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Review: taking Chlorpheniramine Maleate and Fexofenadine together

Summary: drug interactions are reported among people who take Chlorpheniramine Maleate and Fexofenadine together.

This review analyzes the effectiveness and drug interactions between Chlorpheniramine Maleate and Fexofenadine. It is created by eHealthMe based on reports of 90 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Chlorpheniramine maleate has active ingredients of chlorpheniramine maleate. It is often used in allergies. (latest outcomes from 3,083 Chlorpheniramine maleate users)

Fexofenadine hydrochloride has active ingredients of fexofenadine hydrochloride. It is often used in allergies. (latest outcomes from 1,821 Fexofenadine hydrochloride users)

On Feb, 26, 2015: 90 people who take Chlorpheniramine Maleate, Fexofenadine Hydrochloride are studied

Chlorpheniramine Maleate, Fexofenadine Hydrochloride outcomes

Drug combinations in study:
- Chlorpheniramine Maleate (chlorpheniramine maleate)
- Fexofenadine Hydrochloride (fexofenadine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Chlorpheniramine Maleate is effective0.00%
(0 of 3 people)
(0 of 2 people)
(0 of 1 people)
(1 of 1 people)
Fexofenadine Hydrochloride is effective0.00%
(0 of 2 people)
(0 of 2 people)
(0 of 2 people)
(0 of 1 people)

Drug effectiveness by gender :

Chlorpheniramine Maleate is effective20.00%
(1 of 5 people)
(0 of 2 people)
Fexofenadine Hydrochloride is effective0.00%
(0 of 5 people)
(0 of 2 people)

Drug effectiveness by age :

Chlorpheniramine Maleate is effectiven/an/an/a0.00%
(0 of 3 people)
(0 of 1 people)
(1 of 4 people)
Fexofenadine Hydrochloride is effectiven/an/an/a0.00%
(0 of 3 people)
(0 of 1 people)
(0 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Atrial FibrillationInterstitial Lung Diseasen/aSedationSedationn/an/aCompleted Suicide
Drug Rash With Eosinophilia And Systemic SymptomsLip SwellingDiarrhoeaDiarrhoeaWeight Increased
Cerebral InfarctionHyperglycaemiaProteinuria Present
Multi-organ FailureDiabetes MellitusCardio-respiratory Arrest
Disseminated Intravascular CoagulationInterstitial Lung Disease
SepsisDiabetes Mellitus
PalpitationsElectrocardiogram Qt Corrected Interval Prolonged
Pericardial EffusionAtrial Fibrillation
Pleural EffusionChest Pain
WheezingNephrotic Syndrome

Most common drug interactions by gender * :

Completed SuicideProteinuria Present
Cardio-respiratory ArrestWeight Increased
Abdominal PainElectrocardiogram Qt Corrected Interval Prolonged
Respiratory ArrestDiabetes Mellitus
UrticariaOedema Lower Limb
Cardiac ArrestNephrotic Syndrome
OverdoseRenal Failure Nos
Acute Myeloid LeukaemiaCholecystitis Infective
Acute SinusitisWeight Decreased
SyncopeDisseminated Intravascular Coagulation

Most common drug interactions by age * :

n/an/an/aAbortion SpontaneousWeight IncreasedDiabetes MellitusCompleted SuicideInterstitial Lung Disease
HyperhidrosisNephrotic SyndromePancreatitisCardio-respiratory ArrestAtrial Fibrillation
SedationProteinuria PresentCholecystitis InfectiveRespiratory ArrestPancytopenia
DiarrhoeaHypoproteinaemiaSeptic ShockCardiac ArrestPalpitations
Oedema Lower LimbUrinary Tract InfectionOverdoseChest Pain
Infusion Related ReactionHepatic SteatosisDiabetes MellitusDrug Hypersensitivity
MelaenaBlood Glucose FluctuationBrugada SyndromeAbdominal Pain Nos
Oropharyngeal PainHypertension NosAtrial FibrillationConstipation
InfectionOedema NosPoisoningDisseminated Intravascular Coagulation
Renal FailureBlood Creatine Phosphokinase IncreasedCondition AggravatedBenign Prostatic Hyperplasia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Chlorpheniramine Maleate and Fexofenadine on

Do you take Chlorpheniramine Maleate and Fexofenadine?

You are not alone! Join a related mobile support group:
- support group for people who take Chlorpheniramine Maleate and Fexofenadine
- support group for people who take Chlorpheniramine Maleate
- support group for people who take Fexofenadine Hydrochloride

Can you answer these questions (Ask a question):

More questions for: Chlorpheniramine Maleate, Fexofenadine Hydrochloride

You may be interested at these reviews (Write a review):

  • Swelling and pain in one of my breasts after using fexofanadine
    I took them for one week or two as an anti allergic drug and I found these conditions in my body. Then I stopped it for 6 months as I was away from allergenic country (Australia) and there was no symptoms. When I came back to Australia and needed Fexofenadine again, I used it for 1 week and I again notice swelling and pain in one of my breasts.
  • Wheezing stopped after topamax sessesion
    Wheezing noted by primary physician in this non-smoker. Stopped Topamax per doctor's instruction. 48 hours later was examined by physician and noted that wheezing stopped.
  • Temazepam & fenfexodine
    Is anyone else finding the Temazepam is not working when taken with fenofexedine? I survive on a few hours of sleep a day.
  • Ear popping and swishing
    I had been taking blood thinners and 81 mgs. aspirin for about a year after heart surgery. I then stopped taking the blood thinner and my cardiologist recommended and adult aspirin (325mgs.)

    a few days later I started to experience a popping and swishing in my ears along with waves of dizziness. This happened most often when I bent over but could also happen when I was just sitting. I hoped these symptoms would go away in time as I really wanted to take the aspirin. It didn't get better so I discussed it with my cardiologist who told me to go back to the baby aspirin (81mgs.) The condition improved dramatically within a week but did not resolve completely. Over the past 5 months it is slowly improving until I now only have the popping/swishing/dizzy occasionally. I am hoping the problem will completely resolve in time.

More reviews for: Chlorpheniramine Maleate, Fexofenadine Hydrochloride

Comments from related studies:

  • From this study (11 months ago):

  • I have been struggling with sinusitis for almost 2 years now and they can't stop the dripping my nose from running,down throat to chest, lots of plegm, and have been congested for over a year and half. Since then, have tried me on every sort of antihistimine, Loradine, Zyrtec, Certirizine, and fluticasone spray, which didn't stop running/congestion. Been to ER three times to get on antibiotics since also caused gum disease/gingivitis per Periodontus who states it's underlying medical not dental. Also started taking regular OTC sudafed for congestion, and occasional cough/congestion. Now allergist says my IgG Immoglobins are high and was told that since I have constant bacterial infections. Allergist believes running nose/congestion is from a fungus infection or vasomotor rhinitis and need culture. Am waiting to see ENT. Prior to this last 2 years, my sinus was always controlled and maybe every year to two years, an infection occurred and antibiotics quickly got rid of it, but not this time. I read infections could also cause liver enzymes to rise to and my past blood tests in 2008 shows only had a mild increase in SGPT ALT only. Prior use, I used pain pills, vicodin/codeine/darvocet/, but stay away from then now due to liver enzymes in ALT rising, and only use motrin, sleeping med., cymbalta and occasional fioricet. Had gall bladder infected and removed, and tests show fatty liver and slight kidney lesion, but not enough for them to do anything.


    help on Apr, 9, 2014:

    F, 48, fibromylagia, chronic sinusitis, repeated infections, which believe long-term pain meds cause elevated liver enzymes, went off most, and now because of constant trying of allergy meds, and can't stop running nose, long term infections of bacteria and possibly fungus, so not sure what is causing elevated enzymes.


Complete drug side effects:

On eHealthMe, Chlorpheniramine Maleate (chlorpheniramine maleate) is often used to treat allergies. Fexofenadine Hydrochloride (fexofenadine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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