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Review: taking Zoloft and Centrum together

Summary: drug interactions are reported among people who take Zoloft and Centrum together. This review analyzes the effectiveness and drug interactions between Zoloft and Centrum. It is created by eHealthMe based on reports of 4,486 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>


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What are the drugs

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from 78,429 Zoloft users)

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. (latest outcomes from 9,087 Centrum users)

On May, 1, 2015: 4,486 people who take Zoloft, Centrum are studied

Zoloft, Centrum outcomes

Drug combinations in study:
- Zoloft (sertraline hydrochloride)
- Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zoloft is effective20.00%
(2 of 10 people)
(8 of 26 people)
(9 of 23 people)
(10 of 20 people)
(14 of 27 people)
(15 of 28 people)
(16 of 20 people)
(1 of 2 people)
Centrum is effective0.00%
(0 of 7 people)
(0 of 7 people)
(2 of 13 people)
(3 of 13 people)
(9 of 22 people)
(10 of 25 people)
(14 of 25 people)
(0 of 1 people)

Drug effectiveness by gender :

Zoloft is effective51.33%
(58 of 113 people)
(17 of 43 people)
Centrum is effective37.18%
(29 of 78 people)
(9 of 35 people)

Drug effectiveness by age :

Zoloft is effectiven/an/a25.00%
(2 of 8 people)
(5 of 48 people)
(14 of 38 people)
(16 of 45 people)
(21 of 90 people)
(17 of 66 people)
Centrum is effectiven/an/a0.00%
(0 of 5 people)
(3 of 45 people)
(11 of 27 people)
(5 of 29 people)
(14 of 67 people)
(5 of 42 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
LethargyVentricular Septal DefectVentricular Septal DefectTransposition Of The Great VesselsDizzinessPulmonary HypoplasiaShort-term Memory LossPain
HypoxiaAtrial Septal DefectRespiratory Tract InfectionDepressionPainPulmonary Artery Stenosis CongenitalFatigueNausea
Drug Exposure During PregnancyPatent Ductus ArteriosusAnomalous Pulmonary Venous ConnectionTricuspid Valve IncompetenceVaginal HaemorrhageSleep Apnoea SyndromeDepressionFatigue
AnxietyDrug Exposure During PregnancyPost Procedural ComplicationAtrial Septal DefectUterine SpasmPatent Ductus ArteriosusDizzinessAnxiety
NauseaMajor DepressionCroup InfectiousPatent Ductus ArteriosusMaternal Exposure During PregnancyHigh Blood PressurePulmonary EmbolismDepression
Confusional StateHypersexualityEar InfectionNeonatal Respiratory Distress SyndromeAtrial Septal DefectInsomniaWeight GainAnaemia
Patent Ductus ArteriosusInjuryDrug Exposure During PregnancyCardiac Failure CongestiveDepressionEcchymosisErythrosisDiarrhoea
Oxygen Saturation DecreasedEmotional DistressOtitis MediaVentricular Septal DefectNauseaTachypnoeaPenicilliosisWeight Decreased
DyspnoeaTransposition Of The Great VesselsUpper Respiratory Tract InfectionPneumothoraxHypersensitivityLeft Ventricular HypertrophyInsomniaHeadache
Atrial Septal DefectCognitive DisorderDepressionFatigueDrug Exposure During PregnancyGait DisturbanceWhite Blood Cell Count IncreasedDyspnoea

Most common drug interactions by gender * :

PainAtrial Septal Defect
FallOsteonecrosis Of Jaw
Weight DecreasedDiarrhoea

Most common drug interactions by age * :

Patent Ductus ArteriosusFoetal Exposure During PregnancyPhotophobiaAnxietyPainDepressionPainFall
Atrial Septal DefectPyrexiaPainPainNauseaPainAnxietyNausea
Cardiac Failure CongestiveNasal CongestionDepressionNauseaFatigueFatigueNauseaPain
CardiomegalyCleft PalateHeadachePregnancyWeight DecreasedNauseaHeadacheAsthenia
Heart Disease CongenitalConductive DeafnessVomitingCholecystitis ChronicAstheniaAnxietyFatigueFatigue
Ventricular Septal DefectHaemangioma Of SkinDiarrhoeaDepressionConvulsionAnaemiaOsteonecrosis Of JawWeight Decreased
CryptorchismCleft LipDizzinessDeep Vein ThrombosisHeadacheBone DisorderBone DisorderDiarrhoea
Failure To ThriveCellulitisCondition AggravatedDrug Exposure During PregnancyAnxietyOsteonecrosis Of JawAnaemiaAnxiety
Maternal Exposure During PregnancyOtitis MediaSinus HeadacheConvulsionInjuryConstipationBack PainArthralgia
Croup InfectiousEar InfectionSuicidal IdeationHeadacheAlanine Aminotransferase IncreasedArthralgiaDepressionDepression

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Zoloft and Centrum on

Do you take Zoloft and Centrum?


You are not alone! Join a related support group:
- support group for people who take Centrum
- support group for people who take Zoloft

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Centrum, Zoloft

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Complete drug side effects:

On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) is often used to treat general physical condition abnormal. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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