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Review: Acetaminophen and Methadone

This review analyzes the effectiveness and drug interactions between Acetaminophen and Methadone. It is created by eHealthMe based on reports of 921 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Acetaminophen (latest outcomes from 70,689 users) has active ingredients of acetaminophen. It is often used in pain.

Methadone hydrochloride (latest outcomes from 2,796 users) has active ingredients of methadone hydrochloride. It is often used in pain.

On Jun, 27, 2014: 921 people who take Acetaminophen, Methadone Hydrochloride are studied

Acetaminophen, Methadone Hydrochloride outcomes

Drug combinations in study:
- Acetaminophen (acetaminophen)
- Methadone Hydrochloride (methadone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Acetaminophen is effective100.00%
(1 of 1 people)
(0 of 1 people)
(0 of 1 people)
Methadone Hydrochloride is effective100.00%
(1 of 1 people)
(0 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DehydrationColostomyPainLower Respiratory Tract InfectionSubarachnoid HaemorrhageConfusional StateTorsade De PointesNausea
HyperglycaemiaHospitalisationDyspnoeaUlcer Haemorrhage NosFallWeight IncreasedLong Qt SyndromePain
Palmar-plantar Erythrodysaesthesia SyndromeColitis UlcerativeCentral Nervous System LesionShockSyncopeRegurgitationAnxiety
Oedema PeripheralIleusElectrocardiogram AbnormalMelaenaVentricular TachycardiaIncreased AppetiteDyspnoea
FatiguePainNauseaAnaemiaSerotonin SyndromeAbdominal DiscomfortConstipation
HyperhidrosisLoss Of ConsciousnessChest DiscomfortRectal HaemorrhageFacial Bones FractureEructationAsthenia
HypoalbuminaemiaHyperhidrosisBlood Creatinine IncreasedOesophageal ErosionsElectrocardiogram Qt ProlongedStomach PainFatigue
AnorexiaIleus ParalyticCalculus UrinaryCirculatory CollapsePainVomiting
Neutrophil Count DecreasedApnoeaLethargyGrand Mal ConvulsionSweating - ExcessiveBack Pain
Haemoglobin DecreasedPupillary Reflex ImpairedVision BlurredHaematemesisStomach PainDepression

Drug effectiveness by gender :

Acetaminophen is effective100.00%
(1 of 1 people)
(0 of 2 people)
Methadone Hydrochloride is effective50.00%
(1 of 2 people)
(0 of 2 people)

Most common drug interactions by gender * :

Osteonecrosis Of JawNausea
Back PainDizziness
Abdominal PainPain

Drug effectiveness by age :

Acetaminophen is effectiven/an/an/a100.00%
(1 of 1 people)
(0 of 3 people)
(0 of 1 people)
Methadone Hydrochloride is effectiven/an/an/a50.00%
(1 of 2 people)
(0 of 3 people)
(0 of 1 people)

Most common drug interactions by age * :

HypertensionViral Infection NosEpistaxisNauseaNauseaBack PainAnxietyNausea
Hypoplastic Left Heart SyndromeFebrile NeutropeniaPyrexiaRespiratory DepressionDyspnoeaConstipationPainVomiting
Hepatic FailureAnorexiaFatiguePulmonary OedemaHeadacheDyspnoeaOsteonecrosis Of JawChest Pain
HypotensionBone PainHypokalaemiaAccidental OverdoseAnxietyDizzinessNauseaDyspnoea
Organ FailureAbdominal Pain NosCaecitisOverdoseAccidental OverdoseNauseaEmotional DistressCompleted Suicide
DyspnoeaDiarrhoea NosMuscle SpasmsCardio-respiratory ArrestFatigueAstheniaDepressionDehydration
ArrhythmiaDisease Progression NosPhotophobiaHepatitis CVision BlurredFatigueAbdominal PainAsthenia
UrticariaNeck PainLower Respiratory Tract Infection FungalVomitingPainVomitingArthralgiaConfusional State
SepsisRespiratory DistressThrombocytopeniaMultiple Drug OverdoseDehydrationWeight DecreasedConstipationHyperhidrosis
Renal InjuryPleural EffusionPruritusMyocardial IschaemiaPalmar-plantar Erythrodysaesthesia SyndromeHeadacheDyspnoeaPain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Comments from related studies:

  • From this study (4 years ago):

  • It seemed that the otc meds may have caused the methadone to wear off very quickly or rush out of my system causing what feels like withdrawal symptoms


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More reviews for: Acetaminophen, Methadone Hydrochloride

Complete drug side effects:

On eHealthMe, Acetaminophen (acetaminophen) is often used to treat pain. Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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