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Review: taking Zoloft and Centrum together

Summary: drug interactions are reported among people who take Zoloft and Centrum together.

This review analyzes the effectiveness and drug interactions between Zoloft and Centrum. It is created by eHealthMe based on reports of 4,484 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Zoloft and Centrum >>>

On Apr, 1, 2015: 4,484 people who take Zoloft, Centrum are studied

Zoloft, Centrum outcomes

Drug combinations in study:
- Zoloft (sertraline hydrochloride)
- Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zoloft is effective11.11%
(1 of 9 people)
(8 of 26 people)
(9 of 23 people)
(10 of 20 people)
(14 of 27 people)
(15 of 28 people)
(16 of 20 people)
(1 of 2 people)
Centrum is effective0.00%
(0 of 7 people)
(0 of 7 people)
(2 of 13 people)
(3 of 13 people)
(9 of 22 people)
(10 of 25 people)
(13 of 24 people)
(0 of 1 people)

Drug effectiveness by gender :

Zoloft is effective50.89%
(57 of 112 people)
(17 of 43 people)
Centrum is effective36.36%
(28 of 77 people)
(9 of 35 people)

Drug effectiveness by age :

Zoloft is effectiven/an/a25.00%
(2 of 8 people)
(5 of 48 people)
(13 of 37 people)
(16 of 45 people)
(21 of 90 people)
(17 of 66 people)
Centrum is effectiven/an/a0.00%
(0 of 5 people)
(3 of 45 people)
(10 of 26 people)
(5 of 29 people)
(14 of 67 people)
(5 of 42 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
LethargyVentricular Septal DefectVentricular Septal DefectTransposition Of The Great VesselsDizzinessPulmonary HypoplasiaShort-term Memory LossPain
HypoxiaAtrial Septal DefectRespiratory Tract InfectionDepressionPainPulmonary Artery Stenosis CongenitalFatigueNausea
Drug Exposure During PregnancyPatent Ductus ArteriosusAnomalous Pulmonary Venous ConnectionTricuspid Valve IncompetenceVaginal HaemorrhageSleep Apnoea SyndromeDepressionFatigue
AnxietyDrug Exposure During PregnancyPost Procedural ComplicationAtrial Septal DefectUterine SpasmPatent Ductus ArteriosusDizzinessAnxiety
NauseaMajor DepressionCroup InfectiousPatent Ductus ArteriosusMaternal Exposure During PregnancyHigh Blood PressurePulmonary EmbolismDepression
Confusional StateHypersexualityEar InfectionNeonatal Respiratory Distress SyndromeAtrial Septal DefectInsomniaWeight GainAnaemia
Patent Ductus ArteriosusInjuryDrug Exposure During PregnancyCardiac Failure CongestiveDepressionEcchymosisErythrosisDiarrhoea
Oxygen Saturation DecreasedEmotional DistressOtitis MediaVentricular Septal DefectNauseaTachypnoeaPenicilliosisWeight Decreased
DyspnoeaTransposition Of The Great VesselsUpper Respiratory Tract InfectionPneumothoraxHypersensitivityLeft Ventricular HypertrophyInsomniaHeadache
Atrial Septal DefectCognitive DisorderDepressionFatigueDrug Exposure During PregnancyGait DisturbanceWhite Blood Cell Count IncreasedDyspnoea

Most common drug interactions by gender * :

PainAtrial Septal Defect
FallOsteonecrosis Of Jaw
Weight DecreasedDiarrhoea

Most common drug interactions by age * :

Patent Ductus ArteriosusFoetal Exposure During PregnancyPhotophobiaAnxietyPainDepressionPainFall
Atrial Septal DefectPyrexiaPainPainNauseaPainAnxietyNausea
Cardiac Failure CongestiveNasal CongestionDepressionNauseaFatigueFatigueNauseaPain
CardiomegalyCleft PalateHeadachePregnancyWeight DecreasedNauseaHeadacheAsthenia
Heart Disease CongenitalConductive DeafnessVomitingCholecystitis ChronicAstheniaAnxietyFatigueFatigue
Ventricular Septal DefectHaemangioma Of SkinDiarrhoeaDepressionConvulsionAnaemiaOsteonecrosis Of JawWeight Decreased
CryptorchismCleft LipDizzinessDeep Vein ThrombosisHeadacheBone DisorderBone DisorderDiarrhoea
Failure To ThriveCellulitisCondition AggravatedDrug Exposure During PregnancyAnxietyOsteonecrosis Of JawAnaemiaAnxiety
Maternal Exposure During PregnancyOtitis MediaSinus HeadacheConvulsionInjuryConstipationBack PainArthralgia
Croup InfectiousEar InfectionSuicidal IdeationHeadacheAlanine Aminotransferase IncreasedArthralgiaDepressionDepression

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Centrum
- support group for people who take Zoloft

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) is often used to treat general physical condition abnormal. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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