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Review: taking Cardizem and Xarelto together

Summary: drug interactions are reported among people who take Cardizem and Xarelto together.

This review analyzes the effectiveness and drug interactions between Cardizem and Xarelto. It is created by eHealthMe based on reports of 100 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Cardizem and Xarelto >>>

What are the drugs

Cardizem has active ingredients of diltiazem hydrochloride. It is often used in high blood pressure. (latest outcomes from 16,424 Cardizem users)

Xarelto has active ingredients of rivaroxaban. It is often used in atrial fibrillation/flutter. (latest outcomes from 4,739 Xarelto users)

On Jan, 26, 2015: 100 people who take Cardizem, Xarelto are studied

Cardizem, Xarelto outcomes

Drug combinations in study:
- Cardizem (diltiazem hydrochloride)
- Xarelto (rivaroxaban)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Cardizem is effective33.33%
(1 of 3 people)
(1 of 3 people)
(0 of 1 people)
(2 of 4 people)
(1 of 1 people)
Xarelto is effective100.00%
(2 of 2 people)
(1 of 2 people)
(1 of 2 people)
(1 of 2 people)
(1 of 1 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Hepatic Enzyme IncreasedHepatic Enzyme IncreasedHepatic Enzyme IncreasedCoughHypertensionn/aNauseaDyspnoea
Gastritis ErosiveGastritis ErosiveGastritis ErosivePain - BackPain - BackGastrointestinal Haemorrhage
Skeletal InjuryGastrointestinal HaemorrhageColon CancerAbdominal PainAbdominal PainHepatic Enzyme Increased
Balance DisorderJaundice CholestaticMelaenaLipidsAstheniaAnaemia
DehydrationDyspnoeaHepatotoxicityCarditisMultiple AllergiesEpistaxis
HallucinationPericardial HaemorrhageAlanine Aminotransferase IncreasedAsthmaHaemoptysis
HypoglycaemiaChest PainErectile DysfunctionFeeling HotGastritis Erosive
HyperkalaemiaCardiac TamponadeHepatocellular InjuryStomach PainFatigue
Decreased AppetiteAbdominal PainEustachian Tube DysfunctionChest Pain
Head InjuryHypotensionAtrial Fibrillation/flutterDizziness

Drug effectiveness by gender :

Cardizem is effective42.86%
(3 of 7 people)
(2 of 5 people)
Xarelto is effective83.33%
(5 of 6 people)
(2 of 4 people)

Most common drug interactions by gender * :

Gastrointestinal HaemorrhageHepatic Enzyme Increased
DizzinessGastritis Erosive
Chest PainHaemoptysis
DehydrationGastrointestinal Haemorrhage
Skeletal InjuryEpistaxis
Balance DisorderHyperkalaemia
Head InjuryHaematuria
FatigueCardiac Failure Congestive

Drug effectiveness by age :

Cardizem is effectiven/an/an/an/an/a0.00%
(0 of 1 people)
(5 of 28 people)
Xarelto is effectiven/an/an/an/an/a0.00%
(0 of 1 people)
(7 of 26 people)

Most common drug interactions by age * :

n/an/an/an/an/aGastrointestinal HaemorrhageGastritis ErosiveDyspnoea
ArrhythmiaHepatic Enzyme IncreasedGastrointestinal Haemorrhage
Gastric UlcerChest PainEpistaxis
FatigueCardiac TamponadeAnaemia
GastritisGastrointestinal HaemorrhageDizziness
Erectile DysfunctionHypotensionAsthenia
Abdominal PainBalance Disorder
Pericardial HaemorrhageHallucination
Jaundice CholestaticSkeletal Injury

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Cardizem and Xarelto?

You are not alone! Join a related mobile support group:
- support group for people who take Cardizem and Xarelto
- support group for people who take Cardizem
- support group for people who take Xarelto

Can you answer these questions (Ask a question):

More questions for: Cardizem, Xarelto

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More reviews for: Cardizem, Xarelto

Comments from related studies:

  • From this study (6 months ago):

  • seems to happen about 6 hours after taking rivaroxaban , always overnight, decreses in the daytime after getting up.


  • From this study (7 months ago):

  • I have had rat bite fever, 1957; pylo9inidal cyst; PVC's, Hypoglycemia,p Hyperglycemia; Esophagitis; Diverticulitis; Ulcerative colitis; heart attack; gall bladder removal; adrenal adenoma; osteoma of the ear canal; kidney stones; prostatitis; agent orange exposure


  • From this study (12 months ago):

  • Just a slight cough, non-productive, involuntary


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Complete drug side effects:

On eHealthMe, Cardizem (diltiazem hydrochloride) is often used to treat high blood pressure. Xarelto (rivaroxaban) is often used to treat atrial fibrillation/flutter. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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