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Review: taking Allegra and Hydrochlorothiazide together

Summary: drug interactions are reported among people who take Allegra and Hydrochlorothiazide together.

This review analyzes the effectiveness and drug interactions between Allegra and Hydrochlorothiazide. It is created by eHealthMe based on reports of 1,402 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Allegra has active ingredients of fexofenadine hydrochloride. It is often used in allergies. (latest outcomes from 23,863 Allegra users)

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. (latest outcomes from 62,004 Hydrochlorothiazide users)

On Feb, 28, 2015: 1,402 people who take Allegra, Hydrochlorothiazide are studied

Allegra, Hydrochlorothiazide outcomes

Drug combinations in study:
- Allegra (fexofenadine hydrochloride)
- Hydrochlorothiazide (hydrochlorothiazide)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Allegra is effective50.00%
(1 of 2 people)
(0 of 2 people)
(0 of 2 people)
(0 of 4 people)
(3 of 5 people)
(5 of 11 people)
(2 of 3 people)
(1 of 1 people)
Hydrochlorothiazide is effectiven/a75.00%
(3 of 4 people)
(1 of 2 people)
(0 of 2 people)
(5 of 10 people)
(5 of 7 people)
(4 of 4 people)

Drug effectiveness by gender :

Allegra is effective39.13%
(9 of 23 people)
(3 of 7 people)
Hydrochlorothiazide is effective60.87%
(14 of 23 people)
(4 of 6 people)

Drug effectiveness by age :

Allegra is effectiven/an/an/a100.00%
(1 of 1 people)
(1 of 2 people)
(4 of 17 people)
(5 of 35 people)
(1 of 7 people)
Hydrochlorothiazide is effectiven/an/an/a100.00%
(1 of 1 people)
(1 of 1 people)
(5 of 18 people)
(8 of 35 people)
(3 of 6 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaWound SecretionCardiac Failure CongestiveDeep Vein ThrombosisDeep Vein ThrombosisEmotional DistressCardiac FailurePain
AstheniaUrticariaSuicidal IdeationAgitationDyspnoeaPainHeart InjuryDyspnoea
Abdominal PainHaemoglobin DecreasedBlood Alkaline Phosphatase DecreasedDisorientationPain In ExtremityPulmonary EmbolismRenal FailureNausea
InsomniaNeutropeniaPathological GamblingPulmonary EmbolismOedema PeripheralMulti-organ FailureHepatic FailureFatigue
Atrial FibrillationWhite Blood Cell Count DecreasedCataractRetrograde AmnesiaCellulitis StaphylococcalAnxietyCardiac Failure CongestiveAnaemia
Colitis IschaemicRash ErythematousObsessive-compulsive DisorderMental Status ChangesCholecystitis ChronicInjuryDeathBack Pain
MalaiseOpen WoundDepressionBlood Electrolytes DecreasedPainRenal FailureSkin Burning SensationDiarrhoea
Frequent Bowel MovementsFallEmotional DistressHypokinesiaBreast Cancer FemaleStressAnxiety, Apprehension, Feeling Uptight, Jitters, Stress, Stress And Anxiety, TensionArthralgia
Muscle SpasmsInsomniaFeeling AbnormalApraxiaShortness Of BreathAnhedoniaFeeling JitteryAnxiety
CoughDermatitisGlaucomaSoporFatigue - ChronicFearMottled SkinOedema Peripheral

Most common drug interactions by gender * :

Oedema PeripheralChest Pain
Pain In ExtremityAbdominal Pain
Back PainMuscle Spasms

Most common drug interactions by age * :

Peritoneal Effusionn/aSomnolenceBronchitisPulmonary EmbolismDyspnoeaNauseaDiarrhoea
Pleural EffusionHyperhidrosisUrinary Tract InfectionHeadachePainPainNausea
Pelvic Fluid CollectionDevice FailureCholecystitisChest PainPain In ExtremityDyspnoeaFatigue
Pancreatitis AcuteInsomniaAnxietyBack PainPyrexiaPain
PneumoniaInfluenza Like IllnessDeep Vein ThrombosisPyrexiaHypertensionDizziness
PyrexiaCardiac Failure CongestivePain In ExtremityPneumoniaHeadacheDyspnoea
Type 2 Diabetes MellitusPresyncopeMyocardial InfarctionOedema PeripheralFatigueArthralgia
VomitingSupraventricular TachycardiaOedema PeripheralFatigueDizzinessChest Pain
Respiratory FailureTuberculin Test PositivePainArthralgiaDeep Vein ThrombosisMyalgia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Allegra and Hydrochlorothiazide?

You are not alone! Join a related mobile support group:
- support group for people who take Allegra and Hydrochlorothiazide
- support group for people who take Allegra
- support group for people who take Hydrochlorothiazide

Can you answer these questions (Ask a question):

More questions for: Allegra, Hydrochlorothiazide

You may be interested at these reviews (Write a review):

  • Hydrochlorothiazide and frontal fibrosing alopecia
    I took Hydrochlorothiazide for almost a year to prevent kidney stone formation. Ten months later, I went to see a Dermatologist because I was having problems with my skin. I had lost all of my eyebrow hair and most of the hair around my facial hairline and my hair was thinning on the rest of my scalp. I was diagnosed with Frontal Fibrosing Alopecia and was informed that Hydrochlorothiazide (HCTZ) can cause this disorder, which is a variant of lichen planopilaris. This disorder causes permanent hair loss due to scarring of the hair follicles all around my facial hairline. The hair I have lost will never grow back. I was advised to stop taking HCTZ.
  • Hydrochlorothiazide made me pour sweat
    Hydroclorothiazide made me absolutely pour sweat for two years. My doctors could not find out what was causing the problem. It took little exertion for me to start dripping sweat. My hair would be absolutely soaked...especially in the summer, but if I was cleaning house in the winter also. I finally did my own research and proposed to my doctor that HCTZ was the problem. He did not agree with me, but agreed to let me go off of it for a short time. The profuse sweating stopped almost immediately.
  • Swelling and pain in one of my breasts after using fexofanadine
    I took them for one week or two as an anti allergic drug and I found these conditions in my body. Then I stopped it for 6 months as I was away from allergenic country (Australia) and there was no symptoms. When I came back to Australia and needed Fexofenadine again, I used it for 1 week and I again notice swelling and pain in one of my breasts.
  • Excessive menstrual cycle bleeding??? here's a possible answer! (1 response)
    I take Hydrochlorothiazide 25mg and Atenolol 50mg daily for high blood pressure. I have had every exam known to man and all blood work and test results come back clear with no indications of a reason as to why my pressure is high. Needless to say, I take the meds and my blood pressure is controlled. I went to the dentist yesterday to have a filling replaced, the doctor gave me a novocaine injection, did the work and I was out of there happy as a pig in mud. The doctor did not ask if I was on my menstrual cycle and today I realize why he should have. I have to use the restroom every 15 minutes MAXIMUM, to change my sanitary napkin and release the blood that has accumulated in my vaginal canal. Wearing a tampon is not even an option! There is no pain however it is so gross. I once took 2 excedrin while on my cycle and had the mini version of what is happening now. Needless to say, the combination of hydrochlorothiazide and novocaine should not be mixed especially during your menstrual cycle.
  • Loss of voice and stomach issues
    Prescribed to take 2 - 300 mg tablets of Clindamycin prior to dental procedure to to knee implant done a month and half before dental procedure. Took two pills one hour prior and immediate severe burning of throat, esophagous and stomach with constant nausea. Still have symptons - ie loss of voice, low grade nausea. have had multitude of tests - ie. EGD's, monometry, transesophageal (with transmitter to determine extent of now reflux) Have to eat small amounts of food at a time. Have lost 23 lbs. Affects my every day life - difficult to talk on phone, talking in groups - just limit my socialization. Could not work if I wanted to with voice. Throat is constantly sore.

More reviews for: Allegra, Hydrochlorothiazide

Comments from related studies:

  • From this study (3 months ago):

  • From Feb. 2014 to Nov. 2014 peripheral vision decreased, eye pressure stable,
    doctors says indication of glaucoma. No known family history. Of white, native American, Scottish origins.
    Added the Bio-Curcumin within last 6 months. Wondering if that or possible use of Duloxeline could be cause.


  • From this study (6 months ago):

  • 4 months after stopping Allegra, I still have itching and rashes.
    Anxiety and panic attacks have stopped


  • From this study (2 years ago):

  • Type I Diabetes
    Secondary Chronic Kidney Disease


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Complete drug side effects:

On eHealthMe, Allegra (fexofenadine hydrochloride) is often used to treat allergies. Hydrochlorothiazide (hydrochlorothiazide) is often used to treat high blood pressure. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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