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Review: Amlodipine and Simvastatin





Summary: drug interactions are reported among people who take Amlodipine and Simvastatin together.

This review analyzes the effectiveness and drug interactions between Amlodipine and Simvastatin. It is created by eHealthMe based on reports of 10,404 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Amlodipine and Simvastatin >>>

What are the drugs

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. (latest outcomes from Amlodipine 46,546 users)

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. (latest outcomes from Simvastatin 80,812 users)

On Nov, 26, 2014: 10,404 people who take Amlodipine, Simvastatin are studied

Amlodipine, Simvastatin outcomes

Drug combinations in study:
- Amlodipine (amlodipine besylate)
- Simvastatin (simvastatin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Amlodipine is effective12.50%
(1 of 8 people)
31.58%
(12 of 38 people)
32.26%
(10 of 31 people)
36.96%
(17 of 46 people)
53.85%
(35 of 65 people)
57.50%
(23 of 40 people)
61.11%
(11 of 18 people)
n/a
Simvastatin is effective14.29%
(1 of 7 people)
29.63%
(8 of 27 people)
23.08%
(6 of 26 people)
35.56%
(16 of 45 people)
52.38%
(33 of 63 people)
61.70%
(29 of 47 people)
80.95%
(17 of 21 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaRhabdomyolysisMyalgiaRhabdomyolysisHypertensionAnxietyIntervertebral Disc ProtrusionNausea
FatigueRenal FailureAnxietyDyspnoeaMyalgiaPainInjuryDyspnoea
Renal FailureGastrointestinal HaemorrhageHypertensionDizzinessDepressionDyspnoeaWeight DecreasedPain
MyalgiaDizzinessChest PainChest PainAstheniaRhabdomyolysisBlood Cholesterol IncreasedFatigue
RhabdomyolysisOedema PeripheralDiabetes MellitusAstheniaMyocardial InfarctionCerebrovascular AccidentInfectionChest Pain
Blood Creatine Phosphokinase IncreasedMyalgiaInsomniaAnxietyInsomniaMyocardial InfarctionDepressionAnxiety
PalpitationsColitisAstheniaPain In ExtremityArthralgiaCardiac Failure CongestiveSciaticaAsthenia
DizzinessPancreatitisSkin UlcerMyalgiaPainDepressionFatigueDizziness
Coronary Artery DiseaseDiarrhoeaAmnesiaRenal Failure AcuteCardiac Failure CongestiveNephrogenic Systemic FibrosisDrug IneffectiveMyocardial Infarction
Chest DiscomfortMyopathyConstipationDepressionMuscle AtrophyEmotional DistressIntervertebral Disc DisorderOedema Peripheral

Drug effectiveness by gender :

FemaleMale
Amlodipine is effective44.23%
(46 of 104 people)
44.37%
(63 of 142 people)
Simvastatin is effective39.58%
(38 of 96 people)
51.43%
(72 of 140 people)

Most common drug interactions by gender * :

FemaleMale
NauseaDyspnoea
PainPain
DyspnoeaChest Pain
FatigueMyocardial Infarction
FallCardiac Failure Congestive
AnxietyAsthenia
Oedema PeripheralAnxiety
DizzinessRenal Failure
AstheniaDizziness
Chest PainRenal Failure Acute

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Amlodipine is effectiven/an/an/a50.00%
(1 of 2 people)
17.86%
(5 of 28 people)
31.71%
(13 of 41 people)
22.39%
(15 of 67 people)
30.12%
(75 of 249 people)
Simvastatin is effectiven/an/an/a0.00%
(0 of 2 people)
12.50%
(3 of 24 people)
44.83%
(13 of 29 people)
27.69%
(18 of 65 people)
31.40%
(76 of 242 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
PneumoniaFaeces DiscolouredOsteoporosis NosHypotensionBlood Cholesterol IncreasedAnxietyNauseaDyspnoea
Renal ImpairmentDuodenal Ulcer HaemorrhageLymphangiomaAstheniaHypertensionPainPainNausea
InfectionDiarrhoeaBack PainDehydrationInsomniaDyspnoeaMyocardial InfarctionPain
PallorLoss Of ConsciousnessPyrexiaBlood Creatinine IncreasedCoughNauseaChest PainFatigue
HyperhidrosisGastrointestinal HaemorrhageHypertensive CrisisAbdominal PainDizzinessChest PainAnxietyAsthenia
Mitral Valve IncompetenceSyncopeVentricular HypertrophyGastrointestinal DisorderAngina PectorisDepressionRenal FailureFall
Haemoglobin DecreasedPruritus NosDehydrationPeritonitisSleep Apnoea SyndromeFatigueDyspnoeaDizziness
Fluid OverloadPurpura NosAlopeciaPharyngeal HaemorrhageCardiac Failure CongestiveDizzinessAstheniaChest Pain
Haematocrit DecreasedPallorHigh Turnover OsteopathyPulmonary CongestionDepressionMyocardial InfarctionDepressionRenal Failure
Pitting OedemaPancreatitis NosSkin NoduleHaemorrhageAbdominal Pain UpperPain In ExtremityFatigueRenal Failure Acute

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Amlodipine and Simvastatin?

You are not alone! Join a related mobile support group:
- support group for people who take Amlodipine and Simvastatin
- support group for people who take Amlodipine
- support group for people who take Simvastatin

Can you answer these questions (Ask a question):

  • Could my occasional a-fib be caused by amlodipine?
    My a-fib comes and goes. A year ago I was having episodes occasionally, usually related to either caffeine or alcohol. After I stopped using either my a-fibs disappeared for 9 months, then in September I started having them again, suddenly increasing this month to 3 times per week. I have been taking 5 mg of amlodipine besylate per day for 7 years. With my cardiologist's permission I just recently reduced my dosage by half since my blood pressure was occasionally very low. Could the reduction in dosage actually have triggered the increased frequency?
  • Can unexplained hypertension be cause by a partial thyroidectomy?
    Doc is trying to figure out why the BP suddenly spiked. I started an exercise regimen after a stress test. I had to be on Metoprolol just to pass the test. Results were no heart-related issues. Lost 6lbs. since starting exercise and don't know if this is Thyroidal or not. No discussion with the doc yet of whether this is related to the thyroidectomy of the past.
  • Will taking simvistatin for dyslipidemia for 5 yrs cause my liver to ache/hurt?
    Been taking simvastatin for about 5 yrs, but in the last 2-3 months have been experiencing ache and sometimes pain from my lower right front emanating around my right side and into my lower back, I have been tested for a possible urinary tract infection that came in negative, doctors are unsure of what could be going on at this point, I am suspicious of the simvastatin affecting my liver but am not sure because of the long time I have been using it and not experiencing any problem until now
  • Alprazolam & amoxicillin
    Have Diverticulitis from having Diverticulosis. Have had high blood pressure for
    about 4 years and it is controlled with the Norvasc & Clonidine. Enlarged prostate is controlled with Flomax & Avodart. Meclizine is for vertigo, take 2 25mg per day, 1 Am & 1 PM. Take 1 Norvasc AM & 1 Flomax PM.
  • When was this study made? can i sue merck?
    I had a cerebral hemmorage and stroke. Was lucky and was at a major casino in Las Vegas. I had surgery through my groin to stop the bleed. I was then left in a coma for 2 months. When I started to wake up I could not move, eat, swallow, I did not know who I was or who my husband of 40 years were. I had to be taught everything over again. I had intense therapy. Physical, speech, cognitive, etc. It was over a year before I caught swallow soft food under supervision. Over a year before I was able to learn how to transfer from my bed to a wheelchair. I lost over 2 years of my life. I am now still recovery but I do have a quality of life that they told me I would never have. I was 2 weeks before my 60 birthday and the only drug I every took was Simvastian. Which was a very common drug I thought was harmless. My story was even published in my local newspaper.

    CAN WE FORM A CLASS ACTION SUIT???

More questions for: Amlodipine, Simvastatin

You may be interested at these reviews (Write a review):

  • A life of depression and fatigue
    1) Family history of depression, 2) Diagnosed depression 1964-not treated until 1973, 3) Worked in medical field 35 years, 4) Emergency on-call 24/7, 5) Hospital 15 times major depression, 6) Tried nearly all MAOI, TCA, SSRI, SNRI, and ECT. 7) 100% Disability in 1998 for depression. Now at age 70 I have dysthymia, chronic fatigue, COPD, and PTSD. My recommendation to younger people - do not over stress,
    do not smoke, avoid horrific or traumatic situations and try to find some enjoyment in life. If you have symptoms like mine seek early treatment put balance in your life. The often heard recommendations - get plenty of sleep, eat properly, learn to relax and avoid bad habits should not be ignored, they are critical to good physical and mental health.
  • Bloody semen after taking amlodipine besylate
    Was started on Amlodipine Besylate 11-13-14. Now -not quite three weeks later- I have bloody semen (Hematospermia)ranging from light pink to dark red. It was fine, and normal before. I feel it is the medication causing this.
  • Amlo dipine and terazosin
    I have taken combination since 04/13 I have experienced ED lower testosterone and elevated PSA. Prior to that I was taking terazosin and hydrochorizide without any side effects. I stop taking the amlodipine during a juice fast and my PSA levels decreased when I stopped fasting and returned to taking the amlodipine my PSA levels rose.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.
  • Not a great experience
    I was on norvasc for two months and had to go off because of severe swelling of feet and legs. Also rapid heart beat and very profuse sweating. it was horrible. It also raised my blood pressure. after going off BP dropped by @least 10 points both diastolic and systolic.

More reviews for: Amlodipine, Simvastatin

Comments from related studies:

  • From this study (3 weeks ago):

  • was in ICU on ventalator for 14 dyas , moved to regular room for 7 days not getting any better mentally

    Reply

  • From this study (3 months ago):

  • Vicky on Sep, 23, 2014:

    Accidentally discovered severe joint swelling as a reaction to Novolog during a pump vacation. Been on an insulin pump for 30 years.

    Female, 56

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Amlodipine (amlodipine besylate) is often used to treat high blood pressure. Simvastatin (simvastatin) is often used to treat high blood cholesterol. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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