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Review: taking Adderall and Trazodone together

Summary: drug interactions are reported among people who take Adderall and Trazodone together.

This review analyzes the effectiveness and drug interactions between Adderall and Trazodone. It is created by eHealthMe based on reports of 549 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 14, 2015: 549 people who take Adderall, Trazodone Hydrochloride are studied

Adderall, Trazodone Hydrochloride outcomes

Drug combinations in study:
- Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate)
- Trazodone Hydrochloride (trazodone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Adderall is effective27.27%
(3 of 11 people)
(20 of 35 people)
(16 of 24 people)
(16 of 21 people)
(13 of 32 people)
(9 of 13 people)
(12 of 14 people)
(2 of 2 people)
Trazodone Hydrochloride is effective10.53%
(2 of 19 people)
(14 of 29 people)
(13 of 28 people)
(18 of 30 people)
(12 of 25 people)
(10 of 13 people)
(3 of 5 people)
(0 of 1 people)

Drug effectiveness by gender :

Adderall is effective59.65%
(68 of 114 people)
(23 of 37 people)
Trazodone Hydrochloride is effective50.89%
(57 of 112 people)
(15 of 38 people)

Drug effectiveness by age :

Adderall is effectiven/an/a70.00%
(7 of 10 people)
(32 of 101 people)
(24 of 91 people)
(16 of 67 people)
(10 of 31 people)
(2 of 6 people)
Trazodone Hydrochloride is effectiven/an/a44.44%
(4 of 9 people)
(15 of 98 people)
(22 of 87 people)
(14 of 68 people)
(14 of 31 people)
(3 of 6 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Muscle SprainPainAnxietyChest PainChest PainDepressionDiabetic RetinopathyDepression
HeadacheCholelithiasisSleepinessAnxietyDyspnoeaAnxietyDiabetes Mellitus Inadequate ControlAnxiety
ChillsInjuryPresyncopePainPulmonary EmbolismMood SwingsBlood Glucose IncreasedPain
AlopeciaCholecystitisPulmonary FibrosisHypersomniaPain - ShoulderHeadachesWeight IncreasedChest Pain
Neck PainSweating IncreasedChest PainExhaustion, Fatigue, Lethargy, Tiredness, WearinessNauseaLipoatrophyProteinuriaSomnolence
WeaknessExhaustion, Fatigue, Lethargy, Tiredness, WearinessPainPulmonary EmbolismSweating IncreasedTolerance DecreasedDiabetic NeuropathyNausea
SleepinessShort-term Memory LossDeep Vein ThrombosisPain In ExtremityHeadacheDizzinessRenal DisorderTremor
SedationDizzinessNon-cardiac Chest PainDepressionNumbness And TinglingAppetite DecreasedDiabetic Eye DiseaseDyspnoea
InsomniaBlood Creatine Phosphokinase Mm IncreasedDyspnoeaDeep Vein ThrombosisDepressionNightmareRenal CystInsomnia
DiarrhoeaMemory LossChest DiscomfortNauseaNight SweatsSuicidal IdeationLoss Of LibidoGait Disturbance

Most common drug interactions by gender * :

Chest PainConvulsion
Gait DisturbanceInsomnia
SomnolenceWeight Increased
InjuryDrug Withdrawal Syndrome

Most common drug interactions by age * :

AggressionScreamingAggressionInsomniaPainMultiple Sclerosis RelapseSomnolenceCondition Aggravated
ConvulsionIntentional Self-injuryDepressionAnxietyWeight IncreasedLeukocytosisAnxietyDepression
Tardive DyskinesiaStaringSomnolenceSubstance AbuseVomitingDyspnoeaOedema PeripheralHallucination, Visual
AgitationWeight IncreasedConvulsionDrug ToxicityDiabetes Mellitus Inadequate ControlUrinary Tract InfectionFallDiabetic Neuropathy
Foaming At MouthAggressionType 1 Diabetes MellitusPolysubstance DependenceDepressionSynovial CystDepressionHyperkinesia
Homicidal IdeationHepatic SteatosisHeadacheProteinuriaProgressive Multifocal LeukoencephalopathyChest PainFall
Suicidal BehaviourDiabetic KetoacidosisDepressionPain In ExtremityMuscle SpasticityNauseaLiver Disorder
Bipolar DisorderPainNauseaInjuryArthritisPainDissociative Fugue
AgitationDyspnoeaBipolar DisorderDiabetic RetinopathyImmune Reconstitution SyndromeInsomniaWithdrawal Syndrome
BiteTardive DyskinesiaParanoiaAnxietyGait DisturbanceTooth FractureTremor

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Adderall
- support group for people who take Trazodone Hydrochloride

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) is often used to treat attention deficit hyperactivity disorder. Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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