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Review: taking Amitriptyline and Zanaflex together

Summary: drug interactions are reported among people who take Amitriptyline and Zanaflex together.

This review analyzes the effectiveness and drug interactions between Amitriptyline and Zanaflex. It is created by eHealthMe based on reports of 773 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Amitriptyline and Zanaflex >>>

What are the drugs

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. (latest outcomes from 7,179 Amitriptyline hydrochloride users)

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from 7,307 Zanaflex users)

On Jan, 29, 2015: 773 people who take Amitriptyline Hydrochloride, Zanaflex are studied

Amitriptyline Hydrochloride, Zanaflex outcomes

Drug combinations in study:
- Amitriptyline Hydrochloride (amitriptyline hydrochloride)
- Zanaflex (tizanidine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Amitriptyline Hydrochloride is effective0.00%
(0 of 3 people)
22.22%
(2 of 9 people)
33.33%
(1 of 3 people)
40.00%
(2 of 5 people)
0.00%
(0 of 4 people)
0.00%
(0 of 2 people)
40.00%
(2 of 5 people)
n/a
Zanaflex is effective0.00%
(0 of 3 people)
0.00%
(0 of 7 people)
25.00%
(1 of 4 people)
28.57%
(2 of 7 people)
33.33%
(2 of 6 people)
0.00%
(0 of 2 people)
0.00%
(0 of 1 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
FallVomitingTremorFatigueSuicidal IdeationMuscle SpasmsRapid Deep Breathing (hyperventilation)Anxiety
Road Traffic AccidentConstipationSkin DiscolourationConstipationSuicide AttemptHallucination, VisualExhaustion, Fatigue, Lethargy, Tiredness, WearinessFatigue
SyncopePancreatitisDrug Withdrawal SyndromeHeadacheIntentional OverdoseWeight Gain - UnintentionalFall
ErythemaHysterectomyDuodenal UlcerIrritabilityDrug IneffectiveSeizure Like PhenomenaPain
Head InjuryHyperglycaemiaAnxietyEmotional DistressDepressionMuscle FibrosisNausea
Depressed Level Of ConsciousnessSwollen TongueArthralgiaDepressed MoodHallucination, VisualDrug Ineffective
MalaiseTongue DryCushingoidCondition AggravatedFatigueConstipation
AmnesiaHospitalisationDehydrationNeck PainHypokalaemiaInsomnia
AnxietyOral ThrushRigorsConfusionMotion SicknessDepression
Cerebrovascular AccidentSwelling Of The Ankles - Feet - LegsVision BlurredGeneral Physical Health DeteriorationCharley HorseAsthenia

Drug effectiveness by gender :

FemaleMale
Amitriptyline Hydrochloride is effective16.67%
(4 of 24 people)
42.86%
(3 of 7 people)
Zanaflex is effective12.50%
(3 of 24 people)
33.33%
(2 of 6 people)

Most common drug interactions by gender * :

FemaleMale
FatigueAnxiety
FallDepression
NauseaConstipation
PainInsomnia
Chest PainDrug Dependence
AnxietyAsthenia
DyspnoeaDrug Ineffective
Drug IneffectiveHeadache
PyrexiaDrug Withdrawal Syndrome
HypertensionFatigue

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Amitriptyline Hydrochloride is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 7 people)
12.00%
(3 of 25 people)
28.57%
(2 of 7 people)
7.69%
(1 of 13 people)
20.00%
(1 of 5 people)
Zanaflex is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 7 people)
6.06%
(2 of 33 people)
16.67%
(1 of 6 people)
15.38%
(2 of 13 people)
0.00%
(0 of 4 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/an/aDrug IneffectiveAstheniaConstipationFallFall
Drug DependenceInsomniaFatigueAnxietyDehydration
PancreatitisAnxietyAnxietyHypertensionDyspnoea
PainNauseaDepressionPyrexiaWeight Decreased
Muscle SpasmsFatigueHeadacheChest PainNausea
SedationDyspnoeaBack PainCoughAnaemia
ConvulsionPainDrug IneffectiveMyocardial InfarctionRenal Failure
Cerebrovascular AccidentTremorHypoaesthesiaPainVomiting
FallChest PainDrug DependenceConstipationPyrexia
ConstipationVomitingInsomniaAnaemiaCellulitis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Amitriptyline and Zanaflex?

You are not alone! Join a related mobile support group:
- support group for people who take Amitriptyline and Zanaflex
- support group for people who take Amitriptyline Hydrochloride
- support group for people who take Zanaflex

Can you answer these questions (Ask a question):

More questions for: Amitriptyline Hydrochloride, Zanaflex

You may be interested at these reviews (Write a review):

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    It seems the roaring in my right ear happens more around taking the tramadol (2-3/day). Of course, I have a (5) day regiment of dexamethasone at (2/day) so maybe there's a connection. This was prescribed by my GP ( highly regarded) for severe lower back bulging disc pain and down left leg. Also prescribed tizanidine for muscle spasms and gabapentin for, maybe nerve swelling? Both at 2/day but I take less of these two.

    Back pain much better but have the roaring in right ear and can't sleep much. Also doing the Dr recommended exercises daily. Will follow up with chiropractic if this doesn't get me there.

    This is a chronic condition, maybe 20 years, no specific injury, just an accumulation of doing dumb things in my youth.
  • Weighted feeling in legs
    I was prescribed tizanidine for lower back pain. I have sciatic nerve issues and fibromyalgia. I also have ptsd and just started remembering skiing accident that I had 19 years ago at age of 15 where I suspect concussion and sinal injury that was left untreated do to to medical neglect (waiting on x-ray results). I thought I was having muscle memories until I seen commercial about varicose vein removal and how weighted or heavy leg feelings where disappeared after surgery. I have very noticeable and thick as a snake varicose veins in my legs. I was looking up side effects I have been having dizziness, numbness in back, nausea, trouble bm while taking pill and hot flashes when messing a dose. I thought why not check deep vein thrombosis (which I suspect I have because of varicose veins). Low and behold there are others with this problem. So now I can add that to list. When I miss a dose my legs feel weighted down. I have only been on tizanidine for 1 month and 2 weeks. Very low dose to start 2mg 3x day. Only other meds are vitamins and metformin (which I am on another break from for 3 days now). I feel side effects of tizanidine are worse than benifits.
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  • Inflammation in leg and around pelvis
    I gave birth two years ago, in my birthing plan it only stated that i wished for gas & air ONlY.
    I was very confused what with all the gas & air.. So all i heared was midewife saying that she will order pethidine. Next minute i know midwife injects me with pethidine in right buttuck.
    Later that day i feel extreamly bruised where i was injected but thought nothing of it. The bruised feeling continued for two weeks getting stronger and more painful when i just couldnt move. I literally couldnt move my leg, the pain had got so bad that i was screaming and had to call 999.
    Doctors had to check if i was paralyed as i couldnt move my leg. Turns out i was not paralysed.
    I was sent home in crazy pain, screaming. It got so bad that i had to urinate myself in bed as i couldnt move to get out. Again i called 999. Hospital kept me in for a week, they though it was sciatica nerve. MRI scan showed inflammation in leg ad around the pelvis area. In hopital i learnt to walk all over again using zimmer frame. (This all happened in july and i finally was off crutches that october.) a couple of weeks after being out of hospital my left collar bone was swallon badly and i couldnt lift my left arm all the way up and my two fingers in left had were slightly numb. Again i had a MRI scan which showed again inflammation.
    A doctor who had been treating me had told me that he has never seen this before and his does not know what has causes all this.. I suggest the pethidine.. And he quickly snaps and says that he does not know the cause but is certain its not the pethidine. I truely believe it was the pethidine. I made a full recovery, but the past year i have been experiencing discomfort in my buttuck and sometimes hip and shooting pains down my leg and in my foot (all the same side where i was injected)
    I had an MRI scan on my spine lumber & sacral and pelvis but strangly results say its normal.
    What is this pain? And been physio but this did not help it made pain worse. It is all a mystery, i want answers, i know it has something to do with the pethidine.

More reviews for: Amitriptyline Hydrochloride, Zanaflex

Comments from related studies:

  • From this study (1 week ago):

  • coolaero on Feb, 7, 2015:

    there wont be side effect other that DEATH

    Reply

    peanuts on Mar, 31, 2010:

    my friend is suffering from rhumatory arthertis.and is currenty taking cocaine. oxy cotin,prestine, wellbutrim, predisone 10mg what side effects should she expect ?????

    Reply

    mtntexas on May, 11, 2013:

    Just ask John Belushi

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used to treat depression. Zanaflex (tizanidine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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