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Review: Zoloft and Centrum

This review analyzes the effectiveness and drug interactions between Zoloft and Centrum. It is created by eHealthMe based on reports of 4,473 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Zoloft and Centrum >>>

What are the drugs

Zoloft (latest outcomes from 78,183 users) has active ingredients of sertraline hydrochloride. It is often used in depression.

Centrum (latest outcomes from 9,059 users) has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation.

On Sep, 16, 2014: 4,473 people who take Zoloft, Centrum are studied

Zoloft, Centrum outcomes

Drug combinations in study:
- Zoloft (sertraline hydrochloride)
- Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zoloft is effective0.00%
(0 of 8 people)
(8 of 25 people)
(8 of 22 people)
(8 of 18 people)
(12 of 25 people)
(14 of 26 people)
(15 of 19 people)
(1 of 1 people)
Centrum is effective0.00%
(0 of 7 people)
(0 of 7 people)
(2 of 12 people)
(3 of 13 people)
(8 of 21 people)
(10 of 23 people)
(13 of 24 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
LethargyVentricular Septal DefectVentricular Septal DefectTransposition Of The Great VesselsPainAtrial Septal DefectShort-term Memory LossPain
Drug Exposure During PregnancyAtrial Septal DefectRespiratory Tract InfectionDepressionDizzinessRespiratory DistressDepressionNausea
HypoxiaPatent Ductus ArteriosusEar InfectionTricuspid Valve IncompetenceVaginal HaemorrhagePatent Ductus ArteriosusPulmonary EmbolismFatigue
AnxietyMajor DepressionCroup InfectiousAtrial Septal DefectAtrial Septal DefectFatiguePenicilliosisAnxiety
NauseaDrug Exposure During PregnancyAnomalous Pulmonary Venous ConnectionPatent Ductus ArteriosusDepressionPulmonary Artery Stenosis CongenitalErythrosisDepression
Confusional StateDouble Outlet Right VentriclePost Procedural ComplicationNeonatal Respiratory Distress SyndromeUterine SpasmVentricular Septal DefectSerotonin SyndromeAnaemia
DyspnoeaInjuryDrug Exposure During PregnancyVentricular Septal DefectMaternal Exposure During PregnancySupraventricular TachycardiaExhaustion, Fatigue, Lethargy, Tiredness, WearinessDiarrhoea
Patent Ductus ArteriosusEmotional DistressOtitis MediaPneumothoraxNauseaPulmonary HypertensionMacular DegenerationWeight Decreased
Oxygen Saturation DecreasedHypersexualityUpper Respiratory Tract InfectionCardiac Failure CongestiveCardiac MurmurTransposition Of The Great VesselsTendon InjuryHeadache
Transposition Of The Great VesselsTransposition Of The Great VesselsStrabismusCongenital Coronary Artery MalformationDrug Exposure During PregnancyDrug Exposure During PregnancyDizzinessDyspnoea

Drug effectiveness by gender :

Zoloft is effective50.00%
(53 of 106 people)
(13 of 38 people)
Centrum is effective37.33%
(28 of 75 people)
(8 of 32 people)

Most common drug interactions by gender * :

PainAtrial Septal Defect
AnaemiaOsteonecrosis Of Jaw
Weight DecreasedHeadache

Drug effectiveness by age :

Zoloft is effectiven/an/a25.00%
(2 of 8 people)
(5 of 48 people)
(10 of 32 people)
(14 of 36 people)
(19 of 83 people)
(16 of 64 people)
Centrum is effectiven/an/a0.00%
(0 of 5 people)
(3 of 45 people)
(10 of 23 people)
(5 of 25 people)
(13 of 63 people)
(5 of 41 people)

Most common drug interactions by age * :

Patent Ductus ArteriosusFoetal Exposure During PregnancyPhotophobiaAnxietyPainDepressionPainFall
Atrial Septal DefectPyrexiaPainPainNauseaPainAnxietyNausea
Cardiac Failure CongestiveNasal CongestionDepressionNauseaFatigueFatigueNauseaPain
CardiomegalyCleft PalateHeadachePregnancyWeight DecreasedNauseaHeadacheAsthenia
Heart Disease CongenitalConductive DeafnessVomitingCholecystitis ChronicAstheniaAnxietyFatigueFatigue
Ventricular Septal DefectHaemangioma Of SkinDiarrhoeaDepressionHeadacheAnaemiaOsteonecrosis Of JawWeight Decreased
CryptorchismCleft LipDizzinessDeep Vein ThrombosisConvulsionBone DisorderBone DisorderDiarrhoea
Failure To ThriveCellulitisCondition AggravatedDrug Exposure During PregnancyDrug Exposure During PregnancyOsteonecrosis Of JawAnaemiaAnxiety
Maternal Exposure During PregnancyOtitis MediaSinus HeadacheConvulsionAlanine Aminotransferase IncreasedConstipationBack PainArthralgia
Croup InfectiousEar InfectionSuicidal IdeationHeadacheAnxietyArthralgiaDepressionDepression

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Zoloft and Centrum?

Get connected! Join a mobile support group:
- group for people who take Zoloft and Centrum
- group for people who take Centrum
- group for people who take Zoloft

Comments from related studies:

  • From this study (5 months ago):

  • Recently all the joints in both of my hands have begun to ache.


  • From this study (7 months ago):

  • Most concerning with outbreaks on chest area and upper arms.


  • From this study (12 months ago):

  • I have Primary progressive MS.I don't know if a lot of my symptoms are because of where the lesions are or the medicine I take. I do know that the nick name for topamax is dopamax. I take 200 mgs a day. I am also hypoglycemic since 16. It does help with my blood sugar I will say however I have brain fog most of the time and can't remember my life. Only in pictures.


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Complete drug side effects:

On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) is often used to treat vitamin supplementation. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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