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Review: Claritin and Methotrexate

This review analyzes the effectiveness and drug interactions between Claritin and Methotrexate. It is created by eHealthMe based on reports of 741 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Claritin and Methotrexate >>>

What are the drugs

Claritin (latest outcomes from 24,181 users) has active ingredients of loratadine. It is often used in allergies.

Methotrexate (latest outcomes from 131,137 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

On Sep, 14, 2014: 741 people who take Claritin, Methotrexate are studied

Claritin, Methotrexate outcomes

Drug combinations in study:
- Claritin (loratadine)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Claritin is effective66.67%
(2 of 3 people)
(0 of 1 people)
(3 of 3 people)
(1 of 2 people)
Methotrexate is effectiven/a33.33%
(1 of 3 people)
(1 of 2 people)
(0 of 2 people)
(1 of 2 people)
(2 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
HypotensionSkin InfectionPancreatitis AcuteRespiratory FailureAstheniaViral InfectionHypertensive EmergencyNausea
PneumonitisPancytopeniaFlatulenceDizzinessArthritisErythemaVentricular HypertrophyDyspnoea
Acute Respiratory Distress SyndromeMacrocytosisFatigueMalaiseDry MouthDiabetes MellitusTricuspid Valve IncompetenceArthralgia
Blood Bilirubin IncreasedPsoriasisGastric PolypsHypoxiaLymphadenopathyOsteoporosisPneumoniaPain
Lung InfectionRashNauseaNauseaDiarrhoeaRotator Cuff SyndromeHerpes ZosterFatigue
Blood Sodium IncreasedLeukopeniaVertigoVomitingArthralgiaUpper Respiratory Tract InfectionRib FracturePyrexia
Pneumonia Respiratory Syncytial ViralConvulsionPyrexiaCoombs Negative Haemolytic AnaemiaDizzinessOsteomyelitis ChronicDecreased AppetiteCough
HypernatraemiaUrticariaEar InfectionBasal Cell CarcinomaRashTachycardiaBronchitisOedema Peripheral
Oxygen Saturation DecreasedUpper Respiratory Tract InfectionDyspepsiaDehydrationMusculoskeletal StiffnessDizzinessMitral Valve IncompetenceHeadache
Neurological SymptomCoughAbdominal DistensionPneumoniaPleural FibrosisStaphylococcal InfectionPulmonary Valve IncompetenceVomiting

Drug effectiveness by gender :

Claritin is effective50.00%
(3 of 6 people)
(3 of 3 people)
Methotrexate is effective28.57%
(2 of 7 people)
(3 of 4 people)

Most common drug interactions by gender * :

Oedema PeripheralNausea
PyrexiaOxygen Saturation Decreased
HypoaesthesiaCondition Aggravated
CoughDrug Ineffective

Drug effectiveness by age :

Claritin is effectiven/an/a100.00%
(1 of 1 people)
(1 of 1 people)
(0 of 1 people)
(3 of 11 people)
(1 of 1 people)
Methotrexate is effectiven/an/a50.00%
(1 of 2 people)
(0 of 1 people)
(1 of 1 people)
(1 of 1 people)
(2 of 11 people)
(0 of 1 people)

Most common drug interactions by age * :

Renal HypertrophyNauseaPneumonitisEpistaxisInjection Site PainArthralgiaNauseaDyspnoea
Bladder DiverticulumDiarrhoeaBlood Bilirubin IncreasedDeep Vein ThrombosisAlanine Aminotransferase IncreasedNauseaArthralgiaNausea
Clostridial InfectionDyspnoeaHypotensionPulmonary EmbolismAphoniaHeadacheAstheniaCough
Reflux NephropathyHeadacheAcute Respiratory Distress SyndromeHaemorrhageHip FractureDrug IneffectiveHypoaesthesiaFatigue
Palatal DisorderSomnolenceAcanthosisPancytopeniaInjection Site Reaction NosHypoaesthesiaDyspnoeaBack Pain
Respiratory Syncytial Virus InfectionNeurological SymptomLung InfectionPurpuraPruritusGait DisturbanceOedema PeripheralOedema Peripheral
Urinary Tract InfectionOxygen Saturation DecreasedHypernatraemiaPancreatitis AcuteLower Limb FracturePruritusVomitingHypertension
MydriasisPneumonia Respiratory Syncytial ViralPain NosErythemaInjection Site HaemorrhagePain In ExtremityPyrexia
PyrexiaBlood Sodium IncreasedRigorsHeadacheInjection Site PainPyrexiaDizziness
HypotensionAcidosis NosOedematous PancreatitisDermatitis NosInjection Site Reaction NosCoughArthralgia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Claritin and Methotrexate?

Get connected! Join a mobile support group:
- group for people who take Claritin and Methotrexate
- group for people who take Claritin
- group for people who take Methotrexate

Comments from related studies:

  • From this study (12 months ago):

  • Lung function tests outcome - OK for someone with Primary Sjogrens Syndrome. Sprirometery Tests - 320 (normal between 300 - 400) GP told me. Hypoxia diagnosed when I went for pre-op testing and again after op. GP told me everything was normal.
    After knee arthroscopy recently - surgeon told me I had chondro-calcinosis (Pseudogout). Now Rheumatologist has informed me that I have real Gout. He is thinking now about putting me on another drug! Nurse Specialist has suggested Iloprost Infusion - yet another drug. I meet none of the risk factors for gout so I am wondering if I am experiencing side effects from the other drugs I am on. I work for the NHS full time and have to for some years to come as I am the only breadwinner. Thanks for your website - very informatve. Kind regards. Chris Kirwan (Mrs)


  • From this study (1 year ago):

  • I want to know if in fact there is a relation between these conditions and if there is any possibility that the adderall which he used for years before getting the other two conditions has anything to do with the two. Also if the chronic asthma medications he was exposed as a baby (proventyl, pulmicort and prednisone). Fyi child has allergy to amoxil. Thank you.


  • From this study (2 years ago):

  • Emma J Sanders on Mar, 12, 2013:

    I am female, 66 yrs old and was living in Las Vegas,NV when my doc prescribed Bystolic for my high blood pressure in Feb/2011. By Feb, 2012, I had an episode of sweating,nausea, cramps, diarrhea and near passing out. Paramedics were call, I was taken to the UMC Emer room. On the 3rd day in the hospital, I was told that the Bystolic I was taking for high blood pressure had weaken my heart to a point that I had acquired A-Fib and that I had to have a pacemaker implanted . WHAT? The cardiologist came in and told me that
    I have a perfectly healthy heart but it was weakened by the Bystolic. 2 days later after having the pacemaker implanted, I had a heart attack. Rushed back to the hospital again. Then I found out that the doctors withdrew the Bystolic without weaning me off of it. Clear warning on medicine bottle, DO NOT DISCONTINUE ABRUPTLY or you could have a ghee art attack. I notified FDA, and the makers of Bystolic (Forest Pharmaceuticals) of my experience. Now I am taking Norvasc. Alone and doing just fine, I have to take aspirin everyday to prevent blood clots because of the pacemaker. Had I died during my heart attack, who would have known that my problem started with the Bystolicd medication.


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Complete drug side effects:

On eHealthMe, Claritin (loratadine) is often used to treat allergen. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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