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Review: taking Amlodipine and Simvastatin together

Summary: drug interactions are reported among people who take Amlodipine and Simvastatin together.

This review analyzes the effectiveness and drug interactions between Amlodipine and Simvastatin. It is created by eHealthMe based on reports of 10,408 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

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What are the drugs

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. (latest outcomes from 46,578 Amlodipine users)

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. (latest outcomes from 80,843 Simvastatin users)

On Jan, 26, 2015: 10,408 people who take Amlodipine, Simvastatin are studied

Amlodipine, Simvastatin outcomes

Drug combinations in study:
- Amlodipine (amlodipine besylate)
- Simvastatin (simvastatin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Amlodipine is effective12.50%
(1 of 8 people)
31.58%
(12 of 38 people)
32.26%
(10 of 31 people)
36.96%
(17 of 46 people)
53.73%
(36 of 67 people)
56.10%
(23 of 41 people)
61.11%
(11 of 18 people)
n/a
Simvastatin is effective14.29%
(1 of 7 people)
29.63%
(8 of 27 people)
23.08%
(6 of 26 people)
35.56%
(16 of 45 people)
51.56%
(33 of 64 people)
62.50%
(30 of 48 people)
81.82%
(18 of 22 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaRhabdomyolysisMyalgiaRhabdomyolysisHypertensionAnxietyIntervertebral Disc ProtrusionNausea
FatigueRenal FailureAnxietyDyspnoeaMyalgiaPainInjuryDyspnoea
Renal FailureGastrointestinal HaemorrhageHypertensionDizzinessDepressionDyspnoeaWeight DecreasedPain
MyalgiaDizzinessChest PainChest PainAstheniaRhabdomyolysisBlood Cholesterol IncreasedFatigue
RhabdomyolysisMyalgiaDiabetes MellitusAstheniaMyocardial InfarctionCerebrovascular AccidentInfectionChest Pain
Blood Creatine Phosphokinase IncreasedColitisInsomniaAnxietyInsomniaMyocardial InfarctionDepressionAnxiety
PalpitationsOedema PeripheralAstheniaPain In ExtremityArthralgiaCardiac Failure CongestiveSciaticaAsthenia
DizzinessPancreatitisSkin UlcerMyalgiaPainDepressionFatigueDizziness
Coronary Artery DiseaseMyopathyAmnesiaRenal Failure AcuteMuscle AtrophyNephrogenic Systemic FibrosisDrug IneffectiveMyocardial Infarction
Chest DiscomfortChest PainConstipationDepressionCerebrovascular AccidentEmotional DistressIntervertebral Disc DisorderOedema Peripheral

Drug effectiveness by gender :

FemaleMale
Amlodipine is effective43.81%
(46 of 105 people)
44.44%
(64 of 144 people)
Simvastatin is effective39.18%
(38 of 97 people)
52.11%
(74 of 142 people)

Most common drug interactions by gender * :

FemaleMale
NauseaDyspnoea
PainPain
DyspnoeaChest Pain
FatigueMyocardial Infarction
FallCardiac Failure Congestive
AnxietyAsthenia
Oedema PeripheralRenal Failure
DizzinessAnxiety
AstheniaDizziness
Chest PainRenal Failure Acute

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Amlodipine is effectiven/an/an/a50.00%
(1 of 2 people)
17.86%
(5 of 28 people)
31.71%
(13 of 41 people)
22.39%
(15 of 67 people)
29.34%
(76 of 259 people)
Simvastatin is effectiven/an/an/a0.00%
(0 of 2 people)
12.50%
(3 of 24 people)
44.83%
(13 of 29 people)
27.69%
(18 of 65 people)
30.95%
(78 of 252 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
PneumoniaFaeces DiscolouredOsteoporosis NosHypotensionBlood Cholesterol IncreasedAnxietyNauseaDyspnoea
Renal ImpairmentDuodenal Ulcer HaemorrhageLymphangiomaAstheniaHypertensionPainPainNausea
InfectionDiarrhoeaBack PainDehydrationInsomniaDyspnoeaMyocardial InfarctionPain
PallorLoss Of ConsciousnessPyrexiaBlood Creatinine IncreasedCoughNauseaChest PainFatigue
HyperhidrosisGastrointestinal HaemorrhageHypertensive CrisisAbdominal PainDizzinessChest PainAnxietyFall
Mitral Valve IncompetenceSyncopeVentricular HypertrophyGastrointestinal DisorderAngina PectorisDepressionRenal FailureAsthenia
Haemoglobin DecreasedPruritus NosDehydrationPeritonitisSleep Apnoea SyndromeFatigueDyspnoeaDizziness
Fluid OverloadPurpura NosAlopeciaPharyngeal HaemorrhageCardiac Failure CongestiveDizzinessAstheniaChest Pain
Haematocrit DecreasedPallorHigh Turnover OsteopathyPulmonary CongestionDepressionMyocardial InfarctionDepressionRenal Failure
Pitting OedemaPancreatitis NosSkin NoduleHaemorrhageAbdominal Pain UpperPain In ExtremityFatigueRenal Failure Acute

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Amlodipine and Simvastatin?

You are not alone! Join a related mobile support group:
- support group for people who take Amlodipine and Simvastatin
- support group for people who take Amlodipine
- support group for people who take Simvastatin

Can you answer these questions (Ask a question):

  • What are the medicines you can take for a cold or/and flu who is taking pradaxa?
    I am taking all of the meds listed especially the newest drug, Pradaxa, which my Primary Doctor knows nothing about. He said since it is new there is no data out there on other medicines you can use with Pradaxa. I have now got the Flu and he doesn't know of any medication I can take with me taking Pradaxa. What am I to do, just die? Does anyone out there that is taking Pradaxa and had the Flu or even a cold what medication did you take for flu and/or cold? PLEASE WILL SOMEBODY HELP ME!
  • Can i use a lidocaine patch for back pain if i am taking prograf for anti-rejection post lung transplant?
    Transplant was 6 years ago.
    Has suffered from PTLD on several occasions before.
    Recently hospitalized for Periodic Fever Syndrome.
    Received Interleukin 6 blocker last week and fevers have resolved, but back pain is still present
  • Can i take phentermine with amlodipine besylate?
    I informed the doctor that I was taking the blood pressure med and really wanted to lose weight but need a little help. Put me on B12 shots 1x per week and phentermine 1x per day along w/ multi-vit.
  • I have been on amlodipine for approximately 3 months and have had terrible swelling in my legs and ankles along with pain and itching. should i be taken off this medication?
    I was previously taking Propranolol for blood pressure which didn't bother me at all, but last year I developed a breathing problem and was given Symbicort to help get rid of wheezing. The Symbicort and Propranolol don't mesh well so I was then put on Amlodipine. The swelling, pain and itching occurred right away. I asked the pharmacist about it and also my doctor and they both said a small percentage of people have this problem on this medication. I have tried many times to get my doctor to take me off of this medication but he insists it is best for me, but I disagree. I really don't want to have this problem for the rest of my life and I also won't have any skin left on my legs from the scratching, not to mention the pain that accompanies the swelling which seem to creep up to my knees and thighs and sometimes is so painful I just go to bed to lay down and hopefully the hydroclorithiazide will remove some of this water so that pain will go away. The doctor also doubled my dose of Losartin and Hydroclorithiazide. I'm up about 4-6 times a night going to the bathroom so it also interrupts my sleep. Is anyone else having this problem. I would prefer to go back on the Propranolol and get something other than Symbicort that won't interact with each other. Then I won't have pain and itching all the time. Does anyone have any input on this. I would really appreciate it.

    Thanks. Debbie CB
  • Unexplained hair loss
    Started Amlodipine 5mg about 5 years ago with no side effects and BP controlled until last year when increase noted. Dosage increased to 10mg Aug 2014. Unexpected surgery for bowel obstruction in Sept 2014 took toll on health for 4-6 weeks and also led to very swollen legs and ankles. GP reduced Amlodipine to 5mg again but BP stayed high, although swelling reduced! so prescribed Ramipril 2.5mg along with Amlodipine 5mg a month ago. Almost immediately started to notice hair loss which has steadily got worse in last few weeks and some ankle swelling again. Is medication mix causing hair loss or is it delayed reaction to surgery/anaesthesia?

More questions for: Amlodipine, Simvastatin

You may be interested at these reviews (Write a review):

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    1) Family history of depression, 2) Diagnosed depression 1964-not treated until 1973, 3) Worked in medical field 35 years, 4) Emergency on-call 24/7, 5) Hospital 15 times major depression, 6) Tried nearly all MAOI, TCA, SSRI, SNRI, and ECT. 7) 100% Disability in 1998 for depression. Now at age 70 I have dysthymia, chronic fatigue, COPD, and PTSD. My recommendation to younger people - do not over stress,
    do not smoke, avoid horrific or traumatic situations and try to find some enjoyment in life. If you have symptoms like mine seek early treatment put balance in your life. The often heard recommendations - get plenty of sleep, eat properly, learn to relax and avoid bad habits should not be ignored, they are critical to good physical and mental health.
  • Bloody semen after taking amlodipine besylate
    Was started on Amlodipine Besylate 11-13-14. Now -not quite three weeks later- I have bloody semen (Hematospermia)ranging from light pink to dark red. It was fine, and normal before. I feel it is the medication causing this.
  • Amlo dipine and terazosin
    I have taken combination since 04/13 I have experienced ED lower testosterone and elevated PSA. Prior to that I was taking terazosin and hydrochorizide without any side effects. I stop taking the amlodipine during a juice fast and my PSA levels decreased when I stopped fasting and returned to taking the amlodipine my PSA levels rose.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.

More reviews for: Amlodipine, Simvastatin

Comments from related studies:

  • From this study (1 month ago):

  • Have had a cough for over 2 years, have changed medications, no effect.
    Getting worse last 2,months

    Reply

  • From this study (2 months ago):

  • was in ICU on ventalator for 14 dyas , moved to regular room for 7 days not getting any better mentally

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  • From this study (5 months ago):

  • Vicky on Sep, 23, 2014:

    Accidentally discovered severe joint swelling as a reaction to Novolog during a pump vacation. Been on an insulin pump for 30 years.

    Female, 56

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Amlodipine (amlodipine besylate) is often used to treat high blood pressure. Simvastatin (simvastatin) is often used to treat high blood cholesterol. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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