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Review: Clonidine and Zoloft

This review analyzes the effectiveness and drug interactions between Clonidine and Zoloft. It is created by eHealthMe based on reports of 703 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Clonidine and Zoloft >>>

What are the drugs

Clonidine (latest outcomes from 9,631 users) has active ingredients of clonidine. It is often used in high blood pressure.

Zoloft (latest outcomes from 78,183 users) has active ingredients of sertraline hydrochloride. It is often used in depression.

On Sep, 21, 2014: 703 people who take Clonidine, Zoloft are studied

Clonidine, Zoloft outcomes

Drug combinations in study:
- Clonidine (clonidine)
- Zoloft (sertraline hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Clonidine is effective0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
25.00%
(1 of 4 people)
100.00%
(1 of 1 people)
0.00%
(0 of 3 people)
71.43%
(5 of 7 people)
n/a50.00%
(1 of 2 people)
Zoloft is effective0.00%
(0 of 1 people)
20.00%
(1 of 5 people)
0.00%
(0 of 5 people)
100.00%
(1 of 1 people)
33.33%
(1 of 3 people)
33.33%
(1 of 3 people)
100.00%
(3 of 3 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
SepsisSomnolenceType 2 Diabetes MellitusPriapismBreast Cancer FemaleExhaustion, Fatigue, Lethargy, Tiredness, WearinessExhaustion, Fatigue, Lethargy, Tiredness, WearinessAnxiety
NeutropeniaVomitingBlood Cholesterol IncreasedChronic PainBreast CystDiverticulumLose WeightPain
Respiratory FailureHyperhidrosisObesityPostoperative Wound ComplicationDuodenitisWeight IncreasedDyspnoea
Multi-organ FailureWeight IncreasedHyperlipidaemiaFatigueGastritis ErosiveAllergiesDepression
ThrombocytopeniaWithdrawal SyndromeBlood Triglycerides IncreasedPainCoronary Artery DiseaseHyperkalaemiaNausea
AcidosisThrombocytopeniaPanic AttacksMental DisorderCataractImpotenceInjury
Cerebrovascular AccidentSepsisStress And AnxietyGallbladder InjuryCardiac Failure CongestiveEjaculation DelayedFatigue
DepressionRespiratory FailureCraniocerebral InjuryCholecystitis ChronicGastrointestinal HaemorrhageAutism Spectrum DisorderHeadache
AnhedoniaNeutropeniaDyslipidaemiaEmotional DistressColitisConstipationVomiting
FearExtrapyramidal DisorderGlaucomaMusculoskeletal DiscomfortHypertonic BladderDiabetic KetoacidosisAsthenia

Drug effectiveness by gender :

FemaleMale
Clonidine is effective36.36%
(4 of 11 people)
44.44%
(4 of 9 people)
Zoloft is effective25.00%
(3 of 12 people)
44.44%
(4 of 9 people)

Most common drug interactions by gender * :

FemaleMale
PainAnxiety
AnxietyDizziness
DepressionBack Pain
NauseaPain
DyspnoeaHeadache
InjuryBronchitis
Pain In ExtremityTremor
ArthralgiaSomnolence
Muscular WeaknessDyspnoea
HypoaesthesiaCardiac Failure Congestive

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Clonidine is effectiven/a0.00%
(0 of 1 people)
27.27%
(3 of 11 people)
0.00%
(0 of 4 people)
0.00%
(0 of 1 people)
25.00%
(1 of 4 people)
44.44%
(4 of 9 people)
0.00%
(0 of 6 people)
Zoloft is effectiven/a0.00%
(0 of 1 people)
20.00%
(2 of 10 people)
11.11%
(1 of 9 people)
0.00%
(0 of 1 people)
25.00%
(1 of 4 people)
33.33%
(3 of 9 people)
0.00%
(0 of 6 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Pancreatitis AcuteWeight IncreasedAggressionRenal Failure AcuteAnxietyPainPainHypotension
DyspnoeaPancreatitisCerebrovascular AccidentHypertensionAnxietyOedema PeripheralVomiting
SomnolenceDiabetic KetoacidosisAnxietyType 2 Diabetes MellitusDepressionAnxietyNausea
TachypnoeaType 1 Diabetes MellitusVomitingBack PainPain In ExtremityDepressionDehydration
VomitingSuicidal IdeationMalaiseHeadacheNeuropathy PeripheralMobility DecreasedAsthenia
Cardio-respiratory ArrestAbnormal BehaviourAbdominal PainDyspnoeaInjuryNauseaDiarrhoea
Blood Pressure DecreasedAnxietyDepressionPainDyspnoeaFallPain
DystoniaDeathConvulsionPanic AttackSpinal OsteoarthritisArthralgiaPneumonia
EnuresisAkathisiaChest PainChest PainArthralgiaDyspnoeaDizziness
HyperhidrosisAgitationBlood Pressure FluctuationEmotional DistressOsteonecrosis Of JawDeformityHypertension

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Clonidine and Zoloft?

Comments from related studies:

  • From this study (2 months ago):

  • Upon taking the Clonidine & melatonin before bedtime, this 4 year old develops severe knee clicking which seems to hurt her upon falling asleep. If she gets angry during the day she can involuntarily start the knee clicking. She is very double jointed.

    Reply

  • From this study (7 months ago):

  • Vyvanse is my most recently prescribed ADD medication, but I have been on various other prescriptions since the age of 9. (Adderall at first for a short time [< 1 month], stopped because it caused severe panic attacks; Concerta in increasing doses over the next 5 years, but never more than 72mg; Vyvanse for the past 3 years, at 60mg for two years, moved up to 70mg last year). Already had trouble falling asleep; when I started taking these stimulants, it became full blown insomnia, requiring prescription of Clonidine (started at .1mg, has increased to .2mg). During the school day all symptoms are managed very well- no trouble focusing, less impulsiveness, more self-control. After Vyvanse wears off (normally seven and a half to eight hours after ingestion), all symptoms of ADD return in full force. A few years ago I was diagnosed with Panic Disorder (without Agoraphobia) when I started getting frequent panic attacks. I was prescribed Hydroxyzine Pamoate 50mg, which I take whenever I feel a panic attack coming on. I had problems with asthma and acid reflux problems since my birth, and the asthma became very severe. I spent much time in the NICU when I was born, and I had to be rushed to the hospital several times in the first few years of my life. I used to carry an inhaler everywhere, but at the age of 10, 3 years after my last major problem with asthma, my physician and I decided that I had successfully overcome my problems with asthma (insofar as one can overcome such problems- in any case, I haven't had a problem with it in nearly a decade. The acid reflux recently returned, but with very low severity. The only problems I've had with it recently are occasionally waking up with feelings of heartburn and acid rising in my chest. My physician told me to take one dose of over-the-counter Pepcid Complete before bed, and that has remedied all problems with the acid reflux. Last year I was diagnosed with Major Depressive Disorder, and prescribed Sertraline.
    When I started the ADD stimulants, I had large weight fluctuations, because during the day I had no appetite, but at night I was very hungry. My weight stayed within a range of approximately 40lbs, but there would be months when I gained a lot of weight quickly, and others when I would lose weight just as quickly.
    When my workload increased as I began High School, even with a boost in Vyvanse dosage, I found it hard to get all my work done without staying up all night.
    I once procrastinated on a project and wound up a week away from the due date with very little done. I stopped taking my Clonidine, and started taking extra Vyvanse and drinking several cups of coffee a day (approx. 10 a day) so I could stay up several nights in a row. After not sleeping from Monday morning to Thursday afternoon, the sleep deprivation resulted in severe bruxism, clicking of my tongue at the back of my teeth uncontrollably, dry mouth, dizziness, rapid heart rate, and eventually auditory hallucinations and syncope. Since then I have not done anything as reckless as abusing stimulants to stay awake.
    In times of high stress (the week before opening night for the school musical, for example), I develop an uncontrollable muscle twitch, primarily in my left shoulder but occasionally in my right hand, both at varied and unpredictable intervals. The hand twitch can be very noticeable and very disruptive, especially if it persists for more than a minute. The shoulder twitch is less noticeable, but once acknowledged, it becomes more severe. I have tried holding the limb down, but the only thing that works is riding it out. Never has a single period of muscle twitching exceeded 4 minutes.

    Reply

  • From this study (1 year ago):

  • Have had leaking right breast occasionally during peri-menopausal years. Just noticed same clear yellow liquid in same (right) breast. No pain, lumps, swelling, redness, etc., but the liquid is darker. Should I be concerned?

    Reply

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Complete drug side effects:

On eHealthMe, Clonidine (clonidine) is often used to treat high blood pressure. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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