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Review: taking Buspar and Wellbutrin Sr together

Summary: drug interactions are reported among people who take Buspar and Wellbutrin Sr together.

This review analyzes the effectiveness and drug interactions between Buspar and Wellbutrin Sr. It is created by eHealthMe based on reports of 1,406 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 6, 2015: 1,406 people who take Buspar, Wellbutrin Sr are studied

Buspar, Wellbutrin Sr outcomes

Drug combinations in study:
- Buspar (buspirone hydrochloride)
- Wellbutrin Sr (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Buspar is effective9.52%
(2 of 21 people)
(8 of 34 people)
(6 of 23 people)
(6 of 20 people)
(11 of 25 people)
(6 of 12 people)
(8 of 15 people)
(0 of 1 people)
Wellbutrin Sr is effective18.18%
(2 of 11 people)
(10 of 36 people)
(3 of 17 people)
(11 of 28 people)
(14 of 34 people)
(11 of 21 people)
(10 of 20 people)
(0 of 1 people)

Drug effectiveness by gender :

Buspar is effective29.63%
(32 of 108 people)
(15 of 43 people)
Wellbutrin Sr is effective35.83%
(43 of 120 people)
(17 of 47 people)

Drug effectiveness by age :

Buspar is effectiven/a0.00%
(0 of 1 people)
(0 of 3 people)
(3 of 24 people)
(11 of 49 people)
(16 of 69 people)
(9 of 39 people)
(8 of 46 people)
Wellbutrin Sr is effectiven/a0.00%
(0 of 1 people)
(0 of 4 people)
(8 of 35 people)
(14 of 52 people)
(21 of 73 people)
(11 of 46 people)
(6 of 46 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaVision BlurredDiabetes MellitusGrand Mal ConvulsionWeight IncreasedDepressionExhaustion, Fatigue, Lethargy, Tiredness, WearinessDepression
VomitingDepressionAbdominal PainType 2 Diabetes MellitusDepressionAgitationSerotonin SyndromeAnxiety
Back PainFatigueNauseaSuicidal IdeationDiabetes Mellitus Inadequate ControlAggressionAnorgasmiaNausea
Abdominal Pain UpperNeuropathy PeripheralRetchingNeuropathy PeripheralDiabetic RetinopathyAbnormal DreamsSexual DysfunctionPain
Abdominal DiscomfortOptic NeuropathyDiarrhoeaDiabetes MellitusBlood Glucose IncreasedPulmonary EmbolismAppetite IncreasedDrug Ineffective
Biliary DyskinesiaCondition AggravatedType 2 Diabetes MellitusHyperglycaemiaPost-traumatic Stress DisorderAbnormal BehaviourWeight Above NormalDiabetes Mellitus
Gallbladder InjuryDizzinessCholecystitis ChronicAggressionGeneralised Anxiety DisorderMood AlteredWeight Gain PoorChest Pain
HypertensionRed Blood Cell Count DecreasedVomitingObesityMyocardial InfarctionSerotonin SyndromeLoss Of SmellSuicidal Ideation
Dry MouthLoss Of LibidoBiliary DyskinesiaConvulsionProteinuriaCompleted SuicideLoss Of TasteWeight Decreased
Vision BlurredNauseaPremature BabyAbnormal DreamsSleep DisorderHomicidal IdeationThirstFatigue

Most common drug interactions by gender * :

DepressionDrug Ineffective
NauseaDiabetes Mellitus
PainConfusional State
Chest PainWeight Decreased
FatigueSuicidal Ideation
VomitingChest Pain
Diabetes MellitusWeight Increased

Most common drug interactions by age * :

Weight IncreasedOedema NosNauseaVomitingDiabetes MellitusDepressionDepressionFall
Suicidal IdeationSerum SicknessVomitingDiarrhoeaNauseaAnxietyNauseaDepression
PollakiuriaUrticaria NosAbdominal DiscomfortPainInsomniaChest PainDizzinessDrug Ineffective
Major DepressionMyalgiaGallbladder InjuryType 2 Diabetes MellitusHeadachePainWeight DecreasedFatigue
Double UreterDyspnoea NosBiliary DyskinesiaDyspnoeaDrug DependenceType 2 Diabetes MellitusPainHypertension
Maternal Drugs Affecting FoetusArthralgiaAbdominal Pain UpperAbdominal PainWeight IncreasedDiabetes MellitusAstheniaDizziness
Jaundice NosBronchospasm NosBack PainNauseaDiabetic NeuropathyOedema PeripheralVomitingVision Blurred
Ventricular Septal DefectMiddle InsomniaAbdominal PainEczemaSuicidal IdeationDrug IneffectiveChest PainConstipation
Pulmonary Artery StenosisPainPneumothoraxAnxietyWeight DecreasedFatigueDyspnoea
InjuryAnxietyCholecystitis ChronicDyspnoeaRashDrug Withdrawal SyndromeNausea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Buspar
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Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Buspar (buspirone hydrochloride) is often used to treat stress and anxiety. Wellbutrin Sr (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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