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Review: taking Alphagan and HCTZ together

Summary: drug interactions are reported among people who take Alphagan and HCTZ together.

This review analyzes the effectiveness and drug interactions between Alphagan and HCTZ. It is created by eHealthMe based on reports of 217 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Alphagan and HCTZ >>>

What are the drugs

Alphagan has active ingredients of brimonidine tartrate. It is often used in glaucoma. (latest outcomes from 3,406 Alphagan users)

Hctz has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. (latest outcomes from 1,143 Hctz users)

On Feb, 17, 2015: 217 people who take Alphagan, HCTZ are studied

Alphagan, HCTZ outcomes

Drug combinations in study:
- Alphagan (brimonidine tartrate)
- HCTZ (hydrochlorothiazide)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Alphagan is effectiven/a0.00%
(0 of 1 people)
(0 of 1 people)
(0 of 1 people)
(1 of 1 people)
HCTZ is effectiven/an/an/a0.00%
(0 of 1 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Renal Failure AcuteLoss Of Consciousnessn/aPruritusn/aEmotional Distressn/aDyspnoea
SyncopeNauseaLymphocyte Count DecreasedHypertensionOedema Peripheral
Sepsis SyndromeRhinorrhoeaCataractMental DisorderAsthenia
Renal Tubular NecrosisSyncopeFatiguePulmonary EmbolismFall
Mental Status ChangesHypersensitivityDizzinessCardiac MurmurSyncope
HypertensionFatigueChromatopsiaArthropathyLoss Of Consciousness
Loss Of ConsciousnessAstheniaDizzinessInsomnia
AmnesiaBlood Pressure AbnormalTinnitusVomiting
Ankle FractureBlood Pressure DecreasedPneumonia
Syncope VasovagalEye RednessHypertension

Drug effectiveness by gender :

Alphagan is effective33.33%
(1 of 3 people)
(0 of 1 people)
HCTZ is effective100.00%
(1 of 1 people)
(0 of 1 people)

Most common drug interactions by gender * :

DyspnoeaIntraocular Pressure Increased
Oedema PeripheralSyncope
VomitingRenal Failure Acute
PainMental Status Changes
FallBlood Urea Increased
Loss Of ConsciousnessAsthenia
AstheniaWeight Decreased
HypoaesthesiaSepsis Syndrome
SyncopeRenal Tubular Necrosis

Drug effectiveness by age :

Alphagan is effectiven/an/an/an/an/an/a0.00%
(0 of 1 people)
(1 of 4 people)
HCTZ is effectiven/an/an/an/an/an/a100.00%
(1 of 1 people)
(0 of 1 people)

Most common drug interactions by age * :

Haemoglobin DecreasedScotomaLoss Of Consciousness
Neutrophil Count DecreasedEye PainVomiting
Oral PainHeadacheAsthenia
PancytopeniaRetinal ScarPneumonia
Haematocrit DecreasedOptic Ischaemic NeuropathySyncope
Urinary IncontinenceRetinal AneurysmFall
SyncopeOptic AtrophyInsomnia
TinnitusVitreous HaemorrhageOedema Peripheral

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Alphagan and HCTZ?

You are not alone! Join a related mobile support group:
- support group for people who take Alphagan and HCTZ
- support group for people who take Alphagan
- support group for people who take HCTZ

Can you answer these questions (Ask a question):

More questions for: Alphagan, HCTZ

You may be interested at these reviews (Write a review):

  • Hydrochlorothiazide and frontal fibrosing alopecia
    I took Hydrochlorothiazide for almost a year to prevent kidney stone formation. Ten months later, I went to see a Dermatologist because I was having problems with my skin. I had lost all of my eyebrow hair and most of the hair around my facial hairline and my hair was thinning on the rest of my scalp. I was diagnosed with Frontal Fibrosing Alopecia and was informed that Hydrochlorothiazide (HCTZ) can cause this disorder, which is a variant of lichen planopilaris. This disorder causes permanent hair loss due to scarring of the hair follicles all around my facial hairline. The hair I have lost will never grow back. I was advised to stop taking HCTZ.
  • Hydrochlorothiazide made me pour sweat
    Hydroclorothiazide made me absolutely pour sweat for two years. My doctors could not find out what was causing the problem. It took little exertion for me to start dripping sweat. My hair would be absolutely soaked...especially in the summer, but if I was cleaning house in the winter also. I finally did my own research and proposed to my doctor that HCTZ was the problem. He did not agree with me, but agreed to let me go off of it for a short time. The profuse sweating stopped almost immediately.
  • Excessive menstrual cycle bleeding??? here's a possible answer! (1 response)
    I take Hydrochlorothiazide 25mg and Atenolol 50mg daily for high blood pressure. I have had every exam known to man and all blood work and test results come back clear with no indications of a reason as to why my pressure is high. Needless to say, I take the meds and my blood pressure is controlled. I went to the dentist yesterday to have a filling replaced, the doctor gave me a novocaine injection, did the work and I was out of there happy as a pig in mud. The doctor did not ask if I was on my menstrual cycle and today I realize why he should have. I have to use the restroom every 15 minutes MAXIMUM, to change my sanitary napkin and release the blood that has accumulated in my vaginal canal. Wearing a tampon is not even an option! There is no pain however it is so gross. I once took 2 excedrin while on my cycle and had the mini version of what is happening now. Needless to say, the combination of hydrochlorothiazide and novocaine should not be mixed especially during your menstrual cycle.
  • Loss of voice and stomach issues
    Prescribed to take 2 - 300 mg tablets of Clindamycin prior to dental procedure to to knee implant done a month and half before dental procedure. Took two pills one hour prior and immediate severe burning of throat, esophagous and stomach with constant nausea. Still have symptons - ie loss of voice, low grade nausea. have had multitude of tests - ie. EGD's, monometry, transesophageal (with transmitter to determine extent of now reflux) Have to eat small amounts of food at a time. Have lost 23 lbs. Affects my every day life - difficult to talk on phone, talking in groups - just limit my socialization. Could not work if I wanted to with voice. Throat is constantly sore.
  • Ranexa and erectile dysfunction
    I have experienced moderate ED with taking multiple heart and NO meds. This has been manageable and acceptable. Cardiologist added Ranexa (Ranalozine) 3 weeks ago and I am now experiencing complete erectile and ejaculatory failure.

More reviews for: Alphagan, HCTZ

Comments from related studies:

  • From this study (2 years ago):

  • Right shoulder pain, clavicle pain, left knee pain, right lower leg pain, stiff joints on right hand more severe after being in bed for 4 hours or more.
    Blood pressure higher 140/82 to 170/84 when measured between 2 am to 4:30 am. Difficulty staying asleep because of pain.


  • From this study (2 years ago):

  • After a 4 month trial of Lumigan, stopped because of onset of bilateral tinnitus and fullness of ears. Started Alphagan and fullness went away but tinnitus persists! ENT said she doesn't see any hearing loss on test and thinks its random. I hold to the fact that it Started with Lumigan and hasn't gone away with Alphagan.. ophthalmologist says its not the drops.....?????


  • From this study (5 years ago):

  • osteoperosis and spinal deterioration within a year. Was tested right before and had none of these conditions.


Complete drug side effects:

On eHealthMe, Alphagan (brimonidine tartrate) is often used to treat glaucoma. Hctz (hydrochlorothiazide) is often used to treat high blood pressure. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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