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Review: taking Amitriptyline and Cymbalta together

Summary: drug interactions are reported among people who take Amitriptyline and Cymbalta together.

This review analyzes the effectiveness and drug interactions between Amitriptyline and Cymbalta. It is created by eHealthMe based on reports of 1,382 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Amitriptyline and Cymbalta >>>

What are the drugs

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. (latest outcomes from 7,179 Amitriptyline hydrochloride users)

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from 49,355 Cymbalta users)

On Feb, 2, 2015: 1,382 people who take Amitriptyline Hydrochloride, Cymbalta are studied

Amitriptyline Hydrochloride, Cymbalta outcomes

Drug combinations in study:
- Amitriptyline Hydrochloride (amitriptyline hydrochloride)
- Cymbalta (duloxetine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Amitriptyline Hydrochloride is effective45.45%
(5 of 11 people)
14.29%
(2 of 14 people)
7.69%
(1 of 13 people)
23.81%
(5 of 21 people)
42.11%
(8 of 19 people)
22.22%
(2 of 9 people)
80.00%
(12 of 15 people)
0.00%
(0 of 1 people)
Cymbalta is effective0.00%
(0 of 8 people)
21.74%
(5 of 23 people)
16.67%
(3 of 18 people)
23.81%
(5 of 21 people)
21.74%
(5 of 23 people)
44.44%
(4 of 9 people)
n/a0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaDizzinessBack PainInsomniaPainDepressionNauseaPain
FallFallDry MouthFatigueMigraineMalaiseMigraineNausea
Abdominal Pain UpperHeadacheHypertensionVomitingConstipationFluid RetentionConstipationAnxiety
AnxietyDrug IneffectiveMenorrhagiaConstipationType 2 Diabetes MellitusType 2 Diabetes MellitusChronic Tonsillar DiseaseFall
DiarrhoeaLoss Of ConsciousnessMeralgia ParaestheticaPainTremorCandidiasisItching ScarInsomnia
Renal FailureAspartate Aminotransferase IncreasedType 2 Diabetes MellitusLymphoedemaMuscle PainDeathSore ThroatFatigue
PruritusAlanine Aminotransferase IncreasedSleep Apnoea SyndromeHypoglycaemiaNauseaStaphylococcal InfectionPainful Red EyesHeadache
ConstipationTremorCarpal Tunnel SyndromeHyperglycaemiaInjuryNauseaEagles SyndromePyrexia
PainBlood Alkaline Phosphatase IncreasedFallMigraineDepressionCondition AggravatedTeeth GrindingArthralgia
RashPneumoniaPancreatitisShort-term Memory LossMemory ImpairmentPruritusDiscolored TeethDizziness

Drug effectiveness by gender :

FemaleMale
Amitriptyline Hydrochloride is effective35.90%
(28 of 78 people)
25.00%
(6 of 24 people)
Cymbalta is effective23.38%
(18 of 77 people)
16.67%
(4 of 24 people)

Most common drug interactions by gender * :

FemaleMale
PainFatigue
NauseaPain
InsomniaPneumonia
FallNausea
AnxietyAnxiety
ArthralgiaChest Pain
HeadacheType 2 Diabetes Mellitus
DiarrhoeaAsthenia
PyrexiaFall
DizzinessDepression

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Amitriptyline Hydrochloride is effectiven/an/an/a8.33%
(3 of 36 people)
31.82%
(7 of 22 people)
18.75%
(9 of 48 people)
18.97%
(11 of 58 people)
17.86%
(5 of 28 people)
Cymbalta is effectiven/an/an/a2.78%
(1 of 36 people)
20.69%
(6 of 29 people)
8.16%
(4 of 49 people)
11.11%
(6 of 54 people)
17.86%
(5 of 28 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Type 2 Diabetes Mellitusn/aLocalised InfectionPainWeight IncreasedPainPainPain
Sensation Of Foreign BodyHypotensionFatigueDeathType 2 Diabetes MellitusAnxietyHeadache
Gallbladder OperationUrinary Tract InfectionAbdominal PainType 2 Diabetes MellitusNauseaNauseaAsthenia
Blood Cholesterol IncreasedDrug IneffectiveInsomniaDizzinessFallPyrexiaFatigue
Gastric UlcerAnxietyLoss Of ConsciousnessAbdominal Pain UpperFallPneumonia
Rectal HaemorrhageMuscle SpasmsInsomniaDiarrhoeaArthralgiaAnaemia
Feeling AbnormalSomnolenceSuicidal IdeationBack PainInsomniaOedema Peripheral
RashMemory ImpairmentAgitationDepressionInjuryWeight Decreased
AnxietyGait DisturbanceNauseaAnxietyDiarrhoeaOsteonecrosis Of Jaw
Erection IncreasedDepressionSomnolenceFatiguePain In JawChest Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Amitriptyline and Cymbalta?

You are not alone! Join a related mobile support group:
- support group for people who take Amitriptyline and Cymbalta
- support group for people who take Amitriptyline Hydrochloride
- support group for people who take Cymbalta

Can you answer these questions (Ask a question):

More questions for: Amitriptyline Hydrochloride, Cymbalta

You may be interested at these reviews (Write a review):

  • Terrible excessive sweating from hydrochlorothiazide
    I guess I fit the profile of who gets excessive sweating from HCTZ. I am a 65 year old female and suffered from excessive sweating for two years. With just very little exertion, I would pour sweat from the top of my head. It would run into my face and all over my hair. My hair would be ringing wet. I had heavy perspiration in the groin area and down my back also. I had to change clothing 2-3 times a day and wash up or shower that many times also. The doctor tried changing my Cymbalta and put me on Wellbutrin instead. It did absolutely no good. I went off the wellbutrin and back onto the Cymbalta. I did some research and saw that HCTZ could cause excessive sweating. Both my doctor and my pharmacist said that they had never heard of that. I went off the HCTZ, and my sweating stopped almost immediately. My doctor and my pharmacist were very surprised. I'm one of those people who frequently have different reactions to drugs than are typical. If you're having excessive perspiration and are on HCTZ, try going off of it. It just may be the culprit!
  • Cymbalta side effects
    Starting Cymbalta, side effects were dizzy,felt drugged. Helped with Arthritis pain. About six weeks after i started i developed rectal bleeding.Doctor had me stop Cymbalta and use Tramadol as needed for withdrawal.
  • Cardio version caused fingernail abnormalities
    Right hip fracture. When prepping for surgery AFIB was found. Surgery was cancelled and they attempted to get AFIB under control. Finally, cardioversion was performed. When my nails started to grow out they all had two horizontal lines that cause the nail to break when it grows out to that point.
  • Amitriptyline involuntary eye movements
    I've began having sparatic involuntary eye movements a few days after I started taking amitriptyline. It's not faint either, it's like my eye is having a seizure, emabrassing. Just wanted to share.
  • Numbness between toes
    This summer I flip flops, with the strap between my toes, almost exclusively. When I switched this fall to regular shoes I noticed a strange, numb sensation between my big toe and second toe. At first I thought it had something to do with the flip flops and thought it would go away. It has been a few weeks now and this has not gone away, and if anything seems to cover a larger area. Oddly enough I mentioned this to a friend today and she says she has the same thing, between her second and third toe...both of us on our right feet. She is also on an antidepressant but couldn't remember which one, but we thought this was an odd coincidence. She explained it as sort of a sensation that there is a hole in your sock or shoe...and that made sense to me...there is still some sensation in the area but it is an odd feeling...something isn't quite right. I am doing some online research right now to try to figure out if this is common with Cymbalta or not?

More reviews for: Amitriptyline Hydrochloride, Cymbalta

Comments from related studies:

  • From this study (4 months ago):

  • Watery very loose stools and occasional watery slight leakage.

    Reply

  • From this study (7 months ago):

  • He is a cancer patient with bowel cancer.he needs the medication because his tumour is hitting off his nerves

    Reply

  • From this study (10 months ago):

  • Occurs periodically usually a short time after food

    Reply

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Complete drug side effects:

On eHealthMe, Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used to treat migraine. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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