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Review: taking Amitriptyline and Wellbutrin together

Summary: drug interactions are reported among people who take Amitriptyline and Wellbutrin together.

This review analyzes the effectiveness and drug interactions between Amitriptyline and Wellbutrin. It is created by eHealthMe based on reports of 1,477 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 16, 2015: 1,477 people who take Amitriptyline Hydrochloride, Wellbutrin are studied

Amitriptyline Hydrochloride, Wellbutrin outcomes

Drug combinations in study:
- Amitriptyline Hydrochloride (amitriptyline hydrochloride)
- Wellbutrin (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Amitriptyline Hydrochloride is effective20.00%
(2 of 10 people)
(5 of 20 people)
(2 of 8 people)
(10 of 20 people)
(6 of 15 people)
(6 of 17 people)
(0 of 2 people)
(0 of 1 people)
Wellbutrin is effective22.22%
(2 of 9 people)
(2 of 15 people)
(5 of 17 people)
(5 of 16 people)
(8 of 24 people)
(9 of 15 people)
(2 of 4 people)
(1 of 1 people)

Drug effectiveness by gender :

Amitriptyline Hydrochloride is effective33.80%
(24 of 71 people)
(7 of 22 people)
Wellbutrin is effective36.00%
(27 of 75 people)
(7 of 25 people)

Drug effectiveness by age :

Amitriptyline Hydrochloride is effectiven/an/a100.00%
(1 of 1 people)
(4 of 31 people)
(7 of 61 people)
(9 of 77 people)
(9 of 38 people)
(1 of 6 people)
Wellbutrin is effectiven/an/a50.00%
(1 of 2 people)
(10 of 36 people)
(6 of 69 people)
(9 of 78 people)
(7 of 42 people)
(1 of 6 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Drug IneffectiveDepressionType 2 Diabetes MellitusFatigueDiabetic NeuropathyDepressionInsomniaDepression
AnxietyNauseaMultiple AllergiesNauseaDiabetes Mellitus Inadequate ControlAnxietyDepressionPain
InsomniaAnxietyMuscle SpasmsGastrooesophageal Reflux DiseaseDepressionLoss Of ConsciousnessExhaustion, Fatigue, Lethargy, Tiredness, WearinessAnxiety
AgitationSuicide AttemptHyperlipidaemiaDepressionWeight IncreasedAggressionPtsdNausea
AmnesiaHeadacheDiabetic NeuropathyConstipationBlood Glucose IncreasedBipolar DisorderInsomnia NecArthralgia
AggressionAnorexiaHypercholesterolaemiaDecreased AppetiteDiabetic RetinopathySuicidal IdeationAnxiety NecBack Pain
ConvulsionSuicidal IdeationNauseaDiarrhoeaProteinuriaWeight GainObesityFatigue
Feeling AbnormalHeart Rate IrregularBlood Cholesterol IncreasedCardio-respiratory ArrestBlood Triglycerides IncreasedIntentional OverdoseWeight IncreasedWeight Increased
DyskinesiaSupraventricular ExtrasystolesSciaticaUrosepsisRenal DisorderSuicide AttemptHyperglycaemiaHeadache
Respiratory Tract InfectionVentricular ExtrasystolesBack PainHypertensionType 2 Diabetes MellitusCognitive DisorderTardive DyskinesiaFall

Most common drug interactions by gender * :

Weight IncreasedBack Pain
DiarrhoeaMusculoskeletal Pain
HeadacheWeight Decreased
FallAtrial Fibrillation

Most common drug interactions by age * :

Diabetes MellitusSudden DeathCompleted SuicideDepressionWeight IncreasedDepressionPainDepression
DeathHeadachePain In ExtremityDepressionPainAnxietyNausea
AggressionMuscle SpasmsDyspnoeaAnxietyArthralgiaFatigue
SyncopeConstipationBack PainBack PainNauseaAnxiety
NauseaHypoaesthesiaType 2 Diabetes MellitusHyperhidrosisFallFall
InsomniaAnxietyFatigueChest PainDiarrhoeaCardiac Failure Congestive
Memory ImpairmentDrug IneffectiveSuicidal IdeationType 2 Diabetes MellitusDepressionConfusional State
RashLoss Of ConsciousnessAnxietyFallAnaemiaPneumonia
Rectal HaemorrhageBipolar Ii DisorderNauseaDiabetes MellitusConstipationSyncope

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Amitriptyline Hydrochloride
- support group for people who take Wellbutrin

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used to treat migraine. Wellbutrin (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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