses over the next 5 years, but never more than 72mg; Vyvanse for the past 3 years, at 60mg for two years, moved up to 70mg last year). Already had trouble falling asleep; when I started taking these stimulants, it became full blown insomnia, requiring prescription of Clonidine (started at .1mg, has increased to .2mg). During the school day all symptoms are managed very well- no trouble focusing, less impulsiveness, more self-control. After Vyvanse wears off (normally seven and a half to eight hours after ingestion), all symptoms of ADD return in full force. A few years ago I was diagnosed with Panic Disorder (without Agoraphobia) when I started getting frequent panic attacks. I was prescribed Hydroxyzine Pamoate 50mg, which I take whenever I feel a panic attack coming on. I had problems with asthma and acid reflux problems since my birth, and the asthma became very severe. I spent much time in the NICU when I was born, and I had to be rushed to the hospital several times in the first few years of my life. I used to carry an inhaler everywhere, but at the age of 10, 3 years after my last major problem with asthma, my physician and I decided that I had successfully overcome my problems with asthma (insofar as one can overcome such problems- in any case, I haven't had a problem with it in nearly a decade. The acid reflux recently returned, but with very low severity. The only problems I've had with it recently are occasionally waking up with feelings of heartburn and acid rising in my chest. My physician told me to take one dose of over-the-counter Pepcid Complete before bed, and that has remedied all problems with the acid reflux. Last year I was diagnosed with Major Depressive Disorder, and prescribed Sertraline.
    When I started the ADD stimulants, I had large weight fluctuations, because during the day I had no appetite, but at night I was very hungry. My weight stayed within a range of approximately 40lbs, but there would be months when I gained a lot of weight quickly, and others when I would lose weight just as quickly.
    When my workload increased as I began High School, even with a boost in Vyvanse dosage, I found it hard to get all my work done without staying up all night.
    I once procrastinated on a project and wound up a week away from the due date with very little done. I stopped taking my Clonidine, and started taking extra Vyvanse and drinking several cups of coffee a day (approx. 10 a day) so I could stay up several nights in a row. After not sleeping from Monday morning to Thursday afternoon, the sleep deprivation resulted in severe bruxism, clicking of my tongue at the back of my teeth uncontrollably, dry mouth, dizziness, rapid heart rate, and eventually auditory hallucinations and syncope. Since then I have not done anything as reckless as abusing stimulants to stay awake.
    In times of high stress (the week before opening night for the school musical, for example), I develop an uncontrollable muscle twitch, primarily in my left shoulder but occasionally in my right hand, both at varied and unpredictable intervals. The hand twitch can be very noticeable and very disruptive, especially if it persists for more than a minute. The shoulder twitch is less noticeable, but once acknowledged, it becomes more severe. I have tried holding the limb down, but the only thing that works is riding it out. Never has a single period of muscle twitching exceeded 4 minutes.

    Reply

  • From this study (2 years ago):

  • Have had leaking right breast occasionally during peri-menopausal years. Just noticed same clear yellow liquid in same (right) breast. No pain, lumps, swelling, redness, etc., but the liquid is darker. Should I be concerned?

    Reply

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Complete drug side effects:

On eHealthMe, Clonidine (clonidine) is often used to treat high blood pressure. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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