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Review: taking Baclofen and Tizanidine together

Summary: drug interactions are reported among people who take Baclofen and Tizanidine together.

This review analyzes the effectiveness and drug interactions between Baclofen and Tizanidine. It is created by eHealthMe based on reports of 1,679 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 9, 2015: 1,679 people who take Baclofen, Tizanidine Hydrochloride are studied

Baclofen, Tizanidine Hydrochloride outcomes

Drug combinations in study:
- Baclofen (baclofen)
- Tizanidine Hydrochloride (tizanidine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Baclofen is effective50.00%
(1 of 2 people)
(1 of 8 people)
(0 of 1 people)
(0 of 4 people)
(1 of 3 people)
(3 of 9 people)
(2 of 6 people)
Tizanidine Hydrochloride is effective0.00%
(0 of 2 people)
(1 of 4 people)
(1 of 2 people)
(2 of 7 people)
(3 of 6 people)
(3 of 5 people)
(4 of 5 people)

Drug effectiveness by gender :

Baclofen is effective23.81%
(5 of 21 people)
(3 of 12 people)
Tizanidine Hydrochloride is effective45.00%
(9 of 20 people)
(5 of 11 people)

Drug effectiveness by age :

Baclofen is effectiven/an/an/a33.33%
(1 of 3 people)
(0 of 8 people)
(0 of 16 people)
(7 of 16 people)
(0 of 5 people)
Tizanidine Hydrochloride is effectiven/an/an/a66.67%
(2 of 3 people)
(0 of 7 people)
(2 of 16 people)
(9 of 15 people)
(1 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
SomnolenceDrug DependenceMalaiseCoeliac Artery Compression SyndromeBiliary DyskinesiaMuscle ContractureFatigueFall
Coeliac Artery Compression SyndromeHepatic NecrosisHypotoniaDrug DependenceBiliary Tract DisorderDiaphragm Muscle WeaknessFallFatigue
Acute Respiratory Distress SyndromeConstipationCondition AggravatedHepatic NecrosisPainUrinary Incontinence AggravatedFacial Bones FractureAsthenia
ConstipationCoeliac Artery Compression SyndromeEosinophiliaPneumoniaDiarrhoeaWalking DisabilityHypotensionMultiple Sclerosis
Drug DependencePneumoniaPleural EffusionAcute Respiratory Distress SyndromeAbdominal Pain UpperHallucination, VisualSyncopeUrinary Tract Infection
Hepatic NecrosisAcute Respiratory Distress SyndromeHypotension NosConstipationNauseaSubdural HaematomaMultiple Sclerosis Relapse
PneumoniaGastritisDiabetes MellitusMalaiseDyspepsiaSinus BradycardiaDepression
ArthralgiaHypotension NosHerniaHypotoniaChange Of Bowel HabitDrug HypersensitivityBack Pain
Muscle SpasticityDrug Withdrawal SyndromeMovement DisorderDrug Withdrawal SyndromeAbdominal PainEncephalomalaciaMuscle Spasms
Influenza Like IllnessHallucinations, MixedBradycardia NosBradycardiaAbdominal DistensionBrain ContusionPain

Most common drug interactions by gender * :

FatigueBack Pain
Multiple SclerosisMuscular Weakness
Multiple Sclerosis RelapseMuscle Spasms
Urinary Tract InfectionPyrexia
NauseaUrinary Tract Infection
Muscle SpasmsAnxiety

Most common drug interactions by age * :

Rectal ProlapseFanconi SyndromeGastritisMuscle SpasmsHypoaesthesiaMultiple SclerosisAstheniaUrinary Tract Infection
VomitingDyspnoeaNauseaPain In ExtremityFallMultiple Sclerosis RelapseFall
RetchingConstipationHypotensionArthralgiaBack PainDepressionFatigue
AminoaciduriaAgitationPulmonary EmbolismOedema PeripheralHeadacheFatigueHypotension
DiarrhoeaGrand Mal ConvulsionMalaiseDeep Vein ThrombosisAstheniaUrinary Tract InfectionConvulsion
Renal Tubular DisorderIleusHypotoniaFatigueMultiple Sclerosis RelapseMuscle SpasmsGait Disturbance
PyrexiaHyperpyrexiaPainBack PainMuscle SpasmsDyspnoeaPneumonia
Muscle TightnessClonic ConvulsionDiarrhoeaDry MouthCondition AggravatedFallSomnolence
FatigueCondition AggravatedMyoclonic JerksHeadacheFatiguePainCondition Aggravated
Muscle SpasticityHypothermiaDyspnoeaArthritisDepressionAnxietyBlood Pressure Increased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Baclofen and Tizanidine on

Do you take Baclofen and Tizanidine?




You are not alone! Join a related support group:
- support group for people who take Baclofen
- support group for people who take Tizanidine Hydrochloride

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Baclofen (baclofen) is often used to treat muscle spasms. Tizanidine Hydrochloride (tizanidine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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