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Review: Ambien and Benadryl

This review analyzes the effectiveness and drug interactions between Ambien and Benadryl. It is created by eHealthMe based on reports of 2,328 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Ambien and Benadryl >>>

What are the drugs

Ambien (latest outcomes from 46,695 users) has active ingredients of zolpidem tartrate. It is often used in insomnia.

Benadryl (latest outcomes from 29,335 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

On Sep, 11, 2014: 2,328 people who take Ambien, Benadryl are studied

Ambien, Benadryl outcomes

Drug combinations in study:
- Ambien (zolpidem tartrate)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Ambien is effective41.18%
(7 of 17 people)
(3 of 5 people)
(7 of 14 people)
(3 of 12 people)
(10 of 19 people)
(4 of 6 people)
(0 of 1 people)
(0 of 1 people)
Benadryl is effective35.71%
(5 of 14 people)
(4 of 13 people)
(2 of 4 people)
(2 of 9 people)
(6 of 11 people)
(0 of 10 people)
(3 of 7 people)
(2 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaRhinorrhoeaDizzinessTrisomy 21DepressionPainFatiguePain
HypotensionSmall Intestinal ObstructionDisturbance In AttentionBronchospasmDysarthriaOedema PeripheralDrug DependenceAnxiety
DyspnoeaImplant Site ErosionGait DisturbancePsychiatric SymptomImpaired Driving AbilityAmnesiaDepressionNausea
DehydrationDeep Vein ThrombosisDysarthriaJaundice NeonatalLacrimation IncreasedArthralgiaAnxietyDyspnoea
Pain In ExtremityAtrial FibrillationConfusional StateCongenital Mitral Valve IncompetenceSomnambulismEating DisorderSleepyArthralgia
MalaiseFolliculitisAstheniaSpinal X-ray AbnormalOcular HyperaemiaSomnambulismHot FlashesFatigue
AstheniaAnxietyAtaxiaAtrial Septal DefectRoad Traffic AccidentAnxietyDermatitis AcneiformBack Pain
Atrial FibrillationPlatelet Count DecreasedBradyarrhythmiaHeart Rate IrregularBalance DisorderEmotional DistressSweating IncreasedPyrexia
LymphopeniaPulmonary EmbolismImpaired Work AbilityInability To CrawlMemory ImpairmentChest PainItchingAnaemia
Confusional StateAstheniaLethargyCystitisSpinal X-ray AbnormalDyspnoea ExertionalMyalgiaVomiting

Drug effectiveness by gender :

Ambien is effective46.55%
(27 of 58 people)
(7 of 17 people)
Benadryl is effective35.19%
(19 of 54 people)
(5 of 18 people)

Most common drug interactions by gender * :

ArthralgiaBack Pain
Osteonecrosis Of JawAsthenia

Drug effectiveness by age :

Ambien is effectiven/an/a50.00%
(3 of 6 people)
(2 of 15 people)
(5 of 28 people)
(13 of 29 people)
(7 of 31 people)
(4 of 9 people)
Benadryl is effectiven/an/a16.67%
(1 of 6 people)
(3 of 15 people)
(5 of 29 people)
(9 of 27 people)
(5 of 29 people)
(1 of 9 people)

Most common drug interactions by age * :

Respiratory ArrestTransfusion ReactionAgitationInsomniaPainPainAnxietyFall
Cardiac ArrestHypokalaemiaPyrexiaNauseaPyrexiaBack PainPainAnaemia
PoisoningFungal Test PositiveHeadacheVomitingDyspnoeaAnxietyDyspnoeaFatigue
ConvulsionRashConvulsionUrinary Tract InfectionHeadacheNauseaInjuryDyspnoea
AggressionBronchiectasisMusculoskeletal StiffnessAstheniaAbdominal PainPain In ExtremityNauseaAnxiety
Drug ToxicityCulture PositiveSuicidal IdeationAnxietyDepressionArthralgiaOsteonecrosis Of JawBack Pain
Orthostatic HypotensionRespiratory Tract Infection FungalWeight IncreasedUpper Respiratory Tract InfectionInsomniaFallArthralgiaNausea
TremorStem Cell TransplantRespiratory DistressWeight DecreasedFatigueInsomniaPyrexiaPain
PneumoniaRestrictive Pulmonary DiseasePneumoniaMulti-organ FailureAnxietyDepressionInsomniaOsteonecrosis Of Jaw
Renal ImpairmentTracheomalaciaBlood Potassium DecreasedPericardial EffusionChest PainHeadacheBone DisorderArthralgia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Ambien and Benadryl?

Comments from related studies:

  • From this study (2 days ago):

  • Episodes can last 36-48 hours with medications. Without the meds the episode must run its course which can be up the 30-45 days;


  • From this study (3 months ago):

  • 27 L knee operations, three massive L knee infections resulting in a third and final arthoplasty revision. Extensive soft tissue damage resulting in perminante subqutanious sutuers and locking full leg brace, also perminante.

    Daily swelling in the knee joint (4 to 6 cm daily). Constant pain as well as additional pain when walking.


  • From this study (13 months ago):

  • Trying to determine best pharma options - I take Wellbutrin for depression but liked the increased e nervy, sex drive, and weight loss. Dr added 90mg cymbalta also. I have been having hot flashes


Post a new comment    OR    Read more comments

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More reviews for: Ambien, Benadryl

Complete drug side effects:

On eHealthMe, Ambien (zolpidem tartrate) is often used to treat insomnia. Benadryl (diphenhydramine hydrochloride) is often used to treat allergen. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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