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Review: Amitriptyline and Zanaflex





Summary: drug interactions are reported among people who take Amitriptyline and Zanaflex together.

This review analyzes the effectiveness and drug interactions between Amitriptyline and Zanaflex. It is created by eHealthMe based on reports of 773 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Amitriptyline and Zanaflex >>>

What are the drugs

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Amitriptyline hydrochloride 7,147 users)

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from Zanaflex 7,305 users)

On Nov, 30, 2014: 773 people who take Amitriptyline Hydrochloride, Zanaflex are studied

Amitriptyline Hydrochloride, Zanaflex outcomes

Drug combinations in study:
- Amitriptyline Hydrochloride (amitriptyline hydrochloride)
- Zanaflex (tizanidine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Amitriptyline Hydrochloride is effective0.00%
(0 of 3 people)
22.22%
(2 of 9 people)
33.33%
(1 of 3 people)
40.00%
(2 of 5 people)
0.00%
(0 of 4 people)
0.00%
(0 of 2 people)
40.00%
(2 of 5 people)
n/a
Zanaflex is effective0.00%
(0 of 3 people)
0.00%
(0 of 7 people)
25.00%
(1 of 4 people)
28.57%
(2 of 7 people)
33.33%
(2 of 6 people)
0.00%
(0 of 2 people)
0.00%
(0 of 1 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
FallVomitingTremorFatigueSuicidal IdeationMuscle SpasmsRapid Deep Breathing (hyperventilation)Anxiety
Road Traffic AccidentConstipationSkin DiscolourationConstipationSuicide AttemptHallucination, VisualExhaustion, Fatigue, Lethargy, Tiredness, WearinessFatigue
SyncopePancreatitisDrug Withdrawal SyndromeHeadacheIntentional OverdoseWeight Gain - UnintentionalFall
ErythemaHysterectomyDuodenal UlcerIrritabilityDrug IneffectiveSeizure Like PhenomenaPain
Head InjuryHyperglycaemiaAnxietyEmotional DistressDepressionMuscle FibrosisNausea
Depressed Level Of ConsciousnessSwollen TongueArthralgiaDepressed MoodHallucination, VisualDrug Ineffective
MalaiseTongue DryCushingoidCondition AggravatedFatigueConstipation
AmnesiaHospitalisationDehydrationNeck PainHypokalaemiaInsomnia
AnxietyOral ThrushRigorsConfusionMotion SicknessDepression
Cerebrovascular AccidentSwelling Of The Ankles - Feet - LegsVision BlurredGeneral Physical Health DeteriorationCharley HorseAsthenia

Drug effectiveness by gender :

FemaleMale
Amitriptyline Hydrochloride is effective16.67%
(4 of 24 people)
42.86%
(3 of 7 people)
Zanaflex is effective12.50%
(3 of 24 people)
33.33%
(2 of 6 people)

Most common drug interactions by gender * :

FemaleMale
FatigueAnxiety
FallDepression
NauseaConstipation
PainInsomnia
Chest PainDrug Dependence
AnxietyAsthenia
DyspnoeaDrug Ineffective
Drug IneffectiveHeadache
PyrexiaDrug Withdrawal Syndrome
HypertensionFatigue

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Amitriptyline Hydrochloride is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 7 people)
12.00%
(3 of 25 people)
28.57%
(2 of 7 people)
7.69%
(1 of 13 people)
20.00%
(1 of 5 people)
Zanaflex is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 7 people)
6.06%
(2 of 33 people)
16.67%
(1 of 6 people)
15.38%
(2 of 13 people)
0.00%
(0 of 4 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/an/aDrug IneffectiveAstheniaConstipationFallFall
Drug DependenceInsomniaFatigueAnxietyDehydration
PancreatitisNauseaAnxietyHypertensionDyspnoea
PainFatigueDepressionPyrexiaWeight Decreased
Muscle SpasmsDyspnoeaHeadacheChest PainNausea
SedationPainBack PainCoughAnaemia
ConvulsionTremorDrug IneffectiveMyocardial InfarctionRenal Failure
Cerebrovascular AccidentChest PainHypoaesthesiaPainVomiting
FallVomitingDrug DependenceConstipationPyrexia
ConstipationArthralgiaInsomniaAnaemiaCellulitis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Amitriptyline and Zanaflex?

You are not alone! Join a related mobile support group:
- support group for people who take Amitriptyline and Zanaflex
- support group for people who take Amitriptyline Hydrochloride
- support group for people who take Zanaflex

Can you answer these questions (Ask a question):

  • Does amitriptyline increase eye pressure when you have acute angle closure glaucoma
    Does taking Amitriptyline increase eye pressure in a case of someone who has had acute angle closure glaucoma for 12 years?
  • I take 20mg of amitriptyline each notgh to help me sleep. i have just been diagnosed with parkinsons and need to takae azilect, whihc is an mao-b inhibotor, can i take them together
    Can I take both these tables together? My consultant said it was ok to take both
    but the Amitriptyline instructions say do not take with MAO-B inhibitors, Azilect is an MAO-B inhibitors
  • I cannot get a direct answer from any of my drs.,is my sciatic pain caused by my interstitail cystitus? (1 answer)
    I have had interstitail cystitus for almost four years now.I have been on every kind of drug,other than pain pills.I will not take them,I don't believe in them they only mask the problem and cause addiction.of course,just my belief.I have had d.s.m.o. repetitively for first year and a half twice a week.I have tried physical therapy .I have had five hydrodistention.I just recently had my first hydrodistention with botox injections.nothing has kept me out of pain .even when I am doing good I can only seem to reach a six in my pain level.my frequency average is and has been 30-40Times a day.I am,or,was a chef kitchen manager.could not perform and lost two jobs because of this disease.my flanks,my lower back ,my legs,my arms all ways in pain.pelvic pain is constant.I'd rather not go into further details way too personal.but this has taken my life.I am 35.I have led a fairly healthy life.I have no life now.I am seeking disability .Every Dr. I go to has a different option about the sciatic part of my problem some Dr.s are very sure and as a matter of fact about how it is in conjunction with I.c..others look at me like I'm nuts?why do I limp?why can't I get in and out of a car,or bend down and touch my toes,pick heavy stuff up.just to laugh at times hurts.this is my life ,I gotta wonder ,is there any one else out there going through the same symptoms and no relief?
  • Does bcaa cause migraines?
    I took 3 capsules of BCAA and within the next hour I developed a very aggressive migraine. Believing the migraine may have been separate to the tablets, I took another 3 capsules the next day and again within 1 hour I developed a very aggressive migraines. Has anyone had a similar adverse reaction?
  • I have cfs and have been treated for depression for years.will adderall replace the antidepressants ect that i'm taking now? (3 answers)
    I have a long history of depression and anxiety disorder.I was recently diagnosed with CFS.Now that I know exactly what this disease entails,everything makes perfect sense.My physical symptoms,with the exception of increased debilitating pain over the last 2 years, I had come to accept as normal! Glandular pain,thunderstorm headaches,sweating and chills and pure exhaustion. I have an appointment with my psyciatrist in a week to discuss Adderall. My family doctor wants to try it because i've been on EVERY antidepressant,add ons ect. out there but nothing helps my sheer exhaustion.She's not very familiar with lamotragene and wants his opinion first.Nothing works for me and I truely believe that because of my history with depression,CFS has been overlooked.



    My life has been a living hell. I have an 11yr old daughter,and i feel like i've been robbed of her childhood. Nothing else matters.I am divorced and because of my illness and lack of ability to look after her,I reserve every ounce of energy i have to spend with her. And even then....Mommy's always tired.This is not a life.I've isolated myself so much that all other relationships in my life i've let slip away.



    I've decreased the wellbutrin and lamotrogene before I see my Doctor so hopefully there will be NO reason for him to start me on Adderall.I'm putting so much hope into this treatment. I've used stimulants in the past(ephedrine,bennies)and that's the only time I've ever felt human in the past 10 years.

    I want this to work soooooo bad but i'm a little scared that I'm setting myself up for a fall.

    Any thoughts?

More questions for: Amitriptyline Hydrochloride, Zanaflex

You may be interested at these reviews (Write a review):

  • Amitriptyline involuntary eye movements
    I've began having sparatic involuntary eye movements a few days after I started taking amitriptyline. It's not faint either, it's like my eye is having a seizure, emabrassing. Just wanted to share.
  • Androgel for secondary hypogonadism
    Severe swelling in legs, ankles and feet after being on my feet for more than one hour. Pain in calves and ankles. Feels like they're being squeezed or compressed. Pain dissipates after laying down for a few hours. Swelling never completely dissipates. Always some swelling in ankles.
  • Inflammation in leg and around pelvis
    I gave birth two years ago, in my birthing plan it only stated that i wished for gas & air ONlY.
    I was very confused what with all the gas & air.. So all i heared was midewife saying that she will order pethidine. Next minute i know midwife injects me with pethidine in right buttuck.
    Later that day i feel extreamly bruised where i was injected but thought nothing of it. The bruised feeling continued for two weeks getting stronger and more painful when i just couldnt move. I literally couldnt move my leg, the pain had got so bad that i was screaming and had to call 999.
    Doctors had to check if i was paralyed as i couldnt move my leg. Turns out i was not paralysed.
    I was sent home in crazy pain, screaming. It got so bad that i had to urinate myself in bed as i couldnt move to get out. Again i called 999. Hospital kept me in for a week, they though it was sciatica nerve. MRI scan showed inflammation in leg ad around the pelvis area. In hopital i learnt to walk all over again using zimmer frame. (This all happened in july and i finally was off crutches that october.) a couple of weeks after being out of hospital my left collar bone was swallon badly and i couldnt lift my left arm all the way up and my two fingers in left had were slightly numb. Again i had a MRI scan which showed again inflammation.
    A doctor who had been treating me had told me that he has never seen this before and his does not know what has causes all this.. I suggest the pethidine.. And he quickly snaps and says that he does not know the cause but is certain its not the pethidine. I truely believe it was the pethidine. I made a full recovery, but the past year i have been experiencing discomfort in my buttuck and sometimes hip and shooting pains down my leg and in my foot (all the same side where i was injected)
    I had an MRI scan on my spine lumber & sacral and pelvis but strangly results say its normal.
    What is this pain? And been physio but this did not help it made pain worse. It is all a mystery, i want answers, i know it has something to do with the pethidine.
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
  • Chills while on tizanidine
    Extremely sensitive to cold and have chills several times a day

More reviews for: Amitriptyline Hydrochloride, Zanaflex

Comments from related studies:

  • From this study (1 month ago):

  • peanuts on Mar, 31, 2010:

    my friend is suffering from rhumatory arthertis.and is currenty taking cocaine. oxy cotin,prestine, wellbutrim, predisone 10mg what side effects should she expect ?????

    Reply

    mtntexas on May, 11, 2013:

    Just ask John Belushi

    Reply

    2cents on Mar, 6, 2013:

    I'll second that!

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used to treat depression. Zanaflex (tizanidine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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