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Review: Amitriptyline and Cymbalta





Summary: drug interactions are reported among people who take Amitriptyline and Cymbalta together.

This review analyzes the effectiveness and drug interactions between Amitriptyline and Cymbalta. It is created by eHealthMe based on reports of 1,382 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Amitriptyline and Cymbalta >>>

What are the drugs

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Amitriptyline hydrochloride 7,147 users)

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (view latest outcomes from 49,275 users)

On Dec, 2, 2014: 1,382 people who take Amitriptyline Hydrochloride, Cymbalta are studied

Amitriptyline Hydrochloride, Cymbalta outcomes

Drug combinations in study:
- Amitriptyline Hydrochloride (amitriptyline hydrochloride)
- Cymbalta (duloxetine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Amitriptyline Hydrochloride is effective45.45%
(5 of 11 people)
14.29%
(2 of 14 people)
7.69%
(1 of 13 people)
23.81%
(5 of 21 people)
42.11%
(8 of 19 people)
22.22%
(2 of 9 people)
80.00%
(12 of 15 people)
0.00%
(0 of 1 people)
Cymbalta is effective0.00%
(0 of 8 people)
21.74%
(5 of 23 people)
16.67%
(3 of 18 people)
23.81%
(5 of 21 people)
21.74%
(5 of 23 people)
44.44%
(4 of 9 people)
n/a0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaDizzinessBack PainInsomniaPainDepressionNauseaPain
FallFallDry MouthFatigueMigraineMalaiseMigraineNausea
Abdominal Pain UpperHeadacheHypertensionVomitingConstipationFluid RetentionConstipationAnxiety
AnxietyDrug IneffectiveMenorrhagiaConstipationType 2 Diabetes MellitusType 2 Diabetes MellitusChronic Tonsillar DiseaseFall
DiarrhoeaLoss Of ConsciousnessMeralgia ParaestheticaPainTremorCandidiasisItching ScarInsomnia
Renal FailureAspartate Aminotransferase IncreasedType 2 Diabetes MellitusLymphoedemaMuscle PainDeathSore ThroatFatigue
PruritusAlanine Aminotransferase IncreasedSleep Apnoea SyndromeHypoglycaemiaNauseaStaphylococcal InfectionPainful Red EyesHeadache
ConstipationTremorCarpal Tunnel SyndromeHyperglycaemiaInjuryNauseaEagles SyndromePyrexia
PainBlood Alkaline Phosphatase IncreasedFallMigraineDepressionCondition AggravatedTeeth GrindingArthralgia
RashPneumoniaPancreatitisShort-term Memory LossMemory ImpairmentPruritusDiscolored TeethDizziness

Drug effectiveness by gender :

FemaleMale
Amitriptyline Hydrochloride is effective35.90%
(28 of 78 people)
25.00%
(6 of 24 people)
Cymbalta is effective23.38%
(18 of 77 people)
16.67%
(4 of 24 people)

Most common drug interactions by gender * :

FemaleMale
PainFatigue
NauseaPain
InsomniaPneumonia
FallNausea
AnxietyAnxiety
ArthralgiaChest Pain
HeadacheType 2 Diabetes Mellitus
DiarrhoeaAsthenia
PyrexiaFall
DizzinessDepression

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Amitriptyline Hydrochloride is effectiven/an/an/a8.33%
(3 of 36 people)
31.82%
(7 of 22 people)
18.75%
(9 of 48 people)
18.97%
(11 of 58 people)
17.86%
(5 of 28 people)
Cymbalta is effectiven/an/an/a2.78%
(1 of 36 people)
20.69%
(6 of 29 people)
8.16%
(4 of 49 people)
11.11%
(6 of 54 people)
17.86%
(5 of 28 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Type 2 Diabetes Mellitusn/aLocalised InfectionPainWeight IncreasedPainPainPain
Sensation Of Foreign BodyHypotensionFatigueDeathType 2 Diabetes MellitusAnxietyHeadache
Gallbladder OperationUrinary Tract InfectionAbdominal PainType 2 Diabetes MellitusNauseaNauseaAsthenia
Blood Cholesterol IncreasedDrug IneffectiveInsomniaDizzinessFallPyrexiaFatigue
Gastric UlcerAnxietyLoss Of ConsciousnessAbdominal Pain UpperFallPneumonia
Rectal HaemorrhageMuscle SpasmsInsomniaDiarrhoeaArthralgiaAnaemia
Feeling AbnormalSomnolenceSuicidal IdeationBack PainInsomniaOedema Peripheral
RashMemory ImpairmentAgitationDepressionInjuryWeight Decreased
AnxietyGait DisturbanceNauseaAnxietyDiarrhoeaOsteonecrosis Of Jaw
Erection IncreasedDepressionSomnolenceFatiguePain In JawChest Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Amitriptyline and Cymbalta?

You are not alone! Join a related mobile support group:
- support group for people who take Amitriptyline and Cymbalta
- support group for people who take Amitriptyline Hydrochloride
- support group for people who take Cymbalta

Recent conversations of related support groups:

  • Support group for people who take Cymbalta
    Now found out I have incompetent vein in leg which may be part of the problem had cystocopy and found cysts in kidney, then developed hypertension but no one will diagnose the pain. Now decided it is the same as diabetic neuropathy but as gp and consultant point out I am a long way from being diabetic with perfect blood glucose so thinks it's just guessing and hope

Can you answer these questions (Ask a question):

More questions for: Amitriptyline Hydrochloride, Cymbalta

You may be interested at these reviews (Write a review):

  • Cardio version caused fingernail abnormalities
    Right hip fracture. When prepping for surgery AFIB was found. Surgery was cancelled and they attempted to get AFIB under control. Finally, cardioversion was performed. When my nails started to grow out they all had two horizontal lines that cause the nail to break when it grows out to that point.
  • Amitriptyline involuntary eye movements
    I've began having sparatic involuntary eye movements a few days after I started taking amitriptyline. It's not faint either, it's like my eye is having a seizure, emabrassing. Just wanted to share.
  • Numbness between toes
    This summer I flip flops, with the strap between my toes, almost exclusively. When I switched this fall to regular shoes I noticed a strange, numb sensation between my big toe and second toe. At first I thought it had something to do with the flip flops and thought it would go away. It has been a few weeks now and this has not gone away, and if anything seems to cover a larger area. Oddly enough I mentioned this to a friend today and she says she has the same thing, between her second and third toe...both of us on our right feet. She is also on an antidepressant but couldn't remember which one, but we thought this was an odd coincidence. She explained it as sort of a sensation that there is a hole in your sock or shoe...and that made sense to me...there is still some sensation in the area but it is an odd feeling...something isn't quite right. I am doing some online research right now to try to figure out if this is common with Cymbalta or not?
  • Cymbalta caused joint pain
    I had taken Cymbalta for about 1.5 years and after taking it for a few months, I started having widespread joint pain. The joint pain has gotten worse and is becoming debilitating. Joint pain in the literature as a side affect of the drug but the joint pain seems to be permanent! I have not taken Cymbalta in a couple years but the joint pain has remained. I have had blood tests and my doctor says the tests show it is not arthritis.
  • Transition from mirtazapine to cymbalta (bipolar ii) 6 week duration taken in conjunction with seroquel, propranalol and implanon
    In early September I approached my Psychiatrist to report that I was having sleep paralysis episodes as well as insatiable appetite. I had put on about 20lb in the space of 6 months since the sleep paralysis started.

    My Psychiatrist opted to wean me off the Mirtazapine and onto Cymbalta. I have now been on 60mg of Cymbalta for about 4 weeks and completely titrated off the Mirtazapine.

    I have noted that since switching to Cymbalta that I no longer have the insatiable appetite, nor have I had any further sleep paralysis episodes (though I have had a brain MRI to rule out any physiological issues - yet to receive results).

    I have noticed that I have had mild to moderate rolling nausea with the Cymbalta and that I now have food aversions. Food does not interest me as much anymore and I find that certain foods (mostly processed snacks) are no longer palatable. I also find that I become full after much smaller meal portions.

    I have found that I can no longer drink wine or spirits because they now taste awful however I can still tolerate certain brands of beer. I also no longer enjoy drinking cola.

    I am also on the Implanon Implant. I have had this implant inserted for about 12 months and my cycles have been rather regular. Since starting the Cymbalta I have had some breakthrough bleeding yet my periods have not been as painful, though they have been heavier and longer.

    My Psychiatrist will commence titrating me off the Seroquel in about two weeks and onto Topamax as it is his belief it will be less sedating than the Seroquel and that it will hopefully help as a mood stabiliser, treat my migraines and allow me to come off the Propranolol. he also hopes that I am able to loose some of the weight gained since the sleep paralysis episodes started.

    As a side note regarding the Propranolol, I have naturally low blood pressure and I find while Propranalol is generally an effective migraine prophylactic, (I do get some breakthrough migraines) it does make my blood pressure even lower which leads to dizziness and faintness when I stand up too quickly from a recumbent position.

More reviews for: Amitriptyline Hydrochloride, Cymbalta

Comments from related studies:

  • From this study (1 month ago):

  • Watery very loose stools and occasional watery slight leakage.

    Reply

  • From this study (4 months ago):

  • He is a cancer patient with bowel cancer.he needs the medication because his tumour is hitting off his nerves

    Reply

  • From this study (7 months ago):

  • Occurs periodically usually a short time after food

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used to treat depression. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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