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Review: taking Ambien and Benadryl together

Summary: drug interactions are reported among people who take Ambien and Benadryl together.

This review analyzes the effectiveness and drug interactions between Ambien and Benadryl. It is created by eHealthMe based on reports of 2,334 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 5, 2015: 2,334 people who take Ambien, Benadryl are studied

Ambien, Benadryl outcomes

Drug combinations in study:
- Ambien (zolpidem tartrate)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Ambien is effective41.18%
(7 of 17 people)
(3 of 7 people)
(8 of 15 people)
(3 of 12 people)
(10 of 19 people)
(5 of 7 people)
(1 of 2 people)
(0 of 1 people)
Benadryl is effective35.71%
(5 of 14 people)
(4 of 13 people)
(2 of 5 people)
(3 of 10 people)
(6 of 12 people)
(0 of 10 people)
(3 of 9 people)
(2 of 4 people)

Drug effectiveness by gender :

Ambien is effective46.67%
(28 of 60 people)
(9 of 20 people)
Benadryl is effective33.93%
(19 of 56 people)
(6 of 21 people)

Drug effectiveness by age :

Ambien is effectiven/an/a50.00%
(3 of 6 people)
(3 of 22 people)
(6 of 29 people)
(13 of 29 people)
(7 of 55 people)
(5 of 10 people)
Benadryl is effectiven/an/a16.67%
(1 of 6 people)
(4 of 22 people)
(5 of 30 people)
(9 of 27 people)
(5 of 53 people)
(1 of 10 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaSmall Intestinal ObstructionDizzinessBronchospasmDepressionPainFatiguePain
HypotensionRhinorrhoeaDisturbance In AttentionPsychiatric SymptomBalance DisorderOedema PeripheralSex - Delayed EjaculationAnxiety
DyspnoeaImplant Site ErosionDysarthriaTrisomy 21Road Traffic AccidentEating DisorderDrug DependenceNausea
DehydrationDeep Vein ThrombosisGait DisturbanceJaundice NeonatalDysarthriaAmnesiaDepressionDyspnoea
Pain In ExtremityPulmonary EmbolismDepressionSpinal X-ray AbnormalOcular HyperaemiaSomnambulismAnxietyArthralgia
MalaiseAtrial FibrillationConfusional StateAtrial Septal DefectSomnambulismArthralgiaSleepyFatigue
AstheniaAnxietyAngerCongenital Mitral Valve IncompetenceLacrimation IncreasedRespiration AbnormalHot FlashesBack Pain
Atrial FibrillationPlatelet Count DecreasedAstheniaHeart Rate IrregularImpaired Driving AbilityDeep Vein ThrombosisDermatitis AcneiformPyrexia
LymphopeniaFolliculitisBradyarrhythmiaOxygen Saturation DecreasedSpinal X-ray AbnormalChest PainProteinuriaAnaemia
Confusional StatePneumothoraxImpaired Work AbilityRinging In The EarsInsomniaDyspnoea ExertionalSweating IncreasedVomiting

Most common drug interactions by gender * :

FatigueBack Pain
Osteonecrosis Of JawAsthenia

Most common drug interactions by age * :

Respiratory ArrestTransfusion ReactionAgitationInsomniaPainPainAnxietyFall
Cardiac ArrestHypokalaemiaPyrexiaNauseaPyrexiaBack PainPainAnaemia
PoisoningFungal Test PositiveHeadacheVomitingDyspnoeaAnxietyDyspnoeaFatigue
ConvulsionRashConvulsionUrinary Tract InfectionHeadacheNauseaNauseaDyspnoea
AggressionBronchiectasisMusculoskeletal StiffnessAstheniaAbdominal PainPain In ExtremityInjuryAnxiety
Drug ToxicityCulture PositiveSuicidal IdeationAnxietyDepressionArthralgiaOsteonecrosis Of JawBack Pain
Orthostatic HypotensionRespiratory Tract Infection FungalWeight IncreasedUpper Respiratory Tract InfectionFatigueFallArthralgiaNausea
TremorStem Cell TransplantRespiratory DistressWeight DecreasedInsomniaInsomniaPyrexiaPain
PneumoniaRestrictive Pulmonary DiseasePneumoniaMulti-organ FailureChest PainDepressionInsomniaOsteonecrosis Of Jaw
Renal ImpairmentTracheomalaciaBlood Potassium DecreasedPericardial EffusionAnxietyHeadacheBone DisorderArthralgia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Ambien (zolpidem tartrate) is often used to treat insomnia. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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