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Review: taking Adderall and Topamax together

Summary: drug interactions are reported among people who take Adderall and Topamax together.

This review analyzes the effectiveness and drug interactions between Adderall and Topamax. It is created by eHealthMe based on reports of 424 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 5, 2015: 424 people who take Adderall, Topamax are studied

Adderall, Topamax outcomes

Drug combinations in study:
- Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate)
- Topamax (topiramate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Adderall is effective10.00%
(1 of 10 people)
(9 of 25 people)
(6 of 14 people)
(20 of 31 people)
(17 of 29 people)
(13 of 19 people)
(5 of 6 people)
(3 of 6 people)
Topamax is effective16.67%
(1 of 6 people)
(4 of 19 people)
(1 of 13 people)
(10 of 28 people)
(14 of 29 people)
(13 of 21 people)
(9 of 11 people)
(0 of 6 people)

Drug effectiveness by gender :

Adderall is effective51.94%
(67 of 129 people)
(4 of 8 people)
Topamax is effective40.48%
(51 of 126 people)
(1 of 7 people)

Drug effectiveness by age :

Adderall is effectiven/a0.00%
(0 of 1 people)
(2 of 13 people)
(21 of 50 people)
(25 of 97 people)
(17 of 74 people)
(6 of 14 people)
(0 of 4 people)
Topamax is effectiven/a0.00%
(0 of 1 people)
(3 of 12 people)
(12 of 49 people)
(12 of 88 people)
(21 of 76 people)
(3 of 14 people)
(1 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
InsomniaChest PainMood SwingsHeadacheNeck PainInsomniaDizzinessFatigue
Suicidal IdeationDizzinessInitial InsomniaInsomniaIrritabilityHyperhidrosisHeadachePain
Dry MouthDissociative FugueUrge IncontinenceDizzinessExhaustion, Fatigue, Lethargy, Tiredness, WearinessDepressionVision BlurredDepression
Weight DecreasedDepressionLethargySneezingDepressionLoss Of EmploymentNight SweatsHeadache
DizzinessDisturbance In AttentionDepression NosNauseaDizzinessHot FlushesItchingDrug Ineffective
Heart Rate IncreasedHallucinationSputum Expectoration DifficultExhaustion, Fatigue, Lethargy, Tiredness, WearinessHeadacheUrinary Tract InfectionSeborrhoeic DermatitisNausea
DepressionDehydrationThroat TightnessUrinary Tract InfectionNauseaThoughts - CloudyFatigueWeight Increased
HeadacheEye PainAir SwallowingUti - RecurrentDry MouthWeight IncreasedAbdominal PainTremor
HallucinationBipolar I DisorderIrritabilityHivesHeadachesCoordination ImpairmentMood ChangesChest Pain
Impaired Work AbilityMenorrhagiaBlood Pressure IncreasedLightheadednessFacial PainSleep AttacksIrritabilityOedema Peripheral

Most common drug interactions by gender * :

PainHaemorrhoidal Haemorrhage
NauseaGastritis Erosive
Oedema PeripheralHypovolaemia
Chest PainColitis
Drug IneffectivePulmonary Embolism
Weight IncreasedDepression

Most common drug interactions by age * :

Musculoskeletal StiffnessTicType 1 Diabetes MellitusFatigueNauseaPainAstheniaLimb Crushing Injury
TremorAttention Deficit/hyperactivity DisorderObesityPsychotic DisorderDepressionFatigueAnxietyNeuralgia
HypersensitivityEmotional DisorderDiabetes MellitusGranulocytopeniaDyspnoeaDehydrationTremorOedema Peripheral
Heart Rate IncreasedWeight DecreasedDiabetic KetoacidosisFeeling AbnormalPneumoniaHeadacheSomnolenceJoint Swelling
FatigueSweating DecreasedAnxietyAggressionHeadacheDepressionDizzinessJaw Fracture
HeadacheGastroenteritis NosHyperglycaemiaInsomniaMigraineDiarrhoeaDyspnoeaHip Fracture
DyspnoeaIntracranial Pressure Increased NosTremorSuicide AttemptSinusitisOedema PeripheralFallHypertonic Bladder
Musculoskeletal DisorderGlycosuriaAstheniaErythemaVomitingSpeech DisorderPain In Extremity
Haemorrhage NosDepressionSneezingChest PainPulmonary EmbolismMental Status ChangesPelvic Fracture
Disturbance In AttentionImpulsive BehaviourJoint InjuryFatigueMultiple Sclerosis RelapseMigraineTransient Ischaemic Attack

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Adderall and Topamax?




You are not alone! Join a related support group:
- support group for people who take Adderall
- support group for people who take Topamax

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) is often used to treat attention deficit hyperactivity disorder. Topamax (topiramate) is often used to treat migraine. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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