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Review: taking Allegra and Zantac together

Summary: drug interactions are reported among people who take Allegra and Zantac together.

This review analyzes the effectiveness and drug interactions between Allegra and Zantac. It is created by eHealthMe based on reports of 1,400 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Allegra and Zantac >>>

What are the drugs

Allegra has active ingredients of fexofenadine hydrochloride. It is often used in allergies. (latest outcomes from 23,863 Allegra users)

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. (latest outcomes from 35,535 Zantac users)

On Feb, 11, 2015: 1,400 people who take Allegra, Zantac are studied

Allegra, Zantac outcomes

Drug combinations in study:
- Allegra (fexofenadine hydrochloride)
- Zantac (ranitidine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Allegra is effective16.67%
(1 of 6 people)
(0 of 7 people)
(0 of 2 people)
(2 of 4 people)
(7 of 11 people)
(1 of 4 people)
(1 of 2 people)
Zantac is effective25.00%
(2 of 8 people)
(2 of 9 people)
(1 of 5 people)
(2 of 5 people)
(2 of 6 people)
(0 of 2 people)
(1 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Abdominal PainAbdominal PainErythema MultiformeNauseaFractureDystoniaParaesthesiaDyspnoea
Febrile NeutropeniaAspartate Aminotransferase IncreasedCholecystitis ChronicVomitingCardiac Failure CongestiveHippusWeaknessPain
HypokalaemiaDizzinessLiver Function Test AbnormalHyperglycaemiaUpper Limb FracturePlatelet CountUrination - Bed WettingAnxiety
NeutropeniaDrug Exposure During PregnancyPulmonary EmbolismType 2 Diabetes MellitusType 2 Diabetes MellitusParaesthesiaPainful RespirationDizziness
Liver Carcinoma RupturedDyspnoeaPainPelvic Fluid CollectionRib FractureChest PainUrinary FrequencyFall
PyrexiaLiver Function Test AbnormalDepressionPneumoniaLower Limb FractureWeaknessNausea
Platelet Count DecreasedSeborrhoeic KeratosisGallbladder DisorderRespiratory FailureOsteoporosisSuicidal IdeationChest Pain
RashDiarrhoeaMental DisorderHyponatraemiaCoronary Artery DiseaseFatigue
PneumoniaLiver Carcinoma RupturedInjuryIschaemiaRenal Failure ChronicDiarrhoea
Aspartate Aminotransferase IncreasedHypokalaemiaDrug Exposure During PregnancyMetabolic AcidosisErythema MultiformeDepression

Drug effectiveness by gender :

Allegra is effective34.48%
(10 of 29 people)
(2 of 7 people)
Zantac is effective26.67%
(8 of 30 people)
(2 of 8 people)

Most common drug interactions by gender * :

AnxietyChest Pain
Back PainHypercholesterolaemia
Chest PainMyalgia

Drug effectiveness by age :

Allegra is effectiven/an/a100.00%
(1 of 1 people)
(1 of 7 people)
(3 of 10 people)
(2 of 17 people)
(3 of 25 people)
(2 of 15 people)
Zantac is effective0.00%
(0 of 1 people)
(1 of 1 people)
(0 of 7 people)
(2 of 11 people)
(3 of 17 people)
(2 of 25 people)
(2 of 15 people)

Most common drug interactions by age * :

Peritoneal EffusionInsomniaNauseaPruritusChest PainChest PainChest PainDiarrhoea
Pleural EffusionSudden DeathFatiguePainDyspnoeaNauseaDizzinessFall
Pelvic Fluid CollectionUnresponsive To StimuliDeep Vein ThrombosisNauseaAnxietyDyspnoeaNauseaDyspnoea
Pancreatitis AcuteVomitingCerebrovascular AccidentAnxietyPainHeadachePainAnxiety
PancreatitisAgitationDepressionCholecystitis ChronicUrticariaDepressionFallBone Disorder
PneumoniaArrhythmiaBrain HerniationDyspnoeaHeadacheFallVomitingCough
PyrexiaAggressionBrain DeathThroat TightnessInjuryBack PainArthralgiaFatigue
Type 2 Diabetes MellitusDyspnoeaDrug HypersensitivityInjuryDrug IneffectiveAbdominal PainBack PainMyalgia
VomitingCoughCerebral IschaemiaDrug Exposure During PregnancyNauseaAnxietyHeadachePain
Respiratory FailureDry ThroatDrug IneffectiveUrticariaArthralgiaPainAnxietyChest Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Allegra and Zantac on

Do you take Allegra and Zantac?

You are not alone! Join a related mobile support group:
- support group for people who take Allegra and Zantac
- support group for people who take Allegra
- support group for people who take Zantac

Can you answer these questions (Ask a question):

  • Can i take zantac with 20mg of rivaroxaban?

    I was wondering if anybody could help me on this i'm currently taking Rivaroxaban Zantac with Rivaroxaban(20mg)(Daily)to treat DVT.

    The thing is whilst doing this i'm suffering greatly with Heartburn, Acid Reflux.

    Can i take the Zantac to soothe my pain with Rivaroxaban?


    Paul Foster.
  • Has anyone with itp been offered or receivedimmunology for severe allergy to grass pollens? if so what was the outcome? our immunologist knows of no-one with itp receiving immunologgy and is fearful.
    Discovered low platelets when had a severe allergic reaction to hayfever & subsequent trip to A&E
    Hospital Allergy Dr's - Grass Pollens - off the scales. His (my son's) low platelets are caused by antibodies attacking platelets (autoimmune thrombocytopenia). No other cause for ITP found so presumed virus or could also be the inflamatory allergic reaction.
    Immunologist scared to give even grazax (orally taken - one a day) and def not quattro injection immunology. Immunologist has said he know of not one single case of immunology and the outcomes on platelett count and ITP and so will not give. has anyone had both immunology who also has ITP?????
    My son has now been diagnosed with ITP for 7 months and is very frustrated and we are dreading this new hayfever season, eventhough the immunologist has upped the fexofenadine to start in march.. We are UK. He is on all treatments for hayfever, eye drops, nasal inhalers, sinus rinse, prventers (prevalin). He has been given prednisolone for 1st week after visit to A&E but none since
  • Is fexotenadine hydrochloride an amphetamine
    just want to know what category this drug comes under before taking same
  • Is it ok to take zantac while taking benicar
    Is it ok to take together. If i take one in morning and one in evening
  • Does nexplanon have nickel in it?
    I have a severe nickel allergy and I have epilepsy. I am considering explain to reduce periodes since my seizures are worse that time of the month. I need to know if nexplanon has nickel because I need to avoid it if it does.

More questions for: Allegra, Zantac

You may be interested at these reviews (Write a review):

  • Zantac long-term use caused symptoms of fibromyalgia and plantar fasciitis (1 response)
    I was taking Zantac every night for acid reflux/GERD that mostly occurred while I slept. After several months of daily use I began waking up with muscle stiffness, tight calves, and it hurt to walk, with extreme heel pain aka Plantar Fasciitis like symptoms and could hardly walk on stairs. Physical therapy, constant stretching and exercise got me nowhere. Magnesium deficiency was suspected and I consumed foods and supplements along with CO Enzyme 2 with no results. Along with previous muscle injuries to neck and shoulders (due to car accidents and sports), and Piriformis syndrome (due to strain from sitting) getting worse I was misdiagnosed for three years with Fibromyalgia (basically a diagnosis of we don't know what is causing your muscle pain and sense it's basically from head to toe now we will stamp you withy this label) Soon as I stopped taking Zantac/ Rantidine, I fully recovered from all the horrible symptoms I was having. Thanks to Dr. Google, and typing in Rantidine and muscle pain I discovered this med was the cause malabsorption of Magnesium. Be warned that any acid blockers or proton pump inhibitors can block the absorption of magnesium, calcium, B12 and other essential minerals and vitamins even causing anemia and fatigue. Instead elevate the foot of your bed or get a foam ramp from back store and take Tums of Milk of Magnesium when symptoms are bad. I also dropped a few stubborn pounds due to water retention caused by the drug which was affecting my kidneys (nephretitis). I learned that some patients encounter a rate drug intolerance using Rantidine which results in this condition. My health is finally robust again with no thanks to three different docs, (my Regular doc two rheumatologists). With the last doc dumbfounded when I told him stoping this med (that he highly encouraged I take among other docs) resolved my symptoms. No more leg stiffness in AM or pain and difficulty walking. My neck/shoulder injuries and Piriformis syndrome rarely cause me issues anymore as they are not aggravated by the lack of magnesium which is responsible for muscle recovery and relaxation. Finally with my immune system no longer fighting drug toxicity I'm no longer catching every cold under the sun and having them turn into horrible sinus infections or bacterial bronchitis. Hallelujah!! I hope this post can help others recover.
  • Swelling and pain in one of my breasts after using fexofanadine
    I took them for one week or two as an anti allergic drug and I found these conditions in my body. Then I stopped it for 6 months as I was away from allergenic country (Australia) and there was no symptoms. When I came back to Australia and needed Fexofenadine again, I used it for 1 week and I again notice swelling and pain in one of my breasts.
  • Ranitidine is bad juju
    Used 3-5 times per week for about 1 1/2 years. Noticed:
    shortness of breath
    contstricted throat
    chest pain/pressure
    heart palpatations
    dryness - more so than usual

    I quit taking it and felt much better within 2-3 days.
  • Wheezing stopped after topamax sessesion
    Wheezing noted by primary physician in this non-smoker. Stopped Topamax per doctor's instruction. 48 hours later was examined by physician and noted that wheezing stopped.
  • Temazepam & fenfexodine
    Is anyone else finding the Temazepam is not working when taken with fenofexedine? I survive on a few hours of sleep a day.

More reviews for: Allegra, Zantac

Comments from related studies:

  • From this study (1 year ago):

  • Flushing started Feb. 2013 with large hives. Face and neck become inflamed with burning pain, not itching. Had been on Celebrex several years ( also tried other NSAIDS including Ibuprofen, mobic and aspirin) For neck and joint pain as well as chronic plantar facitits. Episode seem less often without NSAIDS. Continue to have episodes regardless sometimes daily Although have had periods of no episodes for a week. Areas now have has permanent markings (scaring?)
    I have seen two dermatologist, family doctor, and allergist who cannot diagnose. Many lab test were within normal limits except mast cells were slightly elevated around 300. Aldactone is new Replacing HCTZ; Zantac, Allegra , and Zyrtec are new to help symptoms. Nasonex is also new . Tried topical steroid cream which was not effective. Thanks!


  • From this study (1 year ago):

  • recently diagnosed as having mild ITP


  • From this study (1 year ago):

  • speckled Rash on forearms and neck, new freckles on face


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Complete drug side effects:

On eHealthMe, Allegra (fexofenadine hydrochloride) is often used to treat allergies. Zantac (ranitidine hydrochloride) is often used to treat gastroesophageal reflux disease. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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