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Review: Adderall and Trazodone

This review analyzes the effectiveness and drug interactions between Adderall and Trazodone. It is created by eHealthMe based on reports of 536 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Adderall and Trazodone >>>

What are the drugs

Adderall (latest outcomes from 16,634 users) has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder.

Trazodone hydrochloride (latest outcomes from 6,523 users) has active ingredients of trazodone hydrochloride. It is often used in insomnia.

On Jul, 12, 2014: 536 people who take Adderall, Trazodone Hydrochloride are studied

Adderall, Trazodone Hydrochloride outcomes

Drug combinations in study:
- Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate)
- Trazodone Hydrochloride (trazodone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Adderall is effective33.33%
(3 of 9 people)
(20 of 35 people)
(15 of 23 people)
(15 of 20 people)
(13 of 27 people)
(9 of 13 people)
(10 of 12 people)
(2 of 2 people)
Trazodone Hydrochloride is effective10.53%
(2 of 19 people)
(14 of 29 people)
(12 of 25 people)
(18 of 29 people)
(10 of 21 people)
(9 of 12 people)
(2 of 4 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
HeadachePainSleepinessAnxietyDyspnoeaDepressionDiabetic RetinopathyDepression
Muscle SprainCholelithiasisAnxietyDepressionPainAnxietyDiabetes Mellitus Inadequate ControlAnxiety
ChillsInjuryPresyncopePainAnxietyMood SwingsBlood Glucose IncreasedPain
WeaknessCholecystitisPulmonary FibrosisExhaustion, Fatigue, Lethargy, Tiredness, WearinessPain In ExtremityHeadachesProteinuriaChest Pain
AlopeciaSweating IncreasedChest PainPulmonary EmbolismNight SweatsLipoatrophyWeight IncreasedSomnolence
Neck PainExhaustion, Fatigue, Lethargy, Tiredness, WearinessPainPain In ExtremitySweating IncreasedTolerance DecreasedRenal DisorderNausea
InsomniaShort-term Memory LossDeep Vein ThrombosisChest PainPulmonary EmbolismDizzinessDiabetic NeuropathyTremor
DiarrhoeaDizzinessNon-cardiac Chest PainDeep Vein ThrombosisDeep Vein ThrombosisAppetite DecreasedDiabetic Eye DiseaseDyspnoea
SedationBlood Creatine Phosphokinase Mm IncreasedDyspnoeaDyspnoeaNauseaNightmareRenal CystInsomnia
Heart RacingMemory LossGeneral Physical Health DeteriorationHypersomniaChest PainSuicidal IdeationCoughGait Disturbance

Drug effectiveness by gender :

Adderall is effective62.14%
(64 of 103 people)
(23 of 37 people)
Trazodone Hydrochloride is effective50.98%
(52 of 102 people)
(15 of 38 people)

Most common drug interactions by gender * :

Chest PainAnxiety
Gait DisturbanceInsomnia
SomnolenceWeight Increased
InjuryDrug Withdrawal Syndrome

Drug effectiveness by age :

Adderall is effectiven/an/a70.00%
(7 of 10 people)
(32 of 101 people)
(22 of 49 people)
(15 of 59 people)
(9 of 29 people)
(2 of 5 people)
Trazodone Hydrochloride is effectiven/an/a44.44%
(4 of 9 people)
(15 of 98 people)
(21 of 46 people)
(13 of 60 people)
(12 of 29 people)
(2 of 5 people)

Most common drug interactions by age * :

AggressionScreamingAggressionInsomniaPainMultiple Sclerosis RelapseAnxietyCondition Aggravated
ConvulsionIntentional Self-injuryDepressionAnxietyWeight IncreasedLeukocytosisSomnolenceDepression
Tardive DyskinesiaStaringSomnolenceSubstance AbuseVomitingDyspnoeaOedema PeripheralHallucination, Visual
AgitationWeight IncreasedConvulsionDrug ToxicityDiabetes Mellitus Inadequate ControlArthritisFallDiabetic Neuropathy
Foaming At MouthAggressionType 1 Diabetes MellitusPolysubstance DependencePain In ExtremitySensory DisturbanceDepressionHyperkinesia
Homicidal IdeationHepatic SteatosisHeadacheDepressionUrinary Tract InfectionChest PainFall
Suicidal BehaviourDiabetic KetoacidosisDepressionBlood Glucose IncreasedProgressive Multifocal LeukoencephalopathyNauseaLiver Disorder
Bipolar DisorderPainNauseaDiabetic RetinopathyImmune Reconstitution SyndromeInsomniaDissociative Fugue
AgitationDyspnoeaBipolar DisorderInjurySynovial CystPainWithdrawal Syndrome
BiteTardive DyskinesiaParanoiaGallbladder DisorderGait DisturbanceDyspnoeaTremor

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Adderall and Trazodone
- group for people who take Adderall
- group for people who take Trazodone Hydrochloride

Comments from related studies:

  • From this study (1 month ago):

  • Eyes would begin watering within ten minutes of standing after waking up. They would water to the point where tears would stream down my face for 10-20 minutes; once this stopped, the symptom wouldn't return again until the next morning. Eyes would rarely begin watering before standing or sitting. Symptom went away after dropping dosage from 50mg to 25mg.


  • From this study (2 months ago):

  • Trying to determine if being off of Effexor xr for a month is contributing to chronic fatigue


  • From this study (4 months ago):

  • I gained weight rapidly and want to know if any of these medications or combination of any of them caused the weight gain.


    Ronnie on Apr, 5, 2014:

    Hell yes they could cause weight gain! The progesterone alone could do it! Not to mention all the other meds...


Post a new comment    OR    Read more comments

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Complete drug side effects:

On eHealthMe, Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) is often used to treat attention deficit hyperactivity disorder. Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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