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Review: Ambien and Benadryl

This review analyzes the effectiveness and drug interactions between Ambien and Benadryl. It is created by eHealthMe based on 2,325 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

On Apr, 10, 2014: 2,325 people who take Ambien, Benadryl are studied

Ambien, Benadryl outcomes

Drug combinations in study:
- Ambien (zolpidem tartrate)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Ambien is effective41.18%
(7 of 17 people)
60.00%
(3 of 5 people)
50.00%
(7 of 14 people)
30.00%
(3 of 10 people)
55.56%
(10 of 18 people)
66.67%
(4 of 6 people)
0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
Benadryl is effective35.71%
(5 of 14 people)
30.77%
(4 of 13 people)
50.00%
(2 of 4 people)
25.00%
(2 of 8 people)
54.55%
(6 of 11 people)
0.00%
(0 of 9 people)
42.86%
(3 of 7 people)
50.00%
(2 of 4 people)

Drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Pyrexia
(17 reports)

Hypotension
(15 reports)

Dyspnoea
(13 reports)

Dehydration
(11 reports)

Pain In Extremity
(9 reports)

Rhinorrhoea
(5 reports)

Small Intestinal Obstruction
(5 reports)

Implant Site Erosion
(3 reports)

Deep Vein Thrombosis
(3 reports)

Atrial Fibrillation
(3 reports)

Dizziness
(5 reports)

Disturbance In Attention
(4 reports)

Gait Disturbance
(4 reports)

Dysarthria
(4 reports)

Confusional State
(4 reports)

Psychiatric Symptom
(1 report)

Bronchospasm
(1 report)

Trisomy 21
(1 report)

Congenital Mitral Valve Incompetence
(1 report)

Jaundice Neonatal
(1 report)

Depression
(8 reports)

Dysarthria
(6 reports)

Impaired Driving Ability
(6 reports)

Lacrimation Increased
(6 reports)

Somnambulism
(6 reports)

Pain
(10 reports)

Oedema Peripheral
(7 reports)

Amnesia
(6 reports)

Arthralgia
(6 reports)

Eating Disorder
(6 reports)

Fatigue
(2 reports)

Drug Dependence
(1 report)

Depression
(1 report)

Anxiety
(1 report)

Sleepy
(1 report)

Pain
(321 reports)

Anxiety
(283 reports)

Dyspnoea
(244 reports)

Osteonecrosis Of Jaw
(234 reports)

Nausea
(229 reports)

Drug effectiveness by gender :

FemaleMale
Ambien is effective48.21%
(27 of 56 people)
43.75%
(7 of 16 people)
Benadryl is effective35.85%
(19 of 53 people)
29.41%
(5 of 17 people)

Drug interactions by gender * :

FemaleMale
Common drug interactions Pain
(290 reports)

Anxiety
(264 reports)

Dyspnoea
(241 reports)

Nausea
(236 reports)

Fatigue
(196 reports)

Pain
(93 reports)

Anxiety
(90 reports)

Depression
(75 reports)

Nausea
(74 reports)

Dyspnoea
(72 reports)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Ambien is effectiven/an/a50.00%
(3 of 6 people)
13.33%
(2 of 15 people)
17.86%
(5 of 28 people)
46.43%
(13 of 28 people)
25.00%
(7 of 28 people)
50.00%
(4 of 8 people)
Benadryl is effectiven/an/a16.67%
(1 of 6 people)
20.00%
(3 of 15 people)
17.24%
(5 of 29 people)
33.33%
(9 of 27 people)
19.23%
(5 of 26 people)
12.50%
(1 of 8 people)

Drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Common drug interactions Respiratory Arrest
(4 reports)

Cardiac Arrest
(4 reports)

Poisoning
(3 reports)

Convulsion
(3 reports)

Aggression
(2 reports)

Transfusion Reaction
(3 reports)

Hypokalaemia
(3 reports)

Fungal Test Positive
(3 reports)

Rash
(2 reports)

Bronchiectasis
(2 reports)

Agitation
(9 reports)

Pyrexia
(8 reports)

Headache
(8 reports)

Convulsion
(7 reports)

Musculoskeletal Stiffness
(7 reports)

Insomnia
(24 reports)

Nausea
(21 reports)

Vomiting
(20 reports)

Urinary Tract Infection
(17 reports)

Asthenia
(14 reports)

Pain
(34 reports)

Pyrexia
(33 reports)

Dyspnoea
(28 reports)

Headache
(26 reports)

Abdominal Pain
(24 reports)

Pain
(89 reports)

Back Pain
(81 reports)

Anxiety
(74 reports)

Nausea
(71 reports)

Pain In Extremity
(62 reports)

Anxiety
(113 reports)

Pain
(104 reports)

Dyspnoea
(99 reports)

Injury
(86 reports)

Nausea
(86 reports)

Fall
(90 reports)

Anaemia
(89 reports)

Fatigue
(85 reports)

Dyspnoea
(85 reports)

Anxiety
(84 reports)

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Ambien, Benadryl

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Complete drug side effects:

On eHealthMe, Ambien (zolpidem tartrate) is often used to treat insomnia. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

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  • From this study (12 months ago):

  • All adverse effects are tolerable and preferential to extreme pain and fatigue which can cause severe MS exacerbation.

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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