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Review: Baclofen and Benadryl





Summary: drug interactions are reported among people who take Baclofen and Benadryl together.

This review analyzes the effectiveness and drug interactions between Baclofen and Benadryl. It is created by eHealthMe based on reports of 406 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Baclofen and Benadryl >>>

What are the drugs

Baclofen has active ingredients of baclofen. It is often used in muscle spasms. (latest outcomes from Baclofen 21,180 users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from Benadryl 29,367 users)

On Dec, 14, 2014: 406 people who take Baclofen, Benadryl are studied

Baclofen, Benadryl outcomes

Drug combinations in study:
- Baclofen (baclofen)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Baclofen is effective0.00%
(0 of 2 people)
33.33%
(1 of 3 people)
0.00%
(0 of 3 people)
33.33%
(2 of 6 people)
66.67%
(2 of 3 people)
100.00%
(1 of 1 people)
n/an/a
Benadryl is effective33.33%
(1 of 3 people)
25.00%
(1 of 4 people)
50.00%
(1 of 2 people)
100.00%
(1 of 1 people)
50.00%
(2 of 4 people)
66.67%
(2 of 3 people)
0.00%
(0 of 1 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
HeadacheFatigueConstipationDrug DependenceStomach PainBurning Eyesn/aPain
Suicidal IdeationMicturition Frequency DecreasedHyponatraemiaCoeliac Artery Compression SyndromeMuscle WeaknessNausea
NauseaInterruption Of Aortic ArchIleusAcute Respiratory Distress SyndromeJoint PainFall
FallDrowsinessPostoperative IleusHepatic NecrosisNauseaUrinary Tract Infection
IleusBlood Pressure IncreasedFallConstipationDepression AggravatedVomiting
HyponatraemiaPressure SorePainPneumoniaAnxiety AggravatedAnxiety
PainDiastolic Blood PressureNervousnessDrug Withdrawal SyndromeDiastolic Blood PressureHeadache
Abdominal PainVision BlurredAbnormal DreamsWithdrawal SyndromeFatigueArthralgia
NervousnessPassed OutUrine Output IncreasedSpinal Compression FractureDrowsinessPain In Extremity
Abnormal DreamsMultiple Sclerosis RelapseExcoriationRoad Traffic AccidentPassed OutDyspnoea

Drug effectiveness by gender :

FemaleMale
Baclofen is effective33.33%
(5 of 15 people)
33.33%
(1 of 3 people)
Benadryl is effective46.67%
(7 of 15 people)
33.33%
(1 of 3 people)

Most common drug interactions by gender * :

FemaleMale
NauseaFatigue
FallPain
PainPneumonia
Urinary Tract InfectionNausea
VomitingOsteoarthritis
AnxietyOsteonecrosis Of Jaw
Pain In ExtremityInfection
HeadacheOsteoporosis
DyspnoeaIntervertebral Disc Protrusion
Dry MouthFailure To Thrive

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Baclofen is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
22.22%
(4 of 18 people)
7.14%
(1 of 14 people)
n/a50.00%
(1 of 2 people)
Benadryl is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
22.22%
(4 of 18 people)
21.43%
(3 of 14 people)
n/a50.00%
(1 of 2 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aLymphadenopathyMedical Device ComplicationDyspnoeaNauseaHeadacheFallPain
Lymphoproliferative DisorderDysarthriaPneumoniaDyspnoeaSuicidal IdeationPainNausea
Haematocrit DecreasedXanthochromiaPyrexiaHeadacheNauseaArthralgiaFall
HaematocheziaHeart Rate IncreasedVomitingHyperthyroidismFatigueUrinary Tract InfectionUrinary Tract Infection
Gastric UlcerDrug Withdrawal SyndromeHypotensionHypothyroidismPain In ExtremityAnxietyVomiting
Aphthous StomatitisDeliriumPulmonary EmbolismPneumoniaOedema PeripheralOsteoarthritisConstipation
PneumoniaSleep DisorderBronchitisDizzinessFallSpinal Column StenosisConfusional State
Rectal HaemorrhageHallucinationMental Impairment NosVision BlurredPainEmotional DistressAbdominal Pain
Septicaemia StaphylococcalConvulsionRenal Papillary NecrosisConstipationAstheniaOsteonecrosis Of JawAsthenia
PyrexiaIleusUrinary RetentionPainHysterectomyHypoaesthesiaFatigue

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Baclofen and Benadryl?

You are not alone! Join a related mobile support group:
- support group for people who take Baclofen and Benadryl
- support group for people who take Baclofen
- support group for people who take Benadryl

Can you answer these questions (Ask a question):

More questions for: Baclofen, Benadryl

You may be interested at these reviews (Write a review):

  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
  • Benadryl completed suicide 50 year old
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.
  • Prescribed drugs side effect (1 response)
    I have been on these 2 drugs (Gabapentin and Baclofen) prescribed by my gp for osteoarthritis and nerve damage in my full back.Now also suffering from the grief of losing my beloved companion Harvey (dog),I was diagnosed with deep depression. I was given fluoxetine and have been taking this for almost 4 weeks (along with the other 2 meds) and today I have a very sore tongue and it has been white for a number of days,i am going to the pharmacy tomorrow to seek some advice as I am not sure I should be taking all these together? As I am on the highest dose of depression tablets with the fluoxetine I feel it is unsafe to take with the other 2 as the baclofen can also be used to treat certain types of depression. But I can not do without either and as I am allergic to codeine I am pretty much stuck.

More reviews for: Baclofen, Benadryl

Comments from related studies:

  • From this study (13 months ago):

  • Past distal injuries returning with increased pressure symptoms. Eye pain with movement. Increased pressure and pain with neck movement. Connective tissue disease - Ehlers Danlos Syndrome.

    Reply

  • From this study (2 years ago):

  • I am a 44 year old female with a very low testerone level of 3. I recently just got off of the birth control pill and have suffered from depression and anxiety for half of my life. I have recently reduced the Baclofen and Paxil and have started to feel worse. Can you please let me know the interactions, symptoms and side effects of all these pills?

    Reply

  • From this study (5 years ago):

  • Baclofen I have been taking for 3 months and have had no relief from taking it.

    Reply

Complete drug side effects:

On eHealthMe, Baclofen (baclofen) is often used to treat muscle spasms. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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