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Review: taking Allegra and Zantac together

Summary: drug interactions are reported among people who take Allegra and Zantac together.

This review analyzes the effectiveness and drug interactions between Allegra and Zantac. It is created by eHealthMe based on reports of 1,400 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Allegra has active ingredients of fexofenadine hydrochloride. It is often used in allergies. (latest outcomes from 23,860 Allegra users)

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. (latest outcomes from 35,533 Zantac users)

On Jan, 3, 2015: 1,400 people who take Allegra, Zantac are studied

Allegra, Zantac outcomes

Drug combinations in study:
- Allegra (fexofenadine hydrochloride)
- Zantac (ranitidine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Allegra is effective16.67%
(1 of 6 people)
(0 of 7 people)
(0 of 2 people)
(2 of 4 people)
(7 of 11 people)
(1 of 4 people)
(1 of 2 people)
Zantac is effective25.00%
(2 of 8 people)
(2 of 9 people)
(1 of 5 people)
(2 of 5 people)
(2 of 6 people)
(0 of 2 people)
(1 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Abdominal PainAbdominal PainErythema MultiformeNauseaFractureDystoniaParaesthesiaDyspnoea
Febrile NeutropeniaAspartate Aminotransferase IncreasedCholecystitis ChronicVomitingCardiac Failure CongestiveHippusWeaknessPain
HypokalaemiaDizzinessLiver Function Test AbnormalHyperglycaemiaUpper Limb FracturePlatelet CountUrination - Bed WettingAnxiety
NeutropeniaDrug Exposure During PregnancyPulmonary EmbolismType 2 Diabetes MellitusType 2 Diabetes MellitusParaesthesiaPainful RespirationDizziness
Liver Carcinoma RupturedDyspnoeaPainPelvic Fluid CollectionRib FractureChest PainUrinary FrequencyFall
PyrexiaLiver Function Test AbnormalDepressionPneumoniaLower Limb FractureWeaknessNausea
Platelet Count DecreasedSeborrhoeic KeratosisGallbladder DisorderRespiratory FailureOsteoporosisSuicidal IdeationChest Pain
RashDiarrhoeaMental DisorderHyponatraemiaCoronary Artery DiseaseFatigue
PneumoniaLiver Carcinoma RupturedInjuryIschaemiaRenal Failure ChronicDiarrhoea
Aspartate Aminotransferase IncreasedHypokalaemiaDrug Exposure During PregnancyMetabolic AcidosisErythema MultiformeDepression

Drug effectiveness by gender :

Allegra is effective34.48%
(10 of 29 people)
(2 of 7 people)
Zantac is effective26.67%
(8 of 30 people)
(2 of 8 people)

Most common drug interactions by gender * :

AnxietyChest Pain
Back PainHypercholesterolaemia
Chest PainMyalgia

Drug effectiveness by age :

Allegra is effectiven/an/a100.00%
(1 of 1 people)
(1 of 7 people)
(3 of 10 people)
(2 of 17 people)
(3 of 25 people)
(2 of 15 people)
Zantac is effective0.00%
(0 of 1 people)
(1 of 1 people)
(0 of 7 people)
(2 of 11 people)
(3 of 17 people)
(2 of 25 people)
(2 of 15 people)

Most common drug interactions by age * :

Peritoneal EffusionInsomniaNauseaPruritusChest PainChest PainChest PainDiarrhoea
Pleural EffusionSudden DeathFatiguePainDyspnoeaNauseaDizzinessFall
Pelvic Fluid CollectionUnresponsive To StimuliDeep Vein ThrombosisNauseaAnxietyDyspnoeaNauseaDyspnoea
Pancreatitis AcuteVomitingCerebrovascular AccidentAnxietyPainHeadachePainAnxiety
PancreatitisAgitationDepressionCholecystitis ChronicUrticariaDepressionFallBone Disorder
PneumoniaArrhythmiaBrain HerniationDyspnoeaHeadacheFallVomitingCough
PyrexiaAggressionBrain DeathThroat TightnessInjuryBack PainArthralgiaFatigue
Type 2 Diabetes MellitusDyspnoeaDrug HypersensitivityInjuryDrug IneffectiveAbdominal PainBack PainMyalgia
VomitingCoughCerebral IschaemiaDrug Exposure During PregnancyNauseaAnxietyHeadachePain
Respiratory FailureDry ThroatDrug IneffectiveUrticariaArthralgiaPainAnxietyChest Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Allegra and Zantac?

You are not alone! Join a related mobile support group:
- support group for people who take Allegra and Zantac
- support group for people who take Allegra
- support group for people who take Zantac

Can you answer these questions (Ask a question):

More questions for: Allegra, Zantac

You may be interested at these reviews (Write a review):

  • Swelling and pain in one of my breasts after using fexofanadine
    I took them for one week or two as an anti allergic drug and I found these conditions in my body. Then I stopped it for 6 months as I was away from allergenic country (Australia) and there was no symptoms. When I came back to Australia and needed Fexofenadine again, I used it for 1 week and I again notice swelling and pain in one of my breasts.
  • Ranitidine is bad juju
    Used 3-5 times per week for about 1 1/2 years. Noticed:
    shortness of breath
    contstricted throat
    chest pain/pressure
    heart palpatations
    dryness - more so than usual

    I quit taking it and felt much better within 2-3 days.
  • Wheezing stopped after topamax sessesion
    Wheezing noted by primary physician in this non-smoker. Stopped Topamax per doctor's instruction. 48 hours later was examined by physician and noted that wheezing stopped.
  • Temazepam & fenfexodine
    Is anyone else finding the Temazepam is not working when taken with fenofexedine? I survive on a few hours of sleep a day.
  • Polyuria associated with zantac
    I was prescribed Zantac 150mg before breakfast and before dinner. After two days, I felt tired and had polyuria (by weight change 650 mL). I had kidney pain so drank water with a tiny bit of salt. Felt very nauseous, but more water helped. Continued to sip water til kidney pain eased. Have discontinued Zantac. Kidneys stopped hurting after about 4 hours. Seem to be ok, now.

More reviews for: Allegra, Zantac

Comments from related studies:

  • From this study (1 year ago):

  • Flushing started Feb. 2013 with large hives. Face and neck become inflamed with burning pain, not itching. Had been on Celebrex several years ( also tried other NSAIDS including Ibuprofen, mobic and aspirin) For neck and joint pain as well as chronic plantar facitits. Episode seem less often without NSAIDS. Continue to have episodes regardless sometimes daily Although have had periods of no episodes for a week. Areas now have has permanent markings (scaring?)
    I have seen two dermatologist, family doctor, and allergist who cannot diagnose. Many lab test were within normal limits except mast cells were slightly elevated around 300. Aldactone is new Replacing HCTZ; Zantac, Allegra , and Zyrtec are new to help symptoms. Nasonex is also new . Tried topical steroid cream which was not effective. Thanks!


  • From this study (1 year ago):

  • recently diagnosed as having mild ITP


  • From this study (1 year ago):

  • speckled Rash on forearms and neck, new freckles on face


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Allegra (fexofenadine hydrochloride) is often used to treat allergies. Zantac (ranitidine hydrochloride) is often used to treat gastroesophageal reflux disease. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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