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Review: Amitriptyline and Cymbalta

This review analyzes the effectiveness and drug interactions between Amitriptyline and Cymbalta. It is created by eHealthMe based on reports of 1,377 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Amitriptyline and Cymbalta >>>

What are the drugs

Amitriptyline hydrochloride (latest outcomes from 7,059 users) has active ingredients of amitriptyline hydrochloride. It is often used in migraine.

Cymbalta (latest outcomes from 49,102 users) has active ingredients of duloxetine hydrochloride. It is often used in depression.

On Jul, 16, 2014: 1,377 people who take Amitriptyline Hydrochloride, Cymbalta are studied

Amitriptyline Hydrochloride, Cymbalta outcomes

Drug combinations in study:
- Amitriptyline Hydrochloride (amitriptyline hydrochloride)
- Cymbalta (duloxetine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Amitriptyline Hydrochloride is effective45.45%
(5 of 11 people)
14.29%
(2 of 14 people)
8.33%
(1 of 12 people)
21.05%
(4 of 19 people)
44.44%
(8 of 18 people)
22.22%
(2 of 9 people)
80.00%
(12 of 15 people)
0.00%
(0 of 1 people)
Cymbalta is effective0.00%
(0 of 8 people)
21.74%
(5 of 23 people)
17.65%
(3 of 17 people)
21.05%
(4 of 19 people)
19.05%
(4 of 21 people)
44.44%
(4 of 9 people)
n/a0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaDizzinessBack PainInsomniaPainDepressionNauseaPain
FallFallDry MouthFatigueMigraineMalaiseMigraineNausea
Abdominal Pain UpperHeadacheHypertensionPainType 2 Diabetes MellitusFluid RetentionConstipationAnxiety
AnxietyDrug IneffectiveMenorrhagiaVomitingTremorType 2 Diabetes MellitusChronic Tonsillar DiseaseFall
DiarrhoeaLoss Of ConsciousnessSleep Apnoea SyndromeMigraineSuicidal IdeationCandidiasisItching ScarInsomnia
Renal FailureAlanine Aminotransferase IncreasedType 2 Diabetes MellitusMental Status ChangesConstipationDeathSore ThroatFatigue
PruritusAspartate Aminotransferase IncreasedMeralgia ParaestheticaLymphoedemaNauseaStaphylococcal InfectionPainful Red EyesHeadache
ConstipationBlood Alkaline Phosphatase IncreasedCarpal Tunnel SyndromeNeuropathy PeripheralFatigueNauseaEagles SyndromePyrexia
PainTremorFallSkin CandidaEpilepsyCondition AggravatedTeeth GrindingArthralgia
RashPneumoniaPancreatitisObesityVision BlurredPruritusDiscolored TeethDizziness

Drug effectiveness by gender :

FemaleMale
Amitriptyline Hydrochloride is effective36.36%
(28 of 77 people)
23.81%
(5 of 21 people)
Cymbalta is effective22.37%
(17 of 76 people)
14.29%
(3 of 21 people)

Most common drug interactions by gender * :

FemaleMale
PainFatigue
NauseaPain
InsomniaPneumonia
FallAnxiety
AnxietyNausea
ArthralgiaChest Pain
HeadacheType 2 Diabetes Mellitus
PyrexiaAsthenia
DiarrhoeaFall
DizzinessDepression

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Amitriptyline Hydrochloride is effectiven/an/an/a8.33%
(3 of 36 people)
31.82%
(7 of 22 people)
18.75%
(9 of 48 people)
19.61%
(10 of 51 people)
21.74%
(5 of 23 people)
Cymbalta is effectiven/an/an/a2.78%
(1 of 36 people)
20.69%
(6 of 29 people)
8.16%
(4 of 49 people)
10.64%
(5 of 47 people)
18.18%
(4 of 22 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Type 2 Diabetes Mellitusn/aLocalised InfectionPainWeight IncreasedPainPainPain
Sensation Of Foreign BodyHypotensionFatigueDeathType 2 Diabetes MellitusAnxietyHeadache
Gallbladder OperationUrinary Tract InfectionAbdominal PainType 2 Diabetes MellitusNauseaNauseaAsthenia
Blood Cholesterol IncreasedDrug IneffectiveInsomniaDizzinessFallPyrexiaFatigue
Gastric UlcerAnxietyLoss Of ConsciousnessAbdominal Pain UpperFallPneumonia
Rectal HaemorrhageMuscle SpasmsInsomniaDiarrhoeaArthralgiaAnaemia
Feeling AbnormalSomnolenceSuicidal IdeationBack PainInsomniaWeight Decreased
RashMemory ImpairmentAgitationDepressionInjuryOedema Peripheral
AnxietyGait DisturbanceNauseaAnxietyDiarrhoeaOsteonecrosis Of Jaw
Erection IncreasedDepressionSomnolenceFatiguePain In JawChest Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Amitriptyline and Cymbalta
- group for people who take Amitriptyline Hydrochloride
- group for people who take Cymbalta

Comments from related studies:

  • From this study (2 months ago):

  • Occurs periodically usually a short time after food

    Reply

  • From this study (3 months ago):

  • 3 weeks on Amitriptyline and currently experiencing a migraine for 3 days now.
    Had root canal two weeks ago; percocets for pain following that, but not in past 5-7 days. Still have residual pain in jaw and along jawline up to ear from that. Have been taking Cymbalta for 2+ months with great results.

    Reply

  • From this study (3 months ago):

  • severe vertigo for about 2 years.stress makes it worse.if i can keep my head still and dont move or lean my head backwards it will stop.Has lasted for 2 or 3 weeks at a time.Been so bad that i couldnt even walk.

    Reply

    Happyseniorchic on May, 1, 2014:

    I wanted to comment on the lady over 60 that complained about Vertigo. My experience was very similar to the lady who stated she learned a maneuver to help with her vertigo. My ENT put me through a series of balance tests. I failed all the tests and was diagnosed with Mineers disease. This is very much like vertigo but your inner ear canals and sinuses do not completely get rid of mucus or fluid that builds up. Finally after many years I was able to get on a diuretic,that works at deceasing the amount of fluid that builds up in my ear canals. There are little ear filters, much like hair like that are suppose to be able to reset with an adjustment. Mine situation was much different. Hopefully those people who read this will get advice from an ENT and allow them to further test you. There is also a shot that my ENT gives me yearly to cut down the accumulation of fluid in the ears. I forgot to add that with the accumulation of fluid in my ear canals I did not recover from a cold. Instead one night I fell under my bed and received a concussion. I was Hospitalized for one week due to the severe infection in both ears.

    Reply

    Dotty on Apr, 27, 2014:

    I used to suffer from vertigo like you, until my doctor told me to watch a Youtube video about a vertigo treatment called the epley maneuver. My husband helped me with the moves. We had to do it twice. That was two years ago! Good luck.

    Reply

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Complete drug side effects:

On eHealthMe, Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used to treat migraine. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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