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Review: taking Baclofen and Tylenol together

Summary: drug interactions are reported among people who take Baclofen and Tylenol together. This review analyzes the effectiveness and drug interactions between Baclofen and Tylenol. It is created by eHealthMe based on reports of 1,481 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>


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What are the drugs

Baclofen has active ingredients of baclofen. It is often used in muscle spasms. (latest outcomes from 21,225 Baclofen users)

Tylenol has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from 55,645 Tylenol users)

On May, 15, 2015: 1,480 people who take Baclofen, Tylenol are studied

Baclofen, Tylenol outcomes

Drug combinations in study:
- Baclofen (baclofen)
- Tylenol (acetaminophen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Baclofen is effective0.00%
(0 of 1 people)
(1 of 1 people)
(0 of 2 people)
(0 of 4 people)
(1 of 2 people)
(2 of 4 people)
(1 of 3 people)
Tylenol is effective0.00%
(0 of 1 people)
(1 of 3 people)
(0 of 3 people)
(0 of 3 people)
(0 of 4 people)

Drug effectiveness by gender :

Baclofen is effective30.77%
(4 of 13 people)
(1 of 4 people)
Tylenol is effective8.33%
(1 of 12 people)
(0 of 2 people)

Drug effectiveness by age :

Baclofen is effectiven/an/an/a0.00%
(0 of 1 people)
(1 of 12 people)
(2 of 16 people)
(1 of 8 people)
(1 of 12 people)
Tylenol is effectiven/an/an/a0.00%
(0 of 1 people)
(0 of 11 people)
(0 of 14 people)
(0 of 8 people)
(1 of 11 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PneumoniaHepatitisHypoaesthesiaHypoaesthesiaBone PainPneumoniaDry MouthNausea
HypoxiaPlatelet Count DecreasedParaplegiaParaplegiaDepressionHypoxiaBlood Pressure IncreasedPyrexia
PyrexiaNeutropeniaUrinary Tract InfectionUrinary Tract InfectionParalysisCellulitisMicturition Frequency DecreasedPain
Muscle SpasticityHaemoglobin DecreasedDepressionAnxiety, Apprehension, Feeling Uptight, Jitters, Stress, Stress And Anxiety, TensionHemiparesisMyocardial InfarctionInterruption Of Aortic ArchHeadache
SomnolencePyelonephritisAnxiety AggravatedHigh Blood PressureCerebrovascular AccidentShinglesPressure SoreFall
Progressive Multifocal LeukoencephalopathyHyperthermiaAnxiety, Apprehension, Feeling Uptight, Jitters, Stress, Stress And Anxiety, TensionAnxiety AggravatedAnxietyRectal BleedingFatigueFatigue
HyperthyroidismChillsStress And AnxietyStress And AnxietySleeplessnessVision BlurredUrinary Tract Infection
MalaiseDrug Withdrawal SyndromeNauseaUrinary RetentionRectal BleedingDiastolic Blood PressureDepression
Aspartate Aminotransferase IncreasedSubstance AbuseBone PainDry MouthDizzinessDrowsinessMultiple Sclerosis Relapse
Condition AggravatedGamma-glutamyltransferase IncreasedExhaustion, Fatigue, Lethargy, Tiredness, WearinessDry Eyes AggravatedNauseaConstipationPneumonia

Most common drug interactions by gender * :

Multiple Sclerosis RelapseNausea
HeadacheUrinary Tract Infection
Urinary Tract InfectionAnxiety
Multiple SclerosisPneumonia
Oedema PeripheralFall

Most common drug interactions by age * :

Respiratory FailurePneumoniaElectrocardiogram Qt ProlongedDepressionNauseaPyrexiaPainUrinary Tract Infection
Posterior Reversible Encephalopathy SyndromeAgitationPainPyrexiaHeadacheFatigueFall
Aphthous StomatitisElectrolyte ImbalanceDehydrationArthralgiaMultiple Sclerosis RelapseUrinary Tract InfectionNausea
Muscular WeaknessDiabetes InsipidusHepatic FailureFallPainPneumoniaOedema Peripheral
Lymphoproliferative DisorderMuscle SpasticityDyspnoeaHypoaesthesiaFatigueNauseaPneumonia
ConvulsionHeart Rate IncreasedAstheniaHeadacheNauseaHeadachePain
Gastric UlcerDysarthriaNauseaMultiple Sclerosis RelapseDizzinessMultiple SclerosisHypertension
Haematocrit DecreasedDrug Withdrawal SyndromePyrexiaFatigueDyspnoeaDepressionConfusional State
LymphadenopathyInsomniaVomitingComaBack PainFallBack Pain
HaematocheziaFaeces DiscolouredDyskinesiaUrinary IncontinenceAstheniaPyrexiaPyrexia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Baclofen and Tylenol on

Do you take Baclofen and Tylenol?


You are not alone! Join a related support group:
- support group for people who take Baclofen
- support group for people who take Tylenol

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

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Comments from related studies:

  • From this study (4 months ago):

  • I am waiting for my 2nd revision (3rd attempt) to a supposed routine hip replacement on a 40 year old woman. We found out after the second attempt that as they put it "my bones were just too soft to hold the screws in place, even though I was keeping correct alignment, my bones were just soft." I said like osteoporosis???! They said no, no! Just. soft, like wet wood, from severe arthritis. You think someone would check this before surgery? Right? I don't know.


  • From this study (5 months ago):

  • Difficulty doing daily tasks tire easily and get in very much pain


  • From this study (6 months ago):

  • Bleeding symptoms reduce when off medication for nearly a week. Blood clot type content in loose stool (liquid). blood ranges from very dark to bright in same movement. Amount of blood is concern. There is pain and firm area in between upper pelvic and lower abdomen area that disappears after movement and release of blood. I have had scope tests resulting in small neg pollups, and although have hemorrhoids that may bleed on occasion, stool is loose and no pressure is present at the time on the hemorrhoids


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Complete drug side effects:

On eHealthMe, Baclofen (baclofen) is often used to treat muscle spasms. Tylenol (acetaminophen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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